Denali TherapeuticsDNLI
13F holders, Q3 2025 (September 30)240holders +10
33new positions
22sold out
7famous investors
$14.52avg. 13F price*
At the end of Q3 2025, 240 institutions reported holding Denali Therapeutics Inc. (DNLI) in their 13F filings, up 10 from Q2 2025. 33 opened new positions and 22 sold out. The largest holders were BlackRock, Inc. ($178.4M), Vanguard Group Inc. ($174.1M) and Baillie Gifford & Co. ($168.3M). 7 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Fisher (0.0% of Fisher Asset Management's portfolio).
- Company
- Denali Therapeutics Inc.
- CUSIP
- 24823R105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 33 | $38.0M |
| Exits | 22 | $14.5M |
All 13F filers, Q2 2025 → Q3 2025: 16,480,495 shares bought and 14,509,486 shares sold, net +1,971,009 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 240 holders
| BlackRock, Inc. | 0.00% | Add +2.0% | 12,289,626 | $178.4M |
| Vanguard Group Inc. | 0.00% | Add +1.5% | 11,992,918 | $174.1M |
| Baillie Gifford & Co. | 0.12% | Reduce -3.0% | 11,591,585 | $168.3M |
| FMR LLC | 0.00% | Reduce -15.9% | 6,340,316 | $92.1M |
| T. Rowe Price Investment Management, Inc. | 0.05% | Add +73.7% | 5,638,567 | $81.9M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Reduce -12.7% | 5,465,037 | $79.4M |
| State Street Corp. | 0.00% | Add +20.9% | 5,464,261 | $79.3M |
| Temasek Holdings (Private) Ltd | 0.27% | No change | 5,355,832 | $77.8M |
| Capital Research Global Investors | 0.01% | Add +0.2% | 4,760,858 | $69.1M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -30.6% | 4,568,368 | $66.3M |
| Baker Bros. Advisors LP | 0.39% | No change | 3,731,695 | $54.2M |
| Alliancebernstein L.P. | 0.02% | Add +12.2% | 3,520,414 | $51.1M |
| Geode Capital Management, LLC | 0.00% | Add +9.3% | 3,466,057 | $50.3M |
| Crestline Management, L.P. | 85.26% | Reduce -11.7% | 3,410,732 | $49.5M |
| Holocene Advisors, LP | 0.10% | Add +677.8% | 3,135,712 | $45.5M |
| Point72 Asset Management | 0.08% | Add +13.8% | 2,519,535 | $36.6M |
| Dimensional Fund Advisors LP | 0.01% | Reduce -2.3% | 2,357,214 | $34.2M |
| Goldman Sachs Group Inc. | 0.00% | Add +16.0% | 2,163,705 | $31.4M |
| UBS Group AG | 0.01% | Add +111.7% | 2,012,353 | $29.2M |
| Stempoint Capital LP | 5.08% | Add +145.0% | 1,734,659 | $25.2M |
| Morgan Stanley | 0.00% | Add +28.8% | 1,689,492 | $24.5M |
| Fisher Asset Management | 0.01% | Add +7.6% | 1,631,496 | $23.7M |
| Millennium Management | 0.02% | Add +45.2% | 1,307,171 | $19.0M |
| Principal Financial Group Inc. | 0.01% | Add +18.5% | 1,271,190 | $18.5M |
| Northern Trust Corp. | 0.00% | Add +2.7% | 1,234,179 | $17.9M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +9.0% | 1,151,384 | $16.7M |
| Aberdeen Group plc | 0.03% | Add +23.4% | 1,113,586 | $16.2M |
| Foresite Capital Management VI LLC | 5.61% | New | 1,000,000 | $14.5M |
| Bank of America Corp. | 0.00% | Add +47.8% | 961,138 | $14.0M |
| Voloridge Investment Management, LLC | 0.05% | Add +21.5% | 936,230 | $13.6M |
| Casdin Capital, LLC | 1.08% | No change | 890,000 | $12.9M |
| Candriam S.C.A. | 0.06% | Reduce -1.3% | 833,582 | $12.1M |
| Siren, L.L.C. | 0.47% | No change | 821,513 | $11.9M |
| Bank of New York Mellon Corp | 0.00% | Add +1.3% | 800,747 | $11.6M |
| Marshall Wace, LLP | 0.01% | Reduce -44.0% | 787,029 | $11.4M |
| Masters Capital Management LLC | 1.75% | Add +25.0% | 750,000 | $10.9M |
| Citadel Advisors | 0.01% | Reduce -44.9% | 688,224 | $10.0M |
| Cercano Management LLC | 0.35% | No change | 625,000 | $9.1M |
| Ensign Peak Advisors, Inc | 0.01% | Add +12.8% | 534,071 | $7.8M |
| Segall Bryant & Hamill, LLC | 0.10% | Add +2.5% | 512,958 | $7.4M |
| Pictet Asset Management Holding SA | 0.01% | Add +20.3% | 499,162 | $7.2M |
| Yiheng Capital Management, L.P. | 2.26% | No change | 469,981 | $6.8M |
| Barclays PLC | 0.00% | Add +2.6% | 437,001 | $6.3M |
| Trexquant Investment LP | 0.06% | Add +294.1% | 430,566 | $6.3M |
| Palo Alto Investors LP | 1.10% | Add +70.1% | 408,006 | $5.9M |
| TD Asset Management Inc | 0.00% | Reduce -20.5% | 394,600 | $5.7M |
| Royal Bank of Canada | 0.00% | Reduce -4.6% | 372,176 | $5.4M |
| Clarius Group, LLC | 0.31% | Reduce -2.5% | 359,745 | $5.2M |
| American Century Companies Inc. | 0.00% | Add +12.3% | 357,341 | $5.2M |
| Hudson Bay Capital Management LP | 0.03% | Add +5.2% | 305,000 | $4.4M |
| Pier Capital, LLC | 0.68% | Reduce -4.3% | 301,171 | $4.4M |
| AXA Investment Managers S.A. | 0.01% | — | 294,732 | $4.3M |
| Marex Group Ltd | 0.05% | Add +11.1% | 291,000 | $4.2M |
| Nuveen, LLC | 0.00% | Reduce -52.2% | 284,777 | $4.1M |
| Swiss National Bank | 0.00% | Add +6.6% | 267,500 | $3.9M |
| Two Sigma Investments, LP | 0.01% | Add +1279.8% | 266,292 | $3.9M |
| BNP Paribas Financial Markets | 0.00% | Add +1283.8% | 264,061 | $3.8M |
| Lynx1 Capital Management LP | 0.77% | New | 261,687 | $3.8M |
| Boxer Capital Management, LLC | 1.16% | New | 250,000 | $3.6M |
| Invesco Ltd. | 0.00% | Add +13.5% | 249,467 | $3.6M |
| Cubist Systematic Strategies, LLC | 0.05% | Reduce -41.8% | 230,968 | $3.4M |
| Qube Research & Technologies Ltd | 0.00% | New | 227,990 | $3.3M |
| Schonfeld Strategic Advisors LLC | 0.02% | New | 226,203 | $3.3M |
| Jane Street Group, LLC | 0.00% | Add +163.6% | 224,903 | $3.3M |
| Campbell & CO Investment Adviser LLC | 0.24% | Add +51.9% | 216,774 | $3.1M |
| Schroder Investment Management Group | 0.00% | Reduce -45.8% | 209,595 | $3.0M |
| Deutsche Bank AG | 0.00% | Add +52.7% | 207,594 | $3.0M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -34.7% | 205,845 | $3.0M |
| Edmond DE Rothschild Holding S.A. | 0.05% | No change | 205,680 | $3.0M |
| Rhumbline Advisers | 0.00% | Reduce -5.2% | 201,565 | $2.9M |
| SCS Capital Management LLC | 0.03% | No change | 197,998 | $2.9M |
| Rafferty Asset Management, LLC | 0.01% | Add +49.6% | 182,886 | $2.7M |
| JPMorgan Chase & Co. | 0.00% | Reduce -8.7% | 175,021 | $2.5M |
| Teachers Retirement System of the State of Kentucky | 0.02% | No change | 171,553 | $2.5M |
| DAFNA Capital Management LLC | 0.61% | No change | 168,500 | $2.4M |
| Jump Financial, LLC | 0.03% | New | 166,399 | $2.4M |
| Legal & General Group Plc | 0.00% | Add +9.3% | 143,952 | $2.1M |
| State of New Jersey Common Pension Fund D | 0.01% | Add +1.3% | 139,663 | $2.0M |
| Groupama Asset Managment | 0.03% | Reduce -22.7% | 135,758 | $2.0M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -3.6% | 129,887 | $1.9M |
| California State Teachers Retirement System | 0.00% | Add +8.6% | 129,526 | $1.9M |
| Edgestream Partners, L.P. | 0.05% | Reduce -63.9% | 123,819 | $1.8M |
| Woodline Partners LP | 0.01% | No change | 113,517 | $1.6M |
| Wells Fargo & Company | 0.00% | Add +16.2% | 104,179 | $1.5M |
| Algert Global LLC | 0.02% | Add +18.0% | 101,260 | $1.5M |
| Rhenman & Partners Asset Management AB | 0.16% | No change | 100,000 | $1.5M |
| Ameriprise Financial Inc. | 0.00% | Reduce -2.4% | 99,561 | $1.4M |
| Integrated Wealth Concepts LLC | 0.01% | Reduce -5.2% | 91,074 | $1.3M |
| Two Sigma Advisers, LP | 0.00% | Add +226.1% | 90,000 | $1.3M |
| Squarepoint Ops LLC | 0.00% | New | 80,518 | $1.2M |
| State of Wisconsin Investment Board | 0.00% | Add +0.6% | 80,126 | $1.2M |
| MetLife Investment Management, LLC | 0.01% | No change | 79,075 | $1.1M |
| Savvy Advisors, Inc. | 0.05% | Reduce -21.2% | 77,093 | $1.1M |
| AlphaQuest LLC | 0.07% | Add +224.1% | 74,422 | $1.1M |
| Alps Advisors Inc. | 0.01% | Reduce -10.4% | 70,230 | $1.0M |
| Engineers Gate Manager LP | 0.01% | Reduce -40.4% | 69,216 | $1.0M |
| Pier 88 Investment Partners LLC | 1.08% | Add +18.0% | 67,440 | $979K |
| XTX Topco Ltd | 0.05% | New | 65,345 | $949K |
| TT International Asset Management LTD | 0.18% | No change | 65,000 | $944K |
| Franklin Resources Inc. | 0.00% | Add +0.2% | 64,634 | $938K |
"% of holder's portfolio" is DNLI's weight in each manager's 13F, not the share of Denali Therapeutics Inc. the manager owns.