Apellis PharmaceuticalsAPLS
13F holders, Q3 2025 (September 30)273holders +26
59new positions
30sold out
7famous investors
$22.65avg. 13F price*
At the end of Q3 2025, 273 institutions reported holding Apellis Pharmaceuticals Inc. (APLS) in their 13F filings, up 26 from Q2 2025. 59 opened new positions and 30 sold out. The largest holders were Avoro Capital Advisors LLC ($276.6M), Vanguard Group Inc. ($226.0M) and Morgan Stanley ($218.2M). 7 famous investors held it, including Cliff Asness (0.1% of AQR Capital Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Apellis Pharmaceuticals Inc.
- CUSIP
- 03753U106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 59 | $92.3M |
| Exits | 30 | $50.1M |
All 13F filers, Q2 2025 → Q3 2025: 17,305,541 shares bought and 23,287,517 shares sold, net −5,981,976 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 273 holders
| Avoro Capital Advisors LLC | 3.58% | No change | 12,222,222 | $276.6M |
| Vanguard Group Inc. | 0.00% | Reduce -1.6% | 9,987,394 | $226.0M |
| Morgan Stanley | 0.01% | Reduce -1.1% | 9,643,248 | $218.2M |
| Wellington Management Group LLP | 0.04% | Add +3.5% | 9,290,960 | $210.3M |
| Deep Track Capital, LP | 5.05% | Add +14.3% | 8,000,382 | $181.0M |
| BlackRock, Inc. | 0.00% | Reduce -2.1% | 6,268,465 | $141.9M |
| AQR Capital Management | 0.07% | Reduce -24.9% | 4,487,354 | $101.5M |
| Jennison Associates LLC | 0.06% | Add +63.4% | 4,348,055 | $98.4M |
| State Street Corp. | 0.00% | Add +13.3% | 4,037,644 | $91.4M |
| EcoR1 Capital, LLC | 3.75% | Reduce -71.0% | 3,447,156 | $78.0M |
| UBS Group AG | 0.02% | Reduce -27.6% | 3,429,905 | $77.6M |
| Montanova Capital, LLC | 1.97% | No change | 2,878,000 | $65.1M |
| Polar Capital Holdings Plc | 0.29% | Add +96.0% | 2,650,230 | $60.0M |
| Siren, L.L.C. | 2.28% | No change | 2,578,396 | $58.3M |
| Orbimed Advisors LLC | 1.26% | Add +56.7% | 2,323,368 | $52.6M |
| Geode Capital Management, LLC | 0.00% | Add +3.9% | 2,072,913 | $46.9M |
| Amundi | 0.01% | Reduce -6.9% | 1,493,678 | $36.4M |
| Deutsche Bank AG | 0.01% | Add +0.6% | 1,504,457 | $34.0M |
| Bank of America Corp. | 0.00% | Reduce -39.1% | 1,477,525 | $33.4M |
| Bank of Nova Scotia | 0.06% | Add +144.8% | 1,456,225 | $33.0M |
| Millennium Management | 0.02% | Add +563.7% | 1,343,726 | $30.4M |
| ING Groep NV | 0.14% | Add +281.0% | 1,174,500 | $26.6M |
| Voloridge Investment Management, LLC | 0.08% | Add +111.7% | 992,269 | $22.5M |
| BNP Paribas Financial Markets | 0.02% | Reduce -25.1% | 972,474 | $22.0M |
| Octagon Capital Advisors LP | 3.19% | No change | 903,500 | $20.4M |
| Kynam Capital Management, LP | 1.36% | New | 808,607 | $18.3M |
| Renaissance Technologies | 0.02% | Add +6478.9% | 722,895 | $16.4M |
| Ameriprise Financial Inc. | 0.00% | Reduce -4.3% | 717,703 | $16.2M |
| Nuveen, LLC | 0.00% | Add +41.7% | 665,048 | $15.1M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -34.6% | 647,082 | $14.6M |
| Los Angeles Capital Management LLC | 0.05% | New | 620,790 | $14.0M |
| Trexquant Investment LP | 0.14% | Add +79.3% | 586,939 | $13.3M |
| Citadel Advisors | 0.01% | Add +32.5% | 586,452 | $13.3M |
| Ossiam | 0.16% | No change | 555,953 | $12.6M |
| Northern Trust Corp. | 0.00% | Add +4.4% | 549,248 | $12.4M |
| Woodline Partners LP | 0.06% | Add +2.3% | 542,981 | $12.3M |
| D. E. Shaw & Co. | 0.01% | Add +81.9% | 456,791 | $10.3M |
| Ikarian Capital, LLC | 2.07% | Add +502.5% | 451,902 | $10.2M |
| Citigroup Inc. | 0.01% | Add +221.4% | 444,972 | $10.1M |
| Hudson Bay Capital Management LP | 0.07% | Reduce -11.9% | 418,500 | $9.5M |
| SG Americas Securities, LLC | 0.04% | Add +825.4% | 417,392 | $9.4M |
| Marshall Wace, LLP | 0.01% | Reduce -85.3% | 396,735 | $9.0M |
| Pictet Asset Management Holding SA | 0.01% | Add +4.3% | 363,450 | $8.2M |
| HRT Financial LP | 0.03% | Add +229.9% | 353,649 | $8.0M |
| Susquehanna International Group, LLP | 0.01% | Reduce -4.5% | 313,884 | $7.1M |
| Caption Management, LLC | 0.42% | Add +32.1% | 305,000 | $6.9M |
| Cubist Systematic Strategies, LLC | 0.10% | New | 299,783 | $6.8M |
| Ieq Capital, LLC | 0.02% | Reduce -14.4% | 296,784 | $6.7M |
| Jane Street Group, LLC | 0.01% | Add +19.1% | 293,199 | $6.6M |
| 683 Capital Management, LLC | 0.62% | Reduce -29.8% | 288,000 | $6.5M |
| J. Goldman & Co LP | 0.24% | Add +202.6% | 283,153 | $6.4M |
| Jump Financial, LLC | 0.08% | Reduce -50.3% | 277,648 | $6.3M |
| Barclays PLC | 0.00% | Reduce -1.6% | 269,527 | $6.1M |
| Two Sigma Investments, LP | 0.01% | Reduce -38.0% | 252,068 | $5.7M |
| Jefferies Financial Group Inc. | 0.05% | Reduce -56.5% | 251,555 | $5.7M |
| Integral Health Asset Management, LLC | 0.41% | New | 250,000 | $5.7M |
| Bank of New York Mellon Corp | 0.00% | Add +2.0% | 248,194 | $5.6M |
| Readystate Asset Management LP | 0.53% | New | 241,977 | $5.5M |
| Rhenman & Partners Asset Management AB | 0.58% | Add +149.1% | 232,250 | $5.3M |
| Point72 Asset Management | 0.01% | New | 217,071 | $4.9M |
| Canada Pension Plan Investment Board | 0.00% | Reduce -35.6% | 217,000 | $4.9M |
| Fiduciary Trust Co | 0.05% | Reduce -2.1% | 198,179 | $4.5M |
| ExodusPoint Capital Management, LP | 0.06% | New | 194,758 | $4.4M |
| Silvercrest Asset Management Group LLC | 0.03% | New | 190,526 | $4.3M |
| Invesco Ltd. | 0.00% | Add +10.2% | 183,016 | $4.1M |
| Boothbay Fund Management, LLC | 0.11% | Add +679.4% | 179,226 | $4.1M |
| Schroder Investment Management Group | 0.00% | Reduce -64.4% | 173,087 | $3.9M |
| Voya Investment Management LLC | 0.00% | Add +14.8% | 172,934 | $3.9M |
| Rafferty Asset Management, LLC | 0.01% | Add +17.0% | 168,352 | $3.8M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -44.5% | 167,464 | $3.8M |
| Y-Intercept (Hong Kong) Ltd | 0.09% | Reduce -0.3% | 163,813 | $3.7M |
| Bank of Montreal | 0.00% | Add +0.4% | 160,306 | $3.6M |
| EFG Asset Management (North America) Corp. | 0.45% | Add +48.0% | 155,399 | $3.5M |
| Sei Investments Co. | 0.00% | Add +593.8% | 155,122 | $3.5M |
| Swiss National Bank | 0.00% | Add +1.7% | 146,200 | $3.3M |
| California Public Employees Retirement System | 0.00% | Add +8.6% | 146,188 | $3.3M |
| Royal Bank of Canada | 0.00% | Reduce -81.7% | 146,207 | $3.3M |
| HighVista Strategies LLC | 0.81% | Add +68.2% | 145,729 | $3.3M |
| Walleye Capital LLC | 0.03% | Add +74.9% | 142,158 | $3.2M |
| Aquatic Capital Management LLC | 0.05% | Reduce -26.0% | 130,828 | $3.0M |
| Edgestream Partners, L.P. | 0.09% | Reduce -40.6% | 129,751 | $2.9M |
| Cerity Partners LLC | 0.00% | Add +11.7% | 128,110 | $2.9M |
| Gotham Asset Management | 0.01% | Add +6.7% | 127,158 | $2.9M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -42.4% | 124,373 | $2.8M |
| Qube Research & Technologies Ltd | 0.00% | New | 120,003 | $2.7M |
| Rhumbline Advisers | 0.00% | Reduce -3.8% | 117,429 | $2.7M |
| Steward Partners Investment Advisory, LLC | 0.01% | Reduce -19.1% | 114,088 | $2.6M |
| Worldquant Millennium Advisors LLC | 0.01% | New | 111,979 | $2.5M |
| Algert Global LLC | 0.04% | Reduce -28.8% | 109,733 | $2.5M |
| Simplify Asset Management Inc. | 0.05% | New | 106,888 | $2.4M |
| T. Rowe Price Associates Inc. | 0.00% | Add +6.3% | 97,940 | $2.2M |
| State Board of Administration of Florida Retirement System | 0.00% | Add +4.6% | 95,595 | $2.2M |
| Cwm, LLC | 0.01% | Reduce -26.1% | 94,233 | $2.1M |
| Legal & General Group Plc | 0.00% | Reduce -3.8% | 92,392 | $2.1M |
| Rock Springs Capital Management LP | 0.12% | Add +9.1% | 92,000 | $2.1M |
| Brevan Howard Capital Management LP | 0.03% | New | 91,021 | $2.1M |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -23.0% | 77,508 | $2.0M |
| State of Wisconsin Investment Board | 0.00% | Reduce -9.2% | 85,761 | $1.9M |
| Arax Advisory Partners | 0.03% | New | 82,067 | $1.9M |
| Alliancebernstein L.P. | 0.00% | Add +152.4% | 80,605 | $1.8M |
"% of holder's portfolio" is APLS's weight in each manager's 13F, not the share of Apellis Pharmaceuticals Inc. the manager owns.