Praxis Precision Medicines IPRAX
13F holders, Q3 2025 (September 30)152holders +9
27new positions
19sold out
4famous investors
$53.00avg. 13F price*
At the end of Q3 2025, 152 institutions reported holding Praxis Precision Medicines I (PRAX) in their 13F filings, up 9 from Q2 2025. 27 opened new positions and 19 sold out. The largest holders were Janus Henderson Group PLC ($146.5M), Adage Capital Partners Gp, L.L.C. ($125.8M) and BlackRock, Inc. ($95.5M). 4 famous investors held it, including Steve Cohen (0.2% of Point72 Asset Management's portfolio), David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Praxis Precision Medicines I
- CUSIP
- 74006W207
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 27 | $30.3M |
| Exits | 19 | $44.9M |
All 13F filers, Q2 2025 → Q3 2025: 4,573,537 shares bought and 4,054,029 shares sold, net +519,508 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 152 holders
| Janus Henderson Group PLC | 0.07% | Add +9.1% | 2,763,859 | $146.5M |
| Adage Capital Partners Gp, L.L.C. | 0.20% | Add +20.2% | 2,374,085 | $125.8M |
| BlackRock, Inc. | 0.00% | Add +13.3% | 1,801,080 | $95.5M |
| Perceptive Advisors LLC | 2.43% | Add +107.8% | 1,564,554 | $82.9M |
| Point72 Asset Management | 0.18% | Add +56.8% | 1,495,986 | $79.3M |
| Vanguard Group Inc. | 0.00% | Add +4.3% | 1,267,286 | $67.2M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -31.9% | 1,003,490 | $53.2M |
| Cormorant Asset Management, LP | 3.66% | Reduce -38.5% | 1,000,000 | $53.0M |
| State Street Corp. | 0.00% | Add +29.9% | 907,108 | $48.1M |
| Soleus Capital Management, L.P. | 2.43% | Reduce -11.1% | 859,166 | $45.5M |
| Deerfield Management Company, L.P. | 0.74% | Add +22.4% | 840,851 | $44.6M |
| Baker Bros. Advisors LP | 0.26% | No change | 689,488 | $36.5M |
| Morgan Stanley | 0.00% | Reduce -47.5% | 643,495 | $34.1M |
| Goldman Sachs Group Inc. | 0.00% | Add +162.4% | 593,021 | $31.4M |
| Driehaus Capital Management LLC | 0.19% | Reduce -5.7% | 500,551 | $26.5M |
| Bank of America Corp. | 0.00% | Add +6.5% | 482,861 | $25.6M |
| Geode Capital Management, LLC | 0.00% | Add +1.2% | 457,032 | $24.2M |
| Woodline Partners LP | 0.10% | Add +808.9% | 417,669 | $22.1M |
| Assenagon Asset Management S.A. | 0.03% | Reduce -32.2% | 409,779 | $21.7M |
| CIBC Asset Management Inc | 0.06% | No change | 388,759 | $20.6M |
| Franklin Resources Inc. | 0.00% | Add +0.0% | 314,157 | $16.7M |
| Vivo Capital, LLC | 0.85% | Add +18.7% | 198,895 | $10.5M |
| Sofinnova Investments, Inc. | 0.56% | Add +999.7% | 172,833 | $9.2M |
| 5AM Venture Management, LLC | 3.30% | No change | 170,000 | $9.0M |
| Northern Trust Corp. | 0.00% | Reduce -21.2% | 168,353 | $8.9M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +6.0% | 161,661 | $8.6M |
| Algert Global LLC | 0.14% | Add +483.3% | 160,818 | $8.5M |
| Alyeska Investment Group, L.P. | 0.02% | Add +13.2% | 141,516 | $7.5M |
| Velan Capital Investment Management LP | 6.61% | Reduce -11.1% | 132,805 | $7.0M |
| Logos Global Management LP | 0.65% | Reduce -44.4% | 125,000 | $6.6M |
| Readystate Asset Management LP | 0.56% | New | 109,177 | $5.8M |
| Exome Asset Management LLC | 3.57% | Add +72.9% | 101,996 | $5.4M |
| UBS Group AG | 0.00% | Add +11.9% | 96,812 | $5.1M |
| HighVista Strategies LLC | 1.23% | Add +41.2% | 95,002 | $5.0M |
| Barclays PLC | 0.00% | Reduce -13.6% | 76,637 | $4.1M |
| Kennedy Capital Management LLC | 0.09% | Add +8.2% | 76,218 | $4.0M |
| Tri Locum Partners LP | 0.93% | Reduce -61.1% | 75,986 | $4.0M |
| Marshall Wace, LLP | 0.00% | New | 68,141 | $3.6M |
| 72 Investment Holdings, LLC | 5.14% | No change | 65,933 | $3.5M |
| Candriam S.C.A. | 0.02% | Reduce -1.3% | 62,866 | $3.3M |
| Wellington Management Group LLP | 0.00% | Add +9.6% | 61,241 | $3.2M |
| PFM Health Sciences, LP | 0.28% | Reduce -28.5% | 60,578 | $3.2M |
| Sphera Funds Management LTD. | 0.73% | Reduce -47.3% | 57,901 | $3.1M |
| Qube Research & Technologies Ltd | 0.00% | New | 57,304 | $3.0M |
| Bank of New York Mellon Corp | 0.00% | Add +7.1% | 56,288 | $3.0M |
| Silverarc Capital Management, LLC | 0.39% | Add +412.1% | 51,210 | $2.7M |
| Acuta Capital Partners, LLC | 2.73% | Reduce -32.9% | 49,751 | $2.6M |
| FMR LLC | 0.00% | Add +13.4% | 43,211 | $2.3M |
| TD Asset Management Inc | 0.00% | Reduce -36.1% | 40,884 | $2.2M |
| Boothbay Fund Management, LLC | 0.06% | Reduce -66.4% | 39,660 | $2.1M |
| Nuveen, LLC | 0.00% | No change | 38,549 | $2.0M |
| Rafferty Asset Management, LLC | 0.01% | Add +51.5% | 37,573 | $2.0M |
| Dimensional Fund Advisors LP | 0.00% | New | 37,414 | $2.0M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -36.2% | 35,829 | $1.9M |
| Swiss National Bank | 0.00% | Add +15.3% | 35,500 | $1.9M |
| SummitTX Capital, L.P. | 0.08% | New | 34,928 | $1.9M |
| Y-Intercept (Hong Kong) Ltd | 0.04% | New | 32,186 | $1.7M |
| Jane Street Group, LLC | 0.00% | Add +143.7% | 31,687 | $1.7M |
| B Group, Inc. | 1.67% | Reduce -10.0% | 31,500 | $1.7M |
| Congress Asset Management Co. | 0.01% | New | 30,439 | $1.6M |
| Susquehanna International Group, LLP | 0.00% | Reduce -37.5% | 29,337 | $1.6M |
| First Trust Advisors LP | 0.00% | New | 28,966 | $1.5M |
| Ikarian Capital, LLC | 0.31% | Reduce -89.7% | 28,571 | $1.5M |
| Prelude Capital Management, LLC | 0.12% | Add +41.2% | 28,102 | $1.5M |
| Knott David M Jr | 0.62% | New | 28,000 | $1.5M |
| Rhumbline Advisers | 0.00% | Reduce -2.0% | 26,794 | $1.4M |
| JPMorgan Chase & Co. | 0.00% | Add +88.0% | 26,208 | $1.4M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -75.5% | 23,756 | $1.3M |
| Susquehanna Portfolio Strategies, LLC | 0.02% | Add +304.4% | 23,251 | $1.2M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -4.3% | 22,836 | $1.2M |
| Simplex Trading, LLC | 0.03% | Reduce -11.1% | 22,529 | $1.2M |
| AQR Capital Management | 0.00% | Add +50.2% | 21,904 | $1.2M |
| Dark Forest Capital Management LP | 0.04% | New | 21,684 | $1.1M |
| Invesco Ltd. | 0.00% | Add +30.9% | 20,868 | $1.1M |
| Quarry LP | 0.28% | Add +316.7% | 20,001 | $1.1M |
| D. E. Shaw & Co. | 0.00% | Add +3.9% | 19,796 | $1.0M |
| California State Teachers Retirement System | 0.00% | Add +13.7% | 18,583 | $985K |
| Alliancebernstein L.P. | 0.00% | Add +0.1% | 18,060 | $957K |
| Legal & General Group Plc | 0.00% | Add +0.9% | 16,824 | $892K |
| Group One Trading LLC | 0.03% | New | 16,628 | $881K |
| American Century Companies Inc. | 0.00% | New | 15,268 | $809K |
| PCG Wealth Advisors, LLC | 0.22% | New | 14,483 | $768K |
| Jacobs Levy Equity Management, Inc. | 0.00% | Reduce -69.2% | 13,898 | $737K |
| Deutsche Bank AG | 0.00% | Add +14.3% | 13,856 | $734K |
| Wells Fargo & Company | 0.00% | Add +20.9% | 13,605 | $721K |
| SG Americas Securities, LLC | 0.00% | New | 13,496 | $715K |
| HSBC Holdings PLC | 0.00% | New | 11,172 | $595K |
| MetLife Investment Management, LLC | 0.00% | No change | 10,520 | $558K |
| Hussman Strategic Advisors, Inc. | 0.12% | No change | 10,500 | $557K |
| Alps Advisors Inc. | 0.00% | Reduce -5.2% | 10,424 | $552K |
| State of Wisconsin Investment Board | 0.00% | Reduce -38.8% | 9,033 | $479K |
| Trexquant Investment LP | 0.00% | New | 8,905 | $472K |
| Freestone Grove Partners LP | 0.00% | New | 8,269 | $438K |
| Profund Advisors LLC | 0.01% | Add +53.6% | 8,079 | $428K |
| Citadel Advisors | 0.00% | Reduce -24.8% | 7,798 | $413K |
| Intech Investment Management LLC | 0.00% | Reduce -11.1% | 7,754 | $411K |
| Nisa Investment Advisors, LLC | 0.00% | Add +1033.4% | 7,129 | $378K |
| Phoenix Financial Ltd. | 0.00% | New | 6,817 | $362K |
| Creative Planning | 0.00% | Add +2.5% | 6,660 | $353K |
| New York State Common Retirement Fund | 0.00% | No change | 6,600 | $350K |
"% of holder's portfolio" is PRAX's weight in each manager's 13F, not the share of Praxis Precision Medicines I the manager owns.