Artal Group S.A.

In its 13F for Q1 2024 (holdings as of March 31, 2024, filed May 17, 2024), Artal Group S.A. reported 107 stock positions worth $3.9 billion. Its top holding was Cava (CAVA) at 47.9% of the portfolio, followed by Lexicon Pharmaceuticals (LXRX, 7.3%) and Scholar Rock (SRRK, 5.2%). Compared with Q4 2023, it opened 34 new positions, sold out of 18, added to 29 and reduced 17. The biggest buy was a new position in Crinetics Pharmaceuticals (CRNX) and the biggest sale Cytokinetics (CYTK, shares −58%).

Most Recent 13F
Q2 2026
Location
LUXEMBOURG, N4
CIK
0001053906
Portfolio Value
$3.9B (Q1 2024)
SEC Filing
0001053906-24-000007 ↗ filed May 17, 2024

Holdings Value

0$1.0B$2.0B$3.0B$4.0B Q1 2024: $3.9B $3.9B Q1 2024 Q2 2024: $3.9B Q2 2024 Q3 2024: $2.4B Q3 2024 Q4 2024: $1.2B Q4 2024 Q1 2025: $884.2M Q1 2025 Q2 2025: $930.2M Q2 2025 Q3 2025: $758.2M Q3 2025 Q4 2025: $714.6M Q4 2025 Q1 2026: $1.0B Q1 2026 Q2 2026: $931.1M Q2 2026

Holdings 107 stocks · $3.9B
CAVA Cava Group Inc. 47.86% 26,507,990 $1.9B Reduce -17.2%
LXRX Lexicon Pharmaceuticals Inc. 7.27% 117,553,284 $282.1M No change
SRRK Scholar Rock Holding Corp. 5.15% 11,259,438 $200.0M No change
KYMR Kymera Therapeutics Inc. 3.14% 3,027,135 $121.7M Add +19.6%
ARWR Arrowhead Pharmaceuticals Inc. 2.24% 3,036,668 $86.8M Add +195.3%
MORF Morphic Holding Inc. 2.01% 2,213,188 $77.9M Add +3.5%
APLS Apellis Pharmaceuticals Inc. 1.99% 1,315,282 $77.3M Reduce -7.5%
SWTX Springworks Therapeutics Inc. 1.80% 1,415,348 $69.7M Reduce -12.4%
CRNX Crinetics Pharmaceuticals Inc. 1.68% 1,390,477 $65.1M New
ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD 1.63% 404,782 $63.3M Add +0.1%
SLN Silence Therapeutics PLC-ADR 1.55% 2,779,619 $60.0M Reduce -7.3%
DYN Dyne Therapeutics Inc. 1.11% 1,517,960 $43.1M Add +24.6%
RVMD Revolution Medicines Inc. 1.10% 1,318,649 $42.5M Reduce -22.3%
KURA Kura Oncology Inc. 1.06% 1,919,884 $41.0M Add +8.6%
NMRA Neumora Therapeutics Inc. 1.04% 2,924,052 $40.2M Add +14.6%
KRRO Korro Bio Inc. 0.97% 419,226 $37.7M Add +0.1%
CYTK Cytokinetics Inc. 0.92% 506,584 $35.5M Reduce -58.3%
SLDB Solid Biosciences Inc. 0.86% 2,500,000 $33.3M Add +175.0%
IGMS Igm Biosciences Inc. 0.77% 3,080,422 $29.7M Reduce -0.7%
MDGL Madrigal Pharmaceuticals Inc. 0.76% 110,507 $29.5M New
GLYCOMIMETICS INC 0.66% 8,589,064 $25.8M No change
WVE Wave Life Sciences Ltd. 0.64% 4,051,400 $25.0M Add +34.7%
PRTA Prothena Corp. PLC 0.64% 1,001,360 $24.8M Add +99.7%
VERA Vera Therapeutics Inc. 0.56% 506,019 $21.8M New
VKTX Viking Therapeutics Inc. 0.54% 253,863 $20.8M New
MRUS Merus NV 0.53% 455,081 $20.5M New
NAMS Newamsterdam Pharma Co. NV 0.49% 800,000 $18.9M New
TNGX Tango Therapeutics Inc. 0.45% 2,194,841 $17.4M New
SLRN Acelyrin Inc. 0.42% 2,405,143 $16.2M Reduce -20.8%
ALPN Alpine Immune Sciences Inc. 0.41% 405,784 $16.1M Add +699.4%
CNTA Centessa Pharmaceuticals Ltd. 0.41% 1,412,500 $16.0M Add +39.5%
GOSS Gossamer Bio Inc. 0.40% 13,308,968 $15.7M Add +10.4%
EWTX Edgewise Therapeutics Inc. 0.38% 811,718 $14.8M New
SYRS Syros Pharmaceuticals Inc. 0.35% 2,505,013 $13.4M No change
SE Sea Ltd.-ADR 0.33% 237,500 $12.8M Reduce -36.2%
LXEO Lexeo Therapeutics Inc. 0.32% 801,716 $12.6M Add +32.9%
ATXS Astria Therapeutics Inc. 0.32% 884,214 $12.4M New
FOLD Amicus Therapeutics Inc. 0.31% 1,011,776 $11.9M Reduce -50.1%
GBIO Generation Bio Co. 0.30% 2,830,591 $11.5M Add +0.6%
XENE Xenon Pharmaceuticals Inc. 0.28% 253,387 $10.9M New
CLDX Celldex Therapeutics Inc. 0.27% 253,000 $10.6M New
TSHA Taysha Gene Therapies Inc. 0.27% 3,687,548 $10.6M Add +0.7%
DNLI Denali Therapeutics Inc. 0.27% 502,899 $10.3M Reduce -37.4%
APGE Apogee Therapeutics Inc. 0.26% 152,500 $10.1M New
ERAS Erasca Inc. 0.25% 4,721,194 $9.7M No change
AGEN Agenus Inc. 0.23% 15,631,235 $9.1M No change
SEER Seer Inc. 0.23% 4,750,000 $9.0M No change
RARE Ultragenyx Pharmaceutical Inc. 0.21% 177,932 $8.3M New
ELEV Elevation Oncology Inc. 0.20% 1,513,015 $7.8M New
OVID Ovid Therapeutics Inc. 0.20% 2,500,000 $7.6M No change
TRML Tourmaline Bio Inc. 0.19% 314,496 $7.2M Add +244.0%
APLT Applied Therapeutics Inc. 0.18% 1,009,500 $6.9M New
PDD PDD Holdings Inc. 0.17% 56,500 $6.6M Add +73.8%
GPCR Structure Therapeutics Inc. 0.17% 151,780 $6.5M Add +75.3%
VIGL Vigil Neuroscience Inc. 0.16% 1,811,191 $6.2M No change
AXSM Axsome Therapeutics Inc. 0.16% 76,837 $6.1M New
RNAC Cartesian Therapeutics Inc. 0.15% 9,136,635 $5.9M No change
ANRO Alto Neuroscience Inc. 0.14% 350,000 $5.4M New
BDTX Black Diamond Therapeutics I 0.14% 1,046,517 $5.3M Reduce -48.9%
RGNX Regenxbio Inc. 0.14% 250,000 $5.3M New
ALLOVIR INC 0.13% 6,597,167 $5.0M No change
KYTX Kyverna Therapeutics Inc. 0.13% 200,000 $5.0M New
FHTX Foghorn Therapeutics Inc. 0.12% 720,720 $4.8M No change
OMGAQ Omega Therapeutics Inc. 0.12% 1,323,530 $4.8M No change
TSM Taiwan Semiconductor-SP ADR 0.11% 32,000 $4.4M Reduce -52.9%
GERN Geron Corp. 0.11% 1,281,194 $4.2M New
STOK Stoke Therapeutics Inc. 0.10% 300,000 $4.0M New
HOOKIPA PHARMA INC 0.10% 5,666,410 $4.0M No change
SGMT Sagimet Biosciences Inc. Class A 0.10% 724,771 $3.9M Reduce -21.6%
BEKE Ke Holdings Inc.-ADR filed as KE HLDGS INC 0.10% 275,000 $3.8M Add +10.0%
RPTX Repare Therapeutics Inc. 0.09% 700,000 $3.3M No change
MGX Metagenomi Therapeutics Inc. 0.08% 300,000 $3.2M New
PEPG Pepgen Inc. 0.08% 200,000 $2.9M New
ADAG Adagene Inc.-ADR 0.07% 1,020,000 $2.9M Add +2.0%
GRITSTONE BIO INC 0.07% 1,030,952 $2.6M New
FATE Fate Therapeutics Inc. 0.07% 360,311 $2.6M New
VOR Vor Biopharma Inc. 0.06% 1,000,000 $2.4M Reduce -57.4%
AMZN Amazon.com Inc. 0.06% 12,000 $2.2M No change
JANX Janux Therapeutics Inc. 0.05% 50,000 $1.9M New
NVDA Nvidia Corp. 0.04% 1,900 $1.7M New
AAPL Apple Inc. 0.04% 10,000 $1.7M New
DT Dynatrace Inc. 0.04% 36,000 $1.7M New
ADBE Adobe Inc. 0.04% 3,100 $1.6M New
EDU New Oriental Educatio-SP ADR 0.03% 15,000 $1.3M New
DDOG Datadog Inc. Class A 0.03% 9,600 $1.2M Add +28.0%
KRON Kronos Bio Inc. 0.03% 842,954 $1.1M No change
GOOGL Alphabet Inc. Class A 0.03% 7,000 $1.1M Reduce -10.3%
MSFT Microsoft Corp. 0.03% 2,500 $1.1M No change
SNOW Snowflake Inc. 0.03% 6,500 $1.1M New
INTA Intapp Inc. 0.03% 29,500 $1.0M Add +68.6%
IRWD Ironwood Pharmaceuticals Inc. 0.02% 110,532 $963K No change
ACHL Achilles Therapeutics PL-ADR 0.02% 755,375 $944K Reduce -66.5%
PANW Palo Alto Networks Inc. 0.02% 3,000 $852K New
AMD Advanced Micro Devices 0.02% 4,500 $812K Add +80.0%
PCOR Procore Technologies Inc. 0.02% 9,500 $781K No change
PEGA Pegasystems Inc. 0.02% 11,500 $743K No change
MDB Mongodb Inc. 0.02% 2,000 $717K Add +100.0%
V Visa Inc. Class A 0.02% 2,500 $698K No change
PYPL PayPal Holdings Inc. 0.02% 10,000 $670K Add +100.0%
CFLT Confluent Inc. Class A 0.01% 19,000 $580K No change
CRBU Caribou Biosciences Inc. 0.01% 105,347 $541K No change
CYCLERION THERAPEUTICS INC 0.01% 138,955 $445K No change
CWAN Clearwater Analytics HDS-A 0.01% 25,000 $442K Add +25.0%
DLO Dlocal Ltd. 0.01% 30,000 $441K Add +50.0%
HIPO Hippo Holdings Inc. 0.01% 24,000 $438K No change
TSLA Tesla Inc. 0.01% 2,000 $352K New
INKT Mink Therapeutics Inc. 0.00% 1,916 $2K No change

Options reported separately and not counted above: XBI calls ($23.7M), ARWR calls ($17.2M), PYPL calls ($3.9M), GOSS calls ($244K).

Portfolio Sells Q4 2023 → Q1 2024
CYTK Cytokinetics Inc. Reduce -58.3% 0.92% −2.54
ARGX Argenx SE - ADR Sold out 0.00% −1.51
APLS Apellis Pharmaceuticals Inc. Reduce -7.5% 1.99% −0.91
FOLD Amicus Therapeutics Inc. Reduce -50.1% 0.31% −0.67
RVMD Revolution Medicines Inc. Reduce -22.3% 1.10% −0.56
HARP Harpoon Therapeutics Inc. Sold out 0.00% −0.51
NTRA Natera Inc. Sold out 0.00% −0.43
ROIV Roivant Sciences Ltd. Sold out 0.00% −0.38
SDGR Schrodinger Inc. Sold out 0.00% −0.37
SLRN Acelyrin Inc. Reduce -20.8% 0.42% −0.35
FUSN Fusion Pharmaceuticals Inc. Sold out 0.00% −0.33
DNLI Denali Therapeutics Inc. Reduce -37.4% 0.27% −0.32
CBAY Cymabay Therapeutics Inc. Sold out 0.00% −0.24
SLN Silence Therapeutics PLC-ADR Reduce -7.3% 1.55% −0.23
SWTX Springworks Therapeutics Inc. Reduce -12.4% 1.80% −0.21
SE Sea Ltd.-ADR Reduce -36.2% 0.33% −0.18
ITOS Iteos Therapeutics Inc. Sold out 0.00% −0.15
REPL Replimune Group Inc. Sold out 0.00% −0.14
TSM Taiwan Semiconductor-SP ADR Reduce -52.9% 0.11% −0.13
VOR Vor Biopharma Inc. Reduce -57.4% 0.06% −0.12
IGMS Igm Biosciences Inc. Reduce -0.7% 0.77% −0.11
SGMT Sagimet Biosciences Inc. Class A Reduce -21.6% 0.10% −0.07
IKENA ONCOLOGY INC Sold out 0.00% −0.07
BDTX Black Diamond Therapeutics I Reduce -48.9% 0.14% −0.06
BZ Kanzhun Ltd. - ADR Sold out 0.00% −0.06
CRIS Curis Inc. Sold out 0.00% −0.05
ACHL Achilles Therapeutics PL-ADR Reduce -66.5% 0.02% −0.04
23ANDME HOLDING CO Sold out 0.00% −0.02
LLY Eli Lilly & Co. Sold out 0.00% −0.02
RELY Remitly Global Inc. Sold out 0.00% −0.02
GOOGL Alphabet Inc. Class A Reduce -10.3% 0.03% −0.01
XLO Xilio Therapeutics Inc. Sold out 0.00% −0.01
CERE Cerevel Therapeutics Holding Sold out 0.00% −0.01
SNTI Senti Biosciences Inc. Sold out 0.00% −0.00
CAVA Cava Group Inc. Reduce -17.2% 47.86% +0.96

Portfolio Buys Q4 2023 → Q1 2024
CRNX Crinetics Pharmaceuticals Inc. New 1.68% +1.68
ARWR Arrowhead Pharmaceuticals Inc. Add +195.3% 2.24% +1.17
KYMR Kymera Therapeutics Inc. Add +19.6% 3.14% +0.94
MDGL Madrigal Pharmaceuticals Inc. New 0.76% +0.76
SLDB Solid Biosciences Inc. Add +175.0% 0.86% +0.67
VERA Vera Therapeutics Inc. New 0.56% +0.56
DYN Dyne Therapeutics Inc. Add +24.6% 1.11% +0.56
VKTX Viking Therapeutics Inc. New 0.54% +0.54
MRUS Merus NV New 0.53% +0.53
NAMS Newamsterdam Pharma Co. NV New 0.49% +0.49
TNGX Tango Therapeutics Inc. New 0.45% +0.45
ALPN Alpine Immune Sciences Inc. Add +699.4% 0.41% +0.38
EWTX Edgewise Therapeutics Inc. New 0.38% +0.38
ATXS Astria Therapeutics Inc. New 0.32% +0.32
KRRO Korro Bio Inc. Add +0.1% 0.97% +0.29
XENE Xenon Pharmaceuticals Inc. New 0.28% +0.28
CLDX Celldex Therapeutics Inc. New 0.27% +0.27
APGE Apogee Therapeutics Inc. New 0.26% +0.26
RARE Ultragenyx Pharmaceutical Inc. New 0.21% +0.21
ELEV Elevation Oncology Inc. New 0.20% +0.20
KURA Kura Oncology Inc. Add +8.6% 1.06% +0.19
APLT Applied Therapeutics Inc. New 0.18% +0.18
AXSM Axsome Therapeutics Inc. New 0.16% +0.16
GBIO Generation Bio Co. Add +0.6% 0.30% +0.14
ANRO Alto Neuroscience Inc. New 0.14% +0.14
CNTA Centessa Pharmaceuticals Ltd. Add +39.5% 0.41% +0.14
RGNX Regenxbio Inc. New 0.14% +0.14
KYTX Kyverna Therapeutics Inc. New 0.13% +0.13
WVE Wave Life Sciences Ltd. Add +34.7% 0.64% +0.13
GERN Geron Corp. New 0.11% +0.11
STOK Stoke Therapeutics Inc. New 0.10% +0.10
TRML Tourmaline Bio Inc. Add +244.0% 0.19% +0.10
MGX Metagenomi Therapeutics Inc. New 0.08% +0.08
PEPG Pepgen Inc. New 0.08% +0.08
GRITSTONE BIO INC New 0.07% +0.07
FATE Fate Therapeutics Inc. New 0.07% +0.07
TSHA Taysha Gene Therapies Inc. Add +0.7% 0.27% +0.05
JANX Janux Therapeutics Inc. New 0.05% +0.05
LXEO Lexeo Therapeutics Inc. Add +32.9% 0.32% +0.05
GPCR Structure Therapeutics Inc. Add +75.3% 0.17% +0.05
AAPL Apple Inc. New 0.04% +0.04
NVDA Nvidia Corp. New 0.04% +0.04
DT Dynatrace Inc. New 0.04% +0.04
ADBE Adobe Inc. New 0.04% +0.04
EDU New Oriental Educatio-SP ADR New 0.03% +0.03
GOSS Gossamer Bio Inc. Add +10.4% 0.40% +0.03
SNOW Snowflake Inc. New 0.03% +0.03
PANW Palo Alto Networks Inc. New 0.02% +0.02
PRTA Prothena Corp. PLC Add +99.7% 0.64% +0.02
TSLA Tesla Inc. New 0.01% +0.01

Options Activity Q4 2023 → Q1 2024
FOLD Amicus Therapeutics Inc. call Sold out 2,500,000 $35.5Mbefore exit
MRTX Mirati Therapeutics Inc. call Sold out 500,000 $29.4Mbefore exit
XBI SS SPDR S&P Biotech ETF call New 250,000 $23.7M
ARWR Arrowhead Pharmaceuticals Inc. call Add +200.0% 600,000 $17.2M

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 2$931.1MCAVA, LXRX
Q1 2026 2$1.0BCAVA, LXRX
Q4 2025 2$714.6MCAVA, LXRX
Q3 2025 2$758.2MCAVA, LXRX
Q2 2025 2$930.2MCAVA, LXRX
Q1 2025 2$884.2MCAVA, LXRX
Q4 2024 2$1.2BCAVA, LXRX
Q3 2024 2$2.4BCAVA, LXRX
Q2 2024 108$3.9BCAVA, LXRX, SRRK, KYMR, MORF
Q1 2024Amended 107$3.9BCAVA, LXRX, SRRK, KYMR, ARWR