HighVista Strategies LLC

In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 14, 2025), HighVista Strategies LLC reported 148 stock positions worth $408.0 million. Its top holding was Invesco DB Commodity Index T (DBC) at 7.9% of the portfolio, followed by Abivax SA-ADR (ABVX, 3.8%) and Merus (MRUS, 3.1%). Compared with Q2 2025, it opened 29 new positions, sold out of 27, added to 78 and reduced 38. The biggest buy was Abivax SA-ADR (ABVX, shares +261%) and the biggest sale an exit from Ansys (ANSS).

Most Recent 13F
Q2 2026
Location
BOSTON, MA
CIK
0001335325
Portfolio Value
$408.0M (Q3 2025)
SEC Filing
0001172661-25-004799 ↗ filed Nov 14, 2025

Holdings Value

0$100.0M$200.0M$300.0M$400.0M$500.0M Q1 2024: $280.4M Q1 2024 Q2 2024: $273.8M Q2 2024 Q3 2024: $290.0M Q3 2024 Q4 2024: $268.8M Q4 2024 Q1 2025: $259.5M Q1 2025 Q2 2025: $272.1M Q2 2025 Q3 2025: $408.0M $408.0M Q3 2025 Q4 2025: $388.3M Q4 2025 Q1 2026: $362.2M Q1 2026 Q2 2026: $438.6M Q2 2026

Holdings 148 stocks · $408.0M
DBC Invesco DB Commodity Index T 7.93% 1,436,136 $32.4M No change
ABVX Abivax SA-ADR 3.84% 184,468 $15.7M Add +260.6%
MRUS Merus NV 3.08% 133,321 $12.6M Add +48.5%
VRDN Viridian Therapeutics Inc. 2.48% 469,335 $10.1M Reduce -3.1%
RVMD Revolution Medicines Inc. 2.01% 175,448 $8.2M Add +157.8%
PTGX Protagonist Therapeutics Inc. 1.98% 121,682 $8.1M Add +110.3%
NUVL Nuvalent Inc. Class A 1.98% 93,294 $8.1M Add +84.9%
MLYS Mineralys Therapeutics Inc. 1.95% 209,829 $8.0M Add +39.8%
ACLX Arcellx Inc. 1.94% 96,177 $7.9M Add +169.3%
AGIO Agios Pharmaceuticals Inc. 1.92% 195,298 $7.8M Add +178.5%
CYTK Cytokinetics Inc. 1.79% 132,930 $7.3M Add +93.6%
INSM Insmed Inc. 1.76% 49,949 $7.2M Add +330.8%
CDTX Cidara Therapeutics Inc. 1.66% 70,904 $6.8M New
COGT Cogent Biosciences Inc. 1.63% 462,405 $6.6M Add +63.3%
GPCR Structure Therapeutics Inc. 1.62% 236,236 $6.6M Add +172.7%
AMZN Amazon.com Inc. 1.42% 26,393 $5.8M Add +39.7%
SNDK Sandisk Corp. 1.30% 47,451 $5.3M Add +19.8%
ELVN Enliven Therapeutics Inc. 1.30% 259,135 $5.3M Add +83.1%
AKRO Akero Therapeutics Inc. 1.28% 110,079 $5.2M Add +83.5%
PRAX Praxis Precision Medicines I 1.23% 95,002 $5.0M Add +41.2%
MSFT Microsoft Corp. 1.20% 9,458 $4.9M Reduce -7.8%
OLMA Olema Pharmaceuticals Inc. 1.05% 437,179 $4.3M Add +57.0%
BBIO Bridgebio Pharma Inc. 1.04% 81,959 $4.3M Add +21.4%
APGE Apogee Therapeutics Inc. 1.04% 107,107 $4.3M Add +137.7%
IMVT Immunovant Inc. 1.00% 253,127 $4.1M Add +38.5%
XOMA Xoma Royalty Corporation 1.00% 105,714 $4.1M Reduce -7.7%
GH Guardant Health Inc. 0.99% 64,583 $4.0M Add +128.5%
LQDA Liquidia Corp. 0.98% 176,485 $4.0M Add +46.3%
RYTM Rhythm Pharmaceuticals Inc. 0.93% 37,482 $3.8M Add +33.5%
SYRE Spyre Therapeutics Inc. 0.89% 215,746 $3.6M Add +91.3%
CLDX Celldex Therapeutics Inc. 0.86% 135,258 $3.5M Add +26.9%
GHRS GH Research PLC 0.85% 241,894 $3.5M Add +363.0%
EWTX Edgewise Therapeutics Inc. 0.83% 208,101 $3.4M Add +198.5%
AVGO Broadcom Inc. 0.82% 10,200 $3.4M Reduce -20.3%
META Meta Platforms Inc. Class A 0.81% 4,500 $3.3M Add +45.2%
XENE Xenon Pharmaceuticals Inc. 0.81% 82,190 $3.3M Add +80.2%
APLS Apellis Pharmaceuticals Inc. 0.81% 145,729 $3.3M Add +68.2%
PCVX Vaxcyte Inc. 0.77% 86,802 $3.1M Add +159.4%
CRM Salesforce Inc. 0.75% 12,885 $3.1M Add +15.2%
ARGX Argenx SE - ADR 0.74% 4,068 $3.0M Add +68.5%
RNAM Avidity Biosciences Inc. 0.70% 65,580 $2.9M Add +60.5%
AMD Advanced Micro Devices 0.68% 17,200 $2.8M Add +11.7%
XPO Xpo Inc. 0.67% 21,080 $2.7M No change
U Unity Software Inc. 0.66% 67,229 $2.7M Add +17.7%
V Visa Inc. Class A 0.66% 7,861 $2.7M Add +22.3%
VERA Vera Therapeutics Inc. 0.65% 91,189 $2.6M Add +125.3%
CEG Constellation Energy 0.61% 7,600 $2.5M Reduce -8.4%
NVDA Nvidia Corp. 0.61% 13,400 $2.5M Reduce -14.7%
HPE Hewlett Packard Enterprise 0.59% 98,700 $2.4M Add +14.5%
MA Mastercard Inc. Class A 0.59% 4,205 $2.4M Add +5.1%
GOOG Alphabet Inc. Class C 0.58% 9,800 $2.4M New
CRH CRH PLC 0.57% 19,439 $2.3M New
SRRK Scholar Rock Holding Corp. 0.54% 59,573 $2.2M Add +90.8%
FERG Ferguson Enterprises Inc. 0.53% 9,678 $2.2M Reduce -2.0%
TLN Talen Energy Corp. 0.53% 5,100 $2.2M Reduce -13.6%
PWR Quanta Services Inc. 0.53% 5,200 $2.2M Reduce -18.8%
AVTR Avantor Inc. 0.53% 172,400 $2.2M New
DNTH Dianthus Therapeutics Inc. 0.52% 54,225 $2.1M Add +241.9%
CLH Clean Harbors Inc. 0.52% 9,106 $2.1M New
LITE Lumentum Holdings Inc. 0.52% 12,927 $2.1M New
FLS Flowserve Corp. 0.51% 38,975 $2.1M New
COF Capital One Financial Corp. 0.50% 9,674 $2.1M New
BVN Cia DE Minas Buenaventur-ADR filed as COMPANIA DE MINAS BUENAVENTU 0.49% 82,931 $2.0M Add +9.4%
WDAY Workday Inc. Class A 0.48% 8,191 $2.0M Add +34.3%
PTC PTC Inc. 0.47% 9,522 $1.9M Reduce -5.9%
AGX Argan Inc. 0.47% 7,100 $1.9M Add +24.6%
DVAX Dynavax Technologies Corp. 0.47% 192,849 $1.9M Add +60.4%
APH Amphenol Corp. Class A 0.47% 15,400 $1.9M Reduce -18.9%
FN Fabrinet 0.46% 5,100 $1.9M New
BBD Banco Bradesco-ADR 0.43% 520,100 $1.8M Add +17.3%
NU Nu Holdings Ltd./Cayman Isl-A filed as NU HLDGS LTD 0.43% 109,337 $1.8M Add +8.8%
QXO Qxo Inc. 0.42% 90,200 $1.7M Add +6.8%
WDC Western Digital Corp. 0.42% 14,242 $1.7M Reduce -71.8%
P Everpure Inc. Class A filed as PURE STORAGE INC 0.42% 20,400 $1.7M New
KBR KBR Inc. 0.41% 35,500 $1.7M New
PBR.A Petroleo Brasil-SP Pref ADR 0.40% 138,200 $1.6M Add +31.6%
STX Seagate Technology Holdings 0.40% 6,898 $1.6M Reduce -68.8%
APG Api Group Corp. 0.40% 47,350 $1.6M Add +25.5%
MDGL Madrigal Pharmaceuticals Inc. 0.40% 3,537 $1.6M Add +53.5%
CNTA Centessa Pharmaceuticals Ltd. 0.38% 63,301 $1.5M Add +55.6%
CNM Core & Main Inc. Class A 0.37% 27,900 $1.5M New
ROIV Roivant Sciences Ltd. 0.37% 98,858 $1.5M Add +61.4%
CRBP Corbus Pharmaceuticals Holdi 0.37% 118,027 $1.5M Add +56.8%
CSCO Cisco Systems Inc. 0.37% 21,800 $1.5M Reduce -7.6%
INTU Intuit Inc. 0.36% 2,163 $1.5M Reduce -33.7%
TARS Tarsus Pharmaceuticals Inc. 0.36% 24,854 $1.5M Add +112.8%
ENTG Entegris Inc. 0.36% 15,700 $1.5M Reduce -24.9%
RDDT Reddit Inc. Class A 0.36% 6,300 $1.4M New
MTZ Mastec Inc. 0.35% 6,700 $1.4M Reduce -39.1%
BAC Bank of America Corp. filed as BANK AMERICA CORP 0.35% 27,500 $1.4M Reduce -15.6%
ASND Ascendis Pharma A/S 0.35% 7,082 $1.4M Add +138.1%
ADMA Adma Biologics Inc. 0.34% 95,112 $1.4M New
EOLS Evolus Inc. 0.34% 226,025 $1.4M Add +289.4%
RBC RBC Bearings Inc. 0.33% 3,500 $1.4M Reduce -5.4%
OFIX Orthofix Medical Inc. 0.33% 93,200 $1.4M Reduce -12.5%
PGR Progressive Corp. 0.33% 5,500 $1.4M Reduce -6.8%
JANX Janux Therapeutics Inc. 0.33% 55,250 $1.4M Reduce -11.5%
CORZ Core Scientific Inc. 0.33% 75,163 $1.3M Reduce -58.2%
SCHW Schwab (charles) Corp. 0.33% 14,100 $1.3M Reduce -13.5%
ALKS Alkermes PLC 0.32% 44,081 $1.3M Reduce -16.7%
KROS Keros Therapeutics Inc. 0.32% 83,050 $1.3M Add +57.8%
CAAP Corp. America Airports SA filed as CORPORACION AMER ARPTS S A 0.32% 71,400 $1.3M Add +15.2%
SLNO Soleno Therapeutics Inc. 0.31% 18,700 $1.3M Add +44.5%
RLAY Relay Therapeutics Inc. 0.31% 240,459 $1.3M Add +60.6%
OCUL Ocular Therapeutix Inc. 0.31% 106,611 $1.2M Add +19.9%
RXO Rxo Inc. 0.30% 80,900 $1.2M Add +4.9%
JCI Johnson Controls Internation 0.30% 11,100 $1.2M New
RBLX Roblox Corp. Class A 0.30% 8,700 $1.2M New
NEE Nextera Energy Inc. 0.29% 15,752 $1.2M New
MMM 3M Co. 0.29% 7,600 $1.2M Reduce -47.2%
MELI MercadoLibre Inc. 0.29% 500 $1.2M New
CZR Caesars Entertainment Inc. 0.28% 43,000 $1.2M New
AXSM Axsome Therapeutics Inc. 0.28% 9,348 $1.1M Reduce -14.3%
IBN Icici Bank Ltd.-Spon ADR 0.27% 37,047 $1.1M Add +27.5%
HDB HDFC Bank Ltd.-ADR 0.27% 32,682 $1.1M Add +23.4%
ALV Autoliv Inc. 0.26% 8,700 $1.1M Add +2.4%
NTRA Natera Inc. 0.26% 6,580 $1.1M Add +63.9%
CGON CG Oncology Inc. 0.26% 26,040 $1.0M Add +152.1%
PFSI Pennymac Financial Services 0.25% 8,337 $1.0M Reduce -33.5%
MAGN Magnera Corp. 0.25% 87,100 $1.0M Reduce -12.6%
GEV GE Vernova Inc. 0.25% 1,650 $1.0M Reduce -58.8%
CNX CNX Resources Corp. 0.25% 31,300 $1.0M Reduce -15.6%
FOUR SHIFT4 Payments Inc. Class A 0.24% 12,500 $968K Add +10.6%
TYRA Tyra Biosciences Inc. 0.23% 65,812 $921K Add +163.7%
SE Sea Ltd.-ADR 0.23% 5,141 $919K Reduce -42.5%
AFRM Affirm Holdings Inc. 0.22% 12,500 $914K New
NAMS Newamsterdam Pharma Co. NV 0.22% 31,831 $905K Add +65.2%
ETR Entergy Corp. 0.22% 9,600 $895K Reduce -37.3%
KYMR Kymera Therapeutics Inc. 0.22% 15,728 $890K New
BKNG Booking Holdings Inc. 0.21% 157 $848K Reduce -56.0%
CTMX Cytomx Therapeutics Inc. 0.20% 257,148 $820K New
JD Jd.com Inc.-ADR 0.20% 23,383 $818K Add +21.9%
CPNG Coupang Inc. 0.19% 24,050 $774K Reduce -44.1%
TCOM Trip.com Group Ltd.-ADR 0.18% 9,756 $734K Add +15.4%
CELC Celcuity Inc. 0.17% 13,680 $676K New
BABA Alibaba Group Holding-SP ADR 0.16% 3,757 $671K No change
URGN Urogen Pharma Ltd. 0.16% 31,886 $636K New
NBIS Nebius Group NV 0.14% 5,200 $584K New
ALC Alcon Inc. filed as ALCON AG 0.11% 7,862 $466K Add +28.4%
BZ Kanzhun Ltd. - ADR 0.11% 18,900 $442K Reduce -39.8%
WVE Wave Life Sciences Ltd. 0.11% 59,261 $434K Add +64.8%
NOK Nokia Corp.-Spon ADR 0.10% 82,900 $399K Reduce -0.7%
AVTX Avalo Therapeutics Inc. 0.09% 27,778 $353K New
INBX Inhibrx Biosciences Inc. 0.06% 7,626 $257K New
TAL Tal Education Group- ADR 0.05% 19,600 $220K Add +8.3%
BEKE Ke Holdings Inc.-ADR filed as KE HLDGS INC 0.05% 11,400 $217K New
AURA Aura Biosciences Inc. 0.04% 27,174 $168K New
MLTX Moonlake Immunotherapeutics 0.03% 19,059 $137K Reduce -9.0%

Portfolio Sells Q2 2025 → Q3 2025
ANSS Ansys Inc. Sold out 0.00% −2.21
JNPR Juniper Networks Inc. Sold out 0.00% −1.68
HES Hess Corp. Sold out 0.00% −1.47
AMED Amedisys Inc. Sold out 0.00% −1.42
VRNA Verona Pharma Ltd. Sold out 0.00% −1.00
CORZ Core Scientific Inc. Reduce -58.2% 0.33% −0.80
STX Seagate Technology Holdings Reduce -68.8% 0.40% −0.77
WDC Western Digital Corp. Reduce -71.8% 0.42% −0.77
SNPS Synopsys Inc. Sold out 0.00% −0.73
LYFT LYFT Inc. Class A Sold out 0.00% −0.73
CLF Cleveland-Cliffs Inc. Sold out 0.00% −0.71
MSFT Microsoft Corp. Reduce -7.8% 1.20% −0.67
INTU Intuit Inc. Reduce -33.7% 0.36% −0.58
DAL Delta Air Lines Inc. Sold out 0.00% −0.56
BKNG Booking Holdings Inc. Reduce -56.0% 0.21% −0.55
RCL Royal Caribbean Cruises Ltd. Sold out 0.00% −0.53
GEV GE Vernova Inc. Reduce -58.8% 0.25% −0.53
CME Cme Group Inc. Sold out 0.00% −0.53
MMM 3M Co. Reduce -47.2% 0.29% −0.52
TKO Tko Group Holdings Inc. Sold out 0.00% −0.51
REXR Rexford Industrial Realty Inc. Sold out 0.00% −0.47
AVGO Broadcom Inc. Reduce -20.3% 0.82% −0.47
ADBE Adobe Inc. Sold out 0.00% −0.45
PM Philip Morris International Sold out 0.00% −0.45
HCA HCA Healthcare Inc. Sold out 0.00% −0.44
KGS Kodiak Gas Services Inc. Sold out 0.00% −0.43
LKQ LKQ Corp. Sold out 0.00% −0.40
CEG Constellation Energy Reduce -8.4% 0.61% −0.37
HUBS HubSpot Inc. Sold out 0.00% −0.37
PWR Quanta Services Inc. Reduce -18.8% 0.53% −0.36
MTZ Mastec Inc. Reduce -39.1% 0.35% −0.34
MLTX Moonlake Immunotherapeutics Reduce -9.0% 0.03% −0.33
SE Sea Ltd.-ADR Reduce -42.5% 0.23% −0.30
NVDA Nvidia Corp. Reduce -14.7% 0.61% −0.30
CPNG Coupang Inc. Reduce -44.1% 0.19% −0.28
ENTG Entegris Inc. Reduce -24.9% 0.36% −0.26
FERG Ferguson Enterprises Inc. Reduce -2.0% 0.53% −0.26
ETR Entergy Corp. Reduce -37.3% 0.22% −0.25
PGR Progressive Corp. Reduce -6.8% 0.33% −0.25
CSCO Cisco Systems Inc. Reduce -7.6% 0.37% −0.24
ALKS Alkermes PLC Reduce -16.7% 0.32% −0.23
APH Amphenol Corp. Class A Reduce -18.9% 0.47% −0.22
BAC Bank of America Corp. Reduce -15.6% 0.35% −0.22
SCHW Schwab (charles) Corp. Reduce -13.5% 0.33% −0.22
CNX CNX Resources Corp. Reduce -15.6% 0.25% −0.21
PFSI Pennymac Financial Services Reduce -33.5% 0.25% −0.21
JANX Janux Therapeutics Inc. Reduce -11.5% 0.33% −0.20
MAGN Magnera Corp. Reduce -12.6% 0.25% −0.19
RBC RBC Bearings Inc. Reduce -5.4% 0.33% −0.19
CATX Perspective Therapeutics Inc. Sold out 0.00% −0.17

Portfolio Buys Q2 2025 → Q3 2025
ABVX Abivax SA-ADR Add +260.6% 3.84% +3.70
CDTX Cidara Therapeutics Inc. New 1.66% +1.66
MRUS Merus NV Add +48.5% 3.08% +1.34
INSM Insmed Inc. Add +330.8% 1.76% +1.33
MLYS Mineralys Therapeutics Inc. Add +39.8% 1.95% +1.20
RVMD Revolution Medicines Inc. Add +157.8% 2.01% +1.09
ACLX Arcellx Inc. Add +169.3% 1.94% +1.07
AGIO Agios Pharmaceuticals Inc. Add +178.5% 1.92% +1.06
GPCR Structure Therapeutics Inc. Add +172.7% 1.62% +0.96
CYTK Cytokinetics Inc. Add +93.6% 1.79% +0.96
COGT Cogent Biosciences Inc. Add +63.3% 1.63% +0.88
PTGX Protagonist Therapeutics Inc. Add +110.3% 1.98% +0.81
SNDK Sandisk Corp. Add +19.8% 1.30% +0.65
GHRS GH Research PLC Add +363.0% 0.85% +0.61
OLMA Olema Pharmaceuticals Inc. Add +57.0% 1.05% +0.61
GOOG Alphabet Inc. Class C New 0.58% +0.58
CRH CRH PLC New 0.57% +0.57
NUVL Nuvalent Inc. Class A Add +84.9% 1.98% +0.56
AVTR Avantor Inc. New 0.53% +0.53
CLH Clean Harbors Inc. New 0.52% +0.52
LITE Lumentum Holdings Inc. New 0.52% +0.52
FLS Flowserve Corp. New 0.51% +0.51
COF Capital One Financial Corp. New 0.50% +0.50
EWTX Edgewise Therapeutics Inc. Add +198.5% 0.83% +0.49
FN Fabrinet New 0.46% +0.46
GH Guardant Health Inc. Add +128.5% 0.99% +0.45
LQDA Liquidia Corp. Add +46.3% 0.98% +0.43
P Everpure Inc. Class A New 0.42% +0.42
DNTH Dianthus Therapeutics Inc. Add +241.9% 0.52% +0.41
KBR KBR Inc. New 0.41% +0.41
CNM Core & Main Inc. Class A New 0.37% +0.37
PCVX Vaxcyte Inc. Add +159.4% 0.77% +0.37
RDDT Reddit Inc. Class A New 0.36% +0.36
ADMA Adma Biologics Inc. New 0.34% +0.34
APGE Apogee Therapeutics Inc. Add +137.7% 1.04% +0.32
VERA Vera Therapeutics Inc. Add +125.3% 0.65% +0.30
JCI Johnson Controls Internation New 0.30% +0.30
RBLX Roblox Corp. Class A New 0.30% +0.30
NEE Nextera Energy Inc. New 0.29% +0.29
MELI MercadoLibre Inc. New 0.29% +0.29
CZR Caesars Entertainment Inc. New 0.28% +0.28
XENE Xenon Pharmaceuticals Inc. Add +80.2% 0.81% +0.28
RYTM Rhythm Pharmaceuticals Inc. Add +33.5% 0.93% +0.28
RNAM Avidity Biosciences Inc. Add +60.5% 0.70% +0.27
SYRE Spyre Therapeutics Inc. Add +91.3% 0.89% +0.27
APLS Apellis Pharmaceuticals Inc. Add +68.2% 0.81% +0.26
ELVN Enliven Therapeutics Inc. Add +83.1% 1.30% +0.26
ARGX Argenx SE - ADR Add +68.5% 0.74% +0.25
AFRM Affirm Holdings Inc. New 0.22% +0.22
KYMR Kymera Therapeutics Inc. New 0.22% +0.22

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 147$438.6MDBC, ABVX, RVMD, DFTX, IMVT
Q1 2026 156$362.2MDBC, ABVX, PRAX, COGT, SYRE
Q4 2025 145$388.3MDBC, GPCR, COGT, VRDN, ABVX
Q3 2025 148$408.0MDBC, ABVX, MRUS, VRDN, RVMD
Q2 2025 146$272.1MDBC, VRDN, ANSS, MSFT, MRUS
Q1 2025 148$259.5MDBC, HES, JNPR, ACI, ANSS
Q4 2024 137$268.8MDBC, AMZN, HCP, MSFT, ANSS
Q3 2024 142$290.0MDBC, AMZN, PCVX, ACLX, CTLT
Q2 2024 137$273.8MDBC, INSM, MRUS, CRM, AXSM
Q1 2024 131$280.4MDBC, APGE, SYRE, MRUS, MSFT