Bicycle Therapeutics PLC-ADRBCYC
13F holders, Q4 2025 (December 31)109holders +10
18new positions
11sold out
5famous investors
$7.09avg. 13F price*
At the end of Q4 2025, 109 institutions reported holding Bicycle Therapeutics PLC-ADR (BCYC) in their 13F filings, up 10 from Q3 2025. 18 opened new positions and 11 sold out. The largest holders were Baker Bros. Advisors LP ($77.1M), FCPM III Services B.V. ($24.6M) and Armistice Capital, LLC ($22.9M). 5 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Bicycle Therapeutics PLC-ADR
- CUSIP
- 088786108
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 18 | $10.8M |
| Exits | 11 | $1.7M |
All 13F filers, Q3 2025 → Q4 2025: 3,391,958 shares bought and 2,859,437 shares sold, net +532,521 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 109 holders
| Baker Bros. Advisors LP | 0.45% | No change | 10,885,357 | $77.1M |
| FCPM III Services B.V. | 3.22% | Add +0.5% | 3,468,430 | $24.6M |
| Armistice Capital, LLC | 0.56% | Add +8.7% | 3,236,000 | $22.9M |
| Westfield Capital Management Co. LP | 0.09% | Add +2.1% | 3,016,026 | $21.4M |
| Siren, L.L.C. | 0.43% | No change | 2,012,752 | $14.3M |
| Acadian Asset Management LLC | 0.02% | Add +27.1% | 1,671,258 | $11.8M |
| Long Focus Capital Management, LLC | 0.58% | Add +15.1% | 1,633,091 | $11.6M |
| GSK plc | 1.36% | — | 1,529,561 | $10.8M |
| Candriam S.C.A. | 0.04% | Add +1.7% | 1,192,279 | $8.4M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -15.4% | 1,171,787 | $8.3M |
| Principal Financial Group Inc. | 0.00% | Reduce -0.0% | 1,148,272 | $8.1M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | New | 568,225 | $4.0M |
| Renaissance Technologies | 0.01% | Add +9.2% | 566,600 | $4.0M |
| Schroder Investment Management Group | 0.00% | New | 584,770 | $4.0M |
| Silvercrest Asset Management Group LLC | 0.02% | No change | 476,976 | $3.4M |
| Morgan Stanley | 0.00% | Reduce -43.5% | 465,222 | $3.3M |
| Birchview Capital, LP | 1.92% | Add +200.4% | 462,700 | $3.3M |
| BlackRock, Inc. | 0.00% | Add +17.9% | 332,889 | $2.4M |
| Millennium Management | 0.00% | Reduce -69.0% | 326,626 | $2.3M |
| Jefferies Financial Group Inc. | 0.02% | Reduce -26.0% | 297,247 | $2.1M |
| Moore Capital Management, LP | 0.04% | Add +120.0% | 275,000 | $1.9M |
| Citadel Advisors | 0.00% | Add +43.6% | 271,383 | $1.9M |
| Palo Alto Investors LP | 0.22% | No change | 221,071 | $1.6M |
| Pinnacle Associates Ltd. | 0.02% | Reduce -3.1% | 190,480 | $1.3M |
| Platinum Investment Management Ltd. | 0.30% | No change | 184,603 | $1.3M |
| Eversept Partners, LP | 0.07% | Reduce -8.0% | 178,915 | $1.3M |
| Flax Pond Capital, LLC | 0.91% | — | 173,633 | $1.2M |
| TD Asset Management Inc | 0.00% | Reduce -16.9% | 147,992 | $1.0M |
| Two Sigma Advisers, LP | 0.00% | Reduce -6.8% | 146,100 | $1.0M |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 0.03% | — | 134,689 | $954K |
| Two Sigma Investments, LP | 0.00% | Reduce -28.4% | 132,032 | $935K |
| Rangeley Capital, LLC | 0.82% | Add +1.5% | 132,000 | $935K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -9.0% | 127,863 | $869K |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 30,000 | $801K |
| Walleye Capital LLC | 0.00% | New | 111,659 | $791K |
| Susquehanna International Group, LLP | 0.00% | Add +307.2% | 108,423 | $768K |
| Bank of America Corp. | 0.00% | Reduce -83.7% | 96,401 | $683K |
| Monimus Capital Management, LP | 0.44% | Add +10.1% | 93,840 | $664K |
| Marex Group Ltd | 0.01% | New | 78,406 | $555K |
| Point72 Asset Management | 0.00% | Reduce -82.2% | 76,779 | $544K |
| State Street Corp. | 0.00% | Reduce -5.7% | 70,178 | $497K |
| Nan Fung Group Holdings Ltd | 0.44% | No change | 68,943 | $488K |
| DAFNA Capital Management LLC | 0.11% | No change | 64,492 | $457K |
| Jane Street Group, LLC | 0.00% | Reduce -38.3% | 63,190 | $447K |
| State of Tennessee, Department of Treasury | 0.00% | Add +36.4% | 61,153 | $393K |
| Sei Investments Co. | 0.00% | No change | 49,056 | $347K |
| XTX Topco Ltd | 0.01% | Add +309.3% | 47,674 | $338K |
| Quadrature Capital Ltd | 0.00% | Add +67.5% | 46,728 | $331K |
| Man Group plc | 0.00% | Add +4.8% | 42,860 | $303K |
| Alps Advisors Inc. | 0.00% | Add +69.9% | 40,995 | $290K |
| Harbor Capital Advisors, Inc. | 0.02% | Reduce -2.1% | 40,486 | $287K |
| Marshall Wace, LLP | 0.00% | New | 38,795 | $275K |
| Virtus Investment Advisers, LLC | 0.07% | Add +172.7% | 35,709 | $253K |
| Jump Financial, LLC | 0.00% | Add +44.7% | 31,000 | $219K |
| Woodstock Corp. | 0.02% | Add +21.8% | 29,146 | $206K |
| UBS Group AG | 0.00% | Add +125.8% | 25,676 | $182K |
| Geode Capital Management, LLC | 0.00% | Reduce -37.1% | 25,129 | $178K |
| Goldman Sachs Group Inc. | 0.00% | New | 24,732 | $175K |
| Engineers Gate Manager LP | 0.00% | Add +79.2% | 24,047 | $170K |
| D. E. Shaw & Co. | 0.00% | New | 21,548 | $153K |
| State of New Jersey Common Pension Fund D | 0.00% | No change | 20,105 | $142K |
| Simplex Trading, LLC | 0.00% | New | 19,986 | $142K |
| Fox Run Management, L.L.C. | 0.02% | New | 19,771 | $140K |
| Aquatic Capital Management LLC | 0.00% | New | 18,817 | $133K |
| JPMorgan Chase & Co. | 0.00% | Add +125.8% | 18,355 | $130K |
| Portland Investment Counsel Inc. | 0.03% | No change | 15,000 | $106K |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 14,302 | $101K |
| PNC Financial Services Group, Inc. | 0.00% | Add +8.1% | 14,138 | $100K |
| Horizon Kinetics Asset Management LLC | 0.00% | Reduce -4.2% | 13,792 | $98K |
| Erste Asset Management GmbH | 0.00% | No change | 14,000 | $95K |
| Forefront Analytics, LLC | 0.08% | New | 13,371 | $95K |
| Cerity Partners LLC | 0.00% | Reduce -7.0% | 13,350 | $95K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Reduce -1.4% | 12,776 | $90K |
| Tocqueville Asset Management L.P. | 0.00% | Add +2.4% | 12,600 | $89K |
| Raymond James Financial Inc. | 0.00% | New | 12,336 | $87K |
| Crossmark Global Holdings, Inc. | 0.00% | Add +0.1% | 11,399 | $81K |
| Rhumbline Advisers | 0.00% | Add +241.1% | 11,171 | $79K |
| Royal Bank of Canada | 0.00% | Reduce -16.1% | 10,682 | $76K |
| Commonwealth of Pennsylvania Public School Empls Retrmt SYS | 0.00% | No change | 10,116 | $72K |
| Invesco Ltd. | 0.00% | New | 10,092 | $71K |
| Pinnacle Wealth Management Advisory Group, LLC | 0.00% | New | 10,000 | $71K |
| Vontobel Holding Ltd. | 0.00% | New | 10,000 | $71K |
| Brooklyn Investment Group | 0.00% | New | 10,216 | $69K |
| Legal & General Group Plc | 0.00% | Reduce -95.4% | 9,054 | $64K |
| China Universal Asset Management Co., Ltd. | 0.00% | Reduce -7.0% | 7,540 | $53K |
| FNY Investment Advisers, LLC | 0.02% | Reduce -28.7% | 7,486 | $53K |
| Clearstead Advisors, LLC | 0.00% | Add +234.2% | 4,655 | $33K |
| Natixis | 0.00% | Add +138.6% | 4,645 | $32K |
| Assetmark, Inc. | 0.00% | Add +0.1% | 3,628 | $26K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +25.8% | 2,248 | $16K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +0.2% | 1,668 | $12K |
| GAMMA Investing LLC | 0.00% | Reduce -34.5% | 1,386 | $10K |
| Citigroup Inc. | 0.00% | Reduce -50.4% | 1,291 | $9K |
| BNP Paribas Financial Markets | 0.00% | Add +37.6% | 1,116 | $8K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -8.6% | 909 | $6K |
| Barclays PLC | 0.00% | Reduce -75.3% | 562 | $4K |
| HighMark Wealth Management LLC | 0.00% | No change | 435 | $3K |
| FMR LLC | 0.00% | No change | 316 | $2K |
| Jones Financial Companies LLLP | 0.00% | No change | 250 | $2K |
| Farther Finance Advisors, LLC | 0.00% | New | 218 | $2K |
"% of holder's portfolio" is BCYC's weight in each manager's 13F, not the share of Bicycle Therapeutics PLC-ADR the manager owns.