ZymeworksZYME
13F holders, Q1 2026 (March 31)212holders +2
34new positions
34sold out
5famous investors
$25.04avg. 13F price*
At the end of Q1 2026, 212 institutions reported holding Zymeworks Inc. (ZYME) in their 13F filings, up 2 from Q4 2025. 34 opened new positions and 34 sold out. The largest holders were EcoR1 Capital, LLC ($575.2M), Rubric Capital Management LP ($175.3M) and BlackRock, Inc. ($114.0M). 5 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Zymeworks Inc.
- CUSIP
- 98985Y108
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 34 | $46.3M |
| Exits | 34 | $139.3M |
All 13F filers, Q4 2025 → Q1 2026: 6,264,583 shares bought and 7,398,077 shares sold, net −1,133,494 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 212 holders
| EcoR1 Capital, LLC | 24.58% | No change | 22,970,388 | $575.2M |
| Rubric Capital Management LP | 2.15% | Add +21.7% | 7,000,000 | $175.3M |
| BlackRock, Inc. | 0.00% | Reduce -0.9% | 4,553,888 | $114.0M |
| BVF Inc. | 2.98% | Reduce -5.2% | 3,734,142 | $93.5M |
| Perceptive Advisors LLC | 1.74% | Add +7.6% | 3,510,078 | $87.9M |
| Morgan Stanley | 0.00% | Reduce -4.3% | 2,480,568 | $62.1M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.06% | Add +4.7% | 1,908,039 | $47.8M |
| Vanguard Capital Management LLC | 0.00% | — | 1,705,580 | $42.7M |
| Citadel Advisors | 0.02% | Add +350.4% | 1,150,018 | $28.8M |
| Dimensional Fund Advisors LP | 0.01% | Reduce -1.7% | 1,139,135 | $28.5M |
| Nextech Invest Ltd. | 1.96% | No change | 1,113,946 | $27.9M |
| State Street Corp. | 0.00% | Reduce -2.5% | 1,011,777 | $25.3M |
| Capricorn Fund Managers Ltd | 3.93% | Reduce -1.5% | 1,007,210 | $25.2M |
| Deutsche Bank AG | 0.01% | Reduce -42.3% | 921,250 | $23.1M |
| Arrowstreet Capital, Limited Partnership | 0.01% | Add +6.3% | 743,898 | $18.6M |
| Assenagon Asset Management S.A. | 0.03% | Add +12.4% | 727,986 | $18.2M |
| FMR LLC | 0.00% | Add +19.1% | 667,153 | $16.7M |
| Geode Capital Management, LLC | 0.00% | Add +1.9% | 659,940 | $16.5M |
| Nuveen, LLC | 0.00% | Add +0.5% | 651,662 | $16.3M |
| Goldman Sachs Group Inc. | 0.00% | Add +42.7% | 599,486 | $15.0M |
| MPM Bioimpact LLC | 1.09% | New | 565,249 | $14.2M |
| Prosight Management, LP | 2.21% | Add +1.6% | 539,049 | $13.5M |
| Qube Research & Technologies Ltd | 0.02% | Add +7.9% | 511,937 | $12.8M |
| Vanguard Portfolio Management LLC | 0.00% | — | 499,875 | $12.5M |
| Redmile Group, LLC | 0.82% | No change | 491,654 | $12.3M |
| Hillsdale Investment Management Inc. | 0.24% | Add +45.3% | 345,622 | $8.7M |
| SummitTX Capital, L.P. | 0.26% | Add +43.3% | 321,427 | $8.0M |
| Northern Trust Corp. | 0.00% | Add +4.0% | 320,210 | $8.0M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -0.3% | 319,385 | $8.0M |
| Royce & Associates LP | 0.07% | New | 299,202 | $7.5M |
| Picton Mahoney Asset Management | 0.07% | Add +4.9% | 256,690 | $6.4M |
| Granahan Investment Management, LLC | 0.30% | Add +11.8% | 250,773 | $6.3M |
| HRT Financial LP | 0.01% | Add +96.5% | 237,889 | $6.0M |
| Bank of America Corp. | 0.00% | Add +164.5% | 236,754 | $5.9M |
| D. E. Shaw & Co. | 0.01% | Add +5.3% | 235,621 | $5.9M |
| Jane Street Group, LLC | 0.01% | Add +222.2% | 226,967 | $5.7M |
| Panagora Asset Management Inc. | 0.02% | Add +164.1% | 206,854 | $5.2M |
| Man Group plc | 0.01% | Add +152.1% | 189,890 | $4.8M |
| Wells Fargo & Company | 0.00% | Reduce -9.0% | 189,636 | $4.7M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -16.2% | 185,124 | $4.6M |
| Federated Hermes, Inc. | 0.01% | Add +19.5% | 182,410 | $4.6M |
| Raymond James Financial Inc. | 0.00% | Reduce -6.0% | 176,411 | $4.4M |
| UBS Group AG | 0.00% | Reduce -38.4% | 171,779 | $4.3M |
| Silvercrest Asset Management Group LLC | 0.03% | Reduce -10.0% | 163,649 | $4.1M |
| Kennedy Capital Management LLC | 0.08% | Add +1.9% | 148,226 | $3.7M |
| XTX Topco Ltd | 0.06% | Add +53.9% | 143,882 | $3.6M |
| Diadema Partners LP | 1.47% | New | 142,132 | $3.6M |
| Wellington Management Group LLP | 0.00% | Reduce -23.7% | 138,690 | $3.5M |
| Invesco Ltd. | 0.00% | Reduce -51.2% | 125,630 | $3.1M |
| Bank of New York Mellon Corp | 0.00% | Reduce -3.1% | 124,105 | $3.1M |
| Citigroup Inc. | 0.00% | Add +2.8% | 114,327 | $2.9M |
| JPMorgan Chase & Co. | 0.00% | Add +225.8% | 114,072 | $2.8M |
| Platinum Investment Management Ltd. | 0.66% | No change | 105,184 | $2.6M |
| Tema ETFs LLC | 0.18% | Add +38.1% | 104,931 | $2.6M |
| Tidal Investments LLC | 0.01% | New | 104,931 | $2.6M |
| Fisher Asset Management | 0.00% | Add +48.7% | 101,439 | $2.5M |
| Susquehanna Portfolio Strategies, LLC | 0.04% | No change | 99,795 | $2.5M |
| AQR Capital Management | 0.00% | Reduce -0.5% | 90,669 | $2.3M |
| Kornitzer Capital Management Inc. | 0.05% | No change | 88,800 | $2.2M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 84,403 | $2.1M |
| Squarepoint Ops LLC | 0.00% | New | 83,146 | $2.1M |
| Mackenzie Financial Corp. | 0.00% | Add +82.0% | 82,726 | $2.1M |
| Verdad Advisers, LP | 2.33% | New | 82,698 | $2.1M |
| Principal Financial Group Inc. | 0.00% | New | 78,547 | $2.0M |
| Franklin Resources Inc. | 0.00% | Add +31.6% | 77,659 | $1.9M |
| Stifel Financial Corp. | 0.00% | Add +1.2% | 76,756 | $1.9M |
| Rhumbline Advisers | 0.00% | Reduce -0.1% | 75,399 | $1.9M |
| Credit Agricole S A | 0.01% | No change | 75,000 | $1.9M |
| Ameriprise Financial Inc. | 0.00% | Reduce -34.4% | 74,222 | $1.9M |
| Swiss National Bank | 0.00% | No change | 74,200 | $1.9M |
| American Century Companies Inc. | 0.00% | Add +20.4% | 70,851 | $1.8M |
| State of Wisconsin Investment Board | 0.00% | Reduce -12.5% | 66,106 | $1.7M |
| Alliancebernstein L.P. | 0.00% | Add +11.7% | 55,896 | $1.5M |
| Dana Investment Advisors, Inc. | 0.04% | Add +16.1% | 56,107 | $1.4M |
| Campbell & CO Investment Adviser LLC | 0.08% | Add +63.4% | 54,883 | $1.4M |
| Russell Investments Group, Ltd. | 0.00% | Reduce -18.7% | 47,450 | $1.2M |
| Royal Bank of Canada | 0.00% | Reduce -14.0% | 47,360 | $1.2M |
| Segall Bryant & Hamill, LLC | 0.02% | New | 45,726 | $1.1M |
| North Growth Management Ltd. | 0.17% | Add +2.2% | 46,000 | $1.1M |
| Jacobs Levy Equity Management, Inc. | 0.00% | New | 42,786 | $1.1M |
| Victory Capital Management Inc. | 0.00% | Reduce -1.2% | 42,404 | $1.1M |
| Envestnet Asset Management Inc. | 0.00% | Reduce -1.0% | 40,419 | $1.0M |
| Manatuck Hill Partners, LLC | 0.33% | New | 40,000 | $1.0M |
| Los Angeles Capital Management LLC | 0.00% | Add +10171.3% | 39,750 | $995K |
| Quantinno Capital Management LP | 0.00% | Add +37.2% | 39,640 | $993K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +92.7% | 39,355 | $985K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | New | 37,919 | $949K |
| HSBC Holdings PLC | 0.00% | Add +111.4% | 37,777 | $940K |
| California State Teachers Retirement System | 0.00% | Reduce -1.0% | 37,389 | $936K |
| O'shaughnessy Asset Management, LLC | 0.00% | Reduce -13.8% | 37,129 | $930K |
| Tudor Investment Corporation | 0.01% | Add +21.6% | 36,875 | $923K |
| HighTower Advisors, LLC | 0.00% | New | 36,262 | $908K |
| Persistent Asset Partners Ltd | 0.35% | Add +389.2% | 35,935 | $900K |
| T. Rowe Price Associates Inc. | 0.00% | Add +23.3% | 35,487 | $889K |
| HighVista Strategies LLC | 0.24% | New | 34,085 | $853K |
| Vinva Investment Management Ltd | 0.01% | Add +97.2% | 24,090 | $851K |
| Martingale Asset Management L P | 0.02% | New | 32,764 | $820K |
| Creative Planning | 0.00% | Add +14.5% | 32,394 | $811K |
| Marshall Wace, LLP | 0.00% | New | 32,223 | $807K |
| Manufacturers Life Insurance Company, The | 0.00% | Add +81.2% | 31,592 | $791K |
| Engineers Gate Manager LP | 0.01% | New | 31,548 | $790K |
| SBI Okasan Asset Management Co.Ltd. | 0.03% | No change | 32,000 | $775K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Reduce -7.3% | 30,432 | $762K |
| STRS Ohio | 0.00% | Add +13.2% | 30,100 | $754K |
| MetLife Investment Management, LLC | 0.00% | Add +3.6% | 29,653 | $743K |
| Journey Strategic Wealth LLC | 0.02% | No change | 29,050 | $727K |
| BNP Paribas Financial Markets | 0.00% | Add +20.7% | 28,119 | $704K |
| Oxford Asset Management LLP | 0.28% | New | 27,812 | $696K |
| Schroder Investment Management Group | 0.00% | Reduce -71.0% | 28,349 | $686K |
| ExodusPoint Capital Management, LP | 0.01% | New | 27,374 | $685K |
| Massachusetts Financial Services Co. | 0.00% | Reduce -2.6% | 27,354 | $685K |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | — | 26,279 | $658K |
| Legal & General Group Plc | 0.00% | Reduce -18.5% | 26,209 | $656K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -0.3% | 26,031 | $652K |
| Susquehanna International Group, LLP | 0.00% | Reduce -86.1% | 24,421 | $612K |
| Ritholtz Wealth Management | 0.01% | Reduce -0.4% | 24,243 | $607K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +1.1% | 23,373 | $585K |
| Headlands Technologies LLC | 0.07% | New | 22,845 | $572K |
| Duncan Williams Asset Management, LLC | 0.15% | No change | 22,095 | $553K |
| Prudential Financial Inc. | 0.00% | Add +72.3% | 21,970 | $550K |
| Gsa Capital Partners LLP | 0.03% | New | 20,511 | $514K |
| Jackson Creek Investment Advisors LLC | 0.14% | New | 18,695 | $468K |
| Barclays PLC | 0.00% | Reduce -77.0% | 18,374 | $460K |
| Janus Henderson Group PLC | 0.00% | No change | 18,200 | $456K |
| Bank of Montreal | 0.00% | No change | 17,468 | $437K |
| New York State Common Retirement Fund | 0.00% | No change | 17,371 | $435K |
| State of Wyoming | 0.05% | Add +57.7% | 17,148 | $429K |
| Quadrature Capital Ltd | 0.01% | Reduce -27.3% | 16,735 | $419K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 15,340 | $384K |
| Agf Management Ltd. | 0.00% | No change | 15,000 | $376K |
| Amundi | 0.00% | New | 14,084 | $353K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 13,702 | $343K |
| China Universal Asset Management Co., Ltd. | 0.03% | Add +8.9% | 13,280 | $333K |
| Freestone Grove Partners LP | 0.00% | New | 12,945 | $324K |
| State of New Jersey Common Pension Fund D | 0.00% | New | 12,788 | $320K |
| Northwest & Ethical Investments L.P. | 0.01% | Add +1.7% | 12,244 | $316K |
| Intech Investment Management LLC | 0.00% | Reduce -38.3% | 12,541 | $314K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | Reduce -57.3% | 11,935 | $299K |
| Abacus Wealth Partners, LLC | 0.03% | Add +14.2% | 11,669 | $292K |
| Janney Montgomery Scott LLC | 0.00% | Add +3.8% | 11,487 | $288K |
| James Investment Research, Inc. | 0.03% | No change | 10,925 | $274K |
| Ewing Morris & Co. Investment Partners Ltd. | 0.12% | No change | 10,850 | $272K |
| Virtus Investment Advisers, LLC | 0.07% | Add +2.5% | 10,702 | $268K |
| Lazard Asset Management LLC | 0.00% | Reduce -23.0% | 10,602 | $265K |
| ProShare Advisors LLC | 0.00% | Reduce -14.6% | 10,574 | $265K |
| SG Americas Securities, LLC | 0.00% | Reduce -40.6% | 10,429 | $261K |
| Arizona State Retirement System | 0.00% | Reduce -1.1% | 10,277 | $257K |
| PSP Research LLC | 0.18% | Reduce -50.8% | 10,000 | $250K |
| Soleus Capital Management, L.P. | 0.01% | Reduce -90.0% | 10,000 | $250K |
| Pictet Asset Management Holding SA | 0.00% | Reduce -87.4% | 9,256 | $232K |
| Voya Investment Management LLC | 0.00% | Reduce -2.6% | 8,993 | $225K |
| Allspring Global Investments Holdings, LLC | 0.00% | Add +10.4% | 8,507 | $221K |
| Vanguard Investments Australia, Ltd. | 0.00% | — | 8,803 | $220K |
| WINTON GROUP Ltd | 0.01% | Reduce -24.9% | 8,400 | $210K |
| Cygnus Capital Advisors, LLC | 0.14% | Add +36.7% | 8,197 | $205K |
| KLP Kapitalforvaltning As | 0.00% | No change | 8,000 | $200K |
| Cwm, LLC | 0.00% | Reduce -0.3% | 6,955 | $174K |
| Vanguard Global Advisers, LLC | 0.00% | — | 5,459 | $137K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +259.8% | 4,868 | $122K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 4,164 | $104K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +7.3% | 3,903 | $98K |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 3,843 | $96K |
| GF Fund Management Co. LTD. | 0.00% | Add +14.3% | 1,681 | $42K |
| Global Wealth Strategies & Associates | 0.01% | New | 1,635 | $41K |
| Sofinnova Investments, Inc. | 0.00% | New | 1,610 | $40K |
| TD Waterhouse Canada Inc. | 0.00% | Add +362.7% | 1,439 | $37K |
| Simplex Trading, LLC | 0.00% | Reduce -97.2% | 1,336 | $33K |
| Aviso Financial Inc. | 0.00% | New | 1,146 | $29K |
| GAMMA Investing LLC | 0.00% | Add +11.4% | 1,097 | $27K |
| PNC Financial Services Group, Inc. | 0.00% | Add +26.4% | 987 | $25K |
| Nisa Investment Advisors, LLC | 0.00% | Add +0.3% | 971 | $24K |
| Steward Partners Investment Advisory, LLC | 0.00% | Add +1732.1% | 971 | $24K |
| Optiver Holding B.V. | 0.00% | Reduce -16.6% | 958 | $24K |
| Osaic Holdings, Inc. | 0.00% | Reduce -64.9% | 882 | $22K |
| Lanark Financial, Inc. | 0.00% | No change | 623 | $16K |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 570 | $14K |
| National Bank of Canada | 0.00% | Add +1.6% | 554 | $14K |
| UMB Bank, n.a. | 0.00% | No change | 466 | $12K |
| Jones Financial Companies LLLP | 0.00% | Add +2225.0% | 465 | $11K |
| US Bancorp \de | 0.00% | Add +22.6% | 352 | $9K |
| Parallel Advisors, LLC | 0.00% | Add +7.0% | 352 | $9K |
| Huntington National Bank | 0.00% | Reduce -5.8% | 343 | $9K |
| Sterling Capital Management LLC | 0.00% | Reduce -2.1% | 324 | $8K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +19.8% | 218 | $5K |
| Caitong International Asset Management Co., Ltd | 0.00% | Reduce -84.6% | 216 | $5K |
| Allworth Financial LP | 0.00% | Reduce -25.3% | 109 | $3K |
| IFP Advisors, Inc | 0.00% | No change | 96 | $2K |
| HighMark Wealth Management LLC | 0.00% | Reduce -65.2% | 80 | $2K |
| Rothschild Investment LLC | 0.00% | Add +42.9% | 80 | $2K |
| Walleye Capital LLC | 0.00% | Reduce -99.4% | 78 | $2K |
| Signaturefd, LLC | 0.00% | Add +83.3% | 77 | $2K |
| Fifth Third Bancorp | 0.00% | New | 67 | $2K |
| Kilter Group LLC | 0.00% | No change | 66 | $2K |
| Bare Financial Services, Inc | 0.00% | No change | 64 | $2K |
| Rockefeller Capital Management L.P. | 0.00% | New | 61 | $2K |
| Farther Finance Advisors, LLC | 0.00% | Reduce -79.6% | 57 | $1K |
| True Wealth Design, LLC | 0.00% | No change | 58 | $1K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 51 | $1K |
| Versant Capital Management, Inc | 0.00% | New | 45 | $1K |
| Covestor Ltd | 0.00% | Reduce -48.1% | 28 | $1K |
| Sunbelt Securities, Inc. | 0.00% | No change | 27 | $676 |
| International Assets Investment Management, LLC | 0.00% | No change | 25 | $649 |
| Twin Peaks Wealth Advisors, LLC | 0.00% | New | 20 | $501 |
| Aster Capital Management (DIFC) Ltd | 0.00% | New | 42 | $500 |
| CoreCap Advisors, LLC | 0.00% | No change | 18 | $451 |
| Essential Partners LLC | 0.00% | No change | 12 | $300 |
| Root Financial Partners, LLC | 0.00% | New | 12 | $300 |
| Smartleaf Asset Management LLC | 0.00% | No change | 12 | $291 |
| SBI Securities Co., Ltd. | 0.00% | No change | 11 | $275 |
| MAI Capital Management | 0.00% | Add +40.0% | 7 | $176 |
| Larson Financial Group LLC | 0.00% | No change | 6 | $150 |
| Hughes Financial Services, LLC | 0.00% | New | 4 | $100 |
"% of holder's portfolio" is ZYME's weight in each manager's 13F, not the share of Zymeworks Inc. the manager owns.