Apellis PharmaceuticalsAPLS
13F holders, Q4 2025 (December 31)280holders +7
49new positions
47sold out
9famous investors
$25.10avg. 13F price*
At the end of Q4 2025, 280 institutions reported holding Apellis Pharmaceuticals Inc. (APLS) in their 13F filings, up 7 from Q3 2025. 49 opened new positions and 47 sold out. The largest holders were Wellington Management Group LLP ($319.6M), Avoro Capital Advisors LLC ($307.0M) and Vanguard Group Inc. ($268.2M). 9 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), Cliff Asness (0.0% of AQR Capital Management's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Apellis Pharmaceuticals Inc.
- CUSIP
- 03753U106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 49 | $250.9M |
| Exits | 47 | $132.9M |
All 13F filers, Q3 2025 → Q4 2025: 23,837,220 shares bought and 20,549,105 shares sold, net +3,288,115 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 280 holders
| Wellington Management Group LLP | 0.06% | Add +36.9% | 12,721,352 | $319.6M |
| Avoro Capital Advisors LLC | 3.02% | No change | 12,222,222 | $307.0M |
| Vanguard Group Inc. | 0.00% | Add +6.9% | 10,674,865 | $268.2M |
| Morgan Stanley | 0.01% | Reduce -4.9% | 9,173,004 | $230.4M |
| Deep Track Capital, LP | 4.44% | Reduce -3.1% | 7,750,000 | $194.7M |
| RTW Investments, LP | 1.93% | New | 7,666,764 | $192.6M |
| BlackRock, Inc. | 0.00% | Reduce -0.1% | 6,260,113 | $157.3M |
| State Street Corp. | 0.00% | Add +14.3% | 4,613,446 | $115.9M |
| UBS Group AG | 0.02% | Add +22.1% | 4,186,222 | $105.2M |
| Montanova Capital, LLC | 2.59% | Add +43.8% | 4,139,426 | $104.0M |
| Polar Capital Holdings Plc | 0.43% | Add +39.9% | 3,706,510 | $93.1M |
| Siren, L.L.C. | 1.93% | No change | 2,578,396 | $64.8M |
| Orbimed Advisors LLC | 1.25% | Add +4.6% | 2,429,868 | $61.0M |
| AQR Capital Management | 0.03% | Reduce -49.3% | 2,276,687 | $57.2M |
| Geode Capital Management, LLC | 0.00% | Reduce -2.3% | 2,025,669 | $50.9M |
| Jennison Associates LLC | 0.02% | Reduce -65.4% | 1,504,299 | $37.8M |
| Deutsche Bank AG | 0.01% | Reduce -7.9% | 1,385,263 | $34.8M |
| Norges Bank | 0.00% | — | 1,198,444 | $30.1M |
| Hudson Bay Capital Management LP | 0.19% | Add +181.9% | 1,179,828 | $29.6M |
| Bank of Nova Scotia | 0.04% | Reduce -26.5% | 1,070,141 | $26.9M |
| Marshall Wace, LLP | 0.02% | Add +149.8% | 990,848 | $24.9M |
| Bank of America Corp. | 0.00% | Reduce -35.2% | 956,773 | $24.0M |
| Millennium Management | 0.02% | Reduce -29.6% | 946,459 | $23.8M |
| Kynam Capital Management, LP | 1.49% | Add +12.4% | 908,607 | $22.8M |
| Los Angeles Capital Management LLC | 0.07% | Add +53.3% | 951,716 | $19.7M |
| Northern Trust Corp. | 0.00% | Add +26.8% | 696,521 | $17.5M |
| Nuveen, LLC | 0.00% | Add +2.5% | 681,819 | $17.1M |
| Citadel Advisors | 0.01% | Add +10.5% | 648,229 | $16.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -0.4% | 644,445 | $16.2M |
| Renaissance Technologies | 0.02% | Reduce -12.4% | 633,058 | $15.9M |
| Citigroup Inc. | 0.01% | Add +39.8% | 622,158 | $15.6M |
| Point72 Asset Management | 0.02% | Add +175.3% | 597,672 | $15.0M |
| Ameriprise Financial Inc. | 0.00% | Reduce -17.9% | 589,597 | $14.8M |
| SG Americas Securities, LLC | 0.02% | Add +35.9% | 567,046 | $14.2M |
| Two Sigma Investments, LP | 0.02% | Add +123.1% | 562,361 | $14.1M |
| BNP Paribas Financial Markets | 0.01% | Reduce -42.7% | 557,591 | $14.0M |
| Woodline Partners LP | 0.05% | No change | 542,981 | $13.6M |
| Simplify Asset Management Inc. | 0.22% | Add +403.3% | 538,008 | $13.5M |
| Susquehanna International Group, LLP | 0.02% | Add +70.1% | 533,909 | $13.4M |
| First Trust Advisors LP | 0.01% | New | 495,947 | $12.5M |
| Voloridge Investment Management, LLC | 0.04% | Reduce -53.5% | 461,186 | $11.6M |
| D. E. Shaw & Co. | 0.01% | Reduce -1.6% | 449,676 | $11.3M |
| Ossiam | 0.22% | Reduce -22.3% | 431,779 | $10.8M |
| Pictet Asset Management Holding SA | 0.01% | Add +7.5% | 390,884 | $9.8M |
| Rhenman & Partners Asset Management AB | 0.88% | Add +61.2% | 374,450 | $9.4M |
| Schroder Investment Management Group | 0.01% | Add +90.2% | 329,134 | $8.3M |
| 683 Capital Management, LLC | 0.73% | Add +14.6% | 330,000 | $8.3M |
| Granite Investment Partners, LLC | 0.49% | New | 327,094 | $8.2M |
| J. Goldman & Co LP | 0.28% | Add +1.0% | 285,992 | $7.2M |
| Bank of New York Mellon Corp | 0.00% | Add +9.6% | 271,925 | $6.8M |
| Natixis | 0.03% | Add +392.5% | 257,268 | $6.5M |
| Caption Management, LLC | 0.29% | Reduce -16.5% | 254,563 | $6.4M |
| Sphera Funds Management LTD. | 1.32% | Add +294.2% | 250,961 | $6.3M |
| Janus Henderson Group PLC | 0.00% | Add +569.3% | 230,320 | $5.8M |
| Invesco Ltd. | 0.00% | Add +23.5% | 225,976 | $5.7M |
| Canada Pension Plan Investment Board | 0.00% | Add +2.4% | 222,200 | $5.6M |
| Tudor Investment Corporation | 0.03% | New | 215,000 | $5.4M |
| Acadian Asset Management LLC | 0.01% | Add +1554.1% | 205,986 | $5.2M |
| Integral Health Asset Management, LLC | 0.25% | Reduce -20.0% | 200,000 | $5.0M |
| Trexquant Investment LP | 0.04% | Reduce -66.8% | 194,592 | $4.9M |
| Jump Financial, LLC | 0.07% | Reduce -30.2% | 193,876 | $4.9M |
| HRT Financial LP | 0.02% | Reduce -45.6% | 192,488 | $4.8M |
| Squarepoint Ops LLC | 0.01% | Add +263.7% | 192,156 | $4.8M |
| Apis Capital Advisors, LLC | 0.84% | New | 192,000 | $4.8M |
| Silvercrest Asset Management Group LLC | 0.03% | Add +0.1% | 190,759 | $4.8M |
| Goldman Sachs Group Inc. | 0.00% | Add +52.1% | 189,205 | $4.8M |
| Barclays PLC | 0.00% | Reduce -30.4% | 187,712 | $4.7M |
| California Public Employees Retirement System | 0.00% | Add +27.5% | 186,328 | $4.7M |
| Dimensional Fund Advisors LP | 0.00% | Add +868.0% | 180,925 | $4.5M |
| Fiduciary Trust Co | 0.05% | Reduce -9.0% | 180,254 | $4.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +6.8% | 178,888 | $4.5M |
| Bank of Montreal | 0.00% | Add +10.2% | 176,571 | $4.4M |
| Rafferty Asset Management, LLC | 0.01% | Add +1.8% | 171,456 | $4.3M |
| ExodusPoint Capital Management, LP | 0.05% | Reduce -12.1% | 171,156 | $4.3M |
| Gotham Asset Management | 0.02% | Add +32.5% | 168,455 | $4.2M |
| JPMorgan Chase & Co. | 0.00% | Add +194.8% | 157,754 | $4.0M |
| HighVista Strategies LLC | 0.98% | Add +3.5% | 150,776 | $3.8M |
| Rock Springs Capital Management LP | 0.19% | Add +63.6% | 150,500 | $3.8M |
| Swiss National Bank | 0.00% | Add +2.3% | 149,500 | $3.8M |
| Man Group plc | 0.01% | Add +114.7% | 144,271 | $3.6M |
| Bridgewater Associates | 0.01% | New | 143,805 | $3.6M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 55,000 | $3.5M |
| ING Groep NV | 0.02% | Reduce -88.2% | 139,000 | $3.5M |
| Exome Asset Management LLC | 1.69% | New | 135,849 | $3.4M |
| Rhumbline Advisers | 0.00% | Reduce -0.4% | 116,917 | $2.9M |
| Two Sigma Advisers, LP | 0.01% | New | 110,900 | $2.8M |
| Algert Global LLC | 0.04% | No change | 109,733 | $2.8M |
| New York State Common Retirement Fund | 0.00% | Add +113.0% | 104,018 | $2.6M |
| Wells Fargo & Company | 0.00% | Add +4115.0% | 103,815 | $2.6M |
| Alps Advisors Inc. | 0.02% | Add +65.1% | 103,696 | $2.6M |
| Edgestream Partners, L.P. | 0.07% | Reduce -24.9% | 97,443 | $2.4M |
| Mackenzie Financial Corp. | 0.00% | Add +25.4% | 96,211 | $2.4M |
| State Board of Administration of Florida Retirement System | 0.00% | Add +0.6% | 96,125 | $2.4M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +107.7% | 95,755 | $2.4M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -3.0% | 95,035 | $2.4M |
| Royal Bank of Canada | 0.00% | Reduce -39.3% | 88,687 | $2.2M |
| WINTON GROUP Ltd | 0.08% | New | 86,653 | $2.2M |
| Legal & General Group Plc | 0.00% | Reduce -7.5% | 85,489 | $2.1M |
| Steward Partners Investment Advisory, LLC | 0.01% | Reduce -28.4% | 81,698 | $2.1M |
| Coppell Advisory Solutions LLC | 0.19% | New | 77,390 | $2.0M |
"% of holder's portfolio" is APLS's weight in each manager's 13F, not the share of Apellis Pharmaceuticals Inc. the manager owns.