ZymeworksZYME
13F holders, Q1 2025 (March 31)185holders +12
29new positions
17sold out
6famous investors
$11.91avg. 13F price*
At the end of Q1 2025, 185 institutions reported holding Zymeworks Inc. (ZYME) in their 13F filings, up 12 from Q4 2024. 29 opened new positions and 17 sold out. The largest holders were EcoR1 Capital, LLC ($205.6M), Redmile Group, LLC ($57.0M) and Rubric Capital Management LP ($51.7M). 6 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Zymeworks Inc.
- CUSIP
- 98985Y108
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024 → Q1 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 29 | $13.7M |
| Exits | 17 | $16.7M |
All 13F filers, Q4 2024 → Q1 2025: 9,307,016 shares bought and 5,232,906 shares sold, net +4,074,110 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 185 holders
| EcoR1 Capital, LLC | 12.23% | Add +14.8% | 17,259,548 | $205.6M |
| Redmile Group, LLC | 5.39% | Reduce -1.1% | 4,788,945 | $57.0M |
| Rubric Capital Management LP | 0.93% | Add +10.8% | 4,338,444 | $51.7M |
| BVF Inc. | 2.09% | No change | 4,308,935 | $51.3M |
| BlackRock, Inc. | 0.00% | Reduce -2.3% | 4,089,421 | $48.7M |
| Morgan Stanley | 0.00% | Reduce -3.0% | 4,073,463 | $48.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +184.2% | 3,879,945 | $46.2M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.07% | Add +2.8% | 2,197,879 | $26.2M |
| Perceptive Advisors LLC | 0.79% | Reduce -12.5% | 1,864,672 | $22.2M |
| Vanguard Group Inc. | 0.00% | Reduce -29.1% | 1,767,041 | $21.0M |
| Deutsche Bank AG | 0.01% | Add +0.4% | 1,552,612 | $18.5M |
| Blackstone Inc. | 0.07% | Add +142.7% | 1,382,587 | $16.5M |
| Nextech Invest Ltd. | 3.08% | — | 1,113,946 | $13.3M |
| Tang Capital Management LLC | 0.72% | No change | 1,100,000 | $13.1M |
| State Street Corp. | 0.00% | Add +0.0% | 1,085,133 | $12.9M |
| Dimensional Fund Advisors LP | 0.00% | Add +11.0% | 1,079,458 | $12.9M |
| Prosight Management, LP | 3.75% | Add +16.7% | 957,229 | $11.4M |
| Bridgeway Capital Management, LLC | 0.23% | Add +1.0% | 766,944 | $9.1M |
| Geode Capital Management, LLC | 0.00% | Add +2.2% | 705,035 | $8.4M |
| Samsara Biocapital, LLC | 1.42% | Reduce -33.3% | 666,667 | $7.9M |
| Vestal Point Capital, LP | 0.43% | Add +170.3% | 500,000 | $6.0M |
| Assenagon Asset Management S.A. | 0.01% | Reduce -22.9% | 495,067 | $5.9M |
| Renaissance Technologies | 0.01% | Add +57.7% | 450,600 | $5.4M |
| Granahan Investment Management, LLC | 0.24% | Reduce -0.9% | 407,589 | $4.9M |
| Farallon Capital Management, L.L.C. | 0.03% | Reduce -69.9% | 400,000 | $4.8M |
| Northern Trust Corp. | 0.00% | Reduce -2.0% | 386,923 | $4.6M |
| Jupiter Asset Management Ltd. | 0.04% | No change | 369,499 | $4.4M |
| Empowered Funds, LLC | 0.06% | Add +2.1% | 360,044 | $4.3M |
| Susquehanna International Group, LLP | 0.01% | Add +581.6% | 351,161 | $4.2M |
| Schroder Investment Management Group | 0.00% | Reduce -4.5% | 321,949 | $4.0M |
| Millennium Management | 0.00% | New | 295,606 | $3.5M |
| Silvercrest Asset Management Group LLC | 0.02% | Reduce -0.6% | 280,726 | $3.3M |
| Platinum Investment Management Ltd. | 0.19% | Reduce -9.1% | 278,658 | $3.3M |
| Walleye Capital LLC | 0.04% | Reduce -45.2% | 247,959 | $3.0M |
| Hillsdale Investment Management Inc. | 0.14% | Add +3.0% | 236,925 | $2.8M |
| Trexquant Investment LP | 0.03% | Add +116.5% | 220,809 | $2.6M |
| UBS Group AG | 0.00% | Add +28.4% | 214,300 | $2.6M |
| Picton Mahoney Asset Management | 0.09% | Add +0.7% | 208,029 | $2.5M |
| Norges Bank | 0.00% | No change | 201,700 | $2.4M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -20.0% | 200,047 | $2.4M |
| Nuveen, LLC | 0.00% | — | 198,812 | $2.4M |
| Tejara Capital Ltd | 1.11% | Add +391.5% | 189,409 | $2.3M |
| Wellington Management Group LLP | 0.00% | Reduce -16.8% | 182,246 | $2.2M |
| Federated Hermes, Inc. | 0.00% | Add +0.2% | 181,912 | $2.2M |
| Citadel Advisors | 0.00% | Add +209.6% | 180,670 | $2.2M |
| Opaleye Management Inc. | 0.48% | New | 175,000 | $2.1M |
| Kennedy Capital Management LLC | 0.04% | Reduce -2.6% | 136,319 | $1.6M |
| Jane Street Group, LLC | 0.00% | Add +487.0% | 135,763 | $1.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +1.8% | 133,639 | $1.6M |
| ExodusPoint Capital Management, LP | 0.02% | New | 133,320 | $1.6M |
| Bank of New York Mellon Corp | 0.00% | Add +0.0% | 120,727 | $1.4M |
| Raymond James Financial Inc. | 0.00% | Add +92.5% | 116,711 | $1.4M |
| Verition Fund Management LLC | 0.01% | Add +621.9% | 114,156 | $1.4M |
| Dark Forest Capital Management LP | 0.06% | New | 105,829 | $1.3M |
| Wells Fargo & Company | 0.00% | Reduce -38.9% | 100,309 | $1.2M |
| SG Americas Securities, LLC | 0.00% | Add +266.5% | 98,165 | $1.2M |
| North Growth Management Ltd. | 0.24% | No change | 97,000 | $1.2M |
| O'shaughnessy Asset Management, LLC | 0.01% | Reduce -27.3% | 96,329 | $1.1M |
| Voloridge Investment Management, LLC | 0.00% | Add +118.3% | 95,394 | $1.1M |
| Aquilo Capital Management, LLC | 2.71% | New | 84,482 | $1.0M |
| Rhumbline Advisers | 0.00% | Reduce -20.4% | 82,738 | $985K |
| Swiss National Bank | 0.00% | Reduce -11.2% | 80,100 | $954K |
| Invesco Ltd. | 0.00% | Add +12.7% | 78,206 | $931K |
| Barclays PLC | 0.00% | Reduce -65.8% | 75,430 | $898K |
| Credit Agricole S A | 0.00% | No change | 75,000 | $893K |
| Fisher Asset Management | 0.00% | Add +13.2% | 71,974 | $857K |
| Acuta Capital Partners, LLC | 0.95% | Add +1.8% | 68,459 | $815K |
| Stifel Financial Corp. | 0.00% | Add +4.2% | 67,030 | $798K |
| HRT Financial LP | 0.00% | Reduce -31.9% | 65,380 | $778K |
| Squarepoint Ops LLC | 0.00% | New | 63,602 | $758K |
| D. E. Shaw & Co. | 0.00% | Add +202.8% | 63,099 | $752K |
| Bank of America Corp. | 0.00% | Add +96.0% | 62,131 | $740K |
| Ritholtz Wealth Management | 0.02% | Reduce -18.8% | 60,494 | $720K |
| Royal Bank of Canada | 0.00% | Reduce -6.8% | 56,771 | $676K |
| Alliancebernstein L.P. | 0.00% | No change | 50,030 | $596K |
| ADAR1 Capital Management, LLC | 0.12% | New | 50,000 | $596K |
| Envestnet Asset Management Inc. | 0.00% | Reduce -8.5% | 49,512 | $590K |
| AQR Capital Management | 0.00% | Add +86.0% | 48,485 | $577K |
| Legal & General Group Plc | 0.00% | Reduce -0.6% | 46,790 | $557K |
| Victory Capital Management Inc. | 0.00% | Reduce -14.2% | 44,270 | $527K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | — | 44,175 | $526K |
| California State Teachers Retirement System | 0.00% | No change | 43,783 | $521K |
| Prudential Financial Inc. | 0.00% | Add +116.5% | 42,570 | $507K |
| HighVista Strategies LLC | 0.19% | New | 41,607 | $496K |
| Citigroup Inc. | 0.00% | Reduce -50.5% | 41,198 | $491K |
| Intech Investment Management LLC | 0.00% | Add +18.9% | 40,263 | $480K |
| JPMorgan Chase & Co. | 0.00% | Reduce -65.7% | 38,409 | $457K |
| State of Wisconsin Investment Board | 0.00% | Reduce -42.1% | 37,824 | $450K |
| Commonwealth Equity Services, LLC | 0.00% | Add +21.6% | 37,642 | $448K |
| MetLife Investment Management, LLC | 0.00% | Reduce -1.9% | 33,309 | $397K |
| Tema ETFs LLC | 0.12% | New | 33,001 | $393K |
| NEOS Investment Management LLC | 0.01% | New | 33,001 | $393K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +4.6% | 32,385 | $386K |
| Franklin Resources Inc. | 0.00% | New | 32,160 | $383K |
| AlphaQuest LLC | 0.04% | Add +1028.1% | 31,676 | $377K |
| American Century Companies Inc. | 0.00% | Reduce -22.0% | 31,147 | $371K |
| Journey Strategic Wealth LLC | 0.01% | Add +0.1% | 28,941 | $345K |
| Massachusetts Financial Services Co. | 0.00% | Reduce -2.2% | 26,775 | $319K |
| Corebridge Financial, Inc. | 0.00% | Reduce -1.5% | 26,719 | $318K |
| Bank of Montreal | 0.00% | Reduce -0.1% | 25,912 | $309K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +25.1% | 24,531 | $292K |
| T. Rowe Price Associates Inc. | 0.00% | Add +11.7% | 24,113 | $288K |
| Duncan Williams Asset Management, LLC | 0.10% | New | 22,095 | $263K |
| Schonfeld Strategic Advisors LLC | 0.00% | Reduce -4.0% | 21,900 | $261K |
| Cresset Asset Management, LLC | 0.00% | Reduce -30.8% | 21,320 | $254K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -2.4% | 20,460 | $244K |
| XTX Topco Ltd | 0.01% | Reduce -40.0% | 20,205 | $241K |
| Janus Henderson Group PLC | 0.00% | No change | 18,200 | $225K |
| Susquehanna Fundamental Investments, LLC | 0.00% | Reduce -82.5% | 17,090 | $204K |
| Voya Investment Management LLC | 0.00% | Reduce -73.7% | 15,653 | $186K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 15,340 | $183K |
| ProShare Advisors LLC | 0.00% | Reduce -19.9% | 14,912 | $178K |
| Quantinno Capital Management LP | 0.00% | New | 14,245 | $170K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -5.4% | 13,816 | $165K |
| New York State Common Retirement Fund | 0.00% | No change | 13,371 | $159K |
| Virtus Investment Advisers, LLC | 0.04% | New | 13,006 | $155K |
| FMR LLC | 0.00% | Reduce -41.6% | 12,830 | $153K |
| Magnetar Financial LLC | 0.00% | New | 12,448 | $148K |
| Engineers Gate Manager LP | 0.00% | New | 12,399 | $148K |
| Cibc World Markets Corp. | 0.00% | New | 12,102 | $144K |
| Shell Asset Management Co. | 0.01% | Reduce -2.1% | 12,101 | $144K |
| Jacobs Levy Equity Management, Inc. | 0.00% | Reduce -96.6% | 12,040 | $143K |
| Arizona State Retirement System | 0.00% | Reduce -11.7% | 11,846 | $141K |
| Creative Planning | 0.00% | Add +20640.3% | 11,822 | $141K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 11,669 | $139K |
| Janney Montgomery Scott LLC | 0.00% | Add +12.7% | 11,567 | $138K |
| Teacher Retirement System of Texas | 0.00% | Reduce -18.7% | 11,168 | $133K |
| Man Group plc | 0.00% | New | 10,859 | $129K |
| James Investment Research, Inc. | 0.02% | No change | 10,578 | $126K |
| One Wealth Advisors, LLC | 0.02% | Reduce -25.6% | 10,404 | $124K |
| KLP Kapitalforvaltning As | 0.00% | No change | 10,300 | $123K |
| Exchange Traded Concepts, LLC | 0.00% | Reduce -24.4% | 10,126 | $121K |
| TPG Financial Advisors, LLC | 0.05% | No change | 10,017 | $119K |
| Northwest & Ethical Investments L.P. | 0.00% | Add +83.3% | 10,030 | $119K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 5,616 | $67K |
| Clearstead Advisors, LLC | 0.00% | No change | 5,000 | $60K |
| Simplex Trading, LLC | 0.00% | Add +283.4% | 4,168 | $49K |
| BNP Paribas Financial Markets | 0.00% | Reduce -45.7% | 4,000 | $48K |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 3,843 | $47K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -60.7% | 3,816 | $45K |
| Lazard Asset Management LLC | 0.00% | New | 3,787 | $45K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -93.2% | 3,053 | $36K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +1.5% | 2,330 | $29K |
| Cwm, LLC | 0.00% | Add +1091.2% | 2,299 | $27K |
| Aquatic Capital Management LLC | 0.00% | New | 2,049 | $24K |
| Amalgamated Bank | 0.00% | Add +4.5% | 1,880 | $22K |
| GF Fund Management Co. LTD. | 0.00% | Add +21.9% | 1,763 | $21K |
| Curio Wealth, LLC | 0.01% | Reduce -99.9% | 1 | $15K |
| Sterling Capital Management LLC | 0.00% | Reduce -45.3% | 941 | $11K |
| Wayfinding Financial, LLC | 0.00% | New | 981 | $11K |
| Federation des caisses Desjardins du Quebec | 0.00% | Add +1350.0% | 870 | $10K |
| GAMMA Investing LLC | 0.00% | Add +1.9% | 543 | $6K |
| National Bank of Canada | 0.00% | Reduce -4.4% | 524 | $6K |
| US Bancorp \de | 0.00% | Reduce -13.3% | 423 | $5K |
| Smartleaf Asset Management LLC | 0.00% | Add +65.0% | 401 | $5K |
| Osaic Holdings, Inc. | 0.00% | Reduce -43.5% | 405 | $5K |
| Lindbrook Capital, LLC | 0.00% | No change | 371 | $4K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 332 | $4K |
| Parallel Advisors, LLC | 0.00% | No change | 329 | $4K |
| Truvestments Capital LLC | 0.00% | Reduce -28.8% | 309 | $4K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 311 | $4K |
| Brooklyn Investment Group | 0.00% | Reduce -50.9% | 289 | $3K |
| HighMark Wealth Management LLC | 0.00% | No change | 280 | $3K |
| Daiwa Securities Group Inc. | 0.00% | No change | 286 | $3K |
| Aster Capital Management (DIFC) Ltd | 0.00% | Add +210.0% | 217 | $3K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -19.0% | 230 | $3K |
| Meeder Asset Management Inc. | 0.00% | New | 206 | $2K |
| Parkside Financial Bank & Trust | 0.00% | New | 156 | $2K |
| Farther Finance Advisors, LLC | 0.00% | Reduce -7.3% | 139 | $2K |
| Coldstream Capital Management Inc. | 0.00% | New | 129 | $2K |
| Allworth Financial LP | 0.00% | Add +223.5% | 110 | $1K |
| Amundi | 0.00% | Add +103.8% | 106 | $1K |
| Rothschild Investment LLC | 0.00% | Add +100.0% | 100 | $1K |
| Group One Trading LLC | 0.00% | Reduce -87.5% | 100 | $1K |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 53 | $631 |
| Stephens Consulting, LLC | 0.00% | New | 30 | $358 |
| True Wealth Design, LLC | 0.00% | New | 20 | $239 |
| Ameriflex Group, Inc. | 0.00% | New | 20 | $238 |
| Signaturefd, LLC | 0.00% | New | 19 | $226 |
| CoreCap Advisors, LLC | 0.00% | No change | 18 | $214 |
| EverSource Wealth Advisors, LLC | 0.00% | Add +30.0% | 13 | $155 |
| Versant Capital Management, Inc | 0.00% | New | 12 | $143 |
| SBI Securities Co., Ltd. | 0.00% | No change | 10 | $119 |
| Innovative Advisory Group, LLC | 0.00% | No change | 8 | $95 |
| Covestor Ltd | 0.00% | No change | 27 | $0 |
"% of holder's portfolio" is ZYME's weight in each manager's 13F, not the share of Zymeworks Inc. the manager owns.