Exome Asset Management LLC
In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 14, 2025), Exome Asset Management LLC reported 54 stock positions worth $151.4 million. Its top holding was Ionis Pharmaceuticals (IONS) at 5.7% of the portfolio, followed by Cytokinetics (CYTK, 5.2%) and Bridgebio Pharma (BBIO, 4.6%). Compared with Q2 2025, it opened 21 new positions, sold out of 22, added to 10 and reduced 12. The biggest buy was a new position in Novabridge Biosciences (NBP) and the biggest sale an exit from iShares TR.
- Most Recent 13F
- Q2 2026
- Location
- NEW YORK, NY
- CIK
- 0002011932
- Portfolio Value
- $151.4M (Q3 2025)
- SEC Filing
- 0001420506-25-003369 ↗ filed Nov 14, 2025
Holdings Value
Holdings 54 stocks · $151.4M
| IONS Ionis Pharmaceuticals Inc. | 5.66% | 131,016 | $8.6M | Add +8.2% |
| CYTK Cytokinetics Inc. | 5.17% | 142,417 | $7.8M | Add +23.0% |
| BBIO Bridgebio Pharma Inc. | 4.56% | 133,087 | $6.9M | Reduce -14.4% |
| COGT Cogent Biosciences Inc. | 4.21% | 443,547 | $6.4M | Reduce -16.9% |
| GH Guardant Health Inc. | 4.05% | 98,182 | $6.1M | No change |
| LLY Eli Lilly & Co. | 3.96% | 7,852 | $6.0M | Add +68.0% |
| NBP Novabridge Biosciences filed as I MAB | 3.59% | 1,439,604 | $5.4M | New |
| PRAX Praxis Precision Medicines I | 3.57% | 101,996 | $5.4M | Add +72.9% |
| VERA Vera Therapeutics Inc. | 2.99% | 156,072 | $4.5M | Add +103.5% |
| AZN Astrazeneca PLC-Spons ADR | 2.82% | 28,362 | $4.3M | New |
| IRON Disc Medicine Inc. | 2.68% | 61,356 | $4.1M | No change |
| ETNB 89BIO Inc. | 2.66% | 273,661 | $4.0M | Add +17.2% |
| APGE Apogee Therapeutics Inc. | 2.48% | 94,400 | $3.8M | New |
| TVTX Travere Therapeutics Inc. | 2.48% | 156,917 | $3.8M | Add +2.4% |
| THC Tenet Healthcare Corp. | 2.43% | 18,100 | $3.7M | Reduce -33.0% |
| ARWR Arrowhead Pharmaceuticals Inc. | 2.38% | 104,507 | $3.6M | New |
| CVS CVS Health Corp. | 2.17% | 43,600 | $3.3M | New |
| SLNO Soleno Therapeutics Inc. | 2.16% | 48,445 | $3.3M | Add +16.3% |
| NTRA Natera Inc. | 1.98% | 18,650 | $3.0M | No change |
| CRBP Corbus Pharmaceuticals Holdi | 1.92% | 229,962 | $2.9M | Reduce -17.1% |
| ISRG Intuitive Surgical Inc. | 1.88% | 6,358 | $2.8M | No change |
| EWTX Edgewise Therapeutics Inc. | 1.86% | 173,439 | $2.8M | Add +39.3% |
| UTHR United Therapeutics Corp. | 1.84% | 6,645 | $2.8M | New |
| AKRO Akero Therapeutics Inc. | 1.84% | 58,579 | $2.8M | New |
| IMVT Immunovant Inc. | 1.69% | 158,622 | $2.6M | New |
| GERN Geron Corp. | 1.68% | 1,858,354 | $2.5M | Reduce -45.6% |
| CTMX Cytomx Therapeutics Inc. | 1.57% | 745,305 | $2.4M | New |
| PEN Penumbra Inc. | 1.51% | 9,000 | $2.3M | No change |
| GKOS Glaukos Corp. | 1.46% | 27,143 | $2.2M | New |
| LQDA Liquidia Corp. | 1.42% | 94,235 | $2.1M | Add +359.7% |
| CNTA Centessa Pharmaceuticals Ltd. | 1.41% | 88,024 | $2.1M | Reduce -47.3% |
| TXG 10X Genomics Inc. Class A | 1.26% | 163,658 | $1.9M | No change |
| COR Cencora Inc. | 1.24% | 6,000 | $1.9M | New |
| SNDX Syndax Pharmaceuticals Inc. | 1.20% | 117,783 | $1.8M | Reduce -61.8% |
| WAY Waystar Holding Corp. | 1.17% | 46,900 | $1.8M | No change |
| SAREPTA THERAPEUTICS INC (SRPT 1.25 09/15/27) | 1.17% | 2,000,000 | $1.8M | No change |
| KARYOPHARM THERAPEUTICS (KPTI 3 10/15/25) | 1.08% | 2,000,000 | $1.6M | No change |
| UHS Universal Health Services-B | 1.07% | 7,955 | $1.6M | Reduce -21.2% |
| ORIC Oric Pharmaceuticals Inc. | 0.96% | 120,644 | $1.4M | New |
| PRCT Procept Biorobotics Corp. | 0.94% | 39,900 | $1.4M | New |
| INSP Inspire Medical Systems Inc. | 0.91% | 18,600 | $1.4M | New |
| QURE Uniqure NV | 0.85% | 22,090 | $1.3M | New |
| MLTX Moonlake Immunotherapeutics | 0.84% | 178,084 | $1.3M | New |
| AVTX Avalo Therapeutics Inc. | 0.84% | 100,036 | $1.3M | New |
| GOSS Gossamer Bio Inc. | 0.78% | 451,699 | $1.2M | Reduce -58.9% |
| ALMS Alumis Inc. | 0.77% | 292,770 | $1.2M | New |
| UPB Upstream Bio Inc. | 0.65% | 51,960 | $977K | New |
| MBX MBX Biosciences Inc. | 0.61% | 52,402 | $917K | Reduce -16.9% |
| FULC Fulcrum Therapeutics Inc. | 0.60% | 98,799 | $909K | Reduce -77.8% |
| ESTA Establishment Labs Holdings | 0.35% | 13,100 | $537K | No change |
| ABUS Arbutus Biopharma Corp. | 0.23% | 75,484 | $343K | No change |
| REPL Replimune Group Inc. | 0.20% | 73,614 | $308K | Reduce -81.5% |
| VTYX Ventyx Biosciences Inc. | 0.12% | 60,600 | $188K | New |
| IMUX Immunic Inc. | 0.10% | 173,900 | $153K | New |
Options reported separately and not counted above: PPH calls ($2.7M), TRAVERE THERAPEUTICS INC calls ($2.6M), NOVO-NORDISK A S calls ($1.9M), LIQUIDIA CORPORATION puts ($1.2M), ARCTURUS THERAPEUTICS HLDGS puts ($922K), MBX BIOSCIENCES INC puts ($884K), COGENT BIOSCIENCES INC calls ($646K), CENTESSA PHARMACEUTICALS PLC puts ($606K), PRAXIS PRECISION MEDICINES I calls ($530K), MBX BIOSCIENCES INC calls ($525K), ACAD puts ($427K), PRECIGEN INC puts ($329K), and 2 more.
Portfolio Sells Q2 2025 → Q3 2025
| ISHARES TR | Sold out | 0.00% | −6.06 |
| REPL Replimune Group Inc. | Reduce -81.5% | 0.20% | −2.84 |
| SRRK Scholar Rock Holding Corp. | Sold out | 0.00% | −2.46 |
| GERN Geron Corp. | Reduce -45.6% | 1.68% | −2.29 |
| VSTM Verastem Inc. | Sold out | 0.00% | −2.05 |
| FULC Fulcrum Therapeutics Inc. | Reduce -77.8% | 0.60% | −1.92 |
| NEKTAR THERAPEUTICS | Sold out | 0.00% | −1.60 |
| DYN Dyne Therapeutics Inc. | Sold out | 0.00% | −1.54 |
| RGNX Regenxbio Inc. | Sold out | 0.00% | −1.53 |
| THC Tenet Healthcare Corp. | Reduce -33.0% | 2.43% | −1.49 |
| CRNX Crinetics Pharmaceuticals Inc. | Sold out | 0.00% | −1.49 |
| APLS Apellis Pharmaceuticals Inc. | Sold out | 0.00% | −1.41 |
| TRAVERE THERAPEUTICS INC | Sold out | 0.00% | −1.34 |
| BCRX Biocryst Pharmaceuticals Inc. | Sold out | 0.00% | −1.28 |
| CLDX Celldex Therapeutics Inc. | Sold out | 0.00% | −1.22 |
| SNDX Syndax Pharmaceuticals Inc. | Reduce -61.8% | 1.20% | −1.18 |
| BBIO Bridgebio Pharma Inc. | Reduce -14.4% | 4.56% | −0.97 |
| GPCR Structure Therapeutics Inc. | Sold out | 0.00% | −0.92 |
| LEGN Legend Biotech Corp.-ADR | Sold out | 0.00% | −0.85 |
| ALVO Alvotech SA | Sold out | 0.00% | −0.59 |
| NAMS Newamsterdam Pharma Co. NV | Sold out | 0.00% | −0.55 |
| CMPS Compass Pathways PLC | Sold out | 0.00% | −0.49 |
| UHS Universal Health Services-B | Reduce -21.2% | 1.07% | −0.43 |
| CNTA Centessa Pharmaceuticals Ltd. | Reduce -47.3% | 1.41% | −0.40 |
| GOSS Gossamer Bio Inc. | Reduce -58.9% | 0.78% | −0.33 |
| VYNE THERAPEUTICS INC | Sold out | 0.00% | −0.28 |
| TIL Instil Bio Inc. | Sold out | 0.00% | −0.28 |
| ANAB Anaptysbio Inc. | Sold out | 0.00% | −0.27 |
| ELDN Eledon Pharmaceuticals Inc. | Sold out | 0.00% | −0.26 |
| ELEV Elevation Oncology Inc. | Sold out | 0.00% | −0.03 |
| MEREO BIOPHARMA GROUP PLC | Sold out | 0.00% | −0.03 |
| MBX MBX Biosciences Inc. | Reduce -16.9% | 0.61% | +0.01 |
| CRBP Corbus Pharmaceuticals Holdi | Reduce -17.1% | 1.92% | +0.34 |
| COGT Cogent Biosciences Inc. | Reduce -16.9% | 4.21% | +1.05 |
Portfolio Buys Q2 2025 → Q3 2025
| NBP Novabridge Biosciences | New | 3.59% | +3.59 |
| AZN Astrazeneca PLC-Spons ADR | New | 2.82% | +2.82 |
| APGE Apogee Therapeutics Inc. | New | 2.48% | +2.48 |
| ARWR Arrowhead Pharmaceuticals Inc. | New | 2.38% | +2.38 |
| CVS CVS Health Corp. | New | 2.17% | +2.17 |
| CYTK Cytokinetics Inc. | Add +23.0% | 5.17% | +2.01 |
| UTHR United Therapeutics Corp. | New | 1.84% | +1.84 |
| AKRO Akero Therapeutics Inc. | New | 1.84% | +1.84 |
| IONS Ionis Pharmaceuticals Inc. | Add +8.2% | 5.66% | +1.71 |
| IMVT Immunovant Inc. | New | 1.69% | +1.69 |
| CTMX Cytomx Therapeutics Inc. | New | 1.57% | +1.57 |
| PRAX Praxis Precision Medicines I | Add +72.9% | 3.57% | +1.52 |
| VERA Vera Therapeutics Inc. | Add +103.5% | 2.99% | +1.50 |
| GKOS Glaukos Corp. | New | 1.46% | +1.46 |
| COR Cencora Inc. | New | 1.24% | +1.24 |
| LQDA Liquidia Corp. | Add +359.7% | 1.42% | +1.20 |
| ORIC Oric Pharmaceuticals Inc. | New | 0.96% | +0.96 |
| LLY Eli Lilly & Co. | Add +68.0% | 3.96% | +0.95 |
| PRCT Procept Biorobotics Corp. | New | 0.94% | +0.94 |
| INSP Inspire Medical Systems Inc. | New | 0.91% | +0.91 |
| QURE Uniqure NV | New | 0.85% | +0.85 |
| MLTX Moonlake Immunotherapeutics | New | 0.84% | +0.84 |
| AVTX Avalo Therapeutics Inc. | New | 0.84% | +0.84 |
| ALMS Alumis Inc. | New | 0.77% | +0.77 |
| ETNB 89BIO Inc. | Add +17.2% | 2.66% | +0.77 |
| UPB Upstream Bio Inc. | New | 0.65% | +0.65 |
| TVTX Travere Therapeutics Inc. | Add +2.4% | 2.48% | +0.61 |
| EWTX Edgewise Therapeutics Inc. | Add +39.3% | 1.86% | +0.51 |
| VTYX Ventyx Biosciences Inc. | New | 0.12% | +0.12 |
| IMUX Immunic Inc. | New | 0.10% | +0.10 |
| SLNO Soleno Therapeutics Inc. | Add +16.3% | 2.16% | −0.71 |
Options Activity Q2 2025 → Q3 2025
| AZN Astrazeneca PLC-Spons ADR | put | Sold out | 28,362 | $3.9Mbefore exit |
| AKRO Akero Therapeutics Inc. | put | Sold out | 58,579 | $3.1Mbefore exit |
| PPH Vaneck Pharmaceutical ETF | call | New | 30,000 | $2.7M |
| TRAVERE THERAPEUTICS INC | call | New | 110,000 | $2.6M |
| ACAD Acadia Pharmaceuticals Inc. | call | Sold out | 93,222 | $2.0Mbefore exit |
| NOVO-NORDISK A S | call | New | 35,000 | $1.9M |
| COR Cencora Inc. | call | Sold out | 6,000 | $1.8Mbefore exit |
| ULTRAGENYX PHARMACEUTICAL IN | call | Sold out | 37,500 | $1.4Mbefore exit |
| LIQUIDIA CORPORATION | put | New | 53,000 | $1.2M |
| ARCTURUS THERAPEUTICS HLDGS | put | New | 50,000 | $922K |
| MBX BIOSCIENCES INC | put | New | 50,500 | $884K |
| COGENT BIOSCIENCES INC | call | New | 45,000 | $646K |
| CENTESSA PHARMACEUTICALS PLC | put | New | 25,000 | $606K |
| PRAXIS PRECISION MEDICINES I | call | New | 10,000 | $530K |
| MBX BIOSCIENCES INC | call | New | 30,000 | $525K |
| UNH Unitedhealth Group Inc. | call | Sold out | 1,400 | $437Kbefore exit |
| ACAD Acadia Pharmaceuticals Inc. | put | New | 20,000 | $427K |
| ALTIMMUNE INC | put | Sold out | 107,000 | $414Kbefore exit |
| PRECIGEN INC | put | New | 100,000 | $329K |
| KARYOPHARM THERAPEUTICS INC | put | New | 48,100 | $315K |
| FULCRUM THERAPEUTICS INC | call | Sold out | 20,000 | $138Kbefore exit |
| ATYR Atyr Pharma Inc. | call | New | 40,000 | $29K |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 52 | $162.1M | GH, PRAX, TGTX, COGT, IONS |
| Q1 2026 | 45 | $169.9M | PRAX, COGT, ELVN, IONS, GH |
| Q4 2025 | 53 | $202.4M | PRAX, COGT, GH, IONS, LLY |
| Q3 2025 | 54 | $151.4M | IONS, CYTK, BBIO, COGT, GH |
| Q2 2025Amended | 55 | $121.3M | ISHARES TR, BBIO, GH, GERN, IONS |
| Q1 2025Amended | 49 | $111.6M | BBIO, GH, GERN, AZN, CYTK |
| Q4 2024 | 58 | $132.9M | BBIO, LLY, GERN, HUM, GH |
| Q3 2024Amended | 59 | $147.9M | LLY, ASND, BBIO, GPCR, TGTX |
| Q2 2024Amended | 52 | $112.3M | LLY, SRPT, ONC, TGTX, CI |
| Q1 2024 | 53 | $116.8M | LLY, RDY, ONC, CI, ALPN |