Spyre TherapeuticsSYRE
13F holders, Q3 2024 (September 30)119holders +12
29new positions
18sold out
4famous investors
$29.43avg. 13F price*
At the end of Q3 2024, 119 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, up 12 from Q2 2024. 29 opened new positions and 18 sold out. The largest holders were FMR LLC ($224.2M), Fairmount Funds Management LLC ($118.2M) and RTW Investments, LP ($95.8M). 4 famous investors held it, including George Soros (0.1% of Soros Fund Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2024 → Q3 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 29 | $104.4M |
| Exits | 18 | $59.1M |
All 13F filers, Q2 2024 → Q3 2024: 7,575,215 shares bought and 6,842,650 shares sold, net +732,565 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 119 holders
| FMR LLC | 0.01% | Add +1.5% | 7,623,881 | $224.2M |
| Fairmount Funds Management LLC | 9.58% | No change | 4,018,101 | $118.2M |
| RTW Investments, LP | 1.39% | No change | 3,258,360 | $95.8M |
| Perceptive Advisors LLC | 1.81% | Reduce -5.2% | 2,872,547 | $84.5M |
| Venrock Adviser, LLC | 4.14% | No change | 2,685,448 | $79.0M |
| BlackRock, Inc. | 0.00% | — | 2,663,147 | $78.3M |
| Vanguard Group Inc. | 0.00% | Add +31.6% | 2,515,920 | $74.0M |
| Braidwell LP | 2.77% | Reduce -12.9% | 2,189,836 | $64.4M |
| Commodore Capital LP | 3.65% | No change | 1,988,084 | $58.5M |
| State Street Corp. | 0.00% | Add +9.4% | 1,541,555 | $45.3M |
| Wellington Management Group LLP | 0.01% | Add +89.4% | 1,507,200 | $44.3M |
| Paradigm Biocapital Advisors LP | 1.30% | New | 1,267,581 | $37.3M |
| Assenagon Asset Management S.A. | 0.07% | New | 1,142,768 | $33.6M |
| Janus Henderson Group PLC | 0.02% | Add +66.3% | 1,120,531 | $32.9M |
| Adage Capital Partners Gp, L.L.C. | 0.05% | Reduce -8.4% | 1,055,000 | $31.0M |
| Deep Track Capital, LP | 0.94% | Reduce -43.1% | 1,000,000 | $29.4M |
| Geode Capital Management, LLC | 0.00% | Add +16.4% | 891,048 | $26.2M |
| Pictet Asset Management Holding SA | 0.03% | Add +113.6% | 825,706 | $24.3M |
| Franklin Resources Inc. | 0.01% | Add +2.5% | 760,666 | $23.3M |
| Citadel Advisors | 0.02% | No change | 707,586 | $20.8M |
| Boxer Capital, LLC | 1.01% | No change | 696,480 | $20.5M |
| Driehaus Capital Management LLC | 0.17% | No change | 687,080 | $20.2M |
| Avoro Capital Advisors LLC | 0.26% | Reduce -67.5% | 598,600 | $17.6M |
| Polar Capital Holdings Plc | 0.07% | No change | 500,000 | $14.7M |
| Affinity Asset Advisors, LLC | 2.44% | Reduce -2.9% | 498,420 | $14.7M |
| Jefferies Financial Group Inc. | 0.23% | Add +366.1% | 454,807 | $13.4M |
| T. Rowe Price Associates Inc. | 0.00% | Add +39.3% | 429,127 | $12.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +239.4% | 333,275 | $9.8M |
| Northern Trust Corp. | 0.00% | Add +267.2% | 314,290 | $9.2M |
| Ikarian Capital, LLC | 2.76% | New | 302,247 | $8.9M |
| Blackstone Inc. | 0.04% | No change | 292,995 | $8.6M |
| Emerald Advisers, LLC | 0.33% | New | 292,569 | $8.6M |
| Woodline Partners LP | 0.07% | Add +0.6% | 264,256 | $7.8M |
| Bank of America Corp. | 0.00% | Add +34.9% | 257,797 | $7.6M |
| Emerald Mutual Fund Advisers Trust | 0.39% | New | 253,550 | $7.5M |
| Morgan Stanley | 0.00% | Reduce -40.4% | 243,742 | $7.2M |
| Walleye Capital LLC | 0.08% | Add +61.4% | 243,372 | $7.2M |
| Balyasny Asset Management L.P. | 0.02% | Reduce -16.4% | 227,950 | $6.7M |
| Logos Global Management LP | 0.66% | Reduce -65.2% | 200,000 | $5.9M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -81.0% | 169,314 | $5.0M |
| Voloridge Investment Management, LLC | 0.02% | Reduce -43.1% | 156,481 | $4.6M |
| Soros Fund Management | 0.12% | No change | 145,000 | $4.3M |
| Invesco Ltd. | 0.00% | Add +742.5% | 137,858 | $4.1M |
| Armistice Capital, LLC | 0.10% | No change | 136,000 | $4.0M |
| Nuveen Asset Management, LLC | 0.00% | Add +7.0% | 125,290 | $3.7M |
| Barclays PLC | 0.00% | Add +64.7% | 105,467 | $3.1M |
| HighVista Strategies LLC | 1.07% | Reduce -7.2% | 105,351 | $3.1M |
| Candriam S.C.A. | 0.02% | No change | 105,000 | $3.1M |
| Bank of New York Mellon Corp | 0.00% | Reduce -10.9% | 104,806 | $3.1M |
| Boothbay Fund Management, LLC | 0.09% | New | 91,775 | $2.7M |
| Ensign Peak Advisors, Inc | 0.00% | No change | 82,475 | $2.4M |
| Rafferty Asset Management, LLC | 0.01% | Add +5.2% | 70,586 | $2.1M |
| Cinctive Capital Management LP | 0.10% | New | 61,256 | $1.8M |
| Ghost Tree Capital, LLC | 0.60% | Reduce -76.0% | 60,000 | $1.8M |
| UBS Group AG | 0.00% | Add +30.0% | 57,838 | $1.7M |
| Rhumbline Advisers | 0.00% | Add +3.9% | 53,935 | $1.6M |
| EFG Asset Management (North America) Corp. | 0.26% | Add +42.0% | 52,210 | $1.5M |
| TD Asset Management Inc | 0.00% | Add +50.0% | 52,768 | $1.5M |
| Swiss National Bank | 0.00% | Add +37.4% | 49,600 | $1.5M |
| Schonfeld Strategic Advisors LLC | 0.01% | Reduce -41.3% | 46,072 | $1.4M |
| Manufacturers Life Insurance Company, The | 0.00% | Add +15.0% | 43,460 | $1.3M |
| Superstring Capital Management LP | 0.98% | Reduce -18.2% | 37,287 | $1.1M |
| Alliancebernstein L.P. | 0.00% | No change | 36,230 | $1.1M |
| AQR Capital Management | 0.00% | New | 35,003 | $1.0M |
| Tudor Investment Corporation | 0.01% | New | 31,138 | $916K |
| JPMorgan Chase & Co. | 0.00% | Add +29.4% | 29,473 | $867K |
| Legal & General Group Plc | 0.00% | Add +25.3% | 29,155 | $857K |
| NBW Capital LLC | 0.15% | Reduce -21.6% | 26,930 | $792K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -12.2% | 26,441 | $778K |
| Citigroup Inc. | 0.00% | Add +30.4% | 25,191 | $741K |
| California State Teachers Retirement System | 0.00% | Add +29.1% | 24,675 | $726K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +764.0% | 21,825 | $639K |
| Deutsche Bank AG | 0.00% | Add +32.4% | 21,508 | $633K |
| Teachers Retirement System of the State of Kentucky | 0.01% | New | 21,154 | $622K |
| Jane Street Group, LLC | 0.00% | Add +78.7% | 20,641 | $607K |
| MetLife Investment Management, LLC | 0.00% | Add +129.1% | 20,132 | $592K |
| Corebridge Financial, Inc. | 0.00% | Reduce -0.6% | 18,512 | $544K |
| State of Wisconsin Investment Board | 0.00% | Add +31.5% | 18,315 | $539K |
| Global Endowment Management, LP | 0.05% | No change | 18,184 | $535K |
| Wells Fargo & Company | 0.00% | Add +3.7% | 17,810 | $524K |
| Profund Advisors LLC | 0.02% | Add +11.7% | 14,075 | $414K |
| Susquehanna International Group, LLP | 0.00% | New | 13,198 | $388K |
| SG Americas Securities, LLC | 0.00% | Add +127.0% | 12,589 | $370K |
| ADAR1 Capital Management, LLC | 0.06% | Reduce -64.3% | 12,560 | $369K |
| Voya Investment Management LLC | 0.00% | Reduce -2.2% | 11,351 | $334K |
| New York State Common Retirement Fund | 0.00% | Reduce -28.5% | 10,265 | $302K |
| Two Sigma Investments, LP | 0.00% | Reduce -0.4% | 9,803 | $288K |
| ExodusPoint Capital Management, LP | 0.00% | New | 9,733 | $286K |
| Carlyle Group Inc. | 0.03% | No change | 9,620 | $282K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 9,030 | $266K |
| Squarepoint Ops LLC | 0.00% | New | 8,477 | $249K |
| Intech Investment Management LLC | 0.00% | New | 8,371 | $246K |
| Arizona State Retirement System | 0.00% | New | 7,310 | $215K |
| AlphaQuest LLC | 0.01% | Add +271.2% | 5,654 | $166K |
| Royal Bank of Canada | 0.00% | Add +16.3% | 3,786 | $111K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 3,392 | $100K |
| Virtus Advisers, LLC | 0.04% | Add +1.8% | 2,848 | $84K |
| Public Employees Retirement Association of Colorado | 0.00% | New | 1,589 | $47K |
| Amalgamated Bank | 0.00% | No change | 1,198 | $35K |
| Acadian Asset Management LLC | 0.00% | New | 814 | $23K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -84.6% | 520 | $15K |
| nVerses Capital, LLC | 0.01% | New | 500 | $15K |
| Cwm, LLC | 0.00% | Add +22600.0% | 227 | $7K |
| Russell Investments Group, Ltd. | 0.00% | New | 129 | $4K |
| Sterling Capital Management LLC | 0.00% | — | 115 | $3K |
| IFP Advisors, Inc | 0.00% | No change | 114 | $3K |
| Nisa Investment Advisors, LLC | 0.00% | New | 111 | $3K |
| Osaic Holdings, Inc. | 0.00% | No change | 83 | $2K |
| Earned Wealth Advisors, LLC | 0.00% | New | 46 | $1K |
| Rothschild Investment LLC | 0.00% | Add +700.0% | 40 | $1K |
| Bessemer Group Inc. | 0.00% | New | 45 | $1K |
| Lindbrook Capital, LLC | 0.00% | New | 19 | $559 |
| True Wealth Design, LLC | 0.00% | New | 16 | $471 |
| US Bancorp \de | 0.00% | New | 9 | $265 |
| Pacific Capital Wealth Advisors, Inc. | 0.00% | No change | 8 | $235 |
| Allworth Financial LP | 0.00% | New | 7 | $206 |
| GAMMA Investing LLC | 0.00% | New | 5 | $147 |
| National Bank of Canada | 0.00% | New | 1 | $29 |
| Covestor Ltd | 0.00% | New | 3 | $0 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.