Orchestra Biomed HoldingsOBIO
13F holders, Q3 2025 (September 30)At the end of Q3 2025, 52 institutions reported holding Orchestra Biomed Holdings Inc. (OBIO) in their 13F filings, down 7 from Q2 2025. 10 opened new positions and 17 sold out. The largest holders were RTW Investments, LP ($20.6M), Perceptive Advisors LLC ($13.1M) and Vanguard Group Inc. ($3.7M). 4 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Orchestra Biomed Holdings Inc.
- CUSIP
- 68572M106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 10 | $9.1M |
| Exits | 17 | $659K |
All 13F filers, Q2 2025 → Q3 2025: 5,289,768 shares bought and 534,637 shares sold, net +4,755,131 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 52 holders
| RTW Investments, LP | 0.25% | Add +0.0% | 8,306,063 | $20.6M |
| Perceptive Advisors LLC | 0.38% | Add +15.2% | 5,292,556 | $13.1M |
| Vanguard Group Inc. | 0.00% | Add +28.0% | 1,481,875 | $3.7M |
| Alyeska Investment Group, L.P. | 0.01% | New | 1,365,482 | $3.4M |
| Pathstone Holdings, LLC | 0.01% | New | 1,006,018 | $2.5M |
| Affinity Asset Advisors, LLC | 0.17% | New | 727,272 | $1.8M |
| BlackRock, Inc. | 0.00% | Reduce -2.5% | 664,333 | $1.6M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -3.8% | 421,612 | $1.0M |
| Geode Capital Management, LLC | 0.00% | Add +28.0% | 386,799 | $960K |
| Renaissance Technologies | 0.00% | Add +124.6% | 380,508 | $944K |
| Millennium Management | 0.00% | Reduce -8.7% | 373,987 | $927K |
| DAFNA Capital Management LLC | 0.23% | New | 363,636 | $902K |
| Knott David M Jr | 0.20% | Add +95.0% | 195,000 | $484K |
| Charles Schwab Investment Management Inc. | 0.00% | Add +30.2% | 180,439 | $447K |
| Knoll Capital Management, LLC | 0.23% | No change | 455,128 | $421K |
| AMH Equity Ltd | 0.52% | New | 166,000 | $412K |
| Northern Trust Corp. | 0.00% | Add +2.1% | 102,572 | $254K |
| State Street Corp. | 0.00% | Reduce -22.6% | 100,733 | $250K |
| Susquehanna International Group, LLP | 0.00% | Reduce -17.3% | 98,105 | $243K |
| TD Asset Management Inc | 0.00% | No change | 92,678 | $230K |
| IFP Advisors, Inc | 0.01% | Add +1.6% | 86,698 | $215K |
| Cubist Systematic Strategies, LLC | 0.00% | Add +339.7% | 77,892 | $193K |
| Holos Integrated Wealth LLC | 0.10% | No change | 51,595 | $163K |
| Jane Street Group, LLC | 0.00% | Add +253.9% | 65,524 | $162K |
| Lasry Marc | 1.00% | No change | 60,869 | $151K |
| Citadel Advisors | 0.00% | Add +9.2% | 54,002 | $134K |
| NewEdge Advisors, LLC | 0.00% | No change | 44,083 | $109K |
| XTX Topco Ltd | 0.00% | Add +107.0% | 34,818 | $86K |
| Manufacturers Life Insurance Company, The | 0.00% | No change | 32,518 | $81K |
| Bank of America Corp. | 0.00% | Add +44.2% | 31,119 | $77K |
| Qube Research & Technologies Ltd | 0.00% | New | 25,934 | $64K |
| Bridgeway Capital Management, LLC | 0.00% | No change | 25,000 | $62K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -75.6% | 23,630 | $59K |
| HighTower Advisors, LLC | 0.00% | Reduce -72.5% | 18,275 | $45K |
| AQR Capital Management | 0.00% | New | 17,112 | $42K |
| Creative Planning | 0.00% | Add +14.0% | 17,101 | $42K |
| Quadrature Capital Ltd | 0.00% | New | 15,577 | $38K |
| ABLE Financial Group, LLC | 0.01% | No change | 13,402 | $33K |
| Morgan Stanley | 0.00% | Reduce -22.9% | 10,323 | $26K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.00% | Reduce -50.0% | 9,346 | $23K |
| Royal Bank of Canada | 0.00% | Reduce -18.7% | 6,363 | $16K |
| UBS Group AG | 0.00% | Reduce -85.4% | 3,815 | $9K |
| Harbour Investments, Inc. | 0.00% | No change | 1,988 | $5K |
| BNP Paribas Financial Markets | 0.00% | Reduce -76.5% | 564 | $1K |
| JPMorgan Chase & Co. | 0.00% | No change | 470 | $1K |
| Optiver Holding B.V. | 0.00% | New | 312 | $774 |
| Point72 (DIFC) Ltd | 0.00% | Reduce -23.2% | 272 | $675 |
| Citigroup Inc. | 0.00% | Reduce -99.5% | 41 | $102 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -99.1% | 6 | $15 |
| Barclays PLC | 0.00% | Reduce -99.9% | 1 | $2 |
| Simplex Trading, LLC | 0.00% | New | 324 | $0 |
| Cwm, LLC | 0.00% | Reduce -99.5% | 2 | $0 |
"% of holder's portfolio" is OBIO's weight in each manager's 13F, not the share of Orchestra Biomed Holdings Inc. the manager owns.