Denali TherapeuticsDNLI
13F holders, Q4 2025 (December 31)250holders +10
41new positions
34sold out
7famous investors
$16.51avg. 13F price*
At the end of Q4 2025, 250 institutions reported holding Denali Therapeutics Inc. (DNLI) in their 13F filings, up 10 from Q3 2025. 41 opened new positions and 34 sold out. The largest holders were Vanguard Group Inc. ($215.6M), BlackRock, Inc. ($209.9M) and Baillie Gifford & Co. ($203.3M). 7 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Ken Fisher (0.0% of Fisher Asset Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Denali Therapeutics Inc.
- CUSIP
- 24823R105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 41 | $61.7M |
| Exits | 34 | $31.5M |
All 13F filers, Q3 2025 → Q4 2025: 21,185,336 shares bought and 11,005,637 shares sold, net +10,179,699 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 250 holders
| Vanguard Group Inc. | 0.00% | Add +8.9% | 13,057,890 | $215.6M |
| BlackRock, Inc. | 0.00% | Add +3.5% | 12,715,201 | $209.9M |
| Baillie Gifford & Co. | 0.17% | Add +6.2% | 12,310,889 | $203.3M |
| T. Rowe Price Investment Management, Inc. | 0.08% | Add +28.6% | 7,254,132 | $119.8M |
| Temasek Holdings (Private) Ltd | 0.37% | Add +30.9% | 7,012,974 | $115.8M |
| State Street Corp. | 0.00% | Add +14.6% | 6,263,371 | $103.4M |
| FMR LLC | 0.01% | Reduce -3.8% | 6,097,211 | $100.7M |
| Norges Bank | 0.01% | — | 5,119,622 | $84.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Reduce -8.8% | 4,983,726 | $82.3M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -14.3% | 3,915,951 | $64.7M |
| Goldman Sachs Group Inc. | 0.01% | Add +77.3% | 3,835,803 | $63.3M |
| Baker Bros. Advisors LP | 0.36% | No change | 3,731,695 | $61.6M |
| Capital Research Global Investors | 0.01% | Reduce -21.7% | 3,729,244 | $61.6M |
| Alliancebernstein L.P. | 0.02% | Add +1.1% | 3,557,935 | $58.7M |
| Geode Capital Management, LLC | 0.00% | Reduce -0.2% | 3,458,131 | $57.1M |
| Holocene Advisors, LP | 0.11% | Add +0.5% | 3,152,734 | $52.1M |
| Crestline Management, L.P. | 87.02% | Reduce -17.6% | 2,810,732 | $46.4M |
| Fisher Asset Management | 0.01% | Add +58.7% | 2,589,403 | $42.8M |
| UBS Group AG | 0.01% | Add +19.5% | 2,404,704 | $39.7M |
| Dimensional Fund Advisors LP | 0.01% | Add +0.7% | 2,374,303 | $39.2M |
| Aberdeen Group plc | 0.05% | Add +82.6% | 2,032,967 | $33.6M |
| Casdin Capital, LLC | 1.89% | Add +106.7% | 1,840,000 | $30.4M |
| Lynx1 Capital Management LP | 5.81% | Add +564.4% | 1,738,750 | $28.7M |
| Point72 Asset Management | 0.05% | Reduce -32.5% | 1,700,000 | $28.1M |
| Principal Financial Group Inc. | 0.01% | Add +19.9% | 1,524,123 | $25.2M |
| Siren, L.L.C. | 0.69% | Add +70.0% | 1,396,513 | $23.1M |
| Pictet Asset Management Holding SA | 0.02% | Add +166.3% | 1,329,108 | $22.0M |
| Morgan Stanley | 0.00% | Reduce -27.8% | 1,219,854 | $20.1M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +4.3% | 1,200,475 | $19.8M |
| Northern Trust Corp. | 0.00% | Reduce -2.8% | 1,199,744 | $19.8M |
| Candriam S.C.A. | 0.10% | Add +39.9% | 1,166,379 | $19.3M |
| ExodusPoint Capital Management, LP | 0.19% | New | 1,023,253 | $16.9M |
| Foresite Capital Management VI LLC | 4.99% | No change | 1,000,000 | $16.5M |
| Masters Capital Management LLC | 2.28% | Add +33.3% | 1,000,000 | $16.5M |
| Bank of America Corp. | 0.00% | Reduce -3.0% | 932,144 | $15.4M |
| Alyeska Investment Group, L.P. | 0.04% | New | 859,108 | $14.2M |
| Citadel Advisors | 0.01% | Add +13.2% | 779,148 | $12.9M |
| Marshall Wace, LLP | 0.01% | Reduce -2.9% | 763,892 | $12.6M |
| Bank of New York Mellon Corp | 0.00% | Reduce -4.8% | 762,087 | $12.6M |
| Defilade Capital Management, L.P. | 1.47% | — | 656,713 | $10.8M |
| Palo Alto Investors LP | 1.47% | Add +57.2% | 641,239 | $10.6M |
| Cercano Management LLC | 0.39% | No change | 625,000 | $10.3M |
| Voloridge Investment Management, LLC | 0.03% | Reduce -36.8% | 591,461 | $9.8M |
| Qube Research & Technologies Ltd | 0.01% | Add +158.9% | 590,314 | $9.7M |
| Segall Bryant & Hamill, LLC | 0.12% | Add +4.7% | 537,000 | $8.9M |
| Ensign Peak Advisors, Inc | 0.01% | Reduce -3.4% | 515,721 | $8.5M |
| Vestal Point Capital, LP | 0.28% | New | 465,000 | $7.7M |
| Hudson Bay Capital Management LP | 0.05% | Add +47.5% | 450,000 | $7.4M |
| Schroder Investment Management Group | 0.01% | Add +115.2% | 450,985 | $7.4M |
| Two Sigma Investments, LP | 0.01% | Add +61.5% | 430,177 | $7.1M |
| Stempoint Capital LP | 1.19% | Reduce -75.8% | 419,058 | $6.9M |
| Barclays PLC | 0.00% | Reduce -6.8% | 407,359 | $6.7M |
| American Century Companies Inc. | 0.00% | Add +6.1% | 379,051 | $6.3M |
| Millennium Management | 0.00% | Reduce -71.7% | 369,767 | $6.1M |
| Clarius Group, LLC | 0.35% | Add +2.6% | 368,995 | $6.1M |
| TD Asset Management Inc | 0.00% | Reduce -14.0% | 339,410 | $5.6M |
| DAFNA Capital Management LLC | 1.24% | Add +89.0% | 318,500 | $5.3M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.01% | Add +23408.4% | 298,792 | $4.9M |
| Invesco Ltd. | 0.00% | Add +17.0% | 291,936 | $4.8M |
| Marex Group Ltd | 0.05% | Reduce -1.4% | 287,001 | $4.7M |
| Nuveen, LLC | 0.00% | Reduce -3.3% | 275,508 | $4.5M |
| Swiss National Bank | 0.00% | Add +2.4% | 273,800 | $4.5M |
| Edmond DE Rothschild Holding S.A. | 0.05% | Add +9.7% | 225,680 | $3.7M |
| Trexquant Investment LP | 0.03% | Reduce -51.3% | 209,609 | $3.5M |
| Burkehill Global Management, LP | 0.23% | New | 200,000 | $3.3M |
| SCS Capital Management LLC | 0.03% | No change | 197,998 | $3.3M |
| Wells Fargo & Company | 0.00% | Add +85.9% | 193,681 | $3.2M |
| Rafferty Asset Management, LLC | 0.01% | Add +4.8% | 191,567 | $3.2M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -10.5% | 184,238 | $3.0M |
| Rhumbline Advisers | 0.00% | Reduce -9.2% | 183,000 | $3.0M |
| Ameriprise Financial Inc. | 0.00% | Add +81.0% | 180,221 | $3.0M |
| JPMorgan Chase & Co. | 0.00% | Reduce -1.8% | 171,948 | $2.8M |
| Susquehanna Portfolio Strategies, LLC | 0.04% | New | 167,713 | $2.8M |
| Two Sigma Advisers, LP | 0.01% | Add +72.0% | 154,800 | $2.6M |
| Teachers Retirement System of the State of Kentucky | 0.02% | Reduce -10.4% | 153,781 | $2.5M |
| Groupama Asset Managment | 0.04% | Add +11.7% | 151,591 | $2.5M |
| SG Americas Securities, LLC | 0.00% | Add +291.6% | 149,592 | $2.5M |
| Legal & General Group Plc | 0.00% | Reduce -8.8% | 131,223 | $2.2M |
| California State Teachers Retirement System | 0.00% | Reduce -0.1% | 129,409 | $2.1M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -0.8% | 128,800 | $2.1M |
| Algert Global LLC | 0.03% | Add +25.4% | 127,030 | $2.1M |
| Alps Advisors Inc. | 0.01% | Add +71.9% | 120,718 | $2.0M |
| Woodline Partners LP | 0.01% | Add +0.5% | 114,082 | $1.9M |
| B. Metzler seel. Sohn & Co. AG | 0.02% | New | 112,300 | $1.8M |
| Nomura Asset Management International Inc. | 0.00% | — | 107,493 | $1.8M |
| D.A. Davidson & Co. | 0.01% | New | 106,933 | $1.8M |
| Deutsche Bank AG | 0.00% | Reduce -49.4% | 105,086 | $1.7M |
| Rhenman & Partners Asset Management AB | 0.15% | No change | 100,000 | $1.7M |
| Ghisallo Capital Management LLC | 0.07% | New | 100,000 | $1.7M |
| Integrated Wealth Concepts LLC | 0.02% | Add +3.9% | 94,582 | $1.6M |
| Y-Intercept (Hong Kong) Ltd | 0.03% | New | 93,587 | $1.5M |
| Monashee Investment Management LLC | 0.89% | New | 91,620 | $1.5M |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 59,800 | $1.4M |
| HRT Financial LP | 0.00% | New | 78,352 | $1.3M |
| MetLife Investment Management, LLC | 0.01% | Reduce -5.0% | 75,164 | $1.2M |
| State of Wisconsin Investment Board | 0.00% | Reduce -8.2% | 73,581 | $1.2M |
| Profund Advisors LLC | 0.04% | Add +78.4% | 71,634 | $1.2M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +170.1% | 70,830 | $1.2M |
| Ishara Investments LP | 1.34% | — | 70,000 | $1.2M |
| Pier 88 Investment Partners LLC | 1.28% | Add +1.1% | 68,200 | $1.1M |
| 1492 Capital Management LLC | 0.44% | New | 67,487 | $1.1M |
| Capricorn Fund Managers Ltd | 0.25% | New | 62,197 | $1.0M |
| Creative Planning | 0.00% | Add +10.8% | 60,766 | $1.0M |
| Franklin Resources Inc. | 0.00% | Reduce -6.8% | 60,270 | $995K |
| Janus Henderson Group PLC | 0.00% | No change | 60,028 | $991K |
| Wellington Management Group LLP | 0.00% | Reduce -7.9% | 54,543 | $901K |
| Tudor Investment Corporation | 0.01% | Reduce -4.8% | 53,683 | $886K |
| Intech Investment Management LLC | 0.01% | Add +12.5% | 52,632 | $869K |
| ADAR1 Capital Management, LLC | 0.06% | Add +1.2% | 52,116 | $860K |
| Clough Capital Partners L P | 0.08% | New | 51,830 | $856K |
| Pathstone Holdings, LLC | 0.00% | Add +12.2% | 51,424 | $849K |
| Ironwood Investment Management LLC | 0.35% | Reduce -3.5% | 50,933 | $841K |
| Dana Investment Advisors, Inc. | 0.02% | Reduce -0.3% | 50,582 | $835K |
| Knights of Columbus Asset Advisors LLC | 0.05% | Reduce -2.4% | 49,007 | $809K |
| Man Group plc | 0.00% | New | 48,994 | $809K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | No change | 47,459 | $784K |
| State of New Jersey Common Pension Fund D | 0.00% | Reduce -66.0% | 47,410 | $783K |
| Employees Retirement System of Texas | 0.01% | Add +7.8% | 47,177 | $779K |
| MAI Capital Management | 0.00% | No change | 46,526 | $768K |
| Headlands Technologies LLC | 0.06% | New | 46,383 | $766K |
| Handelsbanken Fonder AB | 0.00% | Add +14.4% | 43,800 | $723K |
| Jane Street Group, LLC | 0.00% | Reduce -80.9% | 42,922 | $709K |
| AlphaQuest LLC | 0.04% | Reduce -42.3% | 42,909 | $708K |
| Jump Financial, LLC | 0.01% | Reduce -75.6% | 40,608 | $670K |
| Savvy Advisors, Inc. | 0.02% | Reduce -49.4% | 39,030 | $644K |
| Capstone Investment Advisors, LLC | 0.01% | New | 38,812 | $641K |
| Envestnet Asset Management Inc. | 0.00% | Add +19.3% | 38,669 | $638K |
| Arizona State Retirement System | 0.00% | Reduce -5.3% | 38,645 | $638K |
| New York State Common Retirement Fund | 0.00% | No change | 38,478 | $635K |
| AQR Capital Management | 0.00% | Add +59.2% | 38,438 | $635K |
| Police & Firemen's Retirement System of New Jersey | 0.01% | Reduce -0.1% | 36,607 | $604K |
| Susquehanna International Group, LLP | 0.00% | Reduce -15.2% | 34,768 | $574K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 34,168 | $564K |
| Thrivent Financial for Lutherans | 0.00% | Reduce -8.6% | 32,555 | $538K |
| PSP Research LLC | 0.46% | — | 31,762 | $524K |
| Citigroup Inc. | 0.00% | Add +107.2% | 30,945 | $511K |
| ProShare Advisors LLC | 0.00% | Add +10.2% | 30,682 | $507K |
| KLP Kapitalforvaltning As | 0.00% | No change | 29,900 | $494K |
| Erste Asset Management GmbH | 0.00% | No change | 26,900 | $446K |
| Polen Capital Management LLC | 0.00% | New | 26,900 | $444K |
| Quantinno Capital Management LP | 0.00% | Add +6.5% | 26,313 | $434K |
| Raymond James Financial Inc. | 0.00% | Add +1.1% | 25,592 | $423K |
| China Universal Asset Management Co., Ltd. | 0.03% | Reduce -6.8% | 23,898 | $395K |
| Voya Investment Management LLC | 0.00% | No change | 23,805 | $393K |
| TT International Asset Management LTD | 0.07% | Reduce -58.5% | 27,000 | $353K |
| Teacher Retirement System of Texas | 0.00% | Reduce -39.3% | 20,540 | $339K |
| Bayforest Capital Ltd | 0.25% | New | 20,433 | $337K |
| Martingale Asset Management L P | 0.01% | New | 18,535 | $306K |
| Graham Capital Management, L.P. | 0.01% | Reduce -53.9% | 18,121 | $299K |
| SBI Okasan Asset Management Co.Ltd. | 0.02% | — | 18,000 | $298K |
| Breakwater Capital Group | 0.04% | Add +3.1% | 16,366 | $270K |
| BNP Paribas Financial Markets | 0.00% | Reduce -94.1% | 15,497 | $256K |
| Victory Capital Management Inc. | 0.00% | No change | 15,064 | $249K |
| Virtus Investment Advisers, LLC | 0.07% | Add +94.1% | 14,795 | $244K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -2.4% | 13,467 | $222K |
| CANADA LIFE ASSURANCE Co | 0.00% | No change | 13,434 | $222K |
| Tower Research Capital LLC (TRC) | 0.01% | Add +75.5% | 12,941 | $214K |
| WINTON GROUP Ltd | 0.01% | New | 12,700 | $210K |
| Walleye Capital LLC | 0.00% | New | 12,652 | $209K |
| Perbak Capital Partners LLP | 0.06% | New | 12,611 | $208K |
| Guggenheim Capital LLC | 0.00% | Reduce -74.8% | 12,468 | $206K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 12,238 | $202K |
| HighTower Advisors, LLC | 0.00% | Reduce -44.9% | 11,757 | $194K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Reduce -6.3% | 11,736 | $194K |
| Royal Bank of Canada | 0.00% | Reduce -97.0% | 11,335 | $187K |
| Empowered Funds, LLC | 0.00% | Add +2.6% | 11,325 | $187K |
| Intrust Bank NA | 0.02% | Add +5.6% | 11,164 | $184K |
| Ameritas Investment Partners, Inc. | 0.01% | No change | 11,065 | $183K |
| Renaissance Technologies | 0.00% | Reduce -82.1% | 10,700 | $177K |
| LPL Financial LLC | 0.00% | Reduce -1.4% | 10,504 | $173K |
| Xponance LLC | 0.00% | Add +0.9% | 10,497 | $173K |
| PNC Financial Services Group, Inc. | 0.00% | Add +2.3% | 8,481 | $140K |
| Sterling Capital Management LLC | 0.00% | Reduce -16.4% | 7,238 | $119K |
| Bellevue Group AG | 0.00% | New | 7,138 | $118K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +26.1% | 7,127 | $118K |
| Quarry LP | 0.02% | Add +60.0% | 7,000 | $116K |
| Lanark Financial, Inc. | 0.01% | Add +1128.6% | 6,536 | $108K |
| KBC Group NV | 0.00% | Add +39.4% | 6,268 | $103K |
| Persistent Asset Partners Ltd | 0.04% | New | 5,670 | $94K |
| Assetmark, Inc. | 0.00% | Add +31.8% | 5,187 | $86K |
| Eurizon Capital SGR S.p.A. | 0.00% | — | 5,045 | $83K |
| Amalgamated Bank | 0.00% | Reduce -3.3% | 4,161 | $69K |
| Aster Capital Management (DIFC) Ltd | 0.03% | New | 3,451 | $57K |
| Pinnacle Wealth Planning Services, Inc. | 0.01% | New | 2,957 | $49K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -8.4% | 2,881 | $48K |
| State of Wyoming | 0.00% | Add +24.7% | 2,686 | $44K |
| Cwm, LLC | 0.00% | Add +8.7% | 2,606 | $43K |
| Bartlett & Co. Wealth Management LLC | 0.00% | No change | 1,500 | $25K |
| Versant Capital Management, Inc | 0.00% | No change | 1,476 | $24K |
| Nisa Investment Advisors, LLC | 0.00% | Reduce -2.3% | 1,449 | $24K |
| Smartleaf Asset Management LLC | 0.00% | Add +37.6% | 1,313 | $22K |
| Comerica Bank | 0.00% | No change | 1,284 | $21K |
| Rockefeller Capital Management L.P. | 0.00% | Add +16.8% | 1,265 | $21K |
| SBI Securities Co., Ltd. | 0.00% | Add +5454.6% | 1,222 | $20K |
| Osaic Holdings, Inc. | 0.00% | Reduce -22.6% | 1,074 | $18K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | No change | 1,001 | $16K |
| GAMMA Investing LLC | 0.00% | Add +32.0% | 962 | $16K |
| US Bancorp \de | 0.00% | Add +19.8% | 834 | $14K |
| Quadrant Capital Group LLC | 0.00% | Reduce -3.1% | 758 | $13K |
| Nemes Rush Group LLC | 0.00% | No change | 700 | $12K |
| Los Angeles Capital Management LLC | 0.00% | New | 627 | $10K |
| Covestor Ltd | 0.01% | No change | 579 | $10K |
| Huntington National Bank | 0.00% | Add +59.4% | 491 | $8K |
| Daiwa Securities Group Inc. | 0.00% | No change | 475 | $8K |
| Optiver Holding B.V. | 0.00% | Reduce -54.4% | 409 | $7K |
| NewEdge Advisors, LLC | 0.00% | No change | 400 | $7K |
| Parallel Advisors, LLC | 0.00% | Reduce -17.5% | 358 | $6K |
| Private Wealth Management Group, LLC | 0.00% | No change | 296 | $5K |
| Eastern Bank | 0.00% | New | 282 | $5K |
| UMB Bank, n.a. | 0.00% | New | 262 | $4K |
| City State Bank | 0.00% | No change | 250 | $4K |
| Signaturefd, LLC | 0.00% | No change | 230 | $4K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +24.7% | 207 | $3K |
| Farther Finance Advisors, LLC | 0.00% | Add +59.1% | 202 | $3K |
| Comprehensive Financial Planning, Inc. | 0.00% | New | 200 | $3K |
| Arax Advisory Partners | 0.00% | New | 198 | $3K |
| Rothschild Investment LLC | 0.00% | Reduce -13.3% | 195 | $3K |
| Parkside Financial Bank & Trust | 0.00% | No change | 189 | $3K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | No change | 143 | $2K |
| ORG Partners LLC | 0.00% | New | 130 | $2K |
| Your Advocates Ltd., LLP | 0.00% | No change | 100 | $2K |
| Root Financial Partners, LLC | 0.00% | Add +42.9% | 100 | $2K |
| Allworth Financial LP | 0.00% | Reduce -9.1% | 90 | $1K |
| Johnson Financial Group, Inc. | 0.00% | Reduce -95.9% | 81 | $1K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 76 | $1K |
| TD Private Client Wealth LLC | 0.00% | No change | 71 | $1K |
| Hantz Financial Services, Inc. | 0.00% | New | 57 | $1K |
| True Wealth Design, LLC | 0.00% | No change | 56 | $925 |
| Blue Trust, Inc. | 0.00% | No change | 40 | $660 |
| Bell Investment Advisors, Inc | 0.00% | Reduce -35.6% | 38 | $628 |
| Larson Financial Group LLC | 0.00% | New | 38 | $627 |
| Manchester Capital Management LLC | 0.00% | New | 36 | $595 |
| Cornerstone Financial Management LLC | 0.00% | — | 34 | $561 |
| Westside Investment Management, Inc. | 0.00% | New | 33 | $545 |
| Basecamp Wealth Advisors LLC | 0.00% | — | 31 | $512 |
| SageView Advisory Group, LLC | 0.00% | New | 25 | $413 |
| Sunbelt Securities, Inc. | 0.00% | No change | 22 | $363 |
| Keating Financial Advisory Services, Inc. | 0.00% | — | 20 | $330 |
| Atlantic Private Wealth, LLC | 0.00% | New | 10 | $165 |
| HFM Investment Advisors, LLC | 0.00% | Add +350.0% | 9 | $149 |
| IFP Advisors, Inc | 0.00% | No change | 9 | $149 |
| JFS Wealth Advisors, LLC | 0.00% | New | 8 | $133 |
| Rialto Wealth Management, LLC | 0.00% | Add +300.0% | 8 | $133 |
| Private Wealth Asset Management, LLC | 0.00% | No change | 8 | $132 |
| Fortitude Family Office, LLC | 0.00% | Reduce -22.2% | 7 | $116 |
| SJS Investment Consulting Inc. | 0.00% | No change | 4 | $67 |
| Bay Harbor Wealth Management, LLC | 0.00% | Add +200.0% | 3 | $49 |
| Dunhill Financial, LLC | 0.00% | New | 2 | $35 |
| Global Retirement Partners, LLC | 0.00% | No change | 1 | $17 |
| Avion Wealth | 0.00% | No change | 40 | $0 |
"% of holder's portfolio" is DNLI's weight in each manager's 13F, not the share of Denali Therapeutics Inc. the manager owns.