Orchestra Biomed HoldingsOBIO
13F holders, Q4 2025 (December 31)63holders +11
19new positions
5sold out
5famous investors
$4.15avg. 13F price*
At the end of Q4 2025, 63 institutions reported holding Orchestra Biomed Holdings Inc. (OBIO) in their 13F filings, up 11 from Q3 2025. 19 opened new positions and 5 sold out. The largest holders were RTW Investments, LP ($34.5M), Perceptive Advisors LLC ($21.3M) and Vanguard Group Inc. ($6.7M). 5 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Orchestra Biomed Holdings Inc.
- CUSIP
- 68572M106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 19 | $4.2M |
| Exits | 5 | $3.0M |
All 13F filers, Q3 2025 → Q4 2025: 2,016,094 shares bought and 2,941,225 shares sold, net −925,131 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 63 holders
| RTW Investments, LP | 0.35% | No change | 8,306,063 | $34.5M |
| Perceptive Advisors LLC | 0.39% | Reduce -3.1% | 5,127,256 | $21.3M |
| Vanguard Group Inc. | 0.00% | Add +8.3% | 1,604,556 | $6.7M |
| Alyeska Investment Group, L.P. | 0.01% | Reduce -26.8% | 1,000,000 | $4.2M |
| BlackRock, Inc. | 0.00% | Reduce -5.0% | 630,901 | $2.6M |
| Affinity Asset Advisors, LLC | 0.18% | Reduce -21.2% | 572,804 | $2.4M |
| Geode Capital Management, LLC | 0.00% | Add +22.4% | 473,363 | $2.0M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -13.5% | 364,645 | $1.5M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +46.2% | 263,788 | $1.1M |
| Knott David M Jr | 0.48% | Add +28.2% | 250,000 | $1.0M |
| Millennium Management | 0.00% | Reduce -34.9% | 243,473 | $1.0M |
| 683 Capital Management, LLC | 0.07% | New | 204,076 | $847K |
| Jane Street Group, LLC | 0.00% | Add +165.2% | 173,765 | $721K |
| Marshall Wace, LLP | 0.00% | New | 171,681 | $712K |
| Point72 Asset Management | 0.00% | New | 161,946 | $672K |
| State Street Corp. | 0.00% | Add +57.9% | 159,033 | $660K |
| Susquehanna International Group, LLP | 0.00% | Add +58.1% | 155,130 | $644K |
| Renaissance Technologies | 0.00% | Reduce -60.2% | 151,300 | $628K |
| Goldman Sachs Group Inc. | 0.00% | Add +467.4% | 134,073 | $556K |
| DAFNA Capital Management LLC | 0.12% | Reduce -65.1% | 126,841 | $526K |
| Northern Trust Corp. | 0.00% | Add +8.1% | 110,899 | $460K |
| Qube Research & Technologies Ltd | 0.00% | Add +311.6% | 106,742 | $443K |
| ExodusPoint Capital Management, LP | 0.00% | New | 95,635 | $397K |
| Barclays PLC | 0.00% | Add +9451600.0% | 94,517 | $392K |
| IFP Advisors, Inc | 0.01% | No change | 86,698 | $360K |
| Two Sigma Investments, LP | 0.00% | New | 86,552 | $359K |
| Morgan Stanley | 0.00% | Add +692.9% | 81,851 | $340K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 67,100 | $278K |
| Holos Integrated Wealth LLC | 0.12% | No change | 51,595 | $222K |
| XTX Topco Ltd | 0.01% | Add +44.6% | 50,358 | $209K |
| Hudson Bay Capital Management LP | 0.00% | New | 49,425 | $205K |
| TD Asset Management Inc | 0.00% | Reduce -50.7% | 45,692 | $190K |
| Squarepoint Ops LLC | 0.00% | New | 44,343 | $184K |
| NewEdge Advisors, LLC | 0.00% | No change | 44,083 | $183K |
| Manufacturers Life Insurance Company, The | 0.00% | No change | 32,518 | $135K |
| Citadel Advisors | 0.00% | Reduce -44.1% | 30,175 | $125K |
| Meramec Financial Planners, LLC | 0.05% | — | 30,000 | $117K |
| Two Sigma Advisers, LP | 0.00% | New | 27,100 | $112K |
| Bridgeway Capital Management, LLC | 0.00% | No change | 25,000 | $104K |
| Lighthouse Investment Partners, LLC | 0.00% | New | 24,900 | $103K |
| Daytona Street Capital LLC | 0.07% | — | 21,500 | $89K |
| Cresset Asset Management, LLC | 0.00% | New | 20,000 | $83K |
| Citigroup Inc. | 0.00% | Add +47358.5% | 19,458 | $81K |
| HighTower Advisors, LLC | 0.00% | No change | 18,275 | $76K |
| Balyasny Asset Management L.P. | 0.00% | New | 18,268 | $76K |
| Bank of America Corp. | 0.00% | Reduce -43.6% | 17,547 | $73K |
| BNP Paribas Financial Markets | 0.00% | Add +2915.4% | 17,007 | $71K |
| AQR Capital Management | 0.00% | Reduce -4.8% | 16,290 | $68K |
| Creative Planning | 0.00% | Reduce -4.7% | 16,290 | $68K |
| Virtu Financial LLC | 0.00% | New | 13,623 | $57K |
| ABLE Financial Group, LLC | 0.01% | No change | 13,402 | $56K |
| UBS Group AG | 0.00% | Add +198.5% | 11,389 | $47K |
| Gsa Capital Partners LLP | 0.00% | New | 10,773 | $45K |
| China Universal Asset Management Co., Ltd. | 0.00% | New | 9,201 | $38K |
| Canada Pension Plan Investment Board | 0.00% | New | 7,100 | $29K |
| JPMorgan Chase & Co. | 0.00% | Add +875.7% | 4,586 | $19K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | New | 2,744 | $11K |
| Harbour Investments, Inc. | 0.00% | No change | 1,988 | $8K |
| GF Fund Management Co. LTD. | 0.00% | New | 1,109 | $5K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 646 | $3K |
| Optiver Holding B.V. | 0.00% | No change | 312 | $1K |
| Royal Bank of Canada | 0.00% | Reduce -94.2% | 371 | $1K |
| SBI Securities Co., Ltd. | 0.00% | No change | 6 | $25 |
"% of holder's portfolio" is OBIO's weight in each manager's 13F, not the share of Orchestra Biomed Holdings Inc. the manager owns.