Xeris Biopharma HoldingsXERS
13F holders, Q3 2025 (September 30)230holders +30
58new positions
26sold out
7famous investors
$8.14avg. 13F price*
At the end of Q3 2025, 230 institutions reported holding Xeris Biopharma Holdings Inc. (XERS) in their 13F filings, up 30 from Q2 2025. 58 opened new positions and 26 sold out. The largest holders were BlackRock, Inc. ($97.1M), Vanguard Group Inc. ($80.0M) and D. E. Shaw & Co. ($47.5M). 7 famous investors held it, including David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Xeris Biopharma Holdings Inc.
- CUSIP
- 98422E103
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 58 | $35.1M |
| Exits | 26 | $11.8M |
All 13F filers, Q2 2025 → Q3 2025: 17,912,366 shares bought and 10,920,743 shares sold, net +6,991,623 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 230 holders
| BlackRock, Inc. | 0.00% | Add +3.4% | 11,927,699 | $97.1M |
| Vanguard Group Inc. | 0.00% | Add +0.1% | 9,827,917 | $80.0M |
| D. E. Shaw & Co. | 0.04% | Add +52.3% | 5,839,886 | $47.5M |
| Geode Capital Management, LLC | 0.00% | Add +13.4% | 4,140,174 | $33.7M |
| State Street Corp. | 0.00% | Reduce -1.2% | 3,738,329 | $30.4M |
| Qube Research & Technologies Ltd | 0.04% | Add +6.0% | 3,274,834 | $26.7M |
| Morgan Stanley | 0.00% | Reduce -11.6% | 3,219,701 | $26.2M |
| Nuveen, LLC | 0.01% | Add +8.8% | 2,827,874 | $23.0M |
| Driehaus Capital Management LLC | 0.15% | Add +26.5% | 2,619,129 | $21.3M |
| Rosalind Advisors, Inc. | 5.17% | Reduce -16.7% | 1,795,766 | $14.6M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -21.0% | 1,795,455 | $14.6M |
| Parkman Healthcare Partners LLC | 1.60% | Reduce -15.0% | 1,791,674 | $14.6M |
| UBS Group AG | 0.00% | Add +682.4% | 1,782,734 | $14.5M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.04% | Add +38.3% | 1,698,757 | $13.8M |
| Renaissance Technologies | 0.02% | Reduce -21.0% | 1,622,840 | $13.2M |
| Two Sigma Investments, LP | 0.02% | Add +32.9% | 1,614,579 | $13.1M |
| Bank of America Corp. | 0.00% | Reduce -4.1% | 1,594,866 | $13.0M |
| Deutsche Bank AG | 0.00% | Add +112.7% | 1,567,645 | $12.8M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +154.9% | 1,446,619 | $11.8M |
| Prudential Financial Inc. | 0.01% | Reduce -7.9% | 1,434,204 | $11.7M |
| Northern Trust Corp. | 0.00% | Add +5.4% | 1,363,129 | $11.1M |
| Legal & General Group Plc | 0.00% | Reduce -24.8% | 1,357,427 | $11.0M |
| Kennedy Capital Management LLC | 0.22% | Add +48.5% | 1,211,583 | $9.9M |
| Voloridge Investment Management, LLC | 0.03% | Add +4.0% | 1,034,553 | $8.4M |
| Knott David M Jr | 3.46% | Reduce -4.3% | 1,015,000 | $8.3M |
| AQR Capital Management | 0.01% | Reduce -6.2% | 983,600 | $8.0M |
| Acadian Asset Management LLC | 0.01% | Add +140.3% | 921,103 | $7.5M |
| Jane Street Group, LLC | 0.01% | Add +2832.0% | 913,758 | $7.4M |
| JPMorgan Chase & Co. | 0.00% | Reduce -12.3% | 905,076 | $7.4M |
| Two Sigma Advisers, LP | 0.01% | Reduce -15.5% | 893,242 | $7.3M |
| Essex Investment Management Co. LLC | 0.93% | Add +3.3% | 750,034 | $6.1M |
| Federated Hermes, Inc. | 0.01% | Add +1.9% | 704,383 | $5.7M |
| CenterBook Partners LP | 0.28% | Reduce -56.2% | 698,204 | $5.7M |
| Squarepoint Ops LLC | 0.01% | Add +138.6% | 679,081 | $5.5M |
| Walleye Capital LLC | 0.05% | Add +156.5% | 623,962 | $5.1M |
| Jump Financial, LLC | 0.07% | Reduce -20.3% | 603,244 | $4.9M |
| Informed Momentum Co LLC | 0.56% | Add +2.8% | 603,101 | $4.9M |
| Invesco Ltd. | 0.00% | Add +576.5% | 583,108 | $4.7M |
| BNP Paribas Financial Markets | 0.00% | Add +3466.6% | 581,719 | $4.7M |
| Wellington Management Group LLP | 0.00% | Add +45.5% | 580,962 | $4.7M |
| Millennium Management | 0.00% | Reduce -82.1% | 524,749 | $4.3M |
| Redmile Group, LLC | 0.36% | No change | 451,099 | $3.7M |
| Bank of New York Mellon Corp | 0.00% | Add +16.6% | 439,838 | $3.6M |
| Citadel Advisors | 0.00% | New | 437,612 | $3.6M |
| Divisadero Street Capital Management, LP | 0.15% | New | 406,334 | $3.3M |
| Voya Investment Management LLC | 0.00% | Add +866.6% | 400,079 | $3.3M |
| Canada Pension Plan Investment Board | 0.00% | New | 375,700 | $3.1M |
| FMR LLC | 0.00% | Add +10.3% | 360,178 | $2.9M |
| State of Wisconsin Investment Board | 0.01% | Add +26.1% | 350,529 | $2.9M |
| Granahan Investment Management, LLC | 0.12% | New | 350,168 | $2.9M |
| Barclays PLC | 0.00% | Reduce -18.3% | 346,639 | $2.8M |
| Harvest Investment Services, LLC | 0.53% | Add +190.8% | 325,555 | $2.7M |
| Swiss National Bank | 0.00% | New | 310,400 | $2.5M |
| Schonfeld Strategic Advisors LLC | 0.02% | Reduce -21.7% | 304,504 | $2.5M |
| Caxton Associates LLP | 0.06% | New | 281,337 | $2.3M |
| IHT Wealth Management, LLC | 0.05% | Reduce -2.1% | 258,175 | $2.1M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.00% | Add +0.8% | 254,000 | $2.1M |
| Russell Investments Group, Ltd. | 0.00% | Add +104.1% | 251,378 | $2.0M |
| Trexquant Investment LP | 0.02% | New | 229,420 | $1.9M |
| Legato Capital Management LLC | 0.19% | No change | 216,805 | $1.8M |
| Rhumbline Advisers | 0.00% | Reduce -0.9% | 213,744 | $1.7M |
| Raymond James Financial Inc. | 0.00% | Reduce -1.9% | 205,213 | $1.7M |
| Commonwealth Equity Services, LLC | 0.00% | No change | 197,743 | $1.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +387.7% | 183,459 | $1.5M |
| T. Rowe Price Associates Inc. | 0.00% | Add +8.8% | 166,788 | $1.4M |
| Algert Global LLC | 0.02% | New | 157,960 | $1.3M |
| Ameriprise Financial Inc. | 0.00% | Add +3.5% | 154,168 | $1.3M |
| Mackenzie Financial Corp. | 0.00% | Add +10.2% | 152,161 | $1.2M |
| California State Teachers Retirement System | 0.00% | Add +1394.8% | 151,886 | $1.2M |
| Alliancebernstein L.P. | 0.00% | No change | 144,830 | $1.2M |
| Calamos Advisors LLC | 0.01% | New | 137,097 | $1.1M |
| Dark Forest Capital Management LP | 0.04% | New | 136,731 | $1.1M |
| Polen Capital Management LLC | 0.00% | Add +0.1% | 133,191 | $1.1M |
| Brevan Howard Capital Management LP | 0.02% | Reduce -35.5% | 132,160 | $1.1M |
| Inspire Investing, LLC | 0.10% | New | 128,494 | $1.0M |
| Creative Planning | 0.00% | Add +7.8% | 126,980 | $1.0M |
| Globeflex Capital L P | 0.15% | Add +53.1% | 123,184 | $1.0M |
| Sei Investments Co. | 0.00% | Add +4.0% | 121,176 | $986K |
| Deerfield Management Company, L.P. | 0.02% | Add +435.6% | 120,900 | $984K |
| Roundview Capital LLC | 0.06% | No change | 120,000 | $977K |
| Engineers Gate Manager LP | 0.01% | Add +189.2% | 109,994 | $895K |
| Franklin Resources Inc. | 0.00% | Add +5.7% | 109,142 | $888K |
| Fred Alger Management, LLC | 0.00% | New | 108,936 | $887K |
| Ieq Capital, LLC | 0.00% | Reduce -0.5% | 107,953 | $879K |
| Principal Financial Group Inc. | 0.00% | Reduce -31.5% | 105,493 | $859K |
| Campbell & CO Investment Adviser LLC | 0.06% | Reduce -21.7% | 103,616 | $843K |
| Thompson Siegel & Walmsley LLC | 0.01% | Reduce -62.1% | 100,884 | $821K |
| Wells Fargo & Company | 0.00% | Add +20.9% | 97,196 | $791K |
| WINTON GROUP Ltd | 0.03% | New | 90,793 | $739K |
| ExodusPoint Capital Management, LP | 0.01% | New | 86,920 | $708K |
| SG Americas Securities, LLC | 0.00% | Add +331.3% | 83,214 | $677K |
| Aquatic Capital Management LLC | 0.01% | New | 83,000 | $676K |
| Quarry LP | 0.18% | Reduce -49.2% | 82,500 | $672K |
| Y-Intercept (Hong Kong) Ltd | 0.02% | Reduce -75.6% | 82,181 | $669K |
| Susquehanna International Group, LLP | 0.00% | Reduce -79.9% | 81,471 | $663K |
| Orbimed Advisors LLC | 0.02% | No change | 80,420 | $655K |
| Diadema Partners LP | 0.42% | New | 74,753 | $608K |
| HRT Financial LP | 0.00% | New | 72,543 | $590K |
| Round Rock Advisors LLC | 0.09% | New | 63,772 | $582K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -13.2% | 71,331 | $581K |
"% of holder's portfolio" is XERS's weight in each manager's 13F, not the share of Xeris Biopharma Holdings Inc. the manager owns.