HighVista Strategies LLC

Name: HighVista Strategies LLC 13F holdings, Q2 2025
Creator: HighVista Strategies LLC
Published: 2025-08-14

Q2 2026Q1 2026Q4 2025Q3 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024

In its 13F for Q2 2025 (holdings as of June 30, 2025, filed August 14, 2025), HighVista Strategies LLC reported 146 stock positions worth $272.1 million. Its top holding was Invesco DB Commodity Index T (DBC) at 11.5% of the portfolio, followed by Viridian Therapeutics (VRDN, 2.5%) and Ansys (ANSS, 2.2%). Compared with Q1 2025, it opened 29 new positions, sold out of 31, added to 50 and reduced 55. The biggest buy was Viridian Therapeutics (VRDN, shares +168%) and the biggest sale an exit from Albertsons Cos Class A (ACI).

Most Recent 13F: Q2 2026
Location: BOSTON, MA
CIK: 0001335325
Portfolio Value: $272.1M (Q2 2025)
SEC Filing: 0001172661-25-003309 ↗ filed Aug 14, 2025

Holdings Value

Holdings 146 stocks · $272.1M


DBC Invesco DB Commodity Index T	11.51%	1,436,136	$31.3M	No change
VRDN Viridian Therapeutics Inc.	2.49%	484,559	$6.8M	Add +168.4%
ANSS Ansys Inc.	2.21%	17,100	$6.0M	Add +33.6%
MSFT Microsoft Corp.	1.88%	10,258	$5.1M	Add +5.1%
MRUS Merus NV	1.74%	89,762	$4.7M	Add +63.1%
JNPR Juniper Networks Inc.	1.68%	114,700	$4.6M	No change
AMZN Amazon.com Inc.	1.52%	18,893	$4.1M	Add +1.1%
HES Hess Corp.	1.47%	28,900	$4.0M	No change
AMED Amedisys Inc.	1.42%	39,250	$3.9M	No change
NUVL Nuvalent Inc. Class A	1.41%	50,460	$3.9M	Add +26.5%
AVGO Broadcom Inc.	1.30%	12,800	$3.5M	Reduce -19.5%
WDC Western Digital Corp.	1.19%	50,600	$3.2M	Add +4.8%
AKRO Akero Therapeutics Inc.	1.18%	59,993	$3.2M	Add +149.3%
PTGX Protagonist Therapeutics Inc.	1.18%	57,851	$3.2M	Reduce -26.3%
STX Seagate Technology Holdings	1.17%	22,100	$3.2M	Reduce -3.9%
CORZ Core Scientific Inc.	1.13%	179,900	$3.1M	Reduce -9.6%
CRM Salesforce Inc.	1.12%	11,185	$3.1M	Add +20.5%
IMVT Immunovant Inc.	1.07%	182,808	$2.9M	Add +91.1%
BBIO Bridgebio Pharma Inc.	1.07%	67,499	$2.9M	Add +45.2%
XOMA Xoma Royalty Corporation	1.06%	114,548	$2.9M	No change
ELVN Enliven Therapeutics Inc.	1.04%	141,516	$2.8M	Add +25.8%
PRAX Praxis Precision Medicines I	1.04%	67,288	$2.8M	Add +71.3%
VRNA Verona Pharma Ltd.	1.00%	28,880	$2.7M	Add +72.9%
CEG Constellation Energy	0.98%	8,300	$2.7M	Reduce -17.8%
XPO Xpo Inc.	0.98%	21,080	$2.7M	Reduce -21.6%
INTU Intuit Inc.	0.94%	3,263	$2.6M	Reduce -15.5%
RVMD Revolution Medicines Inc.	0.92%	68,048	$2.5M	Reduce -7.7%
NVDA Nvidia Corp.	0.91%	15,700	$2.5M	Add +7.5%
PWR Quanta Services Inc.	0.89%	6,400	$2.4M	Reduce -21.0%
ACLX Arcellx Inc.	0.86%	35,714	$2.4M	Reduce -24.8%
AGIO Agios Pharmaceuticals Inc.	0.86%	70,127	$2.3M	Add +59.0%
META Meta Platforms Inc. Class A	0.84%	3,100	$2.3M	Reduce -3.1%
V Visa Inc. Class A	0.84%	6,427	$2.3M	Add +4.9%
CYTK Cytokinetics Inc.	0.83%	68,652	$2.3M	Add +53.4%
MA Mastercard Inc. Class A	0.83%	4,000	$2.2M	Add +8.1%
MMM 3M Co.	0.81%	14,400	$2.2M	Add +6.7%
AMD Advanced Micro Devices	0.80%	15,400	$2.2M	New
CLDX Celldex Therapeutics Inc.	0.80%	106,553	$2.2M	New
FERG Ferguson Enterprises Inc.	0.79%	9,878	$2.2M	New
GEV GE Vernova Inc.	0.78%	4,000	$2.1M	Reduce -59.2%
BKNG Booking Holdings Inc.	0.76%	357	$2.1M	No change
COGT Cogent Biosciences Inc.	0.75%	283,186	$2.0M	Add +1.3%
MLYS Mineralys Therapeutics Inc.	0.75%	150,138	$2.0M	New
SNPS Synopsys Inc.	0.73%	3,900	$2.0M	Add +25.8%
LYFT LYFT Inc. Class A	0.73%	125,800	$2.0M	New
APGE Apogee Therapeutics Inc.	0.72%	45,052	$2.0M	Add +4.3%
CLF Cleveland-Cliffs Inc.	0.71%	255,600	$1.9M	New
APH Amphenol Corp. Class A	0.69%	19,000	$1.9M	Reduce -17.0%
MTZ Mastec Inc.	0.69%	11,000	$1.9M	Reduce -32.5%
QXO Qxo Inc.	0.67%	84,500	$1.8M	Reduce -18.4%
GPCR Structure Therapeutics Inc.	0.66%	86,621	$1.8M	Add +393.3%
SNDK Sandisk Corp.	0.66%	39,600	$1.8M	New
RYTM Rhythm Pharmaceuticals Inc.	0.65%	28,068	$1.8M	Reduce -19.9%
HPE Hewlett Packard Enterprise	0.65%	86,200	$1.8M	Reduce -35.4%
PTC PTC Inc.	0.64%	10,122	$1.7M	Add +0.4%
TLN Talen Energy Corp.	0.63%	5,900	$1.7M	Reduce -23.4%
SYRE Spyre Therapeutics Inc.	0.62%	112,805	$1.7M	Add +18.5%
ENTG Entegris Inc.	0.62%	20,900	$1.7M	New
CSCO Cisco Systems Inc.	0.60%	23,600	$1.6M	Reduce -26.7%
PGR Progressive Corp.	0.58%	5,900	$1.6M	Add +18.0%
BAC Bank of America Corp. filed as BANK AMERICA CORP	0.57%	32,600	$1.5M	New
DAL Delta Air Lines Inc.	0.56%	30,800	$1.5M	No change
ALKS Alkermes PLC	0.56%	52,944	$1.5M	Reduce -25.2%
LQDA Liquidia Corp.	0.55%	120,641	$1.5M	Reduce -40.7%
APLS Apellis Pharmaceuticals Inc.	0.55%	86,663	$1.5M	Reduce -20.3%
SCHW Schwab (charles) Corp.	0.55%	16,300	$1.5M	New
GH Guardant Health Inc.	0.54%	28,265	$1.5M	Reduce -45.4%
WDAY Workday Inc. Class A	0.54%	6,100	$1.5M	Add +8.9%
JANX Janux Therapeutics Inc.	0.53%	62,436	$1.4M	Reduce -16.3%
RCL Royal Caribbean Cruises Ltd.	0.53%	4,600	$1.4M	Reduce -47.7%
CME Cme Group Inc.	0.53%	5,200	$1.4M	New
SE Sea Ltd.-ADR	0.53%	8,941	$1.4M	Reduce -16.0%
XENE Xenon Pharmaceuticals Inc.	0.52%	45,620	$1.4M	Reduce -31.7%
RBC RBC Bearings Inc.	0.52%	3,700	$1.4M	Add +8.8%
TKO Tko Group Holdings Inc.	0.51%	7,600	$1.4M	Reduce -17.4%
U Unity Software Inc.	0.51%	57,100	$1.4M	New
NU Nu Holdings Ltd./Cayman Isl-A filed as NU HLDGS LTD	0.51%	100,537	$1.4M	Add +0.8%
BBD Banco Bradesco-ADR	0.50%	443,600	$1.4M	Reduce -14.2%
ARGX Argenx SE - ADR	0.49%	2,415	$1.3M	Reduce -24.6%
CPNG Coupang Inc.	0.47%	43,000	$1.3M	Reduce -9.5%
REXR Rexford Industrial Realty Inc.	0.47%	36,200	$1.3M	New
APG Api Group Corp.	0.47%	25,150	$1.3M	New
ETR Entergy Corp.	0.47%	15,300	$1.3M	New
AGX Argan Inc.	0.46%	5,700	$1.3M	Reduce -51.3%
CAAP Corp. America Airports SA filed as CORPORACION AMER ARPTS S A	0.46%	62,000	$1.3M	Add +3.0%
CNX CNX Resources Corp.	0.46%	37,100	$1.2M	Reduce -20.6%
PFSI Pennymac Financial Services	0.46%	12,537	$1.2M	Reduce -6.7%
BVN Cia DE Minas Buenaventur-ADR filed as COMPANIA DE MINAS BUENAVENTU	0.46%	75,831	$1.2M	Reduce -6.0%
ADBE Adobe Inc.	0.45%	3,200	$1.2M	New
PM Philip Morris International	0.45%	6,700	$1.2M	Reduce -44.6%
RXO Rxo Inc.	0.45%	77,100	$1.2M	Add +12.7%
PBR.A Petroleo Brasil-SP Pref ADR	0.45%	105,000	$1.2M	Add +18.0%
MAGN Magnera Corp.	0.44%	99,700	$1.2M	Add +49.7%
DVAX Dynavax Technologies Corp.	0.44%	120,271	$1.2M	Reduce -48.9%
HCA HCA Healthcare Inc.	0.44%	3,100	$1.2M	New
OFIX Orthofix Medical Inc.	0.44%	106,500	$1.2M	Add +14.6%
OLMA Olema Pharmaceuticals Inc.	0.44%	278,430	$1.2M	Add +31.2%
INSM Insmed Inc.	0.43%	11,595	$1.2M	Reduce -45.9%
KGS Kodiak Gas Services Inc.	0.43%	34,000	$1.2M	New
RNAM Avidity Biosciences Inc.	0.43%	40,864	$1.2M	Reduce -24.6%
AXSM Axsome Therapeutics Inc.	0.42%	10,909	$1.1M	Reduce -49.3%
FOUR SHIFT4 Payments Inc. Class A	0.41%	11,300	$1.1M	New
SRRK Scholar Rock Holding Corp.	0.41%	31,230	$1.1M	No change
LKQ LKQ Corp.	0.40%	29,500	$1.1M	Reduce -19.6%
PCVX Vaxcyte Inc.	0.40%	33,457	$1.1M	Add +1.1%
SLNO Soleno Therapeutics Inc.	0.40%	12,941	$1.1M	Reduce -9.8%
HDB HDFC Bank Ltd.-ADR	0.37%	13,241	$1.0M	Reduce -27.4%
HUBS HubSpot Inc.	0.37%	1,800	$1.0M	No change
MLTX Moonlake Immunotherapeutics	0.36%	20,953	$989K	Reduce -51.9%
IBN Icici Bank Ltd.-Spon ADR	0.36%	29,047	$977K	Reduce -25.0%
VERA Vera Therapeutics Inc.	0.35%	40,473	$954K	Reduce -22.5%
ALV Autoliv Inc.	0.35%	8,500	$951K	New
EWTX Edgewise Therapeutics Inc.	0.34%	69,723	$914K	Reduce -23.6%
OCUL Ocular Therapeutix Inc.	0.30%	88,876	$825K	Add +4.3%
KROS Keros Therapeutics Inc.	0.26%	52,618	$702K	Add +1.0%
MDGL Madrigal Pharmaceuticals Inc.	0.26%	2,305	$698K	Add +4.3%
ROIV Roivant Sciences Ltd.	0.25%	61,268	$690K	Reduce -46.9%
NTRA Natera Inc.	0.25%	4,014	$678K	Add +4.3%
GHRS GH Research PLC	0.23%	52,247	$637K	New
JD Jd.com Inc.-ADR	0.23%	19,183	$626K	Add +71.5%
BZ Kanzhun Ltd. - ADR	0.21%	31,400	$560K	Add +163.9%
CNTA Centessa Pharmaceuticals Ltd.	0.20%	40,684	$535K	Add +4.3%
EOLS Evolus Inc.	0.20%	58,042	$535K	New
CRBP Corbus Pharmaceuticals Holdi	0.19%	75,292	$520K	No change
RLAY Relay Therapeutics Inc.	0.19%	149,701	$518K	New
ASND Ascendis Pharma A/S	0.19%	2,974	$513K	Reduce -51.0%
TCOM Trip.com Group Ltd.-ADR	0.18%	8,456	$496K	Reduce -32.1%
CATX Perspective Therapeutics Inc.	0.17%	138,350	$476K	No change
TARS Tarsus Pharmaceuticals Inc.	0.17%	11,680	$473K	New
ETNB 89BIO Inc.	0.17%	47,633	$468K	New
NOK Nokia Corp.-Spon ADR	0.16%	83,500	$433K	New
ALC Alcon Inc. filed as ALCON AG	0.16%	6,123	$430K	New
BABA Alibaba Group Holding-SP ADR	0.16%	3,757	$426K	Reduce -49.6%
PHVS Pharvaris NV	0.15%	23,739	$418K	Add +4.3%
ABVX Abivax SA-ADR	0.14%	51,156	$391K	Add +4.3%
IRON Disc Medicine Inc.	0.13%	6,733	$357K	Add +4.3%
NAMS Newamsterdam Pharma Co. NV	0.13%	19,274	$349K	New
DNTH Dianthus Therapeutics Inc.	0.11%	15,861	$295K	Reduce -49.5%
CGON CG Oncology Inc.	0.10%	10,328	$269K	Reduce -53.7%
XNCR Xencor Inc.	0.10%	33,304	$262K	Add +4.3%
DYN Dyne Therapeutics Inc.	0.09%	26,324	$251K	Reduce -66.4%
CGEM Cullinan Therapeutics Inc.	0.09%	31,893	$240K	No change
TYRA Tyra Biosciences Inc.	0.09%	24,962	$239K	Add +4.3%
WVE Wave Life Sciences Ltd.	0.09%	35,958	$234K	Reduce -32.6%
GERN Geron Corp.	0.07%	132,711	$187K	Add +4.3%
TAL Tal Education Group- ADR	0.07%	18,100	$185K	New

Portfolio Sells Q1 2025 → Q2 2025


ACI Albertsons Cos Inc. Class A	Sold out	0.00%	−1.60
SWTX Springworks Therapeutics Inc.	Sold out	0.00%	−1.17
GOOG Alphabet Inc. Class C	Sold out	0.00%	−0.81
BHC Bausch Health Cos Inc.	Sold out	0.00%	−0.78
DVAX Dynavax Technologies Corp.	Reduce -48.9%	0.44%	−0.74
GEHC GE Healthcare Technology	Sold out	0.00%	−0.72
STZ Constellation Brands Inc. Class A	Sold out	0.00%	−0.70
KNSA Kiniksa Pharmaceuticals Inte	Sold out	0.00%	−0.64
NATL NCR Atleos Corp.	Sold out	0.00%	−0.63
LQDA Liquidia Corp.	Reduce -40.7%	0.55%	−0.60
TSM Taiwan Semiconductor-SP ADR	Sold out	0.00%	−0.57
CRH CRH PLC	Sold out	0.00%	−0.57
CIEN Ciena Corp.	Sold out	0.00%	−0.57
ELV Elevance Health Inc.	Sold out	0.00%	−0.55
BN Brookfield Corp.	Sold out	0.00%	−0.55
EYE National Vision Holdings Inc.	Sold out	0.00%	−0.55
AXSM Axsome Therapeutics Inc.	Reduce -49.3%	0.42%	−0.55
UAL United Airlines Holdings Inc.	Sold out	0.00%	−0.54
QSR Restaurant Brands Intern	Sold out	0.00%	−0.52
AAL American Airlines Group Inc.	Sold out	0.00%	−0.51
DUOL Duolingo	Sold out	0.00%	−0.50
ON On Semiconductor	Sold out	0.00%	−0.49
MRVL Marvell Technology Inc.	Sold out	0.00%	−0.48
EWTX Edgewise Therapeutics Inc.	Reduce -23.6%	0.34%	−0.44
GEV GE Vernova Inc.	Reduce -59.2%	0.78%	−0.38
CRNX Crinetics Pharmaceuticals Inc.	Sold out	0.00%	−0.37
APLS Apellis Pharmaceuticals Inc.	Reduce -20.3%	0.55%	−0.36
ALKS Alkermes PLC	Reduce -25.2%	0.56%	−0.34
XENE Xenon Pharmaceuticals Inc.	Reduce -31.7%	0.52%	−0.34
ACLX Arcellx Inc.	Reduce -24.8%	0.86%	−0.34
GH Guardant Health Inc.	Reduce -45.4%	0.54%	−0.31
MLTX Moonlake Immunotherapeutics	Reduce -51.9%	0.36%	−0.29
PM Philip Morris International	Reduce -44.6%	0.45%	−0.29
PTGX Protagonist Therapeutics Inc.	Reduce -26.3%	1.18%	−0.29
JANX Janux Therapeutics Inc.	Reduce -16.3%	0.53%	−0.25
ARGX Argenx SE - ADR	Reduce -24.6%	0.49%	−0.24
DYN Dyne Therapeutics Inc.	Reduce -66.4%	0.09%	−0.22
BABA Alibaba Group Holding-SP ADR	Reduce -49.6%	0.16%	−0.22
ACN Accenture PLC Class A	Sold out	0.00%	−0.22
INSM Insmed Inc.	Reduce -45.9%	0.43%	−0.20
LKQ LKQ Corp.	Reduce -19.6%	0.40%	−0.20
ROIV Roivant Sciences Ltd.	Reduce -46.9%	0.25%	−0.19
ZYME Zymeworks Inc.	Sold out	0.00%	−0.19
RNAM Avidity Biosciences Inc.	Reduce -24.6%	0.43%	−0.19
RARE Ultragenyx Pharmaceutical Inc.	Sold out	0.00%	−0.19
ASND Ascendis Pharma A/S	Reduce -51.0%	0.19%	−0.18
RCL Royal Caribbean Cruises Ltd.	Reduce -47.7%	0.53%	−0.17
CSCO Cisco Systems Inc.	Reduce -26.7%	0.60%	−0.16
MIRM Mirum Pharmaceuticals Inc.	Sold out	0.00%	−0.16
KALV Kalvista Pharmaceuticals Inc.	Sold out	0.00%	−0.15

Portfolio Buys Q1 2025 → Q2 2025


VRDN Viridian Therapeutics Inc.	Add +168.4%	2.49%	+1.55
MRUS Merus NV	Add +63.1%	1.74%	+0.84
AMD Advanced Micro Devices	New	0.80%	+0.80
AKRO Akero Therapeutics Inc.	Add +149.3%	1.18%	+0.80
CLDX Celldex Therapeutics Inc.	New	0.80%	+0.80
FERG Ferguson Enterprises Inc.	New	0.79%	+0.79
MLYS Mineralys Therapeutics Inc.	New	0.75%	+0.75
LYFT LYFT Inc. Class A	New	0.73%	+0.73
CLF Cleveland-Cliffs Inc.	New	0.71%	+0.71
SNDK Sandisk Corp.	New	0.66%	+0.66
ANSS Ansys Inc.	Add +33.6%	2.21%	+0.65
ENTG Entegris Inc.	New	0.62%	+0.62
VRNA Verona Pharma Ltd.	Add +72.9%	1.00%	+0.60
BAC Bank of America Corp.	New	0.57%	+0.57
SCHW Schwab (charles) Corp.	New	0.55%	+0.55
GPCR Structure Therapeutics Inc.	Add +393.3%	0.66%	+0.54
CME Cme Group Inc.	New	0.53%	+0.53
U Unity Software Inc.	New	0.51%	+0.51
REXR Rexford Industrial Realty Inc.	New	0.47%	+0.47
APG Api Group Corp.	New	0.47%	+0.47
ETR Entergy Corp.	New	0.47%	+0.47
PRAX Praxis Precision Medicines I	Add +71.3%	1.04%	+0.47
MSFT Microsoft Corp.	Add +5.1%	1.88%	+0.46
ADBE Adobe Inc.	New	0.45%	+0.45
BBIO Bridgebio Pharma Inc.	Add +45.2%	1.07%	+0.45
IMVT Immunovant Inc.	Add +91.1%	1.07%	+0.45
WDC Western Digital Corp.	Add +4.8%	1.19%	+0.44
HCA HCA Healthcare Inc.	New	0.44%	+0.44
KGS Kodiak Gas Services Inc.	New	0.43%	+0.43
FOUR SHIFT4 Payments Inc. Class A	New	0.41%	+0.41
AGIO Agios Pharmaceuticals Inc.	Add +59.0%	0.86%	+0.36
ALV Autoliv Inc.	New	0.35%	+0.35
NUVL Nuvalent Inc. Class A	Add +26.5%	1.41%	+0.33
NVDA Nvidia Corp.	Add +7.5%	0.91%	+0.30
GHRS GH Research PLC	New	0.23%	+0.23
SNPS Synopsys Inc.	Add +25.8%	0.73%	+0.22
EOLS Evolus Inc.	New	0.20%	+0.20
ELVN Enliven Therapeutics Inc.	Add +25.8%	1.04%	+0.19
RLAY Relay Therapeutics Inc.	New	0.19%	+0.19
TARS Tarsus Pharmaceuticals Inc.	New	0.17%	+0.17
ETNB 89BIO Inc.	New	0.17%	+0.17
CRM Salesforce Inc.	Add +20.5%	1.12%	+0.16
NOK Nokia Corp.-Spon ADR	New	0.16%	+0.16
ALC Alcon Inc.	New	0.16%	+0.16
AMZN Amazon.com Inc.	Add +1.1%	1.52%	+0.15
CYTK Cytokinetics Inc.	Add +53.4%	0.83%	+0.14
OLMA Olema Pharmaceuticals Inc.	Add +31.2%	0.44%	+0.13
NAMS Newamsterdam Pharma Co. NV	New	0.13%	+0.13
BZ Kanzhun Ltd. - ADR	Add +163.9%	0.21%	+0.12
NU Nu Holdings Ltd./Cayman Isl-A	Add +0.8%	0.51%	+0.11

All Filings

Quarter	Positions	13F Reported Value	Top Holdings
Q2 2026	147	$438.6M	DBC, ABVX, RVMD, DFTX, IMVT
Q1 2026	156	$362.2M	DBC, ABVX, PRAX, COGT, SYRE
Q4 2025	145	$388.3M	DBC, GPCR, COGT, VRDN, ABVX
Q3 2025	148	$408.0M	DBC, ABVX, MRUS, VRDN, RVMD
Q2 2025	146	$272.1M	DBC, VRDN, ANSS, MSFT, MRUS
Q1 2025	148	$259.5M	DBC, HES, JNPR, ACI, ANSS
Q4 2024	137	$268.8M	DBC, AMZN, HCP, MSFT, ANSS
Q3 2024	142	$290.0M	DBC, AMZN, PCVX, ACLX, CTLT
Q2 2024	137	$273.8M	DBC, INSM, MRUS, CRM, AXSM
Q1 2024	131	$280.4M	DBC, APGE, SYRE, MRUS, MSFT