Orchestra Biomed HoldingsOBIO
13F holders, Q1 2026 (March 31)65holders +2
16new positions
15sold out
4famous investors
$4.25avg. 13F price*
At the end of Q1 2026, 65 institutions reported holding Orchestra Biomed Holdings Inc. (OBIO) in their 13F filings, up 2 from Q4 2025. 16 opened new positions and 15 sold out. The largest holders were RTW Investments, LP ($35.3M), Perceptive Advisors LLC ($21.4M) and Vanguard Capital Management LLC ($9.4M). 4 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Steve Cohen (0.0% of Point72 Asset Management's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Orchestra Biomed Holdings Inc.
- CUSIP
- 68572M106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 16 | $5.7M |
| Exits | 15 | $3.1M |
All 13F filers, Q4 2025 → Q1 2026: 2,110,236 shares bought and 1,539,177 shares sold, net +571,059 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 65 holders
| RTW Investments, LP | 0.35% | No change | 8,306,063 | $35.3M |
| Perceptive Advisors LLC | 0.42% | Reduce -1.7% | 5,037,906 | $21.4M |
| Vanguard Capital Management LLC | 0.00% | — | 2,204,319 | $9.4M |
| Alyeska Investment Group, L.P. | 0.01% | No change | 1,000,000 | $4.3M |
| Propel Bio Management, LLC | 2.41% | New | 896,701 | $3.8M |
| Millennium Management | 0.00% | Add +188.6% | 702,543 | $3.0M |
| BlackRock, Inc. | 0.00% | Add +0.8% | 635,714 | $2.7M |
| Geode Capital Management, LLC | 0.00% | Add +2.6% | 485,492 | $2.1M |
| Affinity Asset Advisors, LLC | 0.10% | Reduce -29.7% | 402,550 | $1.7M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +0.7% | 265,499 | $1.1M |
| Knott David M Jr | 0.64% | Add +1.5% | 253,651 | $1.1M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 235,214 | $1000K |
| Simplify Asset Management Inc. | 0.01% | New | 219,387 | $932K |
| Marshall Wace, LLP | 0.00% | Add +9.8% | 188,484 | $801K |
| 683 Capital Management, LLC | 0.08% | Reduce -9.3% | 185,000 | $786K |
| State Street Corp. | 0.00% | Add +6.5% | 169,410 | $720K |
| Goldman Sachs Group Inc. | 0.00% | Add +15.8% | 155,242 | $660K |
| DAFNA Capital Management LLC | 0.12% | No change | 126,841 | $539K |
| Northern Trust Corp. | 0.00% | Add +6.7% | 118,274 | $503K |
| Qube Research & Technologies Ltd | 0.00% | Add +2.1% | 108,953 | $463K |
| IFP Advisors, Inc | 0.01% | Add +14.1% | 98,887 | $420K |
| Susquehanna International Group, LLP | 0.00% | Reduce -37.1% | 97,521 | $414K |
| Point72 Asset Management | 0.00% | Reduce -45.7% | 87,888 | $374K |
| Citadel Advisors | 0.00% | Add +162.4% | 79,185 | $337K |
| Hudson Bay Capital Management LP | 0.00% | Add +43.9% | 71,134 | $302K |
| Renaissance Technologies | 0.00% | Reduce -53.1% | 70,900 | $301K |
| Bridgeway Capital Management, LLC | 0.01% | Add +182.4% | 70,600 | $300K |
| Two Sigma Investments, LP | 0.00% | Reduce -30.6% | 60,107 | $255K |
| Barclays PLC | 0.00% | Reduce -37.2% | 59,342 | $252K |
| Jane Street Group, LLC | 0.00% | Reduce -68.0% | 55,680 | $237K |
| Daytona Street Capital LLC | 0.18% | Add +144.7% | 52,600 | $235K |
| Bank of America Corp. | 0.00% | Add +200.7% | 52,761 | $224K |
| Holos Integrated Wealth LLC | 0.11% | No change | 51,595 | $220K |
| UBS Group AG | 0.00% | Add +341.7% | 50,310 | $214K |
| NewEdge Advisors, LLC | 0.00% | No change | 44,083 | $187K |
| Brevan Howard Capital Management LP | 0.00% | New | 36,769 | $156K |
| Morgan Stanley | 0.00% | Reduce -56.5% | 35,639 | $151K |
| Meramec Financial Planners, LLC | 0.05% | No change | 30,000 | $131K |
| Catalyst Funds Management Pty Ltd | 0.02% | New | 27,644 | $117K |
| Citigroup Inc. | 0.00% | Add +31.2% | 25,529 | $108K |
| Cannon Global Investment Management, LLC | 0.23% | New | 22,607 | $96K |
| Rice Hall James & Associates, LLC | 0.00% | New | 19,001 | $81K |
| Diametric Capital, LP | 0.02% | New | 18,919 | $80K |
| HighTower Advisors, LLC | 0.00% | No change | 18,275 | $78K |
| FMR LLC | 0.00% | New | 18,076 | $77K |
| OMERS ADMINISTRATION Corp | 0.00% | Reduce -75.9% | 16,200 | $69K |
| Algert Global LLC | 0.00% | New | 14,656 | $62K |
| Vanguard Global Advisers, LLC | 0.00% | — | 13,948 | $59K |
| ABLE Financial Group, LLC | 0.01% | No change | 13,402 | $57K |
| Frec Markets, Inc. | 0.01% | New | 13,048 | $55K |
| Prelude Capital Management, LLC | 0.00% | New | 12,389 | $53K |
| Canada Pension Plan Investment Board | 0.00% | Add +59.1% | 11,300 | $48K |
| Schonfeld Strategic Advisors LLC | 0.00% | New | 10,953 | $47K |
| Garden State Investment Advisory Services LLC | 0.01% | New | 10,562 | $45K |
| China Universal Asset Management Co., Ltd. | 0.00% | Add +8.9% | 10,020 | $43K |
| JPMorgan Chase & Co. | 0.00% | Reduce -7.2% | 4,258 | $17K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +7.3% | 2,945 | $13K |
| Simplex Trading, LLC | 0.00% | New | 2,381 | $10K |
| AdvisorNet Financial, Inc | 0.00% | New | 1,696 | $7K |
| BNP Paribas Financial Markets | 0.00% | Reduce -91.4% | 1,456 | $6K |
| GF Fund Management Co. LTD. | 0.00% | Add +13.6% | 1,260 | $5K |
| Royal Bank of Canada | 0.00% | Add +152.3% | 936 | $4K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -15.3% | 547 | $2K |
| Jones Financial Companies LLLP | 0.00% | New | 388 | $2K |
| SBI Securities Co., Ltd. | 0.00% | No change | 6 | $26 |
"% of holder's portfolio" is OBIO's weight in each manager's 13F, not the share of Orchestra Biomed Holdings Inc. the manager owns.