Lexicon PharmaceuticalsLXRX
13F holders, Q4 2025 (December 31)125holders +2
21new positions
17sold out
5famous investors
$1.15avg. 13F price*
At the end of Q4 2025, 125 institutions reported holding Lexicon Pharmaceuticals Inc. (LXRX) in their 13F filings, up 2 from Q3 2025. 21 opened new positions and 17 sold out. The largest holders were Artal Group S.A. ($156.6M), Siren, L.L.C. ($44.8M) and FMR LLC ($43.5M). 5 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Lexicon Pharmaceuticals Inc.
- CUSIP
- 528872302
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 21 | $3.5M |
| Exits | 17 | $1.3M |
All 13F filers, Q3 2025 → Q4 2025: 10,782,625 shares bought and 6,256,228 shares sold, net +4,526,397 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 125 holders
| Artal Group S.A. | 21.91% | No change | 136,180,481 | $156.6M |
| Siren, L.L.C. | 1.34% | No change | 38,918,903 | $44.8M |
| FMR LLC | 0.00% | Reduce -2.2% | 37,834,207 | $43.5M |
| Vanguard Group Inc. | 0.00% | Add +0.9% | 9,606,549 | $11.0M |
| Millennium Management | 0.00% | Add +25.9% | 4,821,733 | $5.5M |
| BlackRock, Inc. | 0.00% | Reduce -6.0% | 3,192,448 | $3.7M |
| UBS Group AG | 0.00% | Add +752.1% | 3,007,237 | $3.5M |
| Sessa Capital IM, L.P. | 0.07% | No change | 3,000,000 | $3.5M |
| Geode Capital Management, LLC | 0.00% | Add +4.3% | 2,500,022 | $2.9M |
| CIBC Private Wealth Group LLC | 0.00% | Reduce -18.8% | 1,950,000 | $2.2M |
| Jane Street Group, LLC | 0.00% | Add +277.7% | 1,724,304 | $2.0M |
| Citadel Advisors | 0.00% | Reduce -35.0% | 1,710,975 | $2.0M |
| Marshall Wace, LLP | 0.00% | New | 1,262,367 | $1.5M |
| Susquehanna International Group, LLP | 0.00% | Add +25.5% | 1,207,242 | $1.4M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -7.8% | 1,055,123 | $1.2M |
| Gsa Capital Partners LLP | 0.10% | Reduce -17.2% | 996,235 | $1.1M |
| Goldman Sachs Group Inc. | 0.00% | Add +1452.2% | 921,204 | $1.1M |
| Hennion & Walsh Asset Management, Inc. | 0.04% | Add +15.7% | 901,222 | $1.0M |
| State Street Corp. | 0.00% | Add +0.5% | 884,738 | $1.0M |
| Ishara Investments LP | 1.18% | — | 880,000 | $1.0M |
| Two Sigma Investments, LP | 0.00% | Add +14.0% | 637,308 | $733K |
| Acadian Asset Management LLC | 0.00% | Add +1634.5% | 640,130 | $732K |
| Invesco Ltd. | 0.00% | Add +14.1% | 594,883 | $684K |
| Northern Trust Corp. | 0.00% | Add +11.5% | 412,164 | $474K |
| Compagnie Lombard Odier SCmA | 0.01% | No change | 410,000 | $472K |
| Point72 Asset Management | 0.00% | New | 284,025 | $327K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 273,800 | $315K |
| ExodusPoint Capital Management, LP | 0.00% | New | 268,433 | $309K |
| Renaissance Technologies | 0.00% | Reduce -10.0% | 263,254 | $303K |
| Group One Trading LLC | 0.01% | Add +3.7% | 224,308 | $258K |
| Barclays PLC | 0.00% | Add +511.2% | 194,743 | $224K |
| Morgan Stanley | 0.00% | Add +14.2% | 193,035 | $222K |
| Two Sigma Advisers, LP | 0.00% | New | 180,977 | $208K |
| Ikarian Capital, LLC | 0.02% | Reduce -6.7% | 164,674 | $189K |
| Cerity Partners LLC | 0.00% | Reduce -8.3% | 144,944 | $167K |
| AQR Capital Management | 0.00% | Reduce -52.2% | 144,800 | $167K |
| Headlands Technologies LLC | 0.01% | Add +174.2% | 136,113 | $157K |
| Lighthouse Investment Partners, LLC | 0.00% | New | 126,600 | $146K |
| HRT Financial LP | 0.00% | Add +153.1% | 117,549 | $135K |
| Monaco Asset Management SAM | 0.04% | Reduce -66.5% | 117,188 | $135K |
| Two Sigma Securities, LLC | 0.02% | Add +621.8% | 114,632 | $132K |
| Graham Capital Management, L.P. | 0.01% | New | 109,900 | $126K |
| Bank of America Corp. | 0.00% | Add +76.6% | 102,097 | $117K |
| Hudson Bay Capital Management LP | 0.00% | New | 100,532 | $116K |
| XTX Topco Ltd | 0.00% | Reduce -70.8% | 96,090 | $111K |
| Jefferies Financial Group Inc. | 0.00% | Reduce -5.0% | 92,530 | $106K |
| Citigroup Inc. | 0.00% | Add +405.9% | 91,670 | $105K |
| Quarry LP | 0.02% | New | 88,000 | $101K |
| LPL Financial LLC | 0.00% | Reduce -4.6% | 87,057 | $100K |
| Caxton Associates LLP | 0.00% | New | 71,027 | $82K |
| Bank of Montreal | 0.00% | No change | 70,000 | $81K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | No change | 66,567 | $77K |
| Straight Path Wealth Management | 0.02% | No change | 62,666 | $72K |
| State of Wyoming | 0.01% | Add +610.4% | 60,571 | $70K |
| Squarepoint Ops LLC | 0.00% | Add +3.1% | 60,472 | $70K |
| Optiver Holding B.V. | 0.00% | Reduce -30.7% | 52,595 | $60K |
| Fortis Group Advisors, LLC | 0.01% | Reduce -13.5% | 50,000 | $58K |
| R Squared Ltd | 0.03% | Add +45.3% | 46,579 | $54K |
| Boothbay Fund Management, LLC | 0.00% | Reduce -21.0% | 44,315 | $51K |
| Wedbush Securities Inc. | 0.00% | No change | 40,850 | $47K |
| KWB Wealth | 0.00% | No change | 40,640 | $47K |
| Catalyst Funds Management Pty Ltd | 0.01% | No change | 40,300 | $46K |
| CIBC Asset Management Inc | 0.00% | New | 39,520 | $45K |
| Virtu Financial LLC | 0.00% | New | 36,468 | $42K |
| University of Texas/Texas Am Investment Management Co. | 0.01% | No change | 35,714 | $41K |
| Prudential Financial Inc. | 0.00% | Reduce -3.4% | 33,800 | $39K |
| EntryPoint Capital, LLC | 0.02% | New | 33,618 | $39K |
| Vermillion & White Wealth Management Group, LLC | 0.02% | Reduce -1.5% | 32,000 | $37K |
| Leonteq Securities AG | 0.00% | New | 30,000 | $35K |
| Pathstone Holdings, LLC | 0.00% | Reduce -0.8% | 29,969 | $34K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +22.9% | 29,093 | $33K |
| Pinnacle Associates Ltd. | 0.00% | Reduce -42.9% | 29,015 | $33K |
| Security National Bank of Sioux City Iowa | 0.02% | New | 26,650 | $31K |
| Oppenheimer & Co. Inc. | 0.00% | No change | 23,500 | $27K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Reduce -8.1% | 21,505 | $25K |
| Victory Capital Management Inc. | 0.00% | Add +0.8% | 21,191 | $24K |
| Invera Wealth Advisors, LLC | 0.01% | No change | 20,000 | $23K |
| Tiaa Trust, National Association | 0.00% | No change | 20,000 | $23K |
| Bank of New York Mellon Corp | 0.00% | No change | 19,124 | $22K |
| Credit Agricole S A | 0.00% | New | 18,975 | $22K |
| Quadrature Capital Ltd | 0.00% | Reduce -91.9% | 18,414 | $21K |
| StoneX Group Inc. | 0.00% | New | 16,234 | $19K |
| Simplex Trading, LLC | 0.00% | Reduce -79.9% | 14,758 | $17K |
| Cetera Investment Advisers | 0.00% | Reduce -19.0% | 14,188 | $16K |
| Callan Family Office, LLC | 0.00% | New | 14,090 | $16K |
| Lazard Asset Management LLC | 0.00% | New | 14,090 | $16K |
| Truist Financial Corp. | 0.00% | No change | 14,000 | $16K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -28.4% | 13,520 | $15K |
| Schonfeld Strategic Advisors LLC | 0.00% | Reduce -98.4% | 13,108 | $15K |
| Cwm, LLC | 0.00% | Reduce -50.7% | 13,179 | $15K |
| HBK Sorce Advisory LLC | 0.00% | No change | 11,786 | $14K |
| Chemistry Wealth Management LLC | 0.00% | No change | 12,000 | $14K |
| Captrust Financial Advisors | 0.00% | Reduce -16.6% | 11,735 | $13K |
| FWG Holdings, LLC | 0.01% | New | 11,350 | $13K |
| Perennial Investment Advisors, LLC | 0.00% | No change | 10,990 | $13K |
| NBT Bank, N.A. | 0.00% | No change | 10,000 | $12K |
| Berger Financial Group, Inc | 0.00% | Reduce -8.5% | 10,000 | $12K |
| Royal Bank of Canada | 0.00% | Reduce -99.1% | 6,768 | $7K |
| Golden State Wealth Management, LLC | 0.00% | No change | 3,700 | $4K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -79.9% | 3,018 | $3K |
| Farther Finance Advisors, LLC | 0.00% | Add +119.5% | 2,755 | $3K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 2,592 | $3K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 1,461 | $2K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 1,412 | $2K |
| Rialto Wealth Management, LLC | 0.00% | No change | 1,313 | $2K |
| Jones Financial Companies LLLP | 0.00% | Add +24.0% | 1,106 | $1K |
| Global Retirement Partners, LLC | 0.00% | No change | 1,000 | $1K |
| Avion Wealth | 0.00% | No change | 1,333 | $1K |
| Fortitude Family Office, LLC | 0.00% | No change | 706 | $812 |
| Basecamp Wealth Advisors LLC | 0.00% | — | 691 | $795 |
| Osaic Holdings, Inc. | 0.00% | Reduce -13.5% | 642 | $738 |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -2.7% | 500 | $575 |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -95.4% | 500 | $575 |
| Rockefeller Capital Management L.P. | 0.00% | No change | 335 | $385 |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -65.3% | 158 | $182 |
| Caitong International Asset Management Co., Ltd | 0.00% | Reduce -84.7% | 147 | $169 |
| Syntax Research, Inc. | 0.00% | No change | 142 | $164 |
| Comerica Bank | 0.00% | No change | 122 | $140 |
| Larson Financial Group LLC | 0.00% | No change | 100 | $115 |
| True Wealth Design, LLC | 0.00% | Reduce -42.4% | 49 | $57 |
| Arax Advisory Partners | 0.00% | Reduce -99.2% | 41 | $47 |
| BNP Paribas Financial Markets | 0.00% | Reduce -99.8% | 11 | $13 |
| Wells Fargo & Company | 0.00% | Reduce -99.7% | 1 | $1 |
| Covestor Ltd | 0.00% | No change | 81 | $0 |
| Motiv8 Investments LLC | 0.00% | New | 200 | $0 |
"% of holder's portfolio" is LXRX's weight in each manager's 13F, not the share of Lexicon Pharmaceuticals Inc. the manager owns.