Denali TherapeuticsDNLI
13F holders, Q4 2025 (December 31)250holders +10
41new positions
34sold out
7famous investors
$16.51avg. 13F price*
At the end of Q4 2025, 250 institutions reported holding Denali Therapeutics Inc. (DNLI) in their 13F filings, up 10 from Q3 2025. 41 opened new positions and 34 sold out. The largest holders were Vanguard Group Inc. ($215.6M), BlackRock, Inc. ($209.9M) and Baillie Gifford & Co. ($203.3M). 7 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Ken Fisher (0.0% of Fisher Asset Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Denali Therapeutics Inc.
- CUSIP
- 24823R105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 41 | $61.7M |
| Exits | 34 | $31.5M |
All 13F filers, Q3 2025 → Q4 2025: 21,185,336 shares bought and 11,005,637 shares sold, net +10,179,699 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 250 holders
| Vanguard Group Inc. | 0.00% | Add +8.9% | 13,057,890 | $215.6M |
| BlackRock, Inc. | 0.00% | Add +3.5% | 12,715,201 | $209.9M |
| Baillie Gifford & Co. | 0.17% | Add +6.2% | 12,310,889 | $203.3M |
| T. Rowe Price Investment Management, Inc. | 0.08% | Add +28.6% | 7,254,132 | $119.8M |
| Temasek Holdings (Private) Ltd | 0.37% | Add +30.9% | 7,012,974 | $115.8M |
| State Street Corp. | 0.00% | Add +14.6% | 6,263,371 | $103.4M |
| FMR LLC | 0.01% | Reduce -3.8% | 6,097,211 | $100.7M |
| Norges Bank | 0.01% | — | 5,119,622 | $84.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Reduce -8.8% | 4,983,726 | $82.3M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -14.3% | 3,915,951 | $64.7M |
| Goldman Sachs Group Inc. | 0.01% | Add +77.3% | 3,835,803 | $63.3M |
| Baker Bros. Advisors LP | 0.36% | No change | 3,731,695 | $61.6M |
| Capital Research Global Investors | 0.01% | Reduce -21.7% | 3,729,244 | $61.6M |
| Alliancebernstein L.P. | 0.02% | Add +1.1% | 3,557,935 | $58.7M |
| Geode Capital Management, LLC | 0.00% | Reduce -0.2% | 3,458,131 | $57.1M |
| Holocene Advisors, LP | 0.11% | Add +0.5% | 3,152,734 | $52.1M |
| Crestline Management, L.P. | 87.02% | Reduce -17.6% | 2,810,732 | $46.4M |
| Fisher Asset Management | 0.01% | Add +58.7% | 2,589,403 | $42.8M |
| UBS Group AG | 0.01% | Add +19.5% | 2,404,704 | $39.7M |
| Dimensional Fund Advisors LP | 0.01% | Add +0.7% | 2,374,303 | $39.2M |
| Aberdeen Group plc | 0.05% | Add +82.6% | 2,032,967 | $33.6M |
| Casdin Capital, LLC | 1.89% | Add +106.7% | 1,840,000 | $30.4M |
| Lynx1 Capital Management LP | 5.81% | Add +564.4% | 1,738,750 | $28.7M |
| Point72 Asset Management | 0.05% | Reduce -32.5% | 1,700,000 | $28.1M |
| Principal Financial Group Inc. | 0.01% | Add +19.9% | 1,524,123 | $25.2M |
| Siren, L.L.C. | 0.69% | Add +70.0% | 1,396,513 | $23.1M |
| Pictet Asset Management Holding SA | 0.02% | Add +166.3% | 1,329,108 | $22.0M |
| Morgan Stanley | 0.00% | Reduce -27.8% | 1,219,854 | $20.1M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +4.3% | 1,200,475 | $19.8M |
| Northern Trust Corp. | 0.00% | Reduce -2.8% | 1,199,744 | $19.8M |
| Candriam S.C.A. | 0.10% | Add +39.9% | 1,166,379 | $19.3M |
| ExodusPoint Capital Management, LP | 0.19% | New | 1,023,253 | $16.9M |
| Foresite Capital Management VI LLC | 4.99% | No change | 1,000,000 | $16.5M |
| Masters Capital Management LLC | 2.28% | Add +33.3% | 1,000,000 | $16.5M |
| Bank of America Corp. | 0.00% | Reduce -3.0% | 932,144 | $15.4M |
| Alyeska Investment Group, L.P. | 0.04% | New | 859,108 | $14.2M |
| Citadel Advisors | 0.01% | Add +13.2% | 779,148 | $12.9M |
| Marshall Wace, LLP | 0.01% | Reduce -2.9% | 763,892 | $12.6M |
| Bank of New York Mellon Corp | 0.00% | Reduce -4.8% | 762,087 | $12.6M |
| Defilade Capital Management, L.P. | 1.47% | — | 656,713 | $10.8M |
| Palo Alto Investors LP | 1.47% | Add +57.2% | 641,239 | $10.6M |
| Cercano Management LLC | 0.39% | No change | 625,000 | $10.3M |
| Voloridge Investment Management, LLC | 0.03% | Reduce -36.8% | 591,461 | $9.8M |
| Qube Research & Technologies Ltd | 0.01% | Add +158.9% | 590,314 | $9.7M |
| Segall Bryant & Hamill, LLC | 0.12% | Add +4.7% | 537,000 | $8.9M |
| Ensign Peak Advisors, Inc | 0.01% | Reduce -3.4% | 515,721 | $8.5M |
| Vestal Point Capital, LP | 0.28% | New | 465,000 | $7.7M |
| Hudson Bay Capital Management LP | 0.05% | Add +47.5% | 450,000 | $7.4M |
| Schroder Investment Management Group | 0.01% | Add +115.2% | 450,985 | $7.4M |
| Two Sigma Investments, LP | 0.01% | Add +61.5% | 430,177 | $7.1M |
| Stempoint Capital LP | 1.19% | Reduce -75.8% | 419,058 | $6.9M |
| Barclays PLC | 0.00% | Reduce -6.8% | 407,359 | $6.7M |
| American Century Companies Inc. | 0.00% | Add +6.1% | 379,051 | $6.3M |
| Millennium Management | 0.00% | Reduce -71.7% | 369,767 | $6.1M |
| Clarius Group, LLC | 0.35% | Add +2.6% | 368,995 | $6.1M |
| TD Asset Management Inc | 0.00% | Reduce -14.0% | 339,410 | $5.6M |
| DAFNA Capital Management LLC | 1.24% | Add +89.0% | 318,500 | $5.3M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.01% | Add +23408.4% | 298,792 | $4.9M |
| Invesco Ltd. | 0.00% | Add +17.0% | 291,936 | $4.8M |
| Marex Group Ltd | 0.05% | Reduce -1.4% | 287,001 | $4.7M |
| Nuveen, LLC | 0.00% | Reduce -3.3% | 275,508 | $4.5M |
| Swiss National Bank | 0.00% | Add +2.4% | 273,800 | $4.5M |
| Edmond DE Rothschild Holding S.A. | 0.05% | Add +9.7% | 225,680 | $3.7M |
| Trexquant Investment LP | 0.03% | Reduce -51.3% | 209,609 | $3.5M |
| Burkehill Global Management, LP | 0.23% | New | 200,000 | $3.3M |
| SCS Capital Management LLC | 0.03% | No change | 197,998 | $3.3M |
| Wells Fargo & Company | 0.00% | Add +85.9% | 193,681 | $3.2M |
| Rafferty Asset Management, LLC | 0.01% | Add +4.8% | 191,567 | $3.2M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -10.5% | 184,238 | $3.0M |
| Rhumbline Advisers | 0.00% | Reduce -9.2% | 183,000 | $3.0M |
| Ameriprise Financial Inc. | 0.00% | Add +81.0% | 180,221 | $3.0M |
| JPMorgan Chase & Co. | 0.00% | Reduce -1.8% | 171,948 | $2.8M |
| Susquehanna Portfolio Strategies, LLC | 0.04% | New | 167,713 | $2.8M |
| Two Sigma Advisers, LP | 0.01% | Add +72.0% | 154,800 | $2.6M |
| Teachers Retirement System of the State of Kentucky | 0.02% | Reduce -10.4% | 153,781 | $2.5M |
| Groupama Asset Managment | 0.04% | Add +11.7% | 151,591 | $2.5M |
| SG Americas Securities, LLC | 0.00% | Add +291.6% | 149,592 | $2.5M |
| Legal & General Group Plc | 0.00% | Reduce -8.8% | 131,223 | $2.2M |
| California State Teachers Retirement System | 0.00% | Reduce -0.1% | 129,409 | $2.1M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -0.8% | 128,800 | $2.1M |
| Algert Global LLC | 0.03% | Add +25.4% | 127,030 | $2.1M |
| Alps Advisors Inc. | 0.01% | Add +71.9% | 120,718 | $2.0M |
| Woodline Partners LP | 0.01% | Add +0.5% | 114,082 | $1.9M |
| B. Metzler seel. Sohn & Co. AG | 0.02% | New | 112,300 | $1.8M |
| Nomura Asset Management International Inc. | 0.00% | — | 107,493 | $1.8M |
| D.A. Davidson & Co. | 0.01% | New | 106,933 | $1.8M |
| Deutsche Bank AG | 0.00% | Reduce -49.4% | 105,086 | $1.7M |
| Rhenman & Partners Asset Management AB | 0.15% | No change | 100,000 | $1.7M |
| Ghisallo Capital Management LLC | 0.07% | New | 100,000 | $1.7M |
| Integrated Wealth Concepts LLC | 0.02% | Add +3.9% | 94,582 | $1.6M |
| Y-Intercept (Hong Kong) Ltd | 0.03% | New | 93,587 | $1.5M |
| Monashee Investment Management LLC | 0.89% | New | 91,620 | $1.5M |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 59,800 | $1.4M |
| HRT Financial LP | 0.00% | New | 78,352 | $1.3M |
| MetLife Investment Management, LLC | 0.01% | Reduce -5.0% | 75,164 | $1.2M |
| State of Wisconsin Investment Board | 0.00% | Reduce -8.2% | 73,581 | $1.2M |
| Profund Advisors LLC | 0.04% | Add +78.4% | 71,634 | $1.2M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +170.1% | 70,830 | $1.2M |
| Ishara Investments LP | 1.34% | — | 70,000 | $1.2M |
| Pier 88 Investment Partners LLC | 1.28% | Add +1.1% | 68,200 | $1.1M |
"% of holder's portfolio" is DNLI's weight in each manager's 13F, not the share of Denali Therapeutics Inc. the manager owns.