Spyre TherapeuticsSYRE
13F holders, Q3 2025 (September 30)137holders +8
22new positions
13sold out
2famous investors
$16.76avg. 13F price*
At the end of Q3 2025, 137 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, up 8 from Q2 2025. 22 opened new positions and 13 sold out. The largest holders were FMR LLC ($151.8M), Fairmount Funds Management LLC ($67.3M) and BlackRock, Inc. ($66.8M). 2 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 22 | $37.3M |
| Exits | 13 | $18.3M |
All 13F filers, Q2 2025 → Q3 2025: 4,542,133 shares bought and 3,848,712 shares sold, net +693,421 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 137 holders
| FMR LLC | 0.01% | Add +0.1% | 9,060,144 | $151.8M |
| Fairmount Funds Management LLC | 6.06% | No change | 4,018,101 | $67.3M |
| BlackRock, Inc. | 0.00% | Reduce -0.6% | 3,982,744 | $66.8M |
| RTW Investments, LP | 0.75% | No change | 3,621,996 | $60.7M |
| Tang Capital Management LLC | 2.06% | No change | 3,200,000 | $53.6M |
| Vanguard Group Inc. | 0.00% | Reduce -0.5% | 3,050,730 | $51.1M |
| Venrock Adviser, LLC | 2.53% | No change | 2,685,448 | $45.0M |
| Braidwell LP | 1.75% | No change | 2,578,404 | $43.2M |
| Capital International Investors | 0.01% | No change | 2,392,541 | $40.1M |
| Driehaus Capital Management LLC | 0.25% | Reduce -1.2% | 2,060,375 | $34.5M |
| Commodore Capital LP | 1.63% | No change | 1,988,084 | $33.3M |
| State Street Corp. | 0.00% | Add +11.9% | 1,785,206 | $29.9M |
| Wellington Management Group LLP | 0.00% | Add +8.4% | 1,640,312 | $27.5M |
| Paradigm Biocapital Advisors LP | 0.73% | Reduce -21.6% | 1,467,266 | $24.6M |
| Affinity Asset Advisors, LLC | 2.28% | Add +133.9% | 1,419,299 | $23.8M |
| Jefferies Financial Group Inc. | 0.22% | No change | 1,388,854 | $23.3M |
| Perceptive Advisors LLC | 0.60% | Reduce -19.6% | 1,229,445 | $20.6M |
| Geode Capital Management, LLC | 0.00% | Reduce -0.2% | 1,225,153 | $20.5M |
| TCG Crossover Management, LLC | 0.91% | New | 1,100,582 | $18.4M |
| Pictet Asset Management Holding SA | 0.02% | Reduce -4.0% | 1,036,218 | $17.4M |
| Baker Bros. Advisors LP | 0.12% | Add +59.6% | 1,000,000 | $16.8M |
| Franklin Resources Inc. | 0.00% | No change | 795,275 | $13.3M |
| Polar Capital Holdings Plc | 0.06% | Add +5.9% | 788,788 | $13.2M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -33.3% | 620,620 | $10.4M |
| Deerfield Management Company, L.P. | 0.17% | No change | 613,665 | $10.3M |
| Emerald Advisers, LLC | 0.29% | Reduce -3.0% | 548,712 | $9.2M |
| Blackstone Inc. | 0.04% | Add +2.4% | 500,998 | $8.4M |
| Northern Trust Corp. | 0.00% | Add +1.2% | 442,036 | $7.4M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +1.6% | 425,345 | $7.1M |
| Millennium Management | 0.01% | New | 408,199 | $6.8M |
| Candriam S.C.A. | 0.04% | Add +64.3% | 404,362 | $6.8M |
| UBS Group AG | 0.00% | Reduce -16.7% | 385,589 | $6.5M |
| Siren, L.L.C. | 0.24% | No change | 368,598 | $6.2M |
| Bank of America Corp. | 0.00% | Reduce -13.0% | 344,803 | $5.8M |
| Morgan Stanley | 0.00% | Reduce -50.1% | 334,722 | $5.6M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -37.0% | 329,533 | $5.5M |
| Victory Capital Management Inc. | 0.00% | Reduce -7.9% | 326,081 | $5.5M |
| BNP Paribas Financial Markets | 0.00% | Add +41.5% | 315,909 | $5.3M |
| Emerald Mutual Fund Advisers Trust | 0.27% | Reduce -6.4% | 308,212 | $5.2M |
| JPMorgan Chase & Co. | 0.00% | Add +483.7% | 275,984 | $4.6M |
| Voloridge Investment Management, LLC | 0.01% | Reduce -5.2% | 264,317 | $4.4M |
| HighVista Strategies LLC | 0.89% | Add +91.3% | 215,746 | $3.6M |
| Parkman Healthcare Partners LLC | 0.37% | New | 200,753 | $3.4M |
| Capital World Investors | 0.00% | Reduce -42.9% | 200,172 | $3.4M |
| Barclays PLC | 0.00% | Reduce -22.3% | 168,330 | $2.8M |
| Armistice Capital, LLC | 0.08% | Reduce -9.3% | 156,000 | $2.6M |
| Bank of New York Mellon Corp | 0.00% | Add +2.9% | 135,960 | $2.3M |
| Woodline Partners LP | 0.01% | Reduce -71.7% | 131,876 | $2.2M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +1.1% | 110,456 | $1.9M |
| Mercer Global Advisors Inc. | 0.00% | Add +0.5% | 106,664 | $1.8M |
| Schroder Investment Management Group | 0.00% | Reduce -16.8% | 107,738 | $1.8M |
| B Group, Inc. | 1.67% | Add +25.0% | 100,000 | $1.7M |
| Nuveen, LLC | 0.00% | Reduce -28.8% | 96,172 | $1.6M |
| Jane Street Group, LLC | 0.00% | New | 96,057 | $1.6M |
| Dimensional Fund Advisors LP | 0.00% | New | 84,216 | $1.4M |
| Schonfeld Strategic Advisors LLC | 0.01% | New | 81,474 | $1.4M |
| TD Asset Management Inc | 0.00% | Reduce -36.5% | 72,368 | $1.2M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -9.9% | 71,948 | $1.2M |
| Rhumbline Advisers | 0.00% | Reduce -3.1% | 70,914 | $1.2M |
| Swiss National Bank | 0.00% | Add +2.3% | 70,200 | $1.2M |
| ExodusPoint Capital Management, LP | 0.02% | Reduce -17.4% | 68,563 | $1.1M |
| AlphaQuest LLC | 0.07% | Add +1485.1% | 66,163 | $1.1M |
| Opaleye Management Inc. | 0.15% | New | 65,000 | $1.1M |
| Rafferty Asset Management, LLC | 0.00% | Add +17.1% | 59,667 | $1.0M |
| F/m Investments LLC | 0.04% | Add +4.5% | 54,893 | $920K |
| Invesco Ltd. | 0.00% | Add +46.2% | 50,702 | $850K |
| Verition Fund Management LLC | 0.00% | Reduce -25.4% | 48,496 | $813K |
| Legal & General Group Plc | 0.00% | Add +34.0% | 46,841 | $785K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -53.9% | 39,498 | $662K |
| Wells Fargo & Company | 0.00% | Add +14.3% | 39,319 | $659K |
| Deutsche Bank AG | 0.00% | Add +13.6% | 38,543 | $646K |
| Alliancebernstein L.P. | 0.00% | No change | 36,230 | $607K |
| ADAR1 Capital Management, LLC | 0.06% | No change | 34,051 | $571K |
| State of Wisconsin Investment Board | 0.00% | Reduce -4.3% | 33,546 | $562K |
| California State Teachers Retirement System | 0.00% | Add +0.0% | 33,203 | $556K |
| Citigroup Inc. | 0.00% | Add +12.4% | 32,896 | $551K |
| DLD Asset Management, LP | 0.21% | New | 30,000 | $503K |
| MetLife Investment Management, LLC | 0.00% | No change | 29,918 | $501K |
| Jump Financial, LLC | 0.01% | New | 27,100 | $454K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -11.3% | 26,448 | $442K |
| Waverly Advisors, LLC | 0.00% | Add +33.4% | 25,953 | $435K |
| Teachers Retirement System of the State of Kentucky | 0.00% | No change | 25,799 | $432K |
| Optimize Financial Inc. | 0.22% | New | 24,967 | $418K |
| Assenagon Asset Management S.A. | 0.00% | No change | 22,136 | $371K |
| Susquehanna Portfolio Strategies, LLC | 0.01% | New | 21,739 | $364K |
| Intech Investment Management LLC | 0.00% | Reduce -18.4% | 20,360 | $341K |
| Squarepoint Ops LLC | 0.00% | Reduce -32.7% | 20,232 | $339K |
| Quadrature Capital Ltd | 0.00% | New | 19,366 | $325K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | New | 18,500 | $310K |
| Global Endowment Management, LP | 0.04% | No change | 18,184 | $305K |
| Los Angeles Capital Management LLC | 0.00% | New | 18,172 | $305K |
| AQR Capital Management | 0.00% | Reduce -5.2% | 17,047 | $286K |
| New York State Common Retirement Fund | 0.00% | No change | 16,565 | $278K |
| Dark Forest Capital Management LP | 0.01% | New | 14,733 | $247K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +19.8% | 13,809 | $231K |
| Profund Advisors LLC | 0.01% | Add +19.7% | 13,223 | $222K |
| Janus Henderson Group PLC | 0.00% | No change | 13,000 | $218K |
| DRW Securities, LLC | 0.01% | New | 11,475 | $190K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Reduce -15.5% | 10,874 | $182K |
| Arizona State Retirement System | 0.00% | Add +1.7% | 10,693 | $179K |
| ProShare Advisors LLC | 0.00% | Reduce -14.4% | 10,678 | $179K |
| China Universal Asset Management Co., Ltd. | 0.01% | Reduce -12.7% | 10,587 | $177K |
| Royal Bank of Canada | 0.00% | Reduce -7.0% | 7,883 | $132K |
| KLP Kapitalforvaltning As | 0.00% | No change | 7,800 | $131K |
| Virtus Investment Advisers, LLC | 0.03% | Add +21.0% | 6,425 | $108K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -20.3% | 4,596 | $77K |
| Russell Investments Group, Ltd. | 0.00% | Add +2881.7% | 4,234 | $71K |
| Ameritas Investment Partners, Inc. | 0.00% | Reduce -18.2% | 4,166 | $70K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +0.2% | 2,335 | $39K |
| Cwm, LLC | 0.00% | Add +14.5% | 1,960 | $33K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 1,589 | $27K |
| Huntington National Bank | 0.00% | No change | 1,470 | $25K |
| Amalgamated Bank | 0.00% | No change | 1,379 | $23K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -13.5% | 1,299 | $22K |
| Sterling Capital Management LLC | 0.00% | Add +131.7% | 1,214 | $20K |
| Nisa Investment Advisors, LLC | 0.00% | Add +29.1% | 705 | $12K |
| Optiver Holding B.V. | 0.00% | New | 500 | $8K |
| Rockefeller Capital Management L.P. | 0.00% | New | 401 | $7K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | Reduce -11.1% | 335 | $6K |
| SBI Securities Co., Ltd. | 0.00% | Add +1018.2% | 123 | $6K |
| Osaic Holdings, Inc. | 0.00% | Add +4.7% | 314 | $5K |
| Meeder Asset Management Inc. | 0.00% | Add +27.1% | 216 | $4K |
| GAMMA Investing LLC | 0.00% | Add +19.5% | 208 | $3K |
| Daiwa Securities Group Inc. | 0.00% | No change | 206 | $3K |
| Arax Advisory Partners | 0.00% | New | 121 | $2K |
| PNC Financial Services Group, Inc. | 0.00% | New | 86 | $1K |
| Rothschild Investment LLC | 0.00% | Reduce -42.9% | 80 | $1K |
| Signaturefd, LLC | 0.00% | Reduce -57.6% | 70 | $1K |
| EverSource Wealth Advisors, LLC | 0.00% | No change | 65 | $1K |
| Parkside Financial Bank & Trust | 0.00% | No change | 35 | $587 |
| Allworth Financial LP | 0.00% | Add +6.7% | 32 | $537 |
| IFP Advisors, Inc | 0.00% | Add +4.3% | 24 | $402 |
| Larson Financial Group LLC | 0.00% | Add +100.0% | 12 | $201 |
| US Bancorp \de | 0.00% | No change | 10 | $168 |
| Farther Finance Advisors, LLC | 0.00% | New | 10 | $168 |
| Comerica Bank | 0.00% | New | 5 | $84 |
| Covestor Ltd | 0.00% | No change | 6 | $0 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.