Spyre TherapeuticsSYRE
13F holders, Q4 2024 (December 31)131holders +12
25new positions
19sold out
3famous investors
$23.28avg. 13F price*
At the end of Q4 2024, 131 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, up 12 from Q3 2024. 25 opened new positions and 19 sold out. The largest holders were FMR LLC ($204.9M), Fairmount Funds Management LLC ($93.5M) and RTW Investments, LP ($84.3M). 3 famous investors held it, including George Soros (0.1% of Soros Fund Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2024 → Q4 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 25 | $46.7M |
| Exits | 19 | $37.2M |
All 13F filers, Q3 2024 → Q4 2024: 12,602,498 shares bought and 3,992,850 shares sold, net +8,609,648 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 131 holders
| FMR LLC | 0.01% | Add +15.4% | 8,801,266 | $204.9M |
| Fairmount Funds Management LLC | 9.30% | No change | 4,018,101 | $93.5M |
| RTW Investments, LP | 1.28% | Add +11.2% | 3,621,996 | $84.3M |
| BlackRock, Inc. | 0.00% | Add +27.6% | 3,399,591 | $79.1M |
| Vanguard Group Inc. | 0.00% | Add +13.1% | 2,846,473 | $66.3M |
| Driehaus Capital Management LLC | 0.54% | Add +308.1% | 2,803,655 | $65.3M |
| Venrock Adviser, LLC | 4.29% | No change | 2,685,448 | $62.5M |
| Braidwell LP | 2.68% | Add +17.7% | 2,578,404 | $60.0M |
| Perceptive Advisors LLC | 1.67% | Reduce -10.4% | 2,574,723 | $59.9M |
| Commodore Capital LP | 3.39% | No change | 1,988,084 | $46.3M |
| State Street Corp. | 0.00% | Add +9.0% | 1,680,936 | $39.1M |
| Wellington Management Group LLP | 0.01% | Add +6.5% | 1,604,508 | $37.4M |
| Paradigm Biocapital Advisors LP | 1.24% | Add +20.5% | 1,527,205 | $35.6M |
| Janus Henderson Group PLC | 0.02% | Add +30.0% | 1,456,740 | $33.9M |
| Jefferies Financial Group Inc. | 0.33% | Add +167.6% | 1,216,954 | $28.3M |
| Pictet Asset Management Holding SA | 0.03% | Add +32.3% | 1,092,124 | $25.4M |
| Citadel Advisors | 0.02% | Add +52.5% | 1,079,307 | $25.1M |
| Adage Capital Partners Gp, L.L.C. | 0.04% | Reduce -2.4% | 1,030,000 | $24.0M |
| Geode Capital Management, LLC | 0.00% | Add +8.4% | 966,129 | $22.5M |
| Affinity Asset Advisors, LLC | 3.26% | Add +65.4% | 824,328 | $19.2M |
| Franklin Resources Inc. | 0.01% | Reduce 0.0% | 760,642 | $17.7M |
| Polar Capital Holdings Plc | 0.10% | Add +50.0% | 750,000 | $17.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +341.5% | 747,552 | $17.4M |
| Emerald Advisers, LLC | 0.49% | Add +86.9% | 546,791 | $12.7M |
| T. Rowe Price Associates Inc. | 0.00% | Add +18.0% | 506,450 | $11.8M |
| Logos Global Management LP | 1.36% | Add +150.0% | 500,000 | $11.6M |
| Boxer Capital Management, LLC | 0.93% | — | 466,680 | $10.9M |
| Deerfield Management Company, L.P. | 0.22% | New | 450,000 | $10.5M |
| Blackstone Inc. | 0.05% | Add +53.3% | 449,201 | $10.5M |
| UBS Group AG | 0.00% | Add +578.1% | 392,197 | $9.1M |
| Emerald Mutual Fund Advisers Trust | 0.55% | Add +52.4% | 386,384 | $9.0M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +13.9% | 379,650 | $8.8M |
| Capital World Investors | 0.00% | New | 378,573 | $8.8M |
| Siren, L.L.C. | 0.38% | New | 374,000 | $8.7M |
| Woodline Partners LP | 0.06% | Add +33.5% | 352,680 | $8.2M |
| Northern Trust Corp. | 0.00% | Add +11.0% | 348,983 | $8.1M |
| Ikarian Capital, LLC | 1.88% | Reduce -6.7% | 282,159 | $6.6M |
| Victory Capital Management Inc. | 0.01% | New | 268,076 | $6.2M |
| Morgan Stanley | 0.00% | Add +4.7% | 255,256 | $5.9M |
| Soros Fund Management | 0.15% | Add +72.4% | 250,000 | $5.8M |
| Candriam S.C.A. | 0.03% | Add +135.8% | 247,591 | $5.8M |
| Deep Track Capital, LP | 0.19% | Reduce -78.1% | 219,015 | $5.1M |
| Armistice Capital, LLC | 0.11% | Add +47.1% | 200,000 | $4.7M |
| Millennium Management | 0.00% | New | 167,804 | $3.9M |
| Nuveen Asset Management, LLC | 0.00% | Add +0.3% | 125,668 | $2.9M |
| Barclays PLC | 0.00% | Add +16.7% | 123,071 | $2.9M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | — | 122,153 | $2.8M |
| Voloridge Investment Management, LLC | 0.01% | Reduce -26.2% | 115,470 | $2.7M |
| Schroder Investment Management Group | 0.00% | New | 113,620 | $2.6M |
| Bank of New York Mellon Corp | 0.00% | Reduce -1.1% | 103,688 | $2.4M |
| HighVista Strategies LLC | 0.82% | Reduce -9.7% | 95,159 | $2.2M |
| Boothbay Fund Management, LLC | 0.06% | Reduce -6.7% | 85,618 | $2.0M |
| EFG Asset Management (North America) Corp. | 0.26% | Add +58.6% | 82,818 | $1.9M |
| Ensign Peak Advisors, Inc | 0.00% | No change | 82,475 | $1.9M |
| Prosight Management, LP | 0.52% | New | 80,000 | $1.9M |
| Rafferty Asset Management, LLC | 0.01% | Add +8.7% | 76,740 | $1.8M |
| Citigroup Inc. | 0.00% | Add +192.8% | 73,752 | $1.7M |
| Swiss National Bank | 0.00% | Add +38.3% | 68,600 | $1.6M |
| TD Asset Management Inc | 0.00% | Add +23.1% | 64,968 | $1.5M |
| Rhumbline Advisers | 0.00% | Add +6.9% | 57,657 | $1.3M |
| Manufacturers Life Insurance Company, The | 0.00% | Add +21.4% | 52,762 | $1.2M |
| B Group, Inc. | 0.71% | — | 50,000 | $1.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +85.3% | 48,981 | $1.1M |
| F/m Investments LLC | 0.04% | New | 48,806 | $1.1M |
| Legal & General Group Plc | 0.00% | Add +28.6% | 37,490 | $873K |
| Alliancebernstein L.P. | 0.00% | No change | 36,230 | $843K |
| JPMorgan Chase & Co. | 0.00% | Add +19.6% | 35,248 | $821K |
| California State Teachers Retirement System | 0.00% | Add +32.1% | 32,598 | $759K |
| State of Wisconsin Investment Board | 0.00% | Add +71.9% | 31,484 | $733K |
| Deutsche Bank AG | 0.00% | Add +46.1% | 31,418 | $731K |
| Teachers Retirement System of the State of Kentucky | 0.01% | Add +22.0% | 25,799 | $601K |
| Wells Fargo & Company | 0.00% | Add +38.8% | 24,718 | $575K |
| First Trust Advisors LP | 0.00% | New | 23,550 | $548K |
| Susquehanna International Group, LLP | 0.00% | Add +74.9% | 23,089 | $538K |
| Assenagon Asset Management S.A. | 0.00% | Reduce -98.0% | 22,652 | $527K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +4.2% | 22,741 | $527K |
| MetLife Investment Management, LLC | 0.00% | Add +6.2% | 21,382 | $498K |
| Invesco Ltd. | 0.00% | Reduce -85.7% | 19,663 | $458K |
| Cinctive Capital Management LP | 0.02% | Reduce -68.1% | 19,567 | $456K |
| NBW Capital LLC | 0.08% | Reduce -27.9% | 19,430 | $452K |
| BNP Paribas Financial Markets | 0.00% | New | 18,784 | $437K |
| Global Endowment Management, LP | 0.05% | No change | 18,184 | $423K |
| Natixis Advisors, LLC | 0.00% | New | 17,300 | $403K |
| Corebridge Financial, Inc. | 0.00% | Reduce -7.0% | 17,213 | $401K |
| Brevan Howard Capital Management LP | 0.01% | New | 16,899 | $393K |
| ExodusPoint Capital Management, LP | 0.00% | Add +71.5% | 16,691 | $389K |
| Squarepoint Ops LLC | 0.00% | Add +79.7% | 15,231 | $355K |
| Profund Advisors LLC | 0.01% | Add +5.6% | 14,862 | $346K |
| Intech Investment Management LLC | 0.00% | Add +67.8% | 14,043 | $327K |
| ProShare Advisors LLC | 0.00% | New | 12,531 | $292K |
| China Universal Asset Management Co., Ltd. | 0.03% | New | 12,440 | $290K |
| Aquatic Capital Management LLC | 0.01% | New | 11,767 | $274K |
| Voya Investment Management LLC | 0.00% | Reduce -7.5% | 10,495 | $244K |
| Teacher Retirement System of Texas | 0.00% | New | 10,383 | $242K |
| New York State Common Retirement Fund | 0.00% | No change | 10,265 | $239K |
| Arizona State Retirement System | 0.00% | Add +38.4% | 10,115 | $235K |
| Two Sigma Investments, LP | 0.00% | Reduce -1.7% | 9,638 | $224K |
| Carlyle Group Inc. | 0.01% | No change | 9,620 | $224K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 9,030 | $210K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +1548.8% | 8,574 | $200K |
| KLP Kapitalforvaltning As | 0.00% | — | 7,800 | $182K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | — | 7,378 | $172K |
| Bank of America Corp. | 0.00% | Reduce -97.2% | 7,142 | $166K |
| Royal Bank of Canada | 0.00% | Add +6.2% | 4,022 | $94K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 3,392 | $79K |
| Virtus Advisers, LLC | 0.03% | Add +4.3% | 2,972 | $69K |
| AlphaQuest LLC | 0.01% | Reduce -61.1% | 2,198 | $51K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | New | 1,955 | $46K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 1,589 | $37K |
| Huntington National Bank | 0.00% | New | 1,470 | $34K |
| GF Fund Management Co. LTD. | 0.00% | — | 1,232 | $29K |
| Amalgamated Bank | 0.00% | No change | 1,198 | $28K |
| Sterling Capital Management LLC | 0.00% | Add +777.4% | 1,009 | $23K |
| R Squared Ltd | 0.02% | — | 710 | $17K |
| Venturi Wealth Management, LLC | 0.00% | New | 231 | $5K |
| Sugar Maple Asset Management, LLC | 0.00% | New | 180 | $4K |
| Brooklyn Investment Group | 0.00% | New | 120 | $3K |
| Nisa Investment Advisors, LLC | 0.00% | Add +8.1% | 120 | $3K |
| IFP Advisors, Inc | 0.00% | Reduce -4.4% | 109 | $3K |
| Osaic Holdings, Inc. | 0.00% | Add +26.5% | 105 | $2K |
| Signaturefd, LLC | 0.00% | New | 68 | $2K |
| Simplex Trading, LLC | 0.00% | New | 55 | $1K |
| Rothschild Investment LLC | 0.00% | No change | 40 | $931 |
| Amundi | 0.00% | New | 32 | $769 |
| Caitong International Asset Management Co., Ltd | 0.00% | — | 14 | $326 |
| Allworth Financial LP | 0.00% | Add +28.6% | 9 | $197 |
| EverSource Wealth Advisors, LLC | 0.00% | New | 8 | $186 |
| Pacific Capital Wealth Advisors, Inc. | 0.00% | No change | 8 | $186 |
| SBI Securities Co., Ltd. | 0.00% | — | 5 | $116 |
| Cwm, LLC | 0.00% | Reduce -96.5% | 8 | $0 |
| Covestor Ltd | 0.00% | Add +33.3% | 4 | $0 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.