Spyre TherapeuticsSYRE
13F holders, Q2 2024 (June 30)107holders +5
28new positions
23sold out
2famous investors
$23.50avg. 13F price*
At the end of Q2 2024, 107 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, up 5 from Q1 2024. 28 opened new positions and 23 sold out. The largest holders were FMR LLC ($176.5M), Fairmount Funds Management LLC ($94.5M) and RTW Investments, LP ($76.6M). 2 famous investors held it, including George Soros (0.1% of Soros Fund Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2024 → Q2 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 28 | $34.1M |
| Exits | 23 | $50.4M |
All 13F filers, Q1 2024 → Q2 2024: 20,457,341 shares bought and 1,716,445 shares sold, net +18,740,896 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 107 holders
| FMR LLC | 0.01% | Add +14.0% | 7,507,983 | $176.5M |
| Fairmount Funds Management LLC | 10.67% | Add +961.8% | 4,018,101 | $94.5M |
| RTW Investments, LP | 1.19% | Add +45.9% | 3,258,360 | $76.6M |
| Perceptive Advisors LLC | 1.72% | Add +18.6% | 3,031,018 | $71.3M |
| Venrock Adviser, LLC | 4.02% | Add +23.6% | 2,685,448 | $63.1M |
| Braidwell LP | 3.03% | Add +388.3% | 2,514,538 | $59.1M |
| BlackRock Inc. | 0.00% | Add +331.7% | 2,403,441 | $56.5M |
| Commodore Capital LP | 3.19% | Add +5.5% | 1,988,084 | $46.7M |
| Vanguard Group Inc. | 0.00% | Add +284.5% | 1,911,566 | $44.9M |
| Avoro Capital Advisors LLC | 0.58% | No change | 1,839,138 | $43.2M |
| Deep Track Capital, LP | 1.23% | Add +44.8% | 1,756,667 | $41.3M |
| State Street Corp. | 0.00% | Add +948.6% | 1,409,659 | $33.1M |
| Adage Capital Partners Gp, L.L.C. | 0.05% | Add +4.3% | 1,152,411 | $27.1M |
| Goldman Sachs Group Inc. | 0.00% | Add +272.3% | 893,083 | $21.0M |
| Wellington Management Group LLP | 0.00% | Reduce -2.1% | 795,946 | $18.7M |
| Geode Capital Management, LLC | 0.00% | Add +131.9% | 765,834 | $18.0M |
| Franklin Resources Inc. | 0.01% | No change | 741,904 | $17.4M |
| Citadel Advisors | 0.02% | Reduce 0.0% | 707,586 | $16.6M |
| Boxer Capital, LLC | 0.86% | Add +178.6% | 696,480 | $16.4M |
| Driehaus Capital Management LLC | 0.16% | No change | 687,080 | $16.2M |
| Janus Henderson Group PLC | 0.01% | Add +4721.3% | 673,867 | $15.9M |
| Farallon Capital Management, L.L.C. | 0.09% | Add +42.9% | 666,000 | $15.7M |
| Logos Global Management LP | 1.56% | Add +130.0% | 575,000 | $13.5M |
| Affinity Asset Advisors, LLC | 2.10% | Add +25.2% | 513,420 | $12.1M |
| Polar Capital Holdings Plc | 0.07% | No change | 500,000 | $11.8M |
| First Turn Management, LLC | 1.78% | No change | 464,435 | $10.9M |
| Darwin Global Management, Ltd. | 1.19% | Reduce -4.5% | 452,040 | $10.3M |
| Morgan Stanley | 0.00% | Add +698.7% | 408,853 | $9.6M |
| Pictet Asset Management Holding SA | 0.01% | New | 386,617 | $9.1M |
| T. Rowe Price Associates Inc. | 0.00% | Add +292.2% | 307,976 | $7.2M |
| Blackstone Inc. | 0.03% | Add +1365.6% | 292,995 | $6.9M |
| Voloridge Investment Management, LLC | 0.02% | Add +46.4% | 275,226 | $6.5M |
| Balyasny Asset Management L.P. | 0.02% | Add +741.5% | 272,636 | $6.4M |
| Woodline Partners LP | 0.06% | Add +161.2% | 262,616 | $6.2M |
| Ghost Tree Capital, LLC | 2.05% | Add +150.2% | 250,237 | $5.9M |
| Avidity Partners Management LP | 0.19% | New | 195,000 | $4.6M |
| Bank of America Corp. | 0.00% | Add +426.2% | 191,169 | $4.5M |
| Walleye Capital LLC | 0.04% | Add +35.3% | 150,820 | $3.5M |
| Stempoint Capital LP | 1.04% | Add +141.7% | 150,450 | $3.5M |
| Soros Fund Management | 0.11% | Add +382.7% | 145,000 | $3.4M |
| Armistice Capital, LLC | 0.08% | New | 136,000 | $3.2M |
| Great Point Partners LLC | 0.61% | Add +7.7% | 134,612 | $3.2M |
| Bank of New York Mellon Corp | 0.00% | Add +1845.2% | 117,686 | $2.8M |
| Nuveen Asset Management, LLC | 0.00% | New | 117,140 | $2.8M |
| HighVista Strategies LLC | 0.98% | Reduce -26.4% | 113,550 | $2.7M |
| Montanova Capital, LLC | 0.10% | Reduce -33.9% | 107,310 | $2.5M |
| Candriam S.C.A. | 0.02% | No change | 105,000 | $2.5M |
| Integral Health Asset Management, LLC | 0.23% | No change | 100,000 | $2.4M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +554.5% | 98,181 | $2.3M |
| Jefferies Financial Group Inc. | 0.05% | New | 97,573 | $2.3M |
| Northern Trust Corp. | 0.00% | Add +29.0% | 85,588 | $2.0M |
| Ensign Peak Advisors, Inc | 0.00% | New | 82,475 | $1.9M |
| Schonfeld Strategic Advisors LLC | 0.01% | Add +121.1% | 78,500 | $1.8M |
| Norges Bank | 0.00% | New | 70,843 | $1.7M |
| Rafferty Asset Management, LLC | 0.01% | New | 67,109 | $1.6M |
| Jump Financial, LLC | 0.03% | Add +184.7% | 64,900 | $1.5M |
| Barclays PLC | 0.00% | Add +39.3% | 64,043 | $1.5M |
| Rhumbline Advisers | 0.00% | New | 51,896 | $1.2M |
| Superstring Capital Management LP | 1.35% | New | 45,571 | $1.1M |
| UBS Group AG | 0.00% | Add +1611.0% | 44,504 | $1.0M |
| Manufacturers Life Insurance Company, The | 0.00% | Add +53.2% | 37,782 | $888K |
| EFG Asset Management (North America) Corp. | 0.15% | Add +229.8% | 36,781 | $869K |
| Alliancebernstein L.P. | 0.00% | New | 36,230 | $852K |
| Bridgeway Capital Management, LLC | 0.02% | New | 36,100 | $849K |
| Swiss National Bank | 0.00% | Reduce -7.7% | 36,100 | $849K |
| ADAR1 Capital Management, LLC | 0.17% | Reduce -28.9% | 35,180 | $827K |
| TD Asset Management Inc | 0.00% | Reduce -42.3% | 35,168 | $827K |
| NBW Capital LLC | 0.16% | No change | 34,360 | $808K |
| Alpine Global Management, LLC | 0.15% | New | 33,858 | $796K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 30,121 | $708K |
| Legal & General Group Plc | 0.00% | Add +36.6% | 23,263 | $547K |
| JPMorgan Chase & Co. | 0.00% | Add +206918.2% | 22,772 | $535K |
| Citigroup Inc. | 0.00% | Reduce -39.2% | 19,320 | $454K |
| California State Teachers Retirement System | 0.00% | Add +7.3% | 19,105 | $449K |
| Corebridge Financial, Inc. | 0.00% | — | 18,625 | $438K |
| Global Endowment Management, LP | 0.05% | No change | 18,184 | $428K |
| Informed Momentum Co LLC | 0.07% | No change | 17,938 | $422K |
| Wells Fargo & Company | 0.00% | Add +666.1% | 17,175 | $404K |
| Invesco Ltd. | 0.00% | Reduce -89.3% | 16,364 | $385K |
| Deutsche Bank AG | 0.00% | Add +5351.3% | 16,245 | $382K |
| New York State Common Retirement Fund | 0.00% | Reduce -2.1% | 14,365 | $338K |
| State of Wisconsin Investment Board | 0.00% | Reduce -4.8% | 13,932 | $328K |
| Qube Research & Technologies Ltd | 0.00% | Reduce -78.0% | 12,672 | $298K |
| Profund Advisors LLC | 0.01% | New | 12,606 | $296K |
| Aquatic Capital Management LLC | 0.01% | New | 11,800 | $277K |
| Voya Investment Management LLC | 0.00% | New | 11,607 | $273K |
| Jane Street Group, LLC | 0.00% | Add +60.2% | 11,551 | $272K |
| Virtu Financial LLC | 0.02% | Reduce -32.0% | 11,016 | $259K |
| Two Sigma Investments, LP | 0.00% | Reduce -26.3% | 9,842 | $231K |
| Carlyle Group Inc. | 0.02% | No change | 9,620 | $227K |
| State Board of Administration of Florida Retirement System | 0.00% | New | 9,030 | $212K |
| MetLife Investment Management, LLC | 0.00% | New | 8,788 | $207K |
| SG Americas Securities, LLC | 0.00% | New | 5,545 | $130K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 3,392 | $80K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -11.6% | 3,384 | $80K |
| Royal Bank of Canada | 0.00% | Add +5714.3% | 3,256 | $77K |
| Virtus Advisers, LLC | 0.03% | Reduce -52.1% | 2,797 | $66K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | — | 2,526 | $57K |
| AlphaQuest LLC | 0.00% | New | 1,523 | $36K |
| Amalgamated Bank | 0.00% | New | 1,198 | $28K |
| Pacer Advisors, Inc. | 0.00% | New | 382 | $9K |
| IFP Advisors, Inc | 0.00% | No change | 114 | $3K |
| Osaic Holdings, Inc. | 0.00% | No change | 83 | $2K |
| Simplex Trading, LLC | 0.00% | New | 64 | $1K |
| Pacific Capital Wealth Advisors, Inc. | 0.00% | No change | 8 | $188 |
| Rothschild Investment LLC | 0.00% | New | 5 | $118 |
| Cwm, LLC | 0.00% | New | 1 | $0 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.