Exome Asset Management LLC

In its 13F for Q1 2024 (holdings as of March 31, 2024, filed May 15, 2024), Exome Asset Management LLC reported 53 stock positions worth $116.8 million. Its top holding was Eli Lilly (LLY) at 6.5% of the portfolio, followed by Dr. Reddy's Laboratories-ADR (RDY, 5.4%) and Beone Medicines Ltd.-ADR (ONC, 4.9%). Compared with Q4 2023, it opened 28 new positions, sold out of 27, added to 7 and reduced 10. The biggest buy was a new position in Avidity Biosciences (RNAM) and the biggest sale an exit from Immunogen (IMGN).

Most Recent 13F
Q2 2026
Location
NEW YORK, NY
CIK
0002011932
Portfolio Value
$116.8M (Q1 2024)
SEC Filing
0001420506-24-000954 ↗ filed May 15, 2024

Holdings Value

0$50.0M$100.0M$150.0M$200.0M$250.0M Q1 2024: $116.8M $116.8M Q1 2024 Q2 2024: $112.3M Q2 2024 Q3 2024: $147.9M Q3 2024 Q4 2024: $132.9M Q4 2024 Q1 2025: $111.6M Q1 2025 Q2 2025: $121.3M Q2 2025 Q3 2025: $151.4M Q3 2025 Q4 2025: $202.4M Q4 2025 Q1 2026: $169.9M Q1 2026 Q2 2026: $162.1M Q2 2026

Holdings 53 stocks · $116.8M
LLY Eli Lilly & Co. 6.46% 9,700 $7.5M No change
RDY Dr. Reddy's Laboratories-ADR 5.40% 86,000 $6.3M Reduce -4.4%
ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD 4.93% 36,800 $5.8M Add +187.5%
CI The Cigna Group 4.76% 15,300 $5.6M No change
ALPN Alpine Immune Sciences Inc. 3.97% 117,000 $4.6M Reduce -32.6%
TGTX TG Therapeutics Inc. 3.00% 230,300 $3.5M Add +13.3%
RNAM Avidity Biosciences Inc. 2.95% 135,169 $3.4M New
CRBP Corbus Pharmaceuticals Holdi 2.95% 87,846 $3.4M New
DXCM Dexcom Inc. 2.95% 24,828 $3.4M No change
CNTA Centessa Pharmaceuticals Ltd. 2.66% 274,900 $3.1M New
CLDX Celldex Therapeutics Inc. 2.56% 71,100 $3.0M Reduce -36.1%
GERN Geron Corp. 2.51% 886,800 $2.9M Add +46.0%
AEROVATE THERAPEUTICS INC 2.49% 98,485 $2.9M New
MOR Morphosys AG ADR 2.40% 154,800 $2.8M New
TVTX Travere Therapeutics Inc. 2.39% 362,487 $2.8M Add +331.6%
KRYS Krystal Biotech Inc. 2.24% 14,700 $2.6M New
ISRG Intuitive Surgical Inc. 2.17% 6,358 $2.5M No change
TARS Tarsus Pharmaceuticals Inc. 2.06% 66,300 $2.4M Reduce -21.4%
MDGL Madrigal Pharmaceuticals Inc. 1.81% 7,900 $2.1M Reduce -40.2%
INZY Inozyme Pharma Inc. 1.79% 273,413 $2.1M New
RYTM Rhythm Pharmaceuticals Inc. 1.69% 45,603 $2.0M Reduce -36.8%
INSM Insmed Inc. 1.67% 71,700 $1.9M Add +16.6%
ELEV Elevation Oncology Inc. 1.62% 369,322 $1.9M New
EXAS Exact Sciences Corp. 1.58% 26,700 $1.8M New
CYTK Cytokinetics Inc. 1.56% 26,008 $1.8M Reduce -25.5%
RGNX Regenxbio Inc. 1.52% 84,470 $1.8M New
BIIB Biogen Inc. 1.51% 8,200 $1.8M No change
OCUL Ocular Therapeutix Inc. 1.51% 193,600 $1.8M New
AGIO Agios Pharmaceuticals Inc. 1.50% 59,902 $1.8M New
NTRA Natera Inc. 1.46% 18,650 $1.7M No change
PEN Penumbra Inc. 1.41% 7,353 $1.6M Reduce -14.0%
GH Guardant Health Inc. 1.40% 79,000 $1.6M New
OLMA Olema Pharmaceuticals Inc. 1.39% 143,400 $1.6M New
ARWR Arrowhead Pharmaceuticals Inc. 1.36% 55,700 $1.6M New
BBIO Bridgebio Pharma Inc. 1.29% 48,807 $1.5M Reduce -25.0%
TERN Terns Pharmaceuticals Inc. 1.28% 227,821 $1.5M New
MRNS Marinus Pharmaceuticals Inc. 1.26% 163,100 $1.5M New
NARI Inari Medical Inc. 1.24% 30,100 $1.4M New
QTRX Quanterix Corp. 1.20% 59,650 $1.4M New
ITCI Intra-Cellular Therapies Inc. 1.20% 20,300 $1.4M Reduce -28.3%
SWAV Shockwave Medical Inc. 1.12% 4,000 $1.3M No change
VYNE THERAPEUTICS INC 1.09% 415,434 $1.3M Add +251.8%
RGLS Regulus Therapeutics Inc. 0.99% 402,504 $1.2M Add +125.6%
QTTB Q32 Bio Inc. 0.95% 65,021 $1.1M New
ZLAB Zai Lab Ltd.-ADR 0.90% 65,300 $1.0M New
ELVN Enliven Therapeutics Inc. 0.87% 57,635 $1.0M New
VTYX Ventyx Biosciences Inc. 0.77% 163,922 $902K New
RARE Ultragenyx Pharmaceutical Inc. 0.71% 17,800 $831K New
NBP Novabridge Biosciences filed as I MAB 0.52% 325,762 $606K New
ADAG Adagene Inc.-ADR 0.37% 155,383 $435K New
SGMT Sagimet Biosciences Inc. Class A 0.28% 60,900 $330K New
PACB Pacific Biosciences of Calif 0.24% 75,300 $282K No change
AVROBIO INC 0.07% 61,135 $78K New

Portfolio Sells Q4 2023 → Q1 2024
IMGN Immunogen Inc. Sold out 0.00% −5.48
INHIBRX INC Sold out 0.00% −2.75
GPCR Structure Therapeutics Inc. Sold out 0.00% −2.74
RCKT Rocket Pharmaceuticals Inc. Sold out 0.00% −2.72
LEGN Legend Biotech Corp.-ADR Sold out 0.00% −2.25
BHVN Biohaven Ltd. Sold out 0.00% −1.92
CLDX Celldex Therapeutics Inc. Reduce -36.1% 2.56% −1.81
LNTH Lantheus Holdings Inc. Sold out 0.00% −1.78
CPRX Catalyst Pharmaceuticals Inc. Sold out 0.00% −1.75
RYTM Rhythm Pharmaceuticals Inc. Reduce -36.8% 1.69% −1.59
STTK Shattuck Labs Inc. Sold out 0.00% −1.57
VRTX Vertex Pharmaceuticals Inc. Sold out 0.00% −1.57
IMTX Immatics NV Sold out 0.00% −1.35
CYTK Cytokinetics Inc. Reduce -25.5% 1.56% −1.32
PRTA Prothena Corp. PLC Sold out 0.00% −1.31
BBIO Bridgebio Pharma Inc. Reduce -25.0% 1.29% −1.31
MDGL Madrigal Pharmaceuticals Inc. Reduce -40.2% 1.81% −1.21
TSHA Taysha Gene Therapies Inc. Sold out 0.00% −1.21
MGNX Macrogenics Inc. Sold out 0.00% −1.20
IGMS Igm Biosciences Inc. Sold out 0.00% −1.11
CABA Cabaletta Bio Inc. Sold out 0.00% −1.05
MRTX Mirati Therapeutics Inc. Sold out 0.00% −0.92
PLRX Pliant Therapeutics Inc. Sold out 0.00% −0.89
ITCI Intra-Cellular Therapies Inc. Reduce -28.3% 1.20% −0.80
RDY Dr. Reddy's Laboratories-ADR Reduce -4.4% 5.40% −0.79
SAGE Sage Therapeutics Inc. Sold out 0.00% −0.76
PEN Penumbra Inc. Reduce -14.0% 1.41% −0.72
ESTA Establishment Labs Holdings Sold out 0.00% −0.71
STRO Sutro Biopharma Inc. Com SHS Sold out 0.00% −0.65
EYPT Eyepoint Inc. Sold out 0.00% −0.60
MLTX Moonlake Immunotherapeutics Sold out 0.00% −0.58
PROCF Sofgen Pharma SA Sold out 0.00% −0.51
APLS Apellis Pharmaceuticals Inc. Sold out 0.00% −0.43
GRCL Gracell Biotechnologies-ADR Sold out 0.00% −0.41
KNTE Kinnate Biopharma Inc. Sold out 0.00% −0.20
TARS Tarsus Pharmaceuticals Inc. Reduce -21.4% 2.06% +0.37
ALPN Alpine Immune Sciences Inc. Reduce -32.6% 3.97% +0.70

Portfolio Buys Q4 2023 → Q1 2024
RNAM Avidity Biosciences Inc. New 2.95% +2.95
CRBP Corbus Pharmaceuticals Holdi New 2.95% +2.95
CNTA Centessa Pharmaceuticals Ltd. New 2.66% +2.66
ONC Beone Medicines Ltd.-ADR Add +187.5% 4.93% +2.65
AEROVATE THERAPEUTICS INC New 2.49% +2.49
MOR Morphosys AG ADR New 2.40% +2.40
KRYS Krystal Biotech Inc. New 2.24% +2.24
INZY Inozyme Pharma Inc. New 1.79% +1.79
TVTX Travere Therapeutics Inc. Add +331.6% 2.39% +1.65
ELEV Elevation Oncology Inc. New 1.62% +1.62
EXAS Exact Sciences Corp. New 1.58% +1.58
RGNX Regenxbio Inc. New 1.52% +1.52
OCUL Ocular Therapeutix Inc. New 1.51% +1.51
AGIO Agios Pharmaceuticals Inc. New 1.50% +1.50
GH Guardant Health Inc. New 1.40% +1.40
OLMA Olema Pharmaceuticals Inc. New 1.39% +1.39
ARWR Arrowhead Pharmaceuticals Inc. New 1.36% +1.36
TERN Terns Pharmaceuticals Inc. New 1.28% +1.28
MRNS Marinus Pharmaceuticals Inc. New 1.26% +1.26
GERN Geron Corp. Add +46.0% 2.51% +1.24
NARI Inari Medical Inc. New 1.24% +1.24
QTRX Quanterix Corp. New 1.20% +1.20
QTTB Q32 Bio Inc. New 0.95% +0.95
ZLAB Zai Lab Ltd.-ADR New 0.90% +0.90
ELVN Enliven Therapeutics Inc. New 0.87% +0.87
VYNE THERAPEUTICS INC Add +251.8% 1.09% +0.82
VTYX Ventyx Biosciences Inc. New 0.77% +0.77
RGLS Regulus Therapeutics Inc. Add +125.6% 0.99% +0.77
RARE Ultragenyx Pharmaceutical Inc. New 0.71% +0.71
NBP Novabridge Biosciences New 0.52% +0.52
ADAG Adagene Inc.-ADR New 0.37% +0.37
SGMT Sagimet Biosciences Inc. Class A New 0.28% +0.28
AVROBIO INC New 0.07% +0.07
INSM Insmed Inc. Add +16.6% 1.67% −0.22
TGTX TG Therapeutics Inc. Add +13.3% 3.00% −0.43

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 52$162.1MGH, PRAX, TGTX, COGT, IONS
Q1 2026 45$169.9MPRAX, COGT, ELVN, IONS, GH
Q4 2025 53$202.4MPRAX, COGT, GH, IONS, LLY
Q3 2025 54$151.4MIONS, CYTK, BBIO, COGT, GH
Q2 2025Amended 55$121.3MISHARES TR, BBIO, GH, GERN, IONS
Q1 2025Amended 49$111.6MBBIO, GH, GERN, AZN, CYTK
Q4 2024 58$132.9MBBIO, LLY, GERN, HUM, GH
Q3 2024Amended 59$147.9MLLY, ASND, BBIO, GPCR, TGTX
Q2 2024Amended 52$112.3MLLY, SRPT, ONC, TGTX, CI
Q1 2024 53$116.8MLLY, RDY, ONC, CI, ALPN