HighVista Strategies LLC
In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 14, 2025), HighVista Strategies LLC reported 148 stock positions worth $408.0 million. Its top holding was Invesco DB Commodity Index T (DBC) at 7.9% of the portfolio, followed by Abivax SA-ADR (ABVX, 3.8%) and Merus (MRUS, 3.1%). Compared with Q2 2025, it opened 29 new positions, sold out of 27, added to 78 and reduced 38. The biggest buy was Abivax SA-ADR (ABVX, shares +261%) and the biggest sale an exit from Ansys (ANSS).
- Most Recent 13F
- Q2 2026
- Location
- BOSTON, MA
- CIK
- 0001335325
- Portfolio Value
- $408.0M (Q3 2025)
- SEC Filing
- 0001172661-25-004799 ↗ filed Nov 14, 2025
Holdings Value
Holdings 148 stocks · $408.0M
| DBC Invesco DB Commodity Index T | 7.93% | 1,436,136 | $32.4M | No change |
| ABVX Abivax SA-ADR | 3.84% | 184,468 | $15.7M | Add +260.6% |
| MRUS Merus NV | 3.08% | 133,321 | $12.6M | Add +48.5% |
| VRDN Viridian Therapeutics Inc. | 2.48% | 469,335 | $10.1M | Reduce -3.1% |
| RVMD Revolution Medicines Inc. | 2.01% | 175,448 | $8.2M | Add +157.8% |
| PTGX Protagonist Therapeutics Inc. | 1.98% | 121,682 | $8.1M | Add +110.3% |
| NUVL Nuvalent Inc. Class A | 1.98% | 93,294 | $8.1M | Add +84.9% |
| MLYS Mineralys Therapeutics Inc. | 1.95% | 209,829 | $8.0M | Add +39.8% |
| ACLX Arcellx Inc. | 1.94% | 96,177 | $7.9M | Add +169.3% |
| AGIO Agios Pharmaceuticals Inc. | 1.92% | 195,298 | $7.8M | Add +178.5% |
| CYTK Cytokinetics Inc. | 1.79% | 132,930 | $7.3M | Add +93.6% |
| INSM Insmed Inc. | 1.76% | 49,949 | $7.2M | Add +330.8% |
| CDTX Cidara Therapeutics Inc. | 1.66% | 70,904 | $6.8M | New |
| COGT Cogent Biosciences Inc. | 1.63% | 462,405 | $6.6M | Add +63.3% |
| GPCR Structure Therapeutics Inc. | 1.62% | 236,236 | $6.6M | Add +172.7% |
| AMZN Amazon.com Inc. | 1.42% | 26,393 | $5.8M | Add +39.7% |
| SNDK Sandisk Corp. | 1.30% | 47,451 | $5.3M | Add +19.8% |
| ELVN Enliven Therapeutics Inc. | 1.30% | 259,135 | $5.3M | Add +83.1% |
| AKRO Akero Therapeutics Inc. | 1.28% | 110,079 | $5.2M | Add +83.5% |
| PRAX Praxis Precision Medicines I | 1.23% | 95,002 | $5.0M | Add +41.2% |
| MSFT Microsoft Corp. | 1.20% | 9,458 | $4.9M | Reduce -7.8% |
| OLMA Olema Pharmaceuticals Inc. | 1.05% | 437,179 | $4.3M | Add +57.0% |
| BBIO Bridgebio Pharma Inc. | 1.04% | 81,959 | $4.3M | Add +21.4% |
| APGE Apogee Therapeutics Inc. | 1.04% | 107,107 | $4.3M | Add +137.7% |
| IMVT Immunovant Inc. | 1.00% | 253,127 | $4.1M | Add +38.5% |
| XOMA Xoma Royalty Corporation | 1.00% | 105,714 | $4.1M | Reduce -7.7% |
| GH Guardant Health Inc. | 0.99% | 64,583 | $4.0M | Add +128.5% |
| LQDA Liquidia Corp. | 0.98% | 176,485 | $4.0M | Add +46.3% |
| RYTM Rhythm Pharmaceuticals Inc. | 0.93% | 37,482 | $3.8M | Add +33.5% |
| SYRE Spyre Therapeutics Inc. | 0.89% | 215,746 | $3.6M | Add +91.3% |
| CLDX Celldex Therapeutics Inc. | 0.86% | 135,258 | $3.5M | Add +26.9% |
| GHRS GH Research PLC | 0.85% | 241,894 | $3.5M | Add +363.0% |
| EWTX Edgewise Therapeutics Inc. | 0.83% | 208,101 | $3.4M | Add +198.5% |
| AVGO Broadcom Inc. | 0.82% | 10,200 | $3.4M | Reduce -20.3% |
| META Meta Platforms Inc. Class A | 0.81% | 4,500 | $3.3M | Add +45.2% |
| XENE Xenon Pharmaceuticals Inc. | 0.81% | 82,190 | $3.3M | Add +80.2% |
| APLS Apellis Pharmaceuticals Inc. | 0.81% | 145,729 | $3.3M | Add +68.2% |
| PCVX Vaxcyte Inc. | 0.77% | 86,802 | $3.1M | Add +159.4% |
| CRM Salesforce Inc. | 0.75% | 12,885 | $3.1M | Add +15.2% |
| ARGX Argenx SE - ADR | 0.74% | 4,068 | $3.0M | Add +68.5% |
| RNAM Avidity Biosciences Inc. | 0.70% | 65,580 | $2.9M | Add +60.5% |
| AMD Advanced Micro Devices | 0.68% | 17,200 | $2.8M | Add +11.7% |
| XPO Xpo Inc. | 0.67% | 21,080 | $2.7M | No change |
| U Unity Software Inc. | 0.66% | 67,229 | $2.7M | Add +17.7% |
| V Visa Inc. Class A | 0.66% | 7,861 | $2.7M | Add +22.3% |
| VERA Vera Therapeutics Inc. | 0.65% | 91,189 | $2.6M | Add +125.3% |
| CEG Constellation Energy | 0.61% | 7,600 | $2.5M | Reduce -8.4% |
| NVDA Nvidia Corp. | 0.61% | 13,400 | $2.5M | Reduce -14.7% |
| HPE Hewlett Packard Enterprise | 0.59% | 98,700 | $2.4M | Add +14.5% |
| MA Mastercard Inc. Class A | 0.59% | 4,205 | $2.4M | Add +5.1% |
| GOOG Alphabet Inc. Class C | 0.58% | 9,800 | $2.4M | New |
| CRH CRH PLC | 0.57% | 19,439 | $2.3M | New |
| SRRK Scholar Rock Holding Corp. | 0.54% | 59,573 | $2.2M | Add +90.8% |
| FERG Ferguson Enterprises Inc. | 0.53% | 9,678 | $2.2M | Reduce -2.0% |
| TLN Talen Energy Corp. | 0.53% | 5,100 | $2.2M | Reduce -13.6% |
| PWR Quanta Services Inc. | 0.53% | 5,200 | $2.2M | Reduce -18.8% |
| AVTR Avantor Inc. | 0.53% | 172,400 | $2.2M | New |
| DNTH Dianthus Therapeutics Inc. | 0.52% | 54,225 | $2.1M | Add +241.9% |
| CLH Clean Harbors Inc. | 0.52% | 9,106 | $2.1M | New |
| LITE Lumentum Holdings Inc. | 0.52% | 12,927 | $2.1M | New |
| FLS Flowserve Corp. | 0.51% | 38,975 | $2.1M | New |
| COF Capital One Financial Corp. | 0.50% | 9,674 | $2.1M | New |
| BVN Cia DE Minas Buenaventur-ADR filed as COMPANIA DE MINAS BUENAVENTU | 0.49% | 82,931 | $2.0M | Add +9.4% |
| WDAY Workday Inc. Class A | 0.48% | 8,191 | $2.0M | Add +34.3% |
| PTC PTC Inc. | 0.47% | 9,522 | $1.9M | Reduce -5.9% |
| AGX Argan Inc. | 0.47% | 7,100 | $1.9M | Add +24.6% |
| DVAX Dynavax Technologies Corp. | 0.47% | 192,849 | $1.9M | Add +60.4% |
| APH Amphenol Corp. Class A | 0.47% | 15,400 | $1.9M | Reduce -18.9% |
| FN Fabrinet | 0.46% | 5,100 | $1.9M | New |
| BBD Banco Bradesco-ADR | 0.43% | 520,100 | $1.8M | Add +17.3% |
| NU Nu Holdings Ltd./Cayman Isl-A filed as NU HLDGS LTD | 0.43% | 109,337 | $1.8M | Add +8.8% |
| QXO Qxo Inc. | 0.42% | 90,200 | $1.7M | Add +6.8% |
| WDC Western Digital Corp. | 0.42% | 14,242 | $1.7M | Reduce -71.8% |
| P Everpure Inc. Class A filed as PURE STORAGE INC | 0.42% | 20,400 | $1.7M | New |
| KBR KBR Inc. | 0.41% | 35,500 | $1.7M | New |
| PBR.A Petroleo Brasil-SP Pref ADR | 0.40% | 138,200 | $1.6M | Add +31.6% |
| STX Seagate Technology Holdings | 0.40% | 6,898 | $1.6M | Reduce -68.8% |
| APG Api Group Corp. | 0.40% | 47,350 | $1.6M | Add +25.5% |
| MDGL Madrigal Pharmaceuticals Inc. | 0.40% | 3,537 | $1.6M | Add +53.5% |
| CNTA Centessa Pharmaceuticals Ltd. | 0.38% | 63,301 | $1.5M | Add +55.6% |
| CNM Core & Main Inc. Class A | 0.37% | 27,900 | $1.5M | New |
| ROIV Roivant Sciences Ltd. | 0.37% | 98,858 | $1.5M | Add +61.4% |
| CRBP Corbus Pharmaceuticals Holdi | 0.37% | 118,027 | $1.5M | Add +56.8% |
| CSCO Cisco Systems Inc. | 0.37% | 21,800 | $1.5M | Reduce -7.6% |
| INTU Intuit Inc. | 0.36% | 2,163 | $1.5M | Reduce -33.7% |
| TARS Tarsus Pharmaceuticals Inc. | 0.36% | 24,854 | $1.5M | Add +112.8% |
| ENTG Entegris Inc. | 0.36% | 15,700 | $1.5M | Reduce -24.9% |
| RDDT Reddit Inc. Class A | 0.36% | 6,300 | $1.4M | New |
| MTZ Mastec Inc. | 0.35% | 6,700 | $1.4M | Reduce -39.1% |
| BAC Bank of America Corp. filed as BANK AMERICA CORP | 0.35% | 27,500 | $1.4M | Reduce -15.6% |
| ASND Ascendis Pharma A/S | 0.35% | 7,082 | $1.4M | Add +138.1% |
| ADMA Adma Biologics Inc. | 0.34% | 95,112 | $1.4M | New |
| EOLS Evolus Inc. | 0.34% | 226,025 | $1.4M | Add +289.4% |
| RBC RBC Bearings Inc. | 0.33% | 3,500 | $1.4M | Reduce -5.4% |
| OFIX Orthofix Medical Inc. | 0.33% | 93,200 | $1.4M | Reduce -12.5% |
| PGR Progressive Corp. | 0.33% | 5,500 | $1.4M | Reduce -6.8% |
| JANX Janux Therapeutics Inc. | 0.33% | 55,250 | $1.4M | Reduce -11.5% |
| CORZ Core Scientific Inc. | 0.33% | 75,163 | $1.3M | Reduce -58.2% |
| SCHW Schwab (charles) Corp. | 0.33% | 14,100 | $1.3M | Reduce -13.5% |
| ALKS Alkermes PLC | 0.32% | 44,081 | $1.3M | Reduce -16.7% |
Portfolio Sells Q2 2025 → Q3 2025
| ANSS Ansys Inc. | Sold out | 0.00% | −2.21 |
| JNPR Juniper Networks Inc. | Sold out | 0.00% | −1.68 |
| HES Hess Corp. | Sold out | 0.00% | −1.47 |
| AMED Amedisys Inc. | Sold out | 0.00% | −1.42 |
| VRNA Verona Pharma Ltd. | Sold out | 0.00% | −1.00 |
| CORZ Core Scientific Inc. | Reduce -58.2% | 0.33% | −0.80 |
| STX Seagate Technology Holdings | Reduce -68.8% | 0.40% | −0.77 |
| WDC Western Digital Corp. | Reduce -71.8% | 0.42% | −0.77 |
| SNPS Synopsys Inc. | Sold out | 0.00% | −0.73 |
| LYFT LYFT Inc. Class A | Sold out | 0.00% | −0.73 |
| CLF Cleveland-Cliffs Inc. | Sold out | 0.00% | −0.71 |
| MSFT Microsoft Corp. | Reduce -7.8% | 1.20% | −0.67 |
| INTU Intuit Inc. | Reduce -33.7% | 0.36% | −0.58 |
| DAL Delta Air Lines Inc. | Sold out | 0.00% | −0.56 |
| BKNG Booking Holdings Inc. | Reduce -56.0% | 0.21% | −0.55 |
| RCL Royal Caribbean Cruises Ltd. | Sold out | 0.00% | −0.53 |
| GEV GE Vernova Inc. | Reduce -58.8% | 0.25% | −0.53 |
| CME Cme Group Inc. | Sold out | 0.00% | −0.53 |
| MMM 3M Co. | Reduce -47.2% | 0.29% | −0.52 |
| TKO Tko Group Holdings Inc. | Sold out | 0.00% | −0.51 |
| REXR Rexford Industrial Realty Inc. | Sold out | 0.00% | −0.47 |
| AVGO Broadcom Inc. | Reduce -20.3% | 0.82% | −0.47 |
| ADBE Adobe Inc. | Sold out | 0.00% | −0.45 |
| PM Philip Morris International | Sold out | 0.00% | −0.45 |
| HCA HCA Healthcare Inc. | Sold out | 0.00% | −0.44 |
| KGS Kodiak Gas Services Inc. | Sold out | 0.00% | −0.43 |
| LKQ LKQ Corp. | Sold out | 0.00% | −0.40 |
| CEG Constellation Energy | Reduce -8.4% | 0.61% | −0.37 |
| HUBS HubSpot Inc. | Sold out | 0.00% | −0.37 |
| PWR Quanta Services Inc. | Reduce -18.8% | 0.53% | −0.36 |
| MTZ Mastec Inc. | Reduce -39.1% | 0.35% | −0.34 |
| MLTX Moonlake Immunotherapeutics | Reduce -9.0% | 0.03% | −0.33 |
| SE Sea Ltd.-ADR | Reduce -42.5% | 0.23% | −0.30 |
| NVDA Nvidia Corp. | Reduce -14.7% | 0.61% | −0.30 |
| CPNG Coupang Inc. | Reduce -44.1% | 0.19% | −0.28 |
| ENTG Entegris Inc. | Reduce -24.9% | 0.36% | −0.26 |
| FERG Ferguson Enterprises Inc. | Reduce -2.0% | 0.53% | −0.26 |
| ETR Entergy Corp. | Reduce -37.3% | 0.22% | −0.25 |
| PGR Progressive Corp. | Reduce -6.8% | 0.33% | −0.25 |
| CSCO Cisco Systems Inc. | Reduce -7.6% | 0.37% | −0.24 |
| ALKS Alkermes PLC | Reduce -16.7% | 0.32% | −0.23 |
| APH Amphenol Corp. Class A | Reduce -18.9% | 0.47% | −0.22 |
| BAC Bank of America Corp. | Reduce -15.6% | 0.35% | −0.22 |
| SCHW Schwab (charles) Corp. | Reduce -13.5% | 0.33% | −0.22 |
| CNX CNX Resources Corp. | Reduce -15.6% | 0.25% | −0.21 |
| PFSI Pennymac Financial Services | Reduce -33.5% | 0.25% | −0.21 |
| JANX Janux Therapeutics Inc. | Reduce -11.5% | 0.33% | −0.20 |
| MAGN Magnera Corp. | Reduce -12.6% | 0.25% | −0.19 |
| RBC RBC Bearings Inc. | Reduce -5.4% | 0.33% | −0.19 |
| CATX Perspective Therapeutics Inc. | Sold out | 0.00% | −0.17 |
Portfolio Buys Q2 2025 → Q3 2025
| ABVX Abivax SA-ADR | Add +260.6% | 3.84% | +3.70 |
| CDTX Cidara Therapeutics Inc. | New | 1.66% | +1.66 |
| MRUS Merus NV | Add +48.5% | 3.08% | +1.34 |
| INSM Insmed Inc. | Add +330.8% | 1.76% | +1.33 |
| MLYS Mineralys Therapeutics Inc. | Add +39.8% | 1.95% | +1.20 |
| RVMD Revolution Medicines Inc. | Add +157.8% | 2.01% | +1.09 |
| ACLX Arcellx Inc. | Add +169.3% | 1.94% | +1.07 |
| AGIO Agios Pharmaceuticals Inc. | Add +178.5% | 1.92% | +1.06 |
| GPCR Structure Therapeutics Inc. | Add +172.7% | 1.62% | +0.96 |
| CYTK Cytokinetics Inc. | Add +93.6% | 1.79% | +0.96 |
| COGT Cogent Biosciences Inc. | Add +63.3% | 1.63% | +0.88 |
| PTGX Protagonist Therapeutics Inc. | Add +110.3% | 1.98% | +0.81 |
| SNDK Sandisk Corp. | Add +19.8% | 1.30% | +0.65 |
| GHRS GH Research PLC | Add +363.0% | 0.85% | +0.61 |
| OLMA Olema Pharmaceuticals Inc. | Add +57.0% | 1.05% | +0.61 |
| GOOG Alphabet Inc. Class C | New | 0.58% | +0.58 |
| CRH CRH PLC | New | 0.57% | +0.57 |
| NUVL Nuvalent Inc. Class A | Add +84.9% | 1.98% | +0.56 |
| AVTR Avantor Inc. | New | 0.53% | +0.53 |
| CLH Clean Harbors Inc. | New | 0.52% | +0.52 |
| LITE Lumentum Holdings Inc. | New | 0.52% | +0.52 |
| FLS Flowserve Corp. | New | 0.51% | +0.51 |
| COF Capital One Financial Corp. | New | 0.50% | +0.50 |
| EWTX Edgewise Therapeutics Inc. | Add +198.5% | 0.83% | +0.49 |
| FN Fabrinet | New | 0.46% | +0.46 |
| GH Guardant Health Inc. | Add +128.5% | 0.99% | +0.45 |
| LQDA Liquidia Corp. | Add +46.3% | 0.98% | +0.43 |
| P Everpure Inc. Class A | New | 0.42% | +0.42 |
| DNTH Dianthus Therapeutics Inc. | Add +241.9% | 0.52% | +0.41 |
| KBR KBR Inc. | New | 0.41% | +0.41 |
| CNM Core & Main Inc. Class A | New | 0.37% | +0.37 |
| PCVX Vaxcyte Inc. | Add +159.4% | 0.77% | +0.37 |
| RDDT Reddit Inc. Class A | New | 0.36% | +0.36 |
| ADMA Adma Biologics Inc. | New | 0.34% | +0.34 |
| APGE Apogee Therapeutics Inc. | Add +137.7% | 1.04% | +0.32 |
| VERA Vera Therapeutics Inc. | Add +125.3% | 0.65% | +0.30 |
| JCI Johnson Controls Internation | New | 0.30% | +0.30 |
| RBLX Roblox Corp. Class A | New | 0.30% | +0.30 |
| NEE Nextera Energy Inc. | New | 0.29% | +0.29 |
| MELI MercadoLibre Inc. | New | 0.29% | +0.29 |
| CZR Caesars Entertainment Inc. | New | 0.28% | +0.28 |
| XENE Xenon Pharmaceuticals Inc. | Add +80.2% | 0.81% | +0.28 |
| RYTM Rhythm Pharmaceuticals Inc. | Add +33.5% | 0.93% | +0.28 |
| RNAM Avidity Biosciences Inc. | Add +60.5% | 0.70% | +0.27 |
| SYRE Spyre Therapeutics Inc. | Add +91.3% | 0.89% | +0.27 |
| APLS Apellis Pharmaceuticals Inc. | Add +68.2% | 0.81% | +0.26 |
| ELVN Enliven Therapeutics Inc. | Add +83.1% | 1.30% | +0.26 |
| ARGX Argenx SE - ADR | Add +68.5% | 0.74% | +0.25 |
| AFRM Affirm Holdings Inc. | New | 0.22% | +0.22 |
| KYMR Kymera Therapeutics Inc. | New | 0.22% | +0.22 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 147 | $438.6M | DBC, ABVX, RVMD, DFTX, IMVT |
| Q1 2026 | 156 | $362.2M | DBC, ABVX, PRAX, COGT, SYRE |
| Q4 2025 | 145 | $388.3M | DBC, GPCR, COGT, VRDN, ABVX |
| Q3 2025 | 148 | $408.0M | DBC, ABVX, MRUS, VRDN, RVMD |
| Q2 2025 | 146 | $272.1M | DBC, VRDN, ANSS, MSFT, MRUS |
| Q1 2025 | 148 | $259.5M | DBC, HES, JNPR, ACI, ANSS |
| Q4 2024 | 137 | $268.8M | DBC, AMZN, HCP, MSFT, ANSS |
| Q3 2024 | 142 | $290.0M | DBC, AMZN, PCVX, ACLX, CTLT |
| Q2 2024 | 137 | $273.8M | DBC, INSM, MRUS, CRM, AXSM |
| Q1 2024 | 131 | $280.4M | DBC, APGE, SYRE, MRUS, MSFT |