Exome Asset Management LLC

In its 13F for Q2 2024 (holdings as of June 30, 2024, filed October 3, 2024), Exome Asset Management LLC reported 52 stock positions worth $112.3 million. Its top holding was Eli Lilly (LLY) at 7.8% of the portfolio, followed by Sarepta Therapeutics (SRPT, 4.6%) and Beone Medicines Ltd.-ADR (ONC, 4.2%). Compared with Q1 2024, it opened 28 new positions, sold out of 29, added to 6 and reduced 10. The biggest buy was a new position in Sarepta Therapeutics (SRPT) and the biggest sale an exit from Alpine Immune Sciences (ALPN).

Most Recent 13F
Q2 2026
Location
NEW YORK, NY
CIK
0002011932
Portfolio Value
$112.3M (Q2 2024)
SEC Filing
0001420506-24-002078 ↗ filed Oct 3, 2024

Holdings Value

0$50.0M$100.0M$150.0M$200.0M$250.0M Q1 2024: $116.8M Q1 2024 Q2 2024: $112.3M $112.3M Q2 2024 Q3 2024: $147.9M Q3 2024 Q4 2024: $132.9M Q4 2024 Q1 2025: $111.6M Q1 2025 Q2 2025: $121.3M Q2 2025 Q3 2025: $151.4M Q3 2025 Q4 2025: $202.4M Q4 2025 Q1 2026: $169.9M Q1 2026 Q2 2026: $162.1M Q2 2026

Holdings 52 stocks · $112.3M
LLY Eli Lilly & Co. 7.82% 9,700 $8.8M No change
SRPT Sarepta Therapeutics Inc. 4.63% 32,900 $5.2M New
ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD 4.22% 33,200 $4.7M Reduce -9.8%
TGTX TG Therapeutics Inc. 3.98% 251,600 $4.5M Add +9.3%
CI The Cigna Group 3.59% 12,200 $4.0M Reduce -20.3%
CRBP Corbus Pharmaceuticals Holdi 3.42% 84,790 $3.8M Reduce -3.5%
INSM Insmed Inc. 3.39% 56,800 $3.8M Reduce -20.8%
AMGN Amgen Inc. 3.28% 11,800 $3.7M New
TVTX Travere Therapeutics Inc. 3.24% 443,379 $3.6M Add +22.3%
MDGL Madrigal Pharmaceuticals Inc. 2.69% 10,800 $3.0M Add +36.7%
AVDL Avadel Pharmaceuticals Ltd. 2.62% 209,092 $2.9M New
DXCM Dexcom Inc. 2.62% 25,928 $2.9M Add +4.4%
AUTL Autolus Therapeutics PLC 2.60% 839,472 $2.9M New
ISRG Intuitive Surgical Inc. 2.52% 6,358 $2.8M No change
RDY Dr. Reddy's Laboratories-ADR 2.46% 36,300 $2.8M Reduce -57.8%
IRON Disc Medicine Inc. 2.45% 61,000 $2.7M New
ASND Ascendis Pharma A/S 2.43% 20,000 $2.7M New
KURA Kura Oncology Inc. 2.42% 131,742 $2.7M New
MRUS Merus NV 2.38% 45,100 $2.7M New
MASI Masimo Corp. 2.22% 19,800 $2.5M New
CNTA Centessa Pharmaceuticals Ltd. 2.21% 274,900 $2.5M No change
WVE Wave Life Sciences Ltd. 2.17% 488,135 $2.4M New
GH Guardant Health Inc. 2.03% 79,000 $2.3M No change
CABA Cabaletta Bio Inc. 2.00% 300,200 $2.2M New
ARVN Arvinas Inc. 1.95% 82,400 $2.2M New
NTRA Natera Inc. 1.80% 18,650 $2.0M No change
BHVN Biohaven Ltd. 1.79% 57,800 $2.0M New
BBIO Bridgebio Pharma Inc. 1.78% 78,907 $2.0M Add +61.7%
FULC Fulcrum Therapeutics Inc. 1.67% 302,700 $1.9M New
APLS Apellis Pharmaceuticals Inc. 1.60% 46,900 $1.8M New
ATEC Alphatec Holdings Inc. 1.51% 162,100 $1.7M New
ABCL Abcellera Biologics Inc. 1.36% 514,900 $1.5M New
ZLAB Zai Lab Ltd.-ADR 1.34% 86,700 $1.5M Add +32.8%
PLRX Pliant Therapeutics Inc. 1.19% 124,000 $1.3M New
RZLT Rezolute Inc. 1.08% 282,400 $1.2M New
ALVO Alvotech SA 1.07% 99,000 $1.2M New
GOSS Gossamer Bio Inc. 0.90% 1,127,699 $1.0M New
ELEV Elevation Oncology Inc. 0.89% 369,322 $997K No change
ESTA Establishment Labs Holdings 0.88% 21,700 $986K New
SYRS Syros Pharmaceuticals Inc. 0.73% 159,175 $821K New
QTRX Quanterix Corp. 0.70% 59,650 $788K No change
QTTB Q32 Bio Inc. 0.70% 43,865 $787K Reduce -32.5%
VYNE THERAPEUTICS INC 0.62% 353,434 $696K Reduce -14.9%
PMVP PMV Pharmaceuticals Inc. 0.52% 358,400 $581K New
APRE Aprea Therapeutics Inc. 0.50% 137,174 $558K New
TECX Tectonic Therapeutic Inc. 0.47% 32,389 $533K New
ADAG Adagene Inc.-ADR 0.41% 150,876 $462K Reduce -2.9%
NBP Novabridge Biosciences filed as I MAB 0.40% 271,400 $453K Reduce -16.7%
PROCF Sofgen Pharma SA filed as PROCAPS GROUP SA 0.29% 126,901 $321K New
HLVX Hillevax Inc. 0.23% 18,000 $260K New
SGMT Sagimet Biosciences Inc. Class A 0.15% 50,700 $173K Reduce -16.8%
PACB Pacific Biosciences of Calif 0.09% 75,300 $103K No change

Portfolio Sells Q1 2024 → Q2 2024
ALPN Alpine Immune Sciences Inc. Sold out 0.00% −3.97
RNAM Avidity Biosciences Inc. Sold out 0.00% −2.95
RDY Dr. Reddy's Laboratories-ADR Reduce -57.8% 2.46% −2.94
CLDX Celldex Therapeutics Inc. Sold out 0.00% −2.56
GERN Geron Corp. Sold out 0.00% −2.51
AEROVATE THERAPEUTICS INC Sold out 0.00% −2.49
MOR Morphosys AG ADR Sold out 0.00% −2.40
KRYS Krystal Biotech Inc. Sold out 0.00% −2.24
TARS Tarsus Pharmaceuticals Inc. Sold out 0.00% −2.06
INZY Inozyme Pharma Inc. Sold out 0.00% −1.79
RYTM Rhythm Pharmaceuticals Inc. Sold out 0.00% −1.69
EXAS Exact Sciences Corp. Sold out 0.00% −1.58
CYTK Cytokinetics Inc. Sold out 0.00% −1.56
RGNX Regenxbio Inc. Sold out 0.00% −1.52
BIIB Biogen Inc. Sold out 0.00% −1.51
OCUL Ocular Therapeutix Inc. Sold out 0.00% −1.51
AGIO Agios Pharmaceuticals Inc. Sold out 0.00% −1.50
PEN Penumbra Inc. Sold out 0.00% −1.41
OLMA Olema Pharmaceuticals Inc. Sold out 0.00% −1.39
ARWR Arrowhead Pharmaceuticals Inc. Sold out 0.00% −1.36
TERN Terns Pharmaceuticals Inc. Sold out 0.00% −1.28
MRNS Marinus Pharmaceuticals Inc. Sold out 0.00% −1.26
NARI Inari Medical Inc. Sold out 0.00% −1.24
ITCI Intra-Cellular Therapies Inc. Sold out 0.00% −1.20
CI The Cigna Group Reduce -20.3% 3.59% −1.17
SWAV Shockwave Medical Inc. Sold out 0.00% −1.12
RGLS Regulus Therapeutics Inc. Sold out 0.00% −0.99
ELVN Enliven Therapeutics Inc. Sold out 0.00% −0.87
VTYX Ventyx Biosciences Inc. Sold out 0.00% −0.77
RARE Ultragenyx Pharmaceutical Inc. Sold out 0.00% −0.71
ONC Beone Medicines Ltd.-ADR Reduce -9.8% 4.22% −0.71
VYNE THERAPEUTICS INC Reduce -14.9% 0.62% −0.47
QTTB Q32 Bio Inc. Reduce -32.5% 0.70% −0.25
SGMT Sagimet Biosciences Inc. Class A Reduce -16.8% 0.15% −0.13
NBP Novabridge Biosciences Reduce -16.7% 0.40% −0.12
AVROBIO INC Sold out 0.00% −0.07
ADAG Adagene Inc.-ADR Reduce -2.9% 0.41% +0.04
CRBP Corbus Pharmaceuticals Holdi Reduce -3.5% 3.42% +0.46
INSM Insmed Inc. Reduce -20.8% 3.39% +1.72

Portfolio Buys Q1 2024 → Q2 2024
SRPT Sarepta Therapeutics Inc. New 4.63% +4.63
AMGN Amgen Inc. New 3.28% +3.28
AVDL Avadel Pharmaceuticals Ltd. New 2.62% +2.62
AUTL Autolus Therapeutics PLC New 2.60% +2.60
IRON Disc Medicine Inc. New 2.45% +2.45
ASND Ascendis Pharma A/S New 2.43% +2.43
KURA Kura Oncology Inc. New 2.42% +2.42
MRUS Merus NV New 2.38% +2.38
MASI Masimo Corp. New 2.22% +2.22
WVE Wave Life Sciences Ltd. New 2.17% +2.17
CABA Cabaletta Bio Inc. New 2.00% +2.00
ARVN Arvinas Inc. New 1.95% +1.95
BHVN Biohaven Ltd. New 1.79% +1.79
FULC Fulcrum Therapeutics Inc. New 1.67% +1.67
APLS Apellis Pharmaceuticals Inc. New 1.60% +1.60
ATEC Alphatec Holdings Inc. New 1.51% +1.51
ABCL Abcellera Biologics Inc. New 1.36% +1.36
PLRX Pliant Therapeutics Inc. New 1.19% +1.19
RZLT Rezolute Inc. New 1.08% +1.08
ALVO Alvotech SA New 1.07% +1.07
TGTX TG Therapeutics Inc. Add +9.3% 3.98% +0.99
GOSS Gossamer Bio Inc. New 0.90% +0.90
MDGL Madrigal Pharmaceuticals Inc. Add +36.7% 2.69% +0.89
ESTA Establishment Labs Holdings New 0.88% +0.88
TVTX Travere Therapeutics Inc. Add +22.3% 3.24% +0.85
SYRS Syros Pharmaceuticals Inc. New 0.73% +0.73
PMVP PMV Pharmaceuticals Inc. New 0.52% +0.52
APRE Aprea Therapeutics Inc. New 0.50% +0.50
BBIO Bridgebio Pharma Inc. Add +61.7% 1.78% +0.49
TECX Tectonic Therapeutic Inc. New 0.47% +0.47
ZLAB Zai Lab Ltd.-ADR Add +32.8% 1.34% +0.44
PROCF Sofgen Pharma SA New 0.29% +0.29
HLVX Hillevax Inc. New 0.23% +0.23
DXCM Dexcom Inc. Add +4.4% 2.62% −0.33

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 52$162.1MGH, PRAX, TGTX, COGT, IONS
Q1 2026 45$169.9MPRAX, COGT, ELVN, IONS, GH
Q4 2025 53$202.4MPRAX, COGT, GH, IONS, LLY
Q3 2025 54$151.4MIONS, CYTK, BBIO, COGT, GH
Q2 2025Amended 55$121.3MISHARES TR, BBIO, GH, GERN, IONS
Q1 2025Amended 49$111.6MBBIO, GH, GERN, AZN, CYTK
Q4 2024 58$132.9MBBIO, LLY, GERN, HUM, GH
Q3 2024Amended 59$147.9MLLY, ASND, BBIO, GPCR, TGTX
Q2 2024Amended 52$112.3MLLY, SRPT, ONC, TGTX, CI
Q1 2024 53$116.8MLLY, RDY, ONC, CI, ALPN