Alnylam PharmaceuticalsALNY
13F holders, Q4 2025 (December 31)852holders +29
121new positions
115sold out
7famous investors
$396.97avg. 13F price*
At the end of Q4 2025, 852 institutions reported holding Alnylam Pharmaceuticals Inc. (ALNY) in their 13F filings, up 29 from Q3 2025. 121 opened new positions and 115 sold out. The largest holders were Capital World Investors ($6.5B), FMR LLC ($6.3B) and Vanguard Group Inc. ($5.4B). 7 famous investors held it, including Cliff Asness (0.2% of AQR Capital Management's portfolio), David E. Shaw (0.1% of D. E. Shaw & Co.'s portfolio) and Ray Dalio (0.1% of Bridgewater Associates's portfolio).
- Company
- Alnylam Pharmaceuticals Inc.
- Sector
- Health Care
- CUSIP
- 02043Q107
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 121 | $312.2M |
| Exits | 115 | $1.1B |
All 13F filers, Q3 2025 → Q4 2025: 11,074,940 shares bought and 11,159,258 shares sold, net −84,318 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 852 holders
| Capital World Investors | 0.89% | Reduce -0.8% | 16,301,772 | $6.5B |
| FMR LLC | 0.32% | Reduce -5.2% | 15,902,149 | $6.3B |
| Vanguard Group Inc. | 0.08% | Reduce -0.1% | 13,553,932 | $5.4B |
| BlackRock, Inc. | 0.07% | Add +5.0% | 10,400,874 | $4.1B |
| Capital Research Global Investors | 0.50% | Reduce -6.1% | 6,779,708 | $2.7B |
| Invesco Ltd. | 0.19% | Add +246.5% | 5,133,983 | $2.0B |
| JPMorgan Chase & Co. | 0.13% | Add +3.9% | 4,719,999 | $1.9B |
| State Street Corp. | 0.04% | Add +4.8% | 3,228,956 | $1.3B |
| Geode Capital Management, LLC | 0.07% | Add +6.1% | 2,650,722 | $1.1B |
| Baillie Gifford & Co. | 0.86% | Reduce -6.8% | 2,600,979 | $1.0B |
| Norges Bank | 0.10% | — | 2,252,775 | $895.8M |
| Dodge & Cox | 0.42% | Reduce -15.4% | 1,964,415 | $781.1M |
| T. Rowe Price Investment Management, Inc. | 0.44% | Reduce -19.3% | 1,753,640 | $697.3M |
| T. Rowe Price Associates Inc. | 0.07% | Reduce -5.4% | 1,702,831 | $677.1M |
| Wellington Management Group LLP | 0.11% | Reduce -10.8% | 1,628,931 | $647.7M |
| Orbis Allan Gray Ltd | 2.70% | Reduce -17.1% | 1,618,219 | $643.5M |
| American Century Companies Inc. | 0.30% | Reduce -9.5% | 1,485,161 | $590.6M |
| Two Sigma Advisers, LP | 0.88% | Add +26.9% | 1,132,560 | $450.4M |
| Arrowstreet Capital, Limited Partnership | 0.26% | Reduce -16.9% | 1,127,162 | $448.2M |
| Morgan Stanley | 0.02% | Add +33.6% | 970,157 | $385.8M |
| Legal & General Group Plc | 0.08% | Add +8.3% | 961,496 | $382.3M |
| AQR Capital Management | 0.19% | Add +23.6% | 919,959 | $365.8M |
| Northern Trust Corp. | 0.04% | Add +3.0% | 857,742 | $341.1M |
| UBS Group AG | 0.07% | Add +69.2% | 825,840 | $328.4M |
| Franklin Resources Inc. | 0.08% | Add +10.3% | 787,623 | $313.2M |
| Qube Research & Technologies Ltd | 0.44% | Reduce -4.5% | 774,676 | $308.0M |
| Deutsche Bank AG | 0.09% | Add +17.4% | 711,975 | $283.1M |
| Bank of America Corp. | 0.02% | Reduce -54.3% | 685,177 | $272.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.05% | Reduce -7.9% | 652,366 | $259.4M |
| Charles Schwab Investment Management Inc. | 0.04% | Add +4.7% | 647,839 | $257.6M |
| Federated Hermes, Inc. | 0.42% | Add +14.2% | 628,063 | $249.7M |
| Two Sigma Investments, LP | 0.39% | Add +3.4% | 616,120 | $245.0M |
| Amundi | 0.07% | Add +58.5% | 608,879 | $242.1M |
| Clearbridge Investments, LLC | 0.19% | Reduce -4.1% | 597,013 | $237.4M |
| Royal Bank of Canada | 0.04% | Add +35.4% | 591,495 | $235.2M |
| Nuveen, LLC | 0.06% | Reduce -3.8% | 565,789 | $225.0M |
| Marshall Wace, LLP | 0.21% | Add +8.2% | 549,922 | $218.7M |
| Bank of New York Mellon Corp | 0.04% | Add +20.1% | 504,133 | $200.5M |
| Massachusetts Financial Services Co. | 0.06% | Add +38.9% | 495,307 | $197.0M |
| Loomis Sayles & Co. L P | 0.23% | Reduce -2.4% | 488,897 | $194.4M |
| Bellevue Group AG | 3.36% | Reduce -0.1% | 445,903 | $177.3M |
| D. E. Shaw & Co. | 0.14% | Add +122.9% | 444,493 | $176.8M |
| 1832 Asset Management L.P. | 0.22% | Reduce -4.2% | 440,145 | $175.0M |
| Jacobs Levy Equity Management, Inc. | 0.62% | Reduce -2.2% | 401,371 | $159.6M |
| BNP Paribas Financial Markets | 0.10% | Add +154.5% | 389,435 | $154.9M |
| Raymond James Financial Inc. | 0.05% | Add +3.0% | 388,705 | $154.4M |
| Goldman Sachs Group Inc. | 0.02% | Reduce -30.3% | 375,323 | $149.2M |
| Swiss National Bank | 0.09% | Reduce -4.4% | 359,200 | $142.8M |
| Squarepoint Ops LLC | 0.28% | Add +141.1% | 350,969 | $139.6M |
| KBC Group NV | 0.32% | Add +27.4% | 348,194 | $138.5M |
| Worldquant Millennium Advisors LLC | 0.53% | Add +55.7% | 343,431 | $136.6M |
| Sumitomo Mitsui Trust Group, Inc. | 0.08% | Add +4.2% | 327,763 | $130.3M |
| Gilder Gagnon Howe & Co. LLC | 1.34% | Reduce -3.0% | 319,305 | $127.0M |
| Pictet Asset Management Holding SA | 0.12% | Reduce -18.4% | 316,053 | $125.8M |
| Nomura Asset Management International Inc. | 0.19% | — | 311,757 | $124.0M |
| Jane Street Group, LLC | 0.15% | Reduce -67.5% | 311,288 | $123.8M |
| Dimensional Fund Advisors LP | 0.03% | Add +24.8% | 301,865 | $120.0M |
| Orbimed Advisors LLC | 2.35% | Reduce -4.2% | 288,800 | $114.8M |
| Allspring Global Investments Holdings, LLC | 0.18% | Reduce -10.3% | 278,657 | $111.5M |
| Jennison Associates LLC | 0.07% | Reduce -8.9% | 277,759 | $110.5M |
| Los Angeles Capital Management LLC | 0.37% | Add +50.6% | 240,052 | $107.9M |
| Congress Asset Management Co. | 0.75% | Add +126.6% | 269,239 | $107.1M |
| TD Asset Management Inc | 0.09% | Reduce -13.9% | 269,101 | $107.0M |
| Canada Pension Plan Investment Board | 0.07% | Add +89.8% | 258,711 | $102.9M |
| Wells Fargo & Company | 0.02% | Reduce -8.2% | 257,640 | $102.5M |
| First Trust Advisors LP | 0.07% | Add +22.1% | 256,954 | $102.2M |
| Royal London Asset Management Ltd. | 0.21% | Reduce -1.6% | 253,072 | $100.6M |
| Polar Capital Holdings Plc | 0.44% | Reduce -4.3% | 240,606 | $95.7M |
| California Public Employees Retirement System | 0.05% | Add +3.2% | 237,005 | $94.2M |
| Candriam S.C.A. | 0.45% | Add +5.6% | 224,330 | $89.2M |
| Barclays PLC | 0.04% | Add +135.7% | 222,561 | $88.5M |
| Victory Capital Management Inc. | 0.05% | Add +22.5% | 220,866 | $87.8M |
| FengHe Fund Management Pte. Ltd. | 4.90% | New | 218,700 | $87.0M |
| ProShare Advisors LLC | 0.15% | Add +4457.9% | 211,077 | $83.9M |
| California State Teachers Retirement System | 0.08% | Reduce -1.0% | 201,816 | $80.3M |
| CIBC Private Wealth Group LLC | 0.13% | Reduce -6.4% | 200,425 | $79.7M |
| Voya Investment Management LLC | 0.09% | Reduce -46.8% | 198,613 | $79.0M |
| Rhumbline Advisers | 0.06% | Reduce -0.6% | 195,266 | $77.6M |
| Susquehanna International Group, LLP | 0.10% | Reduce -66.8% | 191,820 | $76.3M |
| Korea Investment CORP | 0.15% | Reduce -3.6% | 189,769 | $75.5M |
| Ameriprise Financial Inc. | 0.02% | Reduce -19.8% | 181,137 | $72.0M |
| Citigroup Inc. | 0.05% | Add +183.5% | 172,562 | $68.6M |
| National Pension Service | 0.05% | Reduce -5.1% | 168,149 | $66.9M |
| Russell Investments Group, Ltd. | 0.07% | Reduce -15.4% | 165,740 | $65.9M |
| Voloridge Investment Management, LLC | 0.22% | Reduce -55.0% | 160,577 | $63.9M |
| SCS Capital Management LLC | 0.63% | Reduce -0.7% | 149,611 | $59.5M |
| Robeco Institutional Asset Management B.V. | 0.08% | Add +28.0% | 144,721 | $57.5M |
| Man Group plc | 0.11% | Add +101.2% | 144,210 | $57.3M |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.04% | Add +14.9% | 138,795 | $55.5M |
| Janus Henderson Group PLC | 0.02% | Add +0.4% | 136,425 | $54.3M |
| Handelsbanken Fonder AB | 0.16% | Reduce -12.3% | 136,185 | $54.2M |
| Aberdeen Group plc | 0.08% | Reduce -15.6% | 132,846 | $52.8M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.08% | Add +12.8% | 124,645 | $49.4M |
| Envestnet Asset Management Inc. | 0.01% | Add +1.3% | 120,521 | $47.9M |
| Capital International Sarl | 0.76% | Reduce -8.0% | 119,352 | $47.5M |
| Neuberger Berman Group LLC | 0.03% | Reduce -11.8% | 115,203 | $45.8M |
| State Board of Administration of Florida Retirement System | 0.08% | Reduce -2.2% | 114,603 | $45.6M |
| Sei Investments Co. | 0.04% | Add +17.6% | 111,112 | $44.2M |
| Aviva PLC | 0.07% | Add +7.2% | 110,662 | $44.0M |
| Tremblant Capital Group | 1.12% | New | 110,132 | $43.8M |
"% of holder's portfolio" is ALNY's weight in each manager's 13F, not the share of Alnylam Pharmaceuticals Inc. the manager owns.