Artal Group S.A.
In its 13F for Q1 2024 (holdings as of March 31, 2024, filed May 17, 2024), Artal Group S.A. reported 107 stock positions worth $3.9 billion. Its top holding was Cava (CAVA) at 47.9% of the portfolio, followed by Lexicon Pharmaceuticals (LXRX, 7.3%) and Scholar Rock (SRRK, 5.2%). Compared with Q4 2023, it opened 34 new positions, sold out of 18, added to 29 and reduced 17. The biggest buy was a new position in Crinetics Pharmaceuticals (CRNX) and the biggest sale Cytokinetics (CYTK, shares −58%).
- Most Recent 13F
- Q2 2026
- Location
- LUXEMBOURG, N4
- CIK
- 0001053906
- Portfolio Value
- $3.9B (Q1 2024)
- SEC Filing
- 0001053906-24-000007 ↗ filed May 17, 2024
Holdings Value
Holdings 107 stocks · $3.9B
| CAVA Cava Group Inc. | 47.86% | 26,507,990 | $1.9B | Reduce -17.2% |
| LXRX Lexicon Pharmaceuticals Inc. | 7.27% | 117,553,284 | $282.1M | No change |
| SRRK Scholar Rock Holding Corp. | 5.15% | 11,259,438 | $200.0M | No change |
| KYMR Kymera Therapeutics Inc. | 3.14% | 3,027,135 | $121.7M | Add +19.6% |
| ARWR Arrowhead Pharmaceuticals Inc. | 2.24% | 3,036,668 | $86.8M | Add +195.3% |
| MORF Morphic Holding Inc. | 2.01% | 2,213,188 | $77.9M | Add +3.5% |
| APLS Apellis Pharmaceuticals Inc. | 1.99% | 1,315,282 | $77.3M | Reduce -7.5% |
| SWTX Springworks Therapeutics Inc. | 1.80% | 1,415,348 | $69.7M | Reduce -12.4% |
| CRNX Crinetics Pharmaceuticals Inc. | 1.68% | 1,390,477 | $65.1M | New |
| ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD | 1.63% | 404,782 | $63.3M | Add +0.1% |
| SLN Silence Therapeutics PLC-ADR | 1.55% | 2,779,619 | $60.0M | Reduce -7.3% |
| DYN Dyne Therapeutics Inc. | 1.11% | 1,517,960 | $43.1M | Add +24.6% |
| RVMD Revolution Medicines Inc. | 1.10% | 1,318,649 | $42.5M | Reduce -22.3% |
| KURA Kura Oncology Inc. | 1.06% | 1,919,884 | $41.0M | Add +8.6% |
| NMRA Neumora Therapeutics Inc. | 1.04% | 2,924,052 | $40.2M | Add +14.6% |
| KRRO Korro Bio Inc. | 0.97% | 419,226 | $37.7M | Add +0.1% |
| CYTK Cytokinetics Inc. | 0.92% | 506,584 | $35.5M | Reduce -58.3% |
| SLDB Solid Biosciences Inc. | 0.86% | 2,500,000 | $33.3M | Add +175.0% |
| IGMS Igm Biosciences Inc. | 0.77% | 3,080,422 | $29.7M | Reduce -0.7% |
| MDGL Madrigal Pharmaceuticals Inc. | 0.76% | 110,507 | $29.5M | New |
| GLYCOMIMETICS INC | 0.66% | 8,589,064 | $25.8M | No change |
| WVE Wave Life Sciences Ltd. | 0.64% | 4,051,400 | $25.0M | Add +34.7% |
| PRTA Prothena Corp. PLC | 0.64% | 1,001,360 | $24.8M | Add +99.7% |
| VERA Vera Therapeutics Inc. | 0.56% | 506,019 | $21.8M | New |
| VKTX Viking Therapeutics Inc. | 0.54% | 253,863 | $20.8M | New |
| MRUS Merus NV | 0.53% | 455,081 | $20.5M | New |
| NAMS Newamsterdam Pharma Co. NV | 0.49% | 800,000 | $18.9M | New |
| TNGX Tango Therapeutics Inc. | 0.45% | 2,194,841 | $17.4M | New |
| SLRN Acelyrin Inc. | 0.42% | 2,405,143 | $16.2M | Reduce -20.8% |
| ALPN Alpine Immune Sciences Inc. | 0.41% | 405,784 | $16.1M | Add +699.4% |
| CNTA Centessa Pharmaceuticals Ltd. | 0.41% | 1,412,500 | $16.0M | Add +39.5% |
| GOSS Gossamer Bio Inc. | 0.40% | 13,308,968 | $15.7M | Add +10.4% |
| EWTX Edgewise Therapeutics Inc. | 0.38% | 811,718 | $14.8M | New |
| SYRS Syros Pharmaceuticals Inc. | 0.35% | 2,505,013 | $13.4M | No change |
| SE Sea Ltd.-ADR | 0.33% | 237,500 | $12.8M | Reduce -36.2% |
| LXEO Lexeo Therapeutics Inc. | 0.32% | 801,716 | $12.6M | Add +32.9% |
| ATXS Astria Therapeutics Inc. | 0.32% | 884,214 | $12.4M | New |
| FOLD Amicus Therapeutics Inc. | 0.31% | 1,011,776 | $11.9M | Reduce -50.1% |
| GBIO Generation Bio Co. | 0.30% | 2,830,591 | $11.5M | Add +0.6% |
| XENE Xenon Pharmaceuticals Inc. | 0.28% | 253,387 | $10.9M | New |
| CLDX Celldex Therapeutics Inc. | 0.27% | 253,000 | $10.6M | New |
| TSHA Taysha Gene Therapies Inc. | 0.27% | 3,687,548 | $10.6M | Add +0.7% |
| DNLI Denali Therapeutics Inc. | 0.27% | 502,899 | $10.3M | Reduce -37.4% |
| APGE Apogee Therapeutics Inc. | 0.26% | 152,500 | $10.1M | New |
| ERAS Erasca Inc. | 0.25% | 4,721,194 | $9.7M | No change |
| AGEN Agenus Inc. | 0.23% | 15,631,235 | $9.1M | No change |
| SEER Seer Inc. | 0.23% | 4,750,000 | $9.0M | No change |
| RARE Ultragenyx Pharmaceutical Inc. | 0.21% | 177,932 | $8.3M | New |
| ELEV Elevation Oncology Inc. | 0.20% | 1,513,015 | $7.8M | New |
| OVID Ovid Therapeutics Inc. | 0.20% | 2,500,000 | $7.6M | No change |
| TRML Tourmaline Bio Inc. | 0.19% | 314,496 | $7.2M | Add +244.0% |
| APLT Applied Therapeutics Inc. | 0.18% | 1,009,500 | $6.9M | New |
| PDD PDD Holdings Inc. | 0.17% | 56,500 | $6.6M | Add +73.8% |
| GPCR Structure Therapeutics Inc. | 0.17% | 151,780 | $6.5M | Add +75.3% |
| VIGL Vigil Neuroscience Inc. | 0.16% | 1,811,191 | $6.2M | No change |
| AXSM Axsome Therapeutics Inc. | 0.16% | 76,837 | $6.1M | New |
| RNAC Cartesian Therapeutics Inc. | 0.15% | 9,136,635 | $5.9M | No change |
| ANRO Alto Neuroscience Inc. | 0.14% | 350,000 | $5.4M | New |
| BDTX Black Diamond Therapeutics I | 0.14% | 1,046,517 | $5.3M | Reduce -48.9% |
| RGNX Regenxbio Inc. | 0.14% | 250,000 | $5.3M | New |
| ALLOVIR INC | 0.13% | 6,597,167 | $5.0M | No change |
| KYTX Kyverna Therapeutics Inc. | 0.13% | 200,000 | $5.0M | New |
| FHTX Foghorn Therapeutics Inc. | 0.12% | 720,720 | $4.8M | No change |
| OMGAQ Omega Therapeutics Inc. | 0.12% | 1,323,530 | $4.8M | No change |
| TSM Taiwan Semiconductor-SP ADR | 0.11% | 32,000 | $4.4M | Reduce -52.9% |
| GERN Geron Corp. | 0.11% | 1,281,194 | $4.2M | New |
| STOK Stoke Therapeutics Inc. | 0.10% | 300,000 | $4.0M | New |
| HOOKIPA PHARMA INC | 0.10% | 5,666,410 | $4.0M | No change |
| SGMT Sagimet Biosciences Inc. Class A | 0.10% | 724,771 | $3.9M | Reduce -21.6% |
| BEKE Ke Holdings Inc.-ADR filed as KE HLDGS INC | 0.10% | 275,000 | $3.8M | Add +10.0% |
| RPTX Repare Therapeutics Inc. | 0.09% | 700,000 | $3.3M | No change |
| MGX Metagenomi Therapeutics Inc. | 0.08% | 300,000 | $3.2M | New |
| PEPG Pepgen Inc. | 0.08% | 200,000 | $2.9M | New |
| ADAG Adagene Inc.-ADR | 0.07% | 1,020,000 | $2.9M | Add +2.0% |
| GRITSTONE BIO INC | 0.07% | 1,030,952 | $2.6M | New |
| FATE Fate Therapeutics Inc. | 0.07% | 360,311 | $2.6M | New |
| VOR Vor Biopharma Inc. | 0.06% | 1,000,000 | $2.4M | Reduce -57.4% |
| AMZN Amazon.com Inc. | 0.06% | 12,000 | $2.2M | No change |
| JANX Janux Therapeutics Inc. | 0.05% | 50,000 | $1.9M | New |
| NVDA Nvidia Corp. | 0.04% | 1,900 | $1.7M | New |
| AAPL Apple Inc. | 0.04% | 10,000 | $1.7M | New |
| DT Dynatrace Inc. | 0.04% | 36,000 | $1.7M | New |
| ADBE Adobe Inc. | 0.04% | 3,100 | $1.6M | New |
| EDU New Oriental Educatio-SP ADR | 0.03% | 15,000 | $1.3M | New |
| DDOG Datadog Inc. Class A | 0.03% | 9,600 | $1.2M | Add +28.0% |
| KRON Kronos Bio Inc. | 0.03% | 842,954 | $1.1M | No change |
| GOOGL Alphabet Inc. Class A | 0.03% | 7,000 | $1.1M | Reduce -10.3% |
| MSFT Microsoft Corp. | 0.03% | 2,500 | $1.1M | No change |
| SNOW Snowflake Inc. | 0.03% | 6,500 | $1.1M | New |
| INTA Intapp Inc. | 0.03% | 29,500 | $1.0M | Add +68.6% |
| IRWD Ironwood Pharmaceuticals Inc. | 0.02% | 110,532 | $963K | No change |
| ACHL Achilles Therapeutics PL-ADR | 0.02% | 755,375 | $944K | Reduce -66.5% |
| PANW Palo Alto Networks Inc. | 0.02% | 3,000 | $852K | New |
| AMD Advanced Micro Devices | 0.02% | 4,500 | $812K | Add +80.0% |
| PCOR Procore Technologies Inc. | 0.02% | 9,500 | $781K | No change |
| PEGA Pegasystems Inc. | 0.02% | 11,500 | $743K | No change |
| MDB Mongodb Inc. | 0.02% | 2,000 | $717K | Add +100.0% |
| V Visa Inc. Class A | 0.02% | 2,500 | $698K | No change |
| PYPL PayPal Holdings Inc. | 0.02% | 10,000 | $670K | Add +100.0% |
| CFLT Confluent Inc. Class A | 0.01% | 19,000 | $580K | No change |
Options reported separately and not counted above: XBI calls ($23.7M), ARWR calls ($17.2M), PYPL calls ($3.9M), GOSS calls ($244K).
Portfolio Sells Q4 2023 → Q1 2024
| CYTK Cytokinetics Inc. | Reduce -58.3% | 0.92% | −2.54 |
| ARGX Argenx SE - ADR | Sold out | 0.00% | −1.51 |
| APLS Apellis Pharmaceuticals Inc. | Reduce -7.5% | 1.99% | −0.91 |
| FOLD Amicus Therapeutics Inc. | Reduce -50.1% | 0.31% | −0.67 |
| RVMD Revolution Medicines Inc. | Reduce -22.3% | 1.10% | −0.56 |
| HARP Harpoon Therapeutics Inc. | Sold out | 0.00% | −0.51 |
| NTRA Natera Inc. | Sold out | 0.00% | −0.43 |
| ROIV Roivant Sciences Ltd. | Sold out | 0.00% | −0.38 |
| SDGR Schrodinger Inc. | Sold out | 0.00% | −0.37 |
| SLRN Acelyrin Inc. | Reduce -20.8% | 0.42% | −0.35 |
| FUSN Fusion Pharmaceuticals Inc. | Sold out | 0.00% | −0.33 |
| DNLI Denali Therapeutics Inc. | Reduce -37.4% | 0.27% | −0.32 |
| CBAY Cymabay Therapeutics Inc. | Sold out | 0.00% | −0.24 |
| SLN Silence Therapeutics PLC-ADR | Reduce -7.3% | 1.55% | −0.23 |
| SWTX Springworks Therapeutics Inc. | Reduce -12.4% | 1.80% | −0.21 |
| SE Sea Ltd.-ADR | Reduce -36.2% | 0.33% | −0.18 |
| ITOS Iteos Therapeutics Inc. | Sold out | 0.00% | −0.15 |
| REPL Replimune Group Inc. | Sold out | 0.00% | −0.14 |
| TSM Taiwan Semiconductor-SP ADR | Reduce -52.9% | 0.11% | −0.13 |
| VOR Vor Biopharma Inc. | Reduce -57.4% | 0.06% | −0.12 |
| IGMS Igm Biosciences Inc. | Reduce -0.7% | 0.77% | −0.11 |
| SGMT Sagimet Biosciences Inc. Class A | Reduce -21.6% | 0.10% | −0.07 |
| IKENA ONCOLOGY INC | Sold out | 0.00% | −0.07 |
| BDTX Black Diamond Therapeutics I | Reduce -48.9% | 0.14% | −0.06 |
| BZ Kanzhun Ltd. - ADR | Sold out | 0.00% | −0.06 |
| CRIS Curis Inc. | Sold out | 0.00% | −0.05 |
| ACHL Achilles Therapeutics PL-ADR | Reduce -66.5% | 0.02% | −0.04 |
| 23ANDME HOLDING CO | Sold out | 0.00% | −0.02 |
| LLY Eli Lilly & Co. | Sold out | 0.00% | −0.02 |
| RELY Remitly Global Inc. | Sold out | 0.00% | −0.02 |
| GOOGL Alphabet Inc. Class A | Reduce -10.3% | 0.03% | −0.01 |
| XLO Xilio Therapeutics Inc. | Sold out | 0.00% | −0.01 |
| CERE Cerevel Therapeutics Holding | Sold out | 0.00% | −0.01 |
| SNTI Senti Biosciences Inc. | Sold out | 0.00% | −0.00 |
| CAVA Cava Group Inc. | Reduce -17.2% | 47.86% | +0.96 |
Portfolio Buys Q4 2023 → Q1 2024
| CRNX Crinetics Pharmaceuticals Inc. | New | 1.68% | +1.68 |
| ARWR Arrowhead Pharmaceuticals Inc. | Add +195.3% | 2.24% | +1.17 |
| KYMR Kymera Therapeutics Inc. | Add +19.6% | 3.14% | +0.94 |
| MDGL Madrigal Pharmaceuticals Inc. | New | 0.76% | +0.76 |
| SLDB Solid Biosciences Inc. | Add +175.0% | 0.86% | +0.67 |
| VERA Vera Therapeutics Inc. | New | 0.56% | +0.56 |
| DYN Dyne Therapeutics Inc. | Add +24.6% | 1.11% | +0.56 |
| VKTX Viking Therapeutics Inc. | New | 0.54% | +0.54 |
| MRUS Merus NV | New | 0.53% | +0.53 |
| NAMS Newamsterdam Pharma Co. NV | New | 0.49% | +0.49 |
| TNGX Tango Therapeutics Inc. | New | 0.45% | +0.45 |
| ALPN Alpine Immune Sciences Inc. | Add +699.4% | 0.41% | +0.38 |
| EWTX Edgewise Therapeutics Inc. | New | 0.38% | +0.38 |
| ATXS Astria Therapeutics Inc. | New | 0.32% | +0.32 |
| KRRO Korro Bio Inc. | Add +0.1% | 0.97% | +0.29 |
| XENE Xenon Pharmaceuticals Inc. | New | 0.28% | +0.28 |
| CLDX Celldex Therapeutics Inc. | New | 0.27% | +0.27 |
| APGE Apogee Therapeutics Inc. | New | 0.26% | +0.26 |
| RARE Ultragenyx Pharmaceutical Inc. | New | 0.21% | +0.21 |
| ELEV Elevation Oncology Inc. | New | 0.20% | +0.20 |
| KURA Kura Oncology Inc. | Add +8.6% | 1.06% | +0.19 |
| APLT Applied Therapeutics Inc. | New | 0.18% | +0.18 |
| AXSM Axsome Therapeutics Inc. | New | 0.16% | +0.16 |
| GBIO Generation Bio Co. | Add +0.6% | 0.30% | +0.14 |
| ANRO Alto Neuroscience Inc. | New | 0.14% | +0.14 |
| CNTA Centessa Pharmaceuticals Ltd. | Add +39.5% | 0.41% | +0.14 |
| RGNX Regenxbio Inc. | New | 0.14% | +0.14 |
| KYTX Kyverna Therapeutics Inc. | New | 0.13% | +0.13 |
| WVE Wave Life Sciences Ltd. | Add +34.7% | 0.64% | +0.13 |
| GERN Geron Corp. | New | 0.11% | +0.11 |
| STOK Stoke Therapeutics Inc. | New | 0.10% | +0.10 |
| TRML Tourmaline Bio Inc. | Add +244.0% | 0.19% | +0.10 |
| MGX Metagenomi Therapeutics Inc. | New | 0.08% | +0.08 |
| PEPG Pepgen Inc. | New | 0.08% | +0.08 |
| GRITSTONE BIO INC | New | 0.07% | +0.07 |
| FATE Fate Therapeutics Inc. | New | 0.07% | +0.07 |
| TSHA Taysha Gene Therapies Inc. | Add +0.7% | 0.27% | +0.05 |
| JANX Janux Therapeutics Inc. | New | 0.05% | +0.05 |
| LXEO Lexeo Therapeutics Inc. | Add +32.9% | 0.32% | +0.05 |
| GPCR Structure Therapeutics Inc. | Add +75.3% | 0.17% | +0.05 |
| AAPL Apple Inc. | New | 0.04% | +0.04 |
| NVDA Nvidia Corp. | New | 0.04% | +0.04 |
| DT Dynatrace Inc. | New | 0.04% | +0.04 |
| ADBE Adobe Inc. | New | 0.04% | +0.04 |
| EDU New Oriental Educatio-SP ADR | New | 0.03% | +0.03 |
| GOSS Gossamer Bio Inc. | Add +10.4% | 0.40% | +0.03 |
| SNOW Snowflake Inc. | New | 0.03% | +0.03 |
| PANW Palo Alto Networks Inc. | New | 0.02% | +0.02 |
| PRTA Prothena Corp. PLC | Add +99.7% | 0.64% | +0.02 |
| TSLA Tesla Inc. | New | 0.01% | +0.01 |
Options Activity Q4 2023 → Q1 2024
| FOLD Amicus Therapeutics Inc. | call | Sold out | 2,500,000 | $35.5Mbefore exit |
| MRTX Mirati Therapeutics Inc. | call | Sold out | 500,000 | $29.4Mbefore exit |
| XBI SS SPDR S&P Biotech ETF | call | New | 250,000 | $23.7M |
| ARWR Arrowhead Pharmaceuticals Inc. | call | Add +200.0% | 600,000 | $17.2M |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 2 | $931.1M | CAVA, LXRX |
| Q1 2026 | 2 | $1.0B | CAVA, LXRX |
| Q4 2025 | 2 | $714.6M | CAVA, LXRX |
| Q3 2025 | 2 | $758.2M | CAVA, LXRX |
| Q2 2025 | 2 | $930.2M | CAVA, LXRX |
| Q1 2025 | 2 | $884.2M | CAVA, LXRX |
| Q4 2024 | 2 | $1.2B | CAVA, LXRX |
| Q3 2024 | 2 | $2.4B | CAVA, LXRX |
| Q2 2024 | 108 | $3.9B | CAVA, LXRX, SRRK, KYMR, MORF |
| Q1 2024Amended | 107 | $3.9B | CAVA, LXRX, SRRK, KYMR, ARWR |