Spyre TherapeuticsSYRE
13F holders, Q4 2025 (December 31)153holders +16
27new positions
14sold out
5famous investors
$32.76avg. 13F price*
At the end of Q4 2025, 153 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, up 16 from Q3 2025. 27 opened new positions and 14 sold out. The largest holders were FMR LLC ($381.3M), BlackRock, Inc. ($180.9M) and RTW Investments, LP ($136.7M). 5 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 27 | $104.9M |
| Exits | 14 | $34.7M |
All 13F filers, Q3 2025 → Q4 2025: 21,296,590 shares bought and 6,098,562 shares sold, net +15,198,028 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 153 holders
| FMR LLC | 0.02% | Add +28.5% | 11,638,819 | $381.3M |
| BlackRock, Inc. | 0.00% | Add +38.6% | 5,522,101 | $180.9M |
| RTW Investments, LP | 1.37% | Add +15.2% | 4,171,996 | $136.7M |
| Vanguard Group Inc. | 0.00% | Add +32.3% | 4,035,074 | $132.2M |
| Fairmount Funds Management LLC | 10.02% | No change | 4,018,101 | $131.6M |
| Venrock Adviser, LLC | 5.96% | Add +37.2% | 3,685,448 | $120.7M |
| Capital International Investors | 0.02% | Add +46.0% | 3,492,541 | $114.4M |
| Perceptive Advisors LLC | 1.85% | Add +149.6% | 3,069,225 | $100.5M |
| Driehaus Capital Management LLC | 0.64% | Add +39.9% | 2,882,420 | $94.4M |
| Commodore Capital LP | 5.21% | Add +20.1% | 2,388,245 | $78.2M |
| State Street Corp. | 0.00% | Add +26.8% | 2,262,839 | $74.1M |
| TCG Crossover Management, LLC | 2.06% | Add +72.7% | 1,900,582 | $62.3M |
| Tang Capital Management LLC | 3.06% | Reduce -40.9% | 1,892,200 | $62.0M |
| Janus Henderson Group PLC | 0.03% | Add +13969.3% | 1,829,009 | $59.9M |
| Geode Capital Management, LLC | 0.00% | Add +35.4% | 1,659,140 | $54.4M |
| Braidwell LP | 2.05% | Reduce -36.6% | 1,634,615 | $53.5M |
| Ra Capital Management, L.P. | 0.54% | New | 1,621,620 | $53.1M |
| T. Rowe Price Associates Inc. | 0.01% | Add +158.1% | 1,601,882 | $52.5M |
| Wellington Management Group LLP | 0.01% | Reduce -5.5% | 1,549,284 | $50.8M |
| Paradigm Biocapital Advisors LP | 1.29% | No change | 1,467,266 | $48.1M |
| Remedium Capital Partners, LLC | 28.03% | — | 1,456,231 | $47.7M |
| Affinity Asset Advisors, LLC | 3.48% | Add +0.9% | 1,432,591 | $46.9M |
| Franklin Resources Inc. | 0.01% | Add +39.5% | 1,109,274 | $36.3M |
| Baker Bros. Advisors LP | 0.19% | No change | 1,000,000 | $32.8M |
| Pictet Asset Management Holding SA | 0.03% | Reduce -11.8% | 913,960 | $29.9M |
| Siren, L.L.C. | 0.80% | Add +122.1% | 818,598 | $26.8M |
| Polar Capital Holdings Plc | 0.11% | Reduce -6.1% | 740,326 | $24.3M |
| Deerfield Management Company, L.P. | 0.34% | Add +15.8% | 710,626 | $23.3M |
| UBS Group AG | 0.00% | Add +76.5% | 680,566 | $22.3M |
| Point72 Asset Management | 0.04% | New | 662,351 | $21.7M |
| Emerald Advisers, LLC | 0.64% | Add +15.9% | 636,109 | $20.8M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +35.1% | 574,622 | $18.8M |
| Northern Trust Corp. | 0.00% | Add +26.9% | 561,023 | $18.4M |
| Blackstone Inc. | 0.07% | No change | 500,998 | $16.4M |
| Candriam S.C.A. | 0.07% | Add +5.2% | 425,534 | $13.9M |
| Bank of America Corp. | 0.00% | Add +21.7% | 419,727 | $13.8M |
| Emerald Mutual Fund Advisers Trust | 0.66% | Add +33.8% | 412,371 | $13.5M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -16.5% | 275,065 | $9.0M |
| Woodline Partners LP | 0.03% | Add +101.6% | 265,892 | $8.7M |
| Capital World Investors | 0.00% | No change | 200,172 | $6.6M |
| Armistice Capital, LLC | 0.16% | Add +25.9% | 196,426 | $6.4M |
| Bank of New York Mellon Corp | 0.00% | Add +41.8% | 192,830 | $6.3M |
| HighVista Strategies LLC | 1.59% | Reduce -12.8% | 188,206 | $6.2M |
| Silverarc Capital Management, LLC | 0.89% | New | 187,737 | $6.2M |
| Morgan Stanley | 0.00% | Reduce -45.4% | 182,734 | $6.0M |
| Barclays PLC | 0.00% | Add +8.4% | 182,524 | $6.0M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Add +55.0% | 171,211 | $5.6M |
| Nuveen, LLC | 0.00% | Add +57.0% | 150,980 | $4.9M |
| Invesco Ltd. | 0.00% | Add +197.7% | 150,934 | $4.9M |
| Patient Square Capital LP | 1.05% | New | 150,000 | $4.9M |
| TD Asset Management Inc | 0.00% | Add +107.0% | 149,822 | $4.9M |
| Victory Capital Management Inc. | 0.00% | Reduce -55.2% | 146,079 | $4.8M |
| Manufacturers Life Insurance Company, The | 0.00% | Add +79.3% | 129,013 | $4.1M |
| Parkman Healthcare Partners LLC | 0.39% | Reduce -38.0% | 124,485 | $4.1M |
| Deutsche Bank AG | 0.00% | Add +216.4% | 121,941 | $4.0M |
| Mercer Global Advisors Inc. | 0.01% | Reduce -0.3% | 106,316 | $3.5M |
| F/m Investments LLC | 0.13% | Add +89.0% | 103,718 | $3.4M |
| Citigroup Inc. | 0.00% | Add +204.2% | 100,058 | $3.3M |
| B Group, Inc. | 2.43% | No change | 100,000 | $3.3M |
| Seven Grand Managers, LLC | 0.25% | New | 100,000 | $3.3M |
| Swiss National Bank | 0.00% | Add +37.5% | 96,500 | $3.2M |
| Rhumbline Advisers | 0.00% | Add +17.0% | 82,956 | $2.7M |
| Wells Fargo & Company | 0.00% | Add +109.6% | 82,416 | $2.7M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -8.2% | 77,290 | $2.5M |
| Millennium Management | 0.00% | Reduce -81.3% | 76,194 | $2.5M |
| Balyasny Asset Management L.P. | 0.00% | New | 73,465 | $2.4M |
| Alliancebernstein L.P. | 0.00% | Add +86.3% | 67,500 | $2.2M |
| Citadel Advisors | 0.00% | New | 63,904 | $2.1M |
| Alps Advisors Inc. | 0.01% | New | 63,708 | $2.1M |
| JPMorgan Chase & Co. | 0.00% | Reduce -77.2% | 62,951 | $2.1M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +57.5% | 62,216 | $2.0M |
| Schroder Investment Management Group | 0.00% | Reduce -42.9% | 61,574 | $2.0M |
| Legal & General Group Plc | 0.00% | Add +20.5% | 56,448 | $1.8M |
| Rafferty Asset Management, LLC | 0.01% | Reduce -10.5% | 53,410 | $1.7M |
| Susquehanna Portfolio Strategies, LLC | 0.03% | Add +144.3% | 53,101 | $1.7M |
| California State Teachers Retirement System | 0.00% | Add +44.7% | 48,038 | $1.6M |
| Ameriprise Financial Inc. | 0.00% | New | 38,256 | $1.3M |
| MetLife Investment Management, LLC | 0.01% | Add +27.1% | 38,011 | $1.2M |
| ExodusPoint Capital Management, LP | 0.01% | Reduce -44.8% | 37,871 | $1.2M |
| Cinctive Capital Management LP | 0.07% | New | 35,935 | $1.2M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +32.9% | 35,144 | $1.1M |
| ADAR1 Capital Management, LLC | 0.08% | No change | 34,051 | $1.1M |
| Stempoint Capital LP | 0.18% | New | 32,377 | $1.1M |
| Voya Investment Management LLC | 0.00% | New | 27,277 | $894K |
| State of Wisconsin Investment Board | 0.00% | Reduce -18.8% | 27,252 | $893K |
| Waverly Advisors, LLC | 0.01% | Add +0.0% | 25,954 | $850K |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 25,799 | $845K |
| Optimize Financial Inc. | 0.42% | Add +1.5% | 25,331 | $830K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | Add +34.9% | 24,950 | $817K |
| SG Americas Securities, LLC | 0.00% | New | 23,343 | $765K |
| Assenagon Asset Management S.A. | 0.00% | No change | 22,136 | $725K |
| Profund Advisors LLC | 0.02% | Add +55.7% | 20,593 | $675K |
| New York State Common Retirement Fund | 0.00% | Add +15.7% | 19,165 | $628K |
| Police & Firemen's Retirement System of New Jersey | 0.01% | Add +33.0% | 18,360 | $601K |
| Intech Investment Management LLC | 0.01% | Reduce -10.3% | 18,274 | $599K |
| Neo Ivy Capital Management | 0.09% | New | 18,261 | $598K |
| Global Endowment Management, LP | 0.07% | No change | 18,184 | $596K |
| AQR Capital Management | 0.00% | Add +4.5% | 17,820 | $584K |
| State of New Jersey Common Pension Fund D | 0.00% | New | 16,698 | $547K |
| ProShare Advisors LLC | 0.00% | Add +49.7% | 15,989 | $524K |
| PSP Research LLC | 0.45% | — | 15,840 | $519K |
| Arizona State Retirement System | 0.00% | Add +29.0% | 13,797 | $452K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0.07% | New | 13,724 | $450K |
| China Universal Asset Management Co., Ltd. | 0.03% | Add +19.4% | 12,644 | $414K |
| BNP Paribas Financial Markets | 0.00% | Reduce -96.3% | 11,844 | $388K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +2.7% | 11,164 | $366K |
| KLP Kapitalforvaltning As | 0.00% | Add +33.3% | 10,400 | $341K |
| Tudor Investment Corporation | 0.00% | New | 10,127 | $332K |
| Carlyle Group Inc. | 0.00% | New | 9,620 | $315K |
| Los Angeles Capital Management LLC | 0.00% | Reduce -29.1% | 12,882 | $313K |
| State Board of Administration of Florida Retirement System | 0.00% | New | 9,030 | $296K |
| Caxton Corp. | 6.83% | New | 8,919 | $292K |
| VARCOV Co. | 0.10% | — | 8,008 | $262K |
| Virtus Investment Advisers, LLC | 0.07% | Add +23.2% | 7,913 | $259K |
| Teacher Retirement System of Texas | 0.00% | New | 7,173 | $235K |
| Martingale Asset Management L P | 0.01% | New | 6,930 | $227K |
| Brevan Howard Capital Management LP | 0.00% | New | 6,198 | $203K |
| Sei Investments Co. | 0.00% | New | 6,117 | $200K |
| Susquehanna International Group, LLP | 0.00% | New | 6,111 | $200K |
| Ameritas Investment Partners, Inc. | 0.01% | Add +34.3% | 5,593 | $183K |
| Russell Investments Group, Ltd. | 0.00% | Add +31.2% | 5,554 | $182K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +61.5% | 3,770 | $124K |
| AlphaQuest LLC | 0.01% | Reduce -94.7% | 3,538 | $116K |
| Persistent Asset Partners Ltd | 0.04% | New | 2,246 | $74K |
| Amalgamated Bank | 0.00% | Add +57.0% | 2,165 | $71K |
| Cwm, LLC | 0.00% | Add +0.5% | 1,970 | $65K |
| Royal Bank of Canada | 0.00% | Reduce -74.8% | 1,988 | $65K |
| Sterling Capital Management LLC | 0.00% | Add +32.6% | 1,610 | $53K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 1,589 | $52K |
| GF Fund Management Co. LTD. | 0.00% | Add +17.2% | 1,523 | $50K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 705 | $23K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | Add +95.8% | 656 | $21K |
| Rockefeller Capital Management L.P. | 0.00% | Add +36.9% | 549 | $18K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -90.8% | 425 | $14K |
| Group One Trading LLC | 0.00% | New | 400 | $13K |
| Osaic Holdings, Inc. | 0.00% | Add +16.9% | 367 | $12K |
| GAMMA Investing LLC | 0.00% | Add +58.6% | 330 | $11K |
| Daiwa Securities Group Inc. | 0.00% | Add +25.2% | 258 | $8K |
| Optiver Holding B.V. | 0.00% | Reduce -52.0% | 240 | $8K |
| Meeder Asset Management Inc. | 0.00% | Reduce -16.2% | 181 | $6K |
| Larson Financial Group LLC | 0.00% | Add +1100.0% | 144 | $5K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 86 | $3K |
| Rothschild Investment LLC | 0.00% | Add +2.5% | 82 | $3K |
| Signaturefd, LLC | 0.00% | No change | 70 | $2K |
| EverSource Wealth Advisors, LLC | 0.00% | No change | 65 | $2K |
| Allworth Financial LP | 0.00% | Add +81.3% | 58 | $2K |
| Farther Finance Advisors, LLC | 0.00% | Add +270.0% | 37 | $1K |
| Parkside Financial Bank & Trust | 0.00% | No change | 35 | $1K |
| IFP Advisors, Inc | 0.00% | No change | 24 | $786 |
| US Bancorp \de | 0.00% | No change | 10 | $328 |
| Comerica Bank | 0.00% | No change | 5 | $164 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -95.9% | 5 | $164 |
| Covestor Ltd | 0.00% | No change | 6 | $0 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.