Knott David M Jr

In its 13F for Q2 2026 (holdings as of June 30, 2026, filed August 12, 2026), Knott David M Jr reported 83 stock positions worth $189.2 million. Its top holding was Alphabet Class C (GOOG) at 17.1% of the portfolio, followed by Apollo Global Management (APO, 14.1%) and Syndax Pharmaceuticals (SNDX, 5.1%). Compared with Q1 2026, it opened 10 new positions, sold out of 12, added to 16 and reduced 4. The biggest buy was Travere Therapeutics (TVTX, shares +5%) and the biggest sale an exit from Catalyst Pharmaceuticals (CPRX).

Most Recent 13F
Q2 2026
Location
SYOSSET, NY
CIK
0001892770
Portfolio Value
$189.2M (Q2 2026)
SEC Filing
0001104659-26-094536 ↗ filed Aug 12, 2026

Holdings Value

0$100.0M$200.0M$300.0M Q1 2024: $282.8M Q1 2024 Q2 2024: $250.6M Q2 2024 Q3 2024: $284.6M Q3 2024 Q4 2024: $276.5M Q4 2024 Q1 2025: $212.0M Q1 2025 Q2 2025: $220.6M Q2 2025 Q3 2025: $238.7M Q3 2025 Q4 2025: $215.9M Q4 2025 Q1 2026: $168.0M Q1 2026 Q2 2026: $189.2M $189.2M Q2 2026

Holdings 83 stocks · $189.2M
GOOG Alphabet Inc. Class C 17.07% 91,420 $32.3M No change
APO Apollo Global Management Inc. 14.07% 225,000 $26.6M No change
SNDX Syndax Pharmaceuticals Inc. 5.05% 437,245 $9.6M Add +3.6%
XERS Xeris Biopharma Holdings Inc. 4.44% 1,060,000 $8.4M No change
TVTX Travere Therapeutics Inc. 4.42% 147,282 $8.4M Add +4.7%
PTGX Protagonist Therapeutics Inc. 4.08% 63,000 $7.7M No change
BBIO Bridgebio Pharma Inc. 3.66% 92,850 $6.9M Add +3.2%
IOVA Iovance Biotherapeutics Inc. 3.52% 1,600,000 $6.7M No change
ALKS Alkermes PLC 3.37% 121,759 $6.4M Add +1.5%
JPM JPMorgan Chase & Co. 3.13% 18,098 $5.9M Reduce -7.1%
JAAA Janus Henderson Aaa Clo ETF 2.50% 93,528 $4.7M No change
LPL Financial Holdings Inc. 2.46% 16,500 $4.6M No change
COGT Cogent Biosciences Inc. 2.27% 111,081 $4.3M Add +6.8%
TGTX TG Therapeutics Inc. 1.94% 66,839 $3.7M Reduce -25.7%
CLST Catalyst Bancorp Inc. 1.89% 114,000 $3.6M New
AGIO Agios Pharmaceuticals Inc. 1.86% 95,058 $3.5M Add +2.1%
VRDN Viridian Therapeutics Inc. 1.76% 181,000 $3.3M No change
RLMD Relmada Therapeutics Inc. 1.65% 451,000 $3.1M Add +2.7%
RCUS Arcus Biosciences Inc. 1.32% 81,241 $2.5M No change
HELP Cybin Inc. 1.29% 370,000 $2.4M Add +5.7%
XBI SS SPDR S&P Biotech ETF 1.25% 15,000 $2.4M No change
RZLT Rezolute Inc. 1.02% 370,000 $1.9M No change
AB Alliancebernstein Holding LP 0.89% 48,000 $1.7M No change
MDGL Madrigal Pharmaceuticals Inc. 0.85% 3,000 $1.6M Add +50.0%
ATRC Atricure Inc. 0.76% 51,400 $1.4M No change
DCGO Docgo Inc. 0.73% 2,670,850 $1.4M No change
ARDX Ardelyx Inc. 0.71% 263,168 $1.3M Add +27.1%
RARE Ultragenyx Pharmaceutical Inc. 0.67% 38,069 $1.3M Add +15.1%
CLOZ Eldridge BBB-B Clo ETF 0.67% 47,807 $1.3M No change
CGEM Cullinan Therapeutics Inc. 0.67% 69,182 $1.3M Add +185.9%
JNJ Johnson & Johnson 0.66% 4,922 $1.3M No change
VERA Vera Therapeutics Inc. 0.59% 26,000 $1.1M No change
OBIO Orchestra Biomed Holdings Inc. 0.58% 253,651 $1.1M No change
SPRB Spruce Biosciences Inc. 0.57% 20,000 $1.1M New
CNTB Connect Biopharma Holdings L 0.56% 444,862 $1.1M Add +14.7%
IBB iShares Biotechnology ETF 0.55% 5,500 $1.0M No change
BIIB Biogen Inc. 0.46% 4,000 $864K No change
PFE Pfizer Inc. 0.41% 32,337 $779K No change
AAPL Apple Inc. 0.38% 2,494 $722K No change
CNQ Canadian Natural Resources 0.35% 16,800 $664K No change
PTHS Pelthos Therapeutics Inc. 0.33% 22,073 $624K Add +4.8%
IBM Intl Business Machines Corp. filed as INTERNATIONAL BUSINESS MACHS 0.32% 2,142 $602K No change
MSFT Microsoft Corp. 0.32% 1,600 $597K No change
VSTM Verastem Inc. 0.31% 155,000 $592K Add +49.0%
KURA Kura Oncology Inc. 0.31% 52,767 $579K No change
SLDB Solid Biosciences Inc. 0.30% 56,208 $562K Add +19.2%
DuPont de Nemours, Inc. 0.27% 3,767 $511K New
INSM Insmed Inc. 0.24% 4,253 $453K New
LBRX LB Pharmaceuticals Inc. 0.22% 12,965 $421K New
CDNA Caredx Inc. 0.21% 13,630 $388K New
QTTB Q32 Bio Inc. 0.20% 30,412 $387K New
ELVN Enliven Therapeutics Inc. 0.17% 6,183 $314K New
RHP Ryman Hospitality Properties 0.16% 2,400 $309K No change
AVGO Broadcom Inc. 0.14% 710 $268K No change
KMB Kimberly-Clark Corp. 0.14% 2,400 $263K No change
NVDA Nvidia Corp. 0.14% 1,280 $256K No change
BSX Boston Scientific Corp. 0.14% 6,000 $256K New
WVE Wave Life Sciences Ltd. 0.12% 40,000 $232K No change
RAIN Rain Enhancement Techno Class A 0.11% 101,686 $210K No change
MDLZ Mondelez International Inc. Class A 0.09% 3,000 $174K No change
PWR Quanta Services Inc. 0.07% 176 $127K No change
BMY Bristol-Myers Squibb Co. 0.06% 2,000 $115K Reduce -85.3%
EBC Eastern Bankshares Inc. 0.06% 5,000 $111K No change
GOOGL Alphabet Inc. Class A 0.06% 300 $107K No change
LEGH Legacy Housing Corp. 0.06% 4,000 $105K No change
CTVA Corteva Inc. 0.05% 1,206 $102K No change
IWP iShares Russell Mid-Cap Grow 0.05% 695 $102K No change
URI United Rentals Inc. 0.05% 78 $88K No change
IVVD Invivyd Inc. 0.05% 100,000 $87K No change
AMZN Amazon.com Inc. 0.04% 300 $72K No change
DHR Danaher Corp. 0.02% 180 $34K No change
DOW Dow Inc. filed as DOW HLDGS INC 0.02% 1,206 $33K No change
FSK FS KKR Capital Corp. 0.02% 2,875 $30K New
BRSL Brightstar Lottery PLC 0.01% 2,500 $27K No change
BX Blackstone Inc. 0.01% 210 $25K No change
UNH Unitedhealth Group Inc. 0.01% 57 $24K No change
OXY Occidental Petroleum Corp. 0.01% 469 $23K Reduce -29.3%
TMO Thermo Fisher Scientific Inc. 0.01% 45 $23K No change
CRM Salesforce Inc. 0.01% 77 $12K No change
STWD Starwood Property Trust Inc. 0.00% 400 $7K No change
KD Kyndryl Holdings Inc. 0.00% 428 $5K No change
GEHC GE Healthcare Technology 0.00% 50 $3K No change
WAB Wabtec Corp. 0.00% 6 $2K No change
Other holdings (1): bonds, preferreds, convertibles and warrants · $4K (not counted above)
SecurityClassShares / PrincipalValueChange
OXY.WS Occidental Petroleum-CW27 *W EXP 08/03/202 194$4KNew

Total filed on the 13F, all lines: $189.2M.

Portfolio Sells Q1 2026 → Q2 2026
CPRX Catalyst Pharmaceuticals Inc. Sold out 0.00% −1.77
ACLX Arcellx Inc. Sold out 0.00% −1.33
CYTK Cytokinetics Inc. Sold out 0.00% −0.93
CNTA Centessa Pharmaceuticals Ltd. Sold out 0.00% −0.92
BMY Bristol-Myers Squibb Co. Reduce -85.3% 0.06% −0.43
ADMA Adma Biologics Inc. Sold out 0.00% −0.32
Biohaven Pharmaceutical Holding Co. Ltd Sold out 0.00% −0.31
JPM JPMorgan Chase & Co. Reduce -7.1% 3.13% −0.28
EOLS Evolus Inc. Sold out 0.00% −0.24
LENZ Lenz Therapeutics Inc. Sold out 0.00% −0.18
DD Dupont DE Nemours Inc. Sold out 0.00% −0.10
JSPR Jasper Therapeutics Inc. Sold out 0.00% −0.08
MREO Mereo Biopharma Group PL-ADR Sold out 0.00% −0.06
FSK FS KKR Capital Corp. Sold out 0.00% −0.02
OXY Occidental Petroleum Corp. Reduce -29.3% 0.01% −0.01
TGTX TG Therapeutics Inc. Reduce -25.7% 1.94% +0.16

Portfolio Buys Q1 2026 → Q2 2026
TVTX Travere Therapeutics Inc. Add +4.7% 4.42% +1.94
CLST Catalyst Bancorp Inc. New 1.89% +1.89
ALKS Alkermes PLC Add +1.5% 3.37% +0.85
SPRB Spruce Biosciences Inc. New 0.57% +0.57
CGEM Cullinan Therapeutics Inc. Add +185.9% 0.67% +0.46
HELP Cybin Inc. Add +5.7% 1.29% +0.29
DuPont de Nemours, Inc. New 0.27% +0.27
RARE Ultragenyx Pharmaceutical Inc. Add +15.1% 0.67% +0.26
INSM Insmed Inc. New 0.24% +0.24
MDGL Madrigal Pharmaceuticals Inc. Add +50.0% 0.85% +0.23
LBRX LB Pharmaceuticals Inc. New 0.22% +0.22
CDNA Caredx Inc. New 0.21% +0.21
QTTB Q32 Bio Inc. New 0.20% +0.20
ELVN Enliven Therapeutics Inc. New 0.17% +0.17
BSX Boston Scientific Corp. New 0.14% +0.14
SLDB Solid Biosciences Inc. Add +19.2% 0.30% +0.09
PTHS Pelthos Therapeutics Inc. Add +4.8% 0.33% +0.07
FSK FS KKR Capital Corp. New 0.02% +0.02
AGIO Agios Pharmaceuticals Inc. Add +2.1% 1.86% −0.01
VSTM Verastem Inc. Add +49.0% 0.31% −0.01
ARDX Ardelyx Inc. Add +27.1% 0.71% −0.03
CNTB Connect Biopharma Holdings L Add +14.7% 0.56% −0.04
COGT Cogent Biosciences Inc. Add +6.8% 2.27% −0.11
RLMD Relmada Therapeutics Inc. Add +2.7% 1.65% −0.17
BBIO Bridgebio Pharma Inc. Add +3.2% 3.66% −0.32
SNDX Syndax Pharmaceuticals Inc. Add +3.6% 5.05% −0.81

Notes & Other Activity Q1 2026 → Q2 2026
OXY.WS Occidental Petroleum-CW27 *W EXP 08/03/202 New 194 $4K

Bonds, preferreds, convertibles and warrants; not part of the stock holdings or percentages above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 83$189.2MGOOG, APO, SNDX, XERS, TVTX
Q1 2026 85$168.0MGOOG, APO, SNDX, BBIO, PTGX
Q4 2025 87$215.9MCLMT, APO, GOOG, SNDX, XERS
Q3 2025 87$238.7MCLMT, APO, GOOG, JAAA, XERS
Q2 2025 85$220.6MCLMT, APO, JAAA, GOOG, JPM
Q1 2025 84$212.0MCLMT, APO, JAAA, GOOG, DCGO
Q4 2024 89$276.5MCLMT, APO, JAAA, GOOG, DCGO
Q3 2024 92$284.6MCLMT, APO, GOOG, AB, CLOZ
Q2 2024 99$250.6MCLMT, APO, GOOG, CLOZ, DCGO
Q1 2024 106$282.8MCLMT, APO, CLOZ, GOOG, FTAI