Praxis Precision Medicines IPRAX
13F holders, Q4 2025 (December 31)250holders +98
103new positions
15sold out
6famous investors
$294.75avg. 13F price*
At the end of Q4 2025, 250 institutions reported holding Praxis Precision Medicines I (PRAX) in their 13F filings, up 98 from Q3 2025. 103 opened new positions and 15 sold out. The largest holders were Janus Henderson Group PLC ($954.8M), BlackRock, Inc. ($612.6M) and Perceptive Advisors LLC ($588.3M). 6 famous investors held it, including Steve Cohen (0.2% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Praxis Precision Medicines I
- CUSIP
- 74006W207
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 103 | $1.1B |
| Exits | 15 | $28.2M |
All 13F filers, Q3 2025 → Q4 2025: 9,761,534 shares bought and 5,060,075 shares sold, net +4,701,459 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 250 holders
| Janus Henderson Group PLC | 0.43% | Add +17.2% | 3,240,086 | $954.8M |
| BlackRock, Inc. | 0.01% | Add +15.4% | 2,078,500 | $612.6M |
| Perceptive Advisors LLC | 10.81% | Add +27.6% | 1,995,986 | $588.3M |
| Vanguard Group Inc. | 0.01% | Add +15.3% | 1,460,933 | $430.6M |
| FMR LLC | 0.02% | Add +3044.3% | 1,358,675 | $400.5M |
| Orbis Allan Gray Ltd | 1.55% | New | 1,255,162 | $369.9M |
| Baker Bros. Advisors LP | 1.95% | Add +63.4% | 1,126,488 | $332.0M |
| Adage Capital Partners Gp, L.L.C. | 0.43% | Reduce -59.3% | 965,313 | $284.5M |
| Cormorant Asset Management, LP | 15.87% | Reduce -5.0% | 950,000 | $280.0M |
| Driehaus Capital Management LLC | 1.87% | Add +86.4% | 933,061 | $275.0M |
| Deerfield Management Company, L.P. | 3.89% | Add +7.4% | 903,351 | $266.3M |
| Morgan Stanley | 0.02% | Add +38.3% | 889,889 | $262.3M |
| State Street Corp. | 0.01% | Reduce -2.7% | 882,215 | $260.0M |
| T. Rowe Price Associates Inc. | 0.03% | Reduce -21.7% | 785,987 | $231.7M |
| Goldman Sachs Group Inc. | 0.03% | Add +20.8% | 716,184 | $211.1M |
| Geode Capital Management, LLC | 0.01% | Add +23.1% | 562,379 | $165.8M |
| Barclays PLC | 0.06% | Add +592.5% | 530,751 | $156.4M |
| Bank of America Corp. | 0.01% | Add +8.3% | 522,763 | $154.1M |
| Point72 Asset Management | 0.24% | Reduce -67.1% | 492,346 | $145.1M |
| Assenagon Asset Management S.A. | 0.18% | Reduce -0.2% | 408,787 | $120.5M |
| Logos Global Management LP | 7.37% | Add +200.0% | 375,000 | $110.5M |
| Ra Capital Management, L.P. | 1.13% | New | 373,787 | $110.2M |
| Soleus Capital Management, L.P. | 4.54% | Reduce -57.8% | 362,966 | $107.0M |
| Franklin Resources Inc. | 0.03% | Add +13.3% | 356,074 | $104.9M |
| Vivo Capital, LLC | 6.27% | Add +65.4% | 328,895 | $96.9M |
| Hood River Capital Management LLC | 0.94% | New | 289,467 | $85.3M |
| T. Rowe Price Investment Management, Inc. | 0.05% | New | 276,392 | $81.5M |
| Pictet Asset Management Holding SA | 0.07% | New | 240,588 | $71.1M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +22.7% | 198,301 | $58.4M |
| Northern Trust Corp. | 0.01% | Add +14.2% | 192,284 | $56.7M |
| Affinity Asset Advisors, LLC | 4.04% | New | 185,000 | $54.5M |
| Wellington Management Group LLP | 0.01% | Add +188.3% | 176,562 | $52.0M |
| Qube Research & Technologies Ltd | 0.07% | Add +194.7% | 168,897 | $49.8M |
| Aberdeen Group plc | 0.06% | New | 134,992 | $39.8M |
| Sofinnova Investments, Inc. | 1.60% | Reduce -27.3% | 125,722 | $37.1M |
| Candriam S.C.A. | 0.16% | Add +75.9% | 110,590 | $32.6M |
| Woodline Partners LP | 0.12% | Reduce -74.8% | 105,412 | $31.1M |
| Velan Capital Investment Management LP | 17.28% | Reduce -24.1% | 100,781 | $29.7M |
| Orbimed Advisors LLC | 0.57% | New | 94,500 | $27.9M |
| UBS Group AG | 0.01% | Reduce -7.9% | 89,200 | $26.3M |
| First Trust Advisors LP | 0.02% | Add +206.2% | 88,704 | $26.1M |
| Ikarian Capital, LLC | 3.30% | Add +203.0% | 86,581 | $25.5M |
| Acuta Capital Partners, LLC | 16.62% | Add +66.9% | 83,036 | $24.5M |
| Silverarc Capital Management, LLC | 3.52% | Add +61.0% | 82,465 | $24.3M |
| Algert Global LLC | 0.37% | Reduce -49.9% | 80,640 | $23.8M |
| Bank of New York Mellon Corp | 0.00% | Add +38.4% | 77,897 | $23.0M |
| Invesco Ltd. | 0.00% | Add +269.4% | 77,088 | $22.7M |
| American Century Companies Inc. | 0.01% | Add +393.6% | 75,366 | $22.2M |
| Alyeska Investment Group, L.P. | 0.06% | Reduce -47.4% | 74,376 | $21.9M |
| Canada Pension Plan Investment Board | 0.01% | New | 69,712 | $20.5M |
| Marshall Wace, LLP | 0.02% | Add +1.6% | 69,242 | $20.4M |
| Eventide Asset Management, LLC | 0.31% | New | 67,100 | $19.8M |
| Renaissance Technologies | 0.03% | New | 66,230 | $19.5M |
| 72 Investment Holdings, LLC | 38.42% | No change | 65,933 | $19.4M |
| Ensign Peak Advisors, Inc | 0.03% | New | 64,283 | $18.9M |
| Exome Asset Management LLC | 8.46% | Reduce -43.0% | 58,122 | $17.1M |
| JPMorgan Chase & Co. | 0.00% | Add +111.0% | 55,300 | $16.3M |
| Deutsche Bank AG | 0.00% | Add +266.7% | 50,811 | $15.0M |
| Nuveen, LLC | 0.00% | Add +29.6% | 49,970 | $14.7M |
| Boxer Capital Management, LLC | 3.00% | New | 46,457 | $13.7M |
| TD Asset Management Inc | 0.01% | Add +12.9% | 46,146 | $13.6M |
| KVP Capital Advisors, LP | 13.06% | — | 42,900 | $12.6M |
| Moody Aldrich Partners LLC | 2.30% | New | 41,731 | $12.3M |
| SummitTX Capital, L.P. | 0.37% | Add +19.2% | 41,629 | $12.3M |
| Swiss National Bank | 0.01% | Add +14.1% | 40,500 | $11.9M |
| Ishara Investments LP | 13.72% | — | 40,000 | $11.8M |
| Integral Health Asset Management, LLC | 0.60% | New | 40,000 | $11.8M |
| D. E. Shaw & Co. | 0.01% | Add +89.3% | 37,481 | $11.0M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | New | 37,377 | $11.0M |
| Empowered Funds, LLC | 0.18% | New | 36,852 | $10.9M |
| Readystate Asset Management LP | 0.83% | Reduce -66.3% | 36,792 | $10.8M |
| First Turn Management, LLC | 1.20% | New | 35,749 | $10.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +48.5% | 35,288 | $10.4M |
| Citadel Advisors | 0.01% | Add +347.8% | 34,917 | $10.3M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -7.1% | 33,291 | $9.9M |
| Caption Management, LLC | 0.45% | Add +423.8% | 33,300 | $9.8M |
| B Group, Inc. | 7.26% | Add +5.5% | 33,237 | $9.8M |
| Congress Asset Management Co. | 0.06% | Add +2.6% | 31,246 | $9.2M |
| PFM Health Sciences, LP | 0.94% | Reduce -48.6% | 31,163 | $9.2M |
| Lord, Abbett & Co. LLC | 0.03% | New | 30,756 | $9.1M |
| ArrowMark Colorado Holdings LLC | 0.19% | New | 30,000 | $8.8M |
| AQR Capital Management | 0.00% | Add +31.6% | 28,828 | $8.5M |
| Rhumbline Advisers | 0.01% | Add +5.7% | 28,324 | $8.3M |
| HighVista Strategies LLC | 1.96% | Reduce -72.8% | 25,841 | $7.6M |
| Neuberger Berman Group LLC | 0.01% | New | 25,678 | $7.6M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.01% | Add +11.9% | 25,559 | $7.5M |
| Wells Fargo & Company | 0.00% | Add +85.5% | 25,235 | $7.4M |
| Alliancebernstein L.P. | 0.00% | Add +38.8% | 25,070 | $7.4M |
| Burkehill Global Management, LP | 0.51% | New | 25,000 | $7.4M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -37.1% | 23,543 | $6.9M |
| Susquehanna Portfolio Strategies, LLC | 0.11% | No change | 23,251 | $6.9M |
| Two Sigma Investments, LP | 0.01% | Add +319.4% | 23,098 | $6.8M |
| Tetragon Partners GP Ltd | 1.43% | New | 22,952 | $6.8M |
| Ameriprise Financial Inc. | 0.00% | New | 22,715 | $6.7M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -40.8% | 22,240 | $6.6M |
| Man Group plc | 0.01% | New | 21,170 | $6.2M |
| Stempoint Capital LP | 1.07% | New | 21,067 | $6.2M |
| Boothbay Fund Management, LLC | 0.17% | Reduce -47.1% | 20,974 | $6.2M |
| Informed Momentum Co LLC | 0.69% | New | 20,941 | $6.2M |
| Russell Investments Group, Ltd. | 0.01% | Add +368.0% | 20,612 | $6.1M |
"% of holder's portfolio" is PRAX's weight in each manager's 13F, not the share of Praxis Precision Medicines I the manager owns.