HighVista Strategies LLC
In its 13F for Q2 2025 (holdings as of June 30, 2025, filed August 14, 2025), HighVista Strategies LLC reported 146 stock positions worth $272.1 million. Its top holding was Invesco DB Commodity Index T (DBC) at 11.5% of the portfolio, followed by Viridian Therapeutics (VRDN, 2.5%) and Ansys (ANSS, 2.2%). Compared with Q1 2025, it opened 29 new positions, sold out of 31, added to 50 and reduced 55. The biggest buy was Viridian Therapeutics (VRDN, shares +168%) and the biggest sale an exit from Albertsons Cos Class A (ACI).
- Most Recent 13F
- Q2 2026
- Location
- BOSTON, MA
- CIK
- 0001335325
- Portfolio Value
- $272.1M (Q2 2025)
- SEC Filing
- 0001172661-25-003309 ↗ filed Aug 14, 2025
Holdings Value
Holdings 146 stocks · $272.1M
| DBC Invesco DB Commodity Index T | 11.51% | 1,436,136 | $31.3M | No change |
| VRDN Viridian Therapeutics Inc. | 2.49% | 484,559 | $6.8M | Add +168.4% |
| ANSS Ansys Inc. | 2.21% | 17,100 | $6.0M | Add +33.6% |
| MSFT Microsoft Corp. | 1.88% | 10,258 | $5.1M | Add +5.1% |
| MRUS Merus NV | 1.74% | 89,762 | $4.7M | Add +63.1% |
| JNPR Juniper Networks Inc. | 1.68% | 114,700 | $4.6M | No change |
| AMZN Amazon.com Inc. | 1.52% | 18,893 | $4.1M | Add +1.1% |
| HES Hess Corp. | 1.47% | 28,900 | $4.0M | No change |
| AMED Amedisys Inc. | 1.42% | 39,250 | $3.9M | No change |
| NUVL Nuvalent Inc. Class A | 1.41% | 50,460 | $3.9M | Add +26.5% |
| AVGO Broadcom Inc. | 1.30% | 12,800 | $3.5M | Reduce -19.5% |
| WDC Western Digital Corp. | 1.19% | 50,600 | $3.2M | Add +4.8% |
| AKRO Akero Therapeutics Inc. | 1.18% | 59,993 | $3.2M | Add +149.3% |
| PTGX Protagonist Therapeutics Inc. | 1.18% | 57,851 | $3.2M | Reduce -26.3% |
| STX Seagate Technology Holdings | 1.17% | 22,100 | $3.2M | Reduce -3.9% |
| CORZ Core Scientific Inc. | 1.13% | 179,900 | $3.1M | Reduce -9.6% |
| CRM Salesforce Inc. | 1.12% | 11,185 | $3.1M | Add +20.5% |
| IMVT Immunovant Inc. | 1.07% | 182,808 | $2.9M | Add +91.1% |
| BBIO Bridgebio Pharma Inc. | 1.07% | 67,499 | $2.9M | Add +45.2% |
| XOMA Xoma Royalty Corporation | 1.06% | 114,548 | $2.9M | No change |
| ELVN Enliven Therapeutics Inc. | 1.04% | 141,516 | $2.8M | Add +25.8% |
| PRAX Praxis Precision Medicines I | 1.04% | 67,288 | $2.8M | Add +71.3% |
| VRNA Verona Pharma Ltd. | 1.00% | 28,880 | $2.7M | Add +72.9% |
| CEG Constellation Energy | 0.98% | 8,300 | $2.7M | Reduce -17.8% |
| XPO Xpo Inc. | 0.98% | 21,080 | $2.7M | Reduce -21.6% |
| INTU Intuit Inc. | 0.94% | 3,263 | $2.6M | Reduce -15.5% |
| RVMD Revolution Medicines Inc. | 0.92% | 68,048 | $2.5M | Reduce -7.7% |
| NVDA Nvidia Corp. | 0.91% | 15,700 | $2.5M | Add +7.5% |
| PWR Quanta Services Inc. | 0.89% | 6,400 | $2.4M | Reduce -21.0% |
| ACLX Arcellx Inc. | 0.86% | 35,714 | $2.4M | Reduce -24.8% |
| AGIO Agios Pharmaceuticals Inc. | 0.86% | 70,127 | $2.3M | Add +59.0% |
| META Meta Platforms Inc. Class A | 0.84% | 3,100 | $2.3M | Reduce -3.1% |
| V Visa Inc. Class A | 0.84% | 6,427 | $2.3M | Add +4.9% |
| CYTK Cytokinetics Inc. | 0.83% | 68,652 | $2.3M | Add +53.4% |
| MA Mastercard Inc. Class A | 0.83% | 4,000 | $2.2M | Add +8.1% |
| MMM 3M Co. | 0.81% | 14,400 | $2.2M | Add +6.7% |
| AMD Advanced Micro Devices | 0.80% | 15,400 | $2.2M | New |
| CLDX Celldex Therapeutics Inc. | 0.80% | 106,553 | $2.2M | New |
| FERG Ferguson Enterprises Inc. | 0.79% | 9,878 | $2.2M | New |
| GEV GE Vernova Inc. | 0.78% | 4,000 | $2.1M | Reduce -59.2% |
| BKNG Booking Holdings Inc. | 0.76% | 357 | $2.1M | No change |
| COGT Cogent Biosciences Inc. | 0.75% | 283,186 | $2.0M | Add +1.3% |
| MLYS Mineralys Therapeutics Inc. | 0.75% | 150,138 | $2.0M | New |
| SNPS Synopsys Inc. | 0.73% | 3,900 | $2.0M | Add +25.8% |
| LYFT LYFT Inc. Class A | 0.73% | 125,800 | $2.0M | New |
| APGE Apogee Therapeutics Inc. | 0.72% | 45,052 | $2.0M | Add +4.3% |
| CLF Cleveland-Cliffs Inc. | 0.71% | 255,600 | $1.9M | New |
| APH Amphenol Corp. Class A | 0.69% | 19,000 | $1.9M | Reduce -17.0% |
| MTZ Mastec Inc. | 0.69% | 11,000 | $1.9M | Reduce -32.5% |
| QXO Qxo Inc. | 0.67% | 84,500 | $1.8M | Reduce -18.4% |
| GPCR Structure Therapeutics Inc. | 0.66% | 86,621 | $1.8M | Add +393.3% |
| SNDK Sandisk Corp. | 0.66% | 39,600 | $1.8M | New |
| RYTM Rhythm Pharmaceuticals Inc. | 0.65% | 28,068 | $1.8M | Reduce -19.9% |
| HPE Hewlett Packard Enterprise | 0.65% | 86,200 | $1.8M | Reduce -35.4% |
| PTC PTC Inc. | 0.64% | 10,122 | $1.7M | Add +0.4% |
| TLN Talen Energy Corp. | 0.63% | 5,900 | $1.7M | Reduce -23.4% |
| SYRE Spyre Therapeutics Inc. | 0.62% | 112,805 | $1.7M | Add +18.5% |
| ENTG Entegris Inc. | 0.62% | 20,900 | $1.7M | New |
| CSCO Cisco Systems Inc. | 0.60% | 23,600 | $1.6M | Reduce -26.7% |
| PGR Progressive Corp. | 0.58% | 5,900 | $1.6M | Add +18.0% |
| BAC Bank of America Corp. filed as BANK AMERICA CORP | 0.57% | 32,600 | $1.5M | New |
| DAL Delta Air Lines Inc. | 0.56% | 30,800 | $1.5M | No change |
| ALKS Alkermes PLC | 0.56% | 52,944 | $1.5M | Reduce -25.2% |
| LQDA Liquidia Corp. | 0.55% | 120,641 | $1.5M | Reduce -40.7% |
| APLS Apellis Pharmaceuticals Inc. | 0.55% | 86,663 | $1.5M | Reduce -20.3% |
| SCHW Schwab (charles) Corp. | 0.55% | 16,300 | $1.5M | New |
| GH Guardant Health Inc. | 0.54% | 28,265 | $1.5M | Reduce -45.4% |
| WDAY Workday Inc. Class A | 0.54% | 6,100 | $1.5M | Add +8.9% |
| JANX Janux Therapeutics Inc. | 0.53% | 62,436 | $1.4M | Reduce -16.3% |
| RCL Royal Caribbean Cruises Ltd. | 0.53% | 4,600 | $1.4M | Reduce -47.7% |
| CME Cme Group Inc. | 0.53% | 5,200 | $1.4M | New |
| SE Sea Ltd.-ADR | 0.53% | 8,941 | $1.4M | Reduce -16.0% |
| XENE Xenon Pharmaceuticals Inc. | 0.52% | 45,620 | $1.4M | Reduce -31.7% |
| RBC RBC Bearings Inc. | 0.52% | 3,700 | $1.4M | Add +8.8% |
| TKO Tko Group Holdings Inc. | 0.51% | 7,600 | $1.4M | Reduce -17.4% |
| U Unity Software Inc. | 0.51% | 57,100 | $1.4M | New |
| NU Nu Holdings Ltd./Cayman Isl-A filed as NU HLDGS LTD | 0.51% | 100,537 | $1.4M | Add +0.8% |
| BBD Banco Bradesco-ADR | 0.50% | 443,600 | $1.4M | Reduce -14.2% |
| ARGX Argenx SE - ADR | 0.49% | 2,415 | $1.3M | Reduce -24.6% |
| CPNG Coupang Inc. | 0.47% | 43,000 | $1.3M | Reduce -9.5% |
| REXR Rexford Industrial Realty Inc. | 0.47% | 36,200 | $1.3M | New |
| APG Api Group Corp. | 0.47% | 25,150 | $1.3M | New |
| ETR Entergy Corp. | 0.47% | 15,300 | $1.3M | New |
| AGX Argan Inc. | 0.46% | 5,700 | $1.3M | Reduce -51.3% |
| CAAP Corp. America Airports SA filed as CORPORACION AMER ARPTS S A | 0.46% | 62,000 | $1.3M | Add +3.0% |
| CNX CNX Resources Corp. | 0.46% | 37,100 | $1.2M | Reduce -20.6% |
| PFSI Pennymac Financial Services | 0.46% | 12,537 | $1.2M | Reduce -6.7% |
| BVN Cia DE Minas Buenaventur-ADR filed as COMPANIA DE MINAS BUENAVENTU | 0.46% | 75,831 | $1.2M | Reduce -6.0% |
| ADBE Adobe Inc. | 0.45% | 3,200 | $1.2M | New |
| PM Philip Morris International | 0.45% | 6,700 | $1.2M | Reduce -44.6% |
| RXO Rxo Inc. | 0.45% | 77,100 | $1.2M | Add +12.7% |
| PBR.A Petroleo Brasil-SP Pref ADR | 0.45% | 105,000 | $1.2M | Add +18.0% |
| MAGN Magnera Corp. | 0.44% | 99,700 | $1.2M | Add +49.7% |
| DVAX Dynavax Technologies Corp. | 0.44% | 120,271 | $1.2M | Reduce -48.9% |
| HCA HCA Healthcare Inc. | 0.44% | 3,100 | $1.2M | New |
| OFIX Orthofix Medical Inc. | 0.44% | 106,500 | $1.2M | Add +14.6% |
| OLMA Olema Pharmaceuticals Inc. | 0.44% | 278,430 | $1.2M | Add +31.2% |
| INSM Insmed Inc. | 0.43% | 11,595 | $1.2M | Reduce -45.9% |
| KGS Kodiak Gas Services Inc. | 0.43% | 34,000 | $1.2M | New |
| RNAM Avidity Biosciences Inc. | 0.43% | 40,864 | $1.2M | Reduce -24.6% |
Portfolio Sells Q1 2025 → Q2 2025
| ACI Albertsons Cos Inc. Class A | Sold out | 0.00% | −1.60 |
| SWTX Springworks Therapeutics Inc. | Sold out | 0.00% | −1.17 |
| GOOG Alphabet Inc. Class C | Sold out | 0.00% | −0.81 |
| BHC Bausch Health Cos Inc. | Sold out | 0.00% | −0.78 |
| DVAX Dynavax Technologies Corp. | Reduce -48.9% | 0.44% | −0.74 |
| GEHC GE Healthcare Technology | Sold out | 0.00% | −0.72 |
| STZ Constellation Brands Inc. Class A | Sold out | 0.00% | −0.70 |
| KNSA Kiniksa Pharmaceuticals Inte | Sold out | 0.00% | −0.64 |
| NATL NCR Atleos Corp. | Sold out | 0.00% | −0.63 |
| LQDA Liquidia Corp. | Reduce -40.7% | 0.55% | −0.60 |
| TSM Taiwan Semiconductor-SP ADR | Sold out | 0.00% | −0.57 |
| CRH CRH PLC | Sold out | 0.00% | −0.57 |
| CIEN Ciena Corp. | Sold out | 0.00% | −0.57 |
| ELV Elevance Health Inc. | Sold out | 0.00% | −0.55 |
| BN Brookfield Corp. | Sold out | 0.00% | −0.55 |
| EYE National Vision Holdings Inc. | Sold out | 0.00% | −0.55 |
| AXSM Axsome Therapeutics Inc. | Reduce -49.3% | 0.42% | −0.55 |
| UAL United Airlines Holdings Inc. | Sold out | 0.00% | −0.54 |
| QSR Restaurant Brands Intern | Sold out | 0.00% | −0.52 |
| AAL American Airlines Group Inc. | Sold out | 0.00% | −0.51 |
| DUOL Duolingo | Sold out | 0.00% | −0.50 |
| ON On Semiconductor | Sold out | 0.00% | −0.49 |
| MRVL Marvell Technology Inc. | Sold out | 0.00% | −0.48 |
| EWTX Edgewise Therapeutics Inc. | Reduce -23.6% | 0.34% | −0.44 |
| GEV GE Vernova Inc. | Reduce -59.2% | 0.78% | −0.38 |
| CRNX Crinetics Pharmaceuticals Inc. | Sold out | 0.00% | −0.37 |
| APLS Apellis Pharmaceuticals Inc. | Reduce -20.3% | 0.55% | −0.36 |
| ALKS Alkermes PLC | Reduce -25.2% | 0.56% | −0.34 |
| XENE Xenon Pharmaceuticals Inc. | Reduce -31.7% | 0.52% | −0.34 |
| ACLX Arcellx Inc. | Reduce -24.8% | 0.86% | −0.34 |
| GH Guardant Health Inc. | Reduce -45.4% | 0.54% | −0.31 |
| MLTX Moonlake Immunotherapeutics | Reduce -51.9% | 0.36% | −0.29 |
| PM Philip Morris International | Reduce -44.6% | 0.45% | −0.29 |
| PTGX Protagonist Therapeutics Inc. | Reduce -26.3% | 1.18% | −0.29 |
| JANX Janux Therapeutics Inc. | Reduce -16.3% | 0.53% | −0.25 |
| ARGX Argenx SE - ADR | Reduce -24.6% | 0.49% | −0.24 |
| DYN Dyne Therapeutics Inc. | Reduce -66.4% | 0.09% | −0.22 |
| BABA Alibaba Group Holding-SP ADR | Reduce -49.6% | 0.16% | −0.22 |
| ACN Accenture PLC Class A | Sold out | 0.00% | −0.22 |
| INSM Insmed Inc. | Reduce -45.9% | 0.43% | −0.20 |
| LKQ LKQ Corp. | Reduce -19.6% | 0.40% | −0.20 |
| ROIV Roivant Sciences Ltd. | Reduce -46.9% | 0.25% | −0.19 |
| ZYME Zymeworks Inc. | Sold out | 0.00% | −0.19 |
| RNAM Avidity Biosciences Inc. | Reduce -24.6% | 0.43% | −0.19 |
| RARE Ultragenyx Pharmaceutical Inc. | Sold out | 0.00% | −0.19 |
| ASND Ascendis Pharma A/S | Reduce -51.0% | 0.19% | −0.18 |
| RCL Royal Caribbean Cruises Ltd. | Reduce -47.7% | 0.53% | −0.17 |
| CSCO Cisco Systems Inc. | Reduce -26.7% | 0.60% | −0.16 |
| MIRM Mirum Pharmaceuticals Inc. | Sold out | 0.00% | −0.16 |
| KALV Kalvista Pharmaceuticals Inc. | Sold out | 0.00% | −0.15 |
Portfolio Buys Q1 2025 → Q2 2025
| VRDN Viridian Therapeutics Inc. | Add +168.4% | 2.49% | +1.55 |
| MRUS Merus NV | Add +63.1% | 1.74% | +0.84 |
| AMD Advanced Micro Devices | New | 0.80% | +0.80 |
| AKRO Akero Therapeutics Inc. | Add +149.3% | 1.18% | +0.80 |
| CLDX Celldex Therapeutics Inc. | New | 0.80% | +0.80 |
| FERG Ferguson Enterprises Inc. | New | 0.79% | +0.79 |
| MLYS Mineralys Therapeutics Inc. | New | 0.75% | +0.75 |
| LYFT LYFT Inc. Class A | New | 0.73% | +0.73 |
| CLF Cleveland-Cliffs Inc. | New | 0.71% | +0.71 |
| SNDK Sandisk Corp. | New | 0.66% | +0.66 |
| ANSS Ansys Inc. | Add +33.6% | 2.21% | +0.65 |
| ENTG Entegris Inc. | New | 0.62% | +0.62 |
| VRNA Verona Pharma Ltd. | Add +72.9% | 1.00% | +0.60 |
| BAC Bank of America Corp. | New | 0.57% | +0.57 |
| SCHW Schwab (charles) Corp. | New | 0.55% | +0.55 |
| GPCR Structure Therapeutics Inc. | Add +393.3% | 0.66% | +0.54 |
| CME Cme Group Inc. | New | 0.53% | +0.53 |
| U Unity Software Inc. | New | 0.51% | +0.51 |
| REXR Rexford Industrial Realty Inc. | New | 0.47% | +0.47 |
| APG Api Group Corp. | New | 0.47% | +0.47 |
| ETR Entergy Corp. | New | 0.47% | +0.47 |
| PRAX Praxis Precision Medicines I | Add +71.3% | 1.04% | +0.47 |
| MSFT Microsoft Corp. | Add +5.1% | 1.88% | +0.46 |
| ADBE Adobe Inc. | New | 0.45% | +0.45 |
| BBIO Bridgebio Pharma Inc. | Add +45.2% | 1.07% | +0.45 |
| IMVT Immunovant Inc. | Add +91.1% | 1.07% | +0.45 |
| WDC Western Digital Corp. | Add +4.8% | 1.19% | +0.44 |
| HCA HCA Healthcare Inc. | New | 0.44% | +0.44 |
| KGS Kodiak Gas Services Inc. | New | 0.43% | +0.43 |
| FOUR SHIFT4 Payments Inc. Class A | New | 0.41% | +0.41 |
| AGIO Agios Pharmaceuticals Inc. | Add +59.0% | 0.86% | +0.36 |
| ALV Autoliv Inc. | New | 0.35% | +0.35 |
| NUVL Nuvalent Inc. Class A | Add +26.5% | 1.41% | +0.33 |
| NVDA Nvidia Corp. | Add +7.5% | 0.91% | +0.30 |
| GHRS GH Research PLC | New | 0.23% | +0.23 |
| SNPS Synopsys Inc. | Add +25.8% | 0.73% | +0.22 |
| EOLS Evolus Inc. | New | 0.20% | +0.20 |
| ELVN Enliven Therapeutics Inc. | Add +25.8% | 1.04% | +0.19 |
| RLAY Relay Therapeutics Inc. | New | 0.19% | +0.19 |
| TARS Tarsus Pharmaceuticals Inc. | New | 0.17% | +0.17 |
| ETNB 89BIO Inc. | New | 0.17% | +0.17 |
| CRM Salesforce Inc. | Add +20.5% | 1.12% | +0.16 |
| NOK Nokia Corp.-Spon ADR | New | 0.16% | +0.16 |
| ALC Alcon Inc. | New | 0.16% | +0.16 |
| AMZN Amazon.com Inc. | Add +1.1% | 1.52% | +0.15 |
| CYTK Cytokinetics Inc. | Add +53.4% | 0.83% | +0.14 |
| OLMA Olema Pharmaceuticals Inc. | Add +31.2% | 0.44% | +0.13 |
| NAMS Newamsterdam Pharma Co. NV | New | 0.13% | +0.13 |
| BZ Kanzhun Ltd. - ADR | Add +163.9% | 0.21% | +0.12 |
| NU Nu Holdings Ltd./Cayman Isl-A | Add +0.8% | 0.51% | +0.11 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 147 | $438.6M | DBC, ABVX, RVMD, DFTX, IMVT |
| Q1 2026 | 156 | $362.2M | DBC, ABVX, PRAX, COGT, SYRE |
| Q4 2025 | 145 | $388.3M | DBC, GPCR, COGT, VRDN, ABVX |
| Q3 2025 | 148 | $408.0M | DBC, ABVX, MRUS, VRDN, RVMD |
| Q2 2025 | 146 | $272.1M | DBC, VRDN, ANSS, MSFT, MRUS |
| Q1 2025 | 148 | $259.5M | DBC, HES, JNPR, ACI, ANSS |
| Q4 2024 | 137 | $268.8M | DBC, AMZN, HCP, MSFT, ANSS |
| Q3 2024 | 142 | $290.0M | DBC, AMZN, PCVX, ACLX, CTLT |
| Q2 2024 | 137 | $273.8M | DBC, INSM, MRUS, CRM, AXSM |
| Q1 2024 | 131 | $280.4M | DBC, APGE, SYRE, MRUS, MSFT |