HighVista Strategies LLC

In its 13F for Q1 2025 (holdings as of March 31, 2025, filed May 15, 2025), HighVista Strategies LLC reported 148 stock positions worth $259.5 million. Its top holding was Invesco DB Commodity Index T (DBC) at 12.5% of the portfolio, followed by Hess (HES, 1.8%) and Juniper Networks (JNPR, 1.6%). Compared with Q4 2024, it opened 35 new positions, sold out of 24, added to 39 and reduced 27. The biggest buy was a new position in Quanta Services (PWR) and the biggest sale an exit from Hashicorp Class A (HCP).

Most Recent 13F
Q2 2026
Location
BOSTON, MA
CIK
0001335325
Portfolio Value
$259.5M (Q1 2025)
SEC Filing
0001172661-25-001991 ↗ filed May 15, 2025

Holdings Value

0$100.0M$200.0M$300.0M$400.0M$500.0M Q1 2024: $280.4M Q1 2024 Q2 2024: $273.8M Q2 2024 Q3 2024: $290.0M Q3 2024 Q4 2024: $268.8M Q4 2024 Q1 2025: $259.5M $259.5M Q1 2025 Q2 2025: $272.1M Q2 2025 Q3 2025: $408.0M Q3 2025 Q4 2025: $388.3M Q4 2025 Q1 2026: $362.2M Q1 2026 Q2 2026: $438.6M Q2 2026

Holdings 148 stocks · $259.5M
DBC Invesco DB Commodity Index T 12.45% 1,436,136 $32.3M No change
HES Hess Corp. 1.78% 28,900 $4.6M No change
JNPR Juniper Networks Inc. 1.60% 114,700 $4.2M No change
ACI Albertsons Cos Inc. Class A 1.60% 188,753 $4.2M No change
ANSS Ansys Inc. 1.56% 12,800 $4.1M No change
PTGX Protagonist Therapeutics Inc. 1.46% 78,452 $3.8M Add +25.5%
MSFT Microsoft Corp. 1.41% 9,758 $3.7M Reduce -7.6%
AMED Amedisys Inc. 1.40% 39,250 $3.6M No change
AMZN Amazon.com Inc. 1.37% 18,693 $3.6M Reduce -45.3%
ACLX Arcellx Inc. 1.20% 47,496 $3.1M Add +8.4%
DVAX Dynavax Technologies Corp. 1.18% 235,172 $3.1M Reduce -21.2%
SWTX Springworks Therapeutics Inc. 1.17% 68,758 $3.0M No change
LQDA Liquidia Corp. 1.16% 203,510 $3.0M No change
GEV GE Vernova Inc. 1.15% 9,800 $3.0M Add +44.1%
XPO Xpo Inc. 1.11% 26,880 $2.9M Add +4.3%
NUVL Nuvalent Inc. Class A 1.09% 39,876 $2.8M No change
AVGO Broadcom Inc. 1.03% 15,900 $2.7M Add +74.7%
RVMD Revolution Medicines Inc. 1.00% 73,752 $2.6M Add +28.8%
AXSM Axsome Therapeutics Inc. 0.97% 21,503 $2.5M Add +25.6%
CRM Salesforce Inc. 0.96% 9,285 $2.5M Reduce -3.1%
VRDN Viridian Therapeutics Inc. 0.94% 180,551 $2.4M Add +16.8%
APLS Apellis Pharmaceuticals Inc. 0.92% 108,714 $2.4M No change
INTU Intuit Inc. 0.91% 3,863 $2.4M Add +50.7%
ALKS Alkermes PLC 0.90% 70,762 $2.3M Add +30.0%
MRUS Merus NV 0.89% 55,039 $2.3M No change
XOMA Xoma Royalty Corporation 0.88% 114,548 $2.3M No change
XENE Xenon Pharmaceuticals Inc. 0.86% 66,788 $2.2M No change
ELVN Enliven Therapeutics Inc. 0.85% 112,459 $2.2M No change
GH Guardant Health Inc. 0.85% 51,718 $2.2M Reduce -45.0%
V Visa Inc. Class A 0.83% 6,127 $2.1M Reduce -4.7%
GOOG Alphabet Inc. Class C 0.81% 13,436 $2.1M Add +1.5%
HPE Hewlett Packard Enterprise 0.79% 133,500 $2.1M Add +126.7%
PWR Quanta Services Inc. 0.79% 8,100 $2.1M New
CEG Constellation Energy 0.78% 10,100 $2.0M Add +65.6%
BHC Bausch Health Cos Inc. 0.78% 217,600 $2.0M New
MA Mastercard Inc. Class A 0.78% 3,700 $2.0M New
JANX Janux Therapeutics Inc. 0.78% 74,556 $2.0M Add +6.9%
EWTX Edgewise Therapeutics Inc. 0.77% 91,207 $2.0M Add +10.2%
CSCO Cisco Systems Inc. 0.77% 32,200 $2.0M Add +8.8%
MMM 3M Co. 0.76% 13,500 $2.0M New
STX Seagate Technology Holdings 0.75% 23,000 $2.0M Add +33.0%
WDC Western Digital Corp. 0.75% 48,300 $2.0M Add +85.8%
PM Philip Morris International 0.74% 12,100 $1.9M Add +5.2%
MTZ Mastec Inc. 0.73% 16,300 $1.9M New
ARGX Argenx SE - ADR 0.73% 3,205 $1.9M Reduce -44.2%
GEHC GE Healthcare Technology 0.72% 23,200 $1.9M Reduce -33.7%
RYTM Rhythm Pharmaceuticals Inc. 0.72% 35,039 $1.9M Reduce -6.4%
META Meta Platforms Inc. Class A 0.71% 3,200 $1.8M Reduce -39.6%
STZ Constellation Brands Inc. Class A 0.70% 9,900 $1.8M Add +59.7%
RCL Royal Caribbean Cruises Ltd. 0.70% 8,800 $1.8M Add +41.9%
CYTK Cytokinetics Inc. 0.69% 44,749 $1.8M Add +213.8%
MLTX Moonlake Immunotherapeutics 0.66% 43,541 $1.7M No change
COGT Cogent Biosciences Inc. 0.65% 279,673 $1.7M No change
KNSA Kiniksa Pharmaceuticals Inte 0.64% 74,639 $1.7M No change
BKNG Booking Holdings Inc. 0.63% 357 $1.6M Reduce -45.7%
INSM Insmed Inc. 0.63% 21,440 $1.6M Reduce -22.4%
IMVT Immunovant Inc. 0.63% 95,648 $1.6M New
NATL NCR Atleos Corp. 0.63% 61,900 $1.6M New
APGE Apogee Therapeutics Inc. 0.62% 43,190 $1.6M No change
BBIO Bridgebio Pharma Inc. 0.62% 46,500 $1.6M No change
RNAM Avidity Biosciences Inc. 0.62% 54,190 $1.6M No change
NVDA Nvidia Corp. 0.61% 14,600 $1.6M Add +33.9%
PTC PTC Inc. 0.60% 10,081 $1.6M Add +14.8%
LKQ LKQ Corp. 0.60% 36,700 $1.6M New
TLN Talen Energy Corp. 0.59% 7,700 $1.5M Add +14.9%
SYRE Spyre Therapeutics Inc. 0.59% 95,159 $1.5M No change
AGX Argan Inc. 0.59% 11,700 $1.5M New
OFIX Orthofix Medical Inc. 0.58% 92,900 $1.5M Add +25.5%
APH Amphenol Corp. Class A 0.58% 22,900 $1.5M New
PRAX Praxis Precision Medicines I 0.57% 39,286 $1.5M Add +258.7%
TSM Taiwan Semiconductor-SP ADR 0.57% 8,900 $1.5M Reduce -19.8%
CNX CNX Resources Corp. 0.57% 46,700 $1.5M New
CRH CRH PLC 0.57% 16,700 $1.5M New
CIEN Ciena Corp. 0.57% 24,300 $1.5M Add +32.1%
CORZ Core Scientific Inc. 0.56% 199,100 $1.4M Add +144.9%
ELV Elevance Health Inc. 0.55% 3,300 $1.4M New
BN Brookfield Corp. 0.55% 27,200 $1.4M New
EYE National Vision Holdings Inc. 0.55% 111,300 $1.4M New
PGR Progressive Corp. 0.55% 5,000 $1.4M Reduce -26.5%
TKO Tko Group Holdings Inc. 0.54% 9,200 $1.4M Reduce -17.1%
QXO Qxo Inc. 0.54% 103,500 $1.4M Add +12.0%
UAL United Airlines Holdings Inc. 0.54% 20,200 $1.4M Add +13.5%
SE Sea Ltd.-ADR 0.54% 10,641 $1.4M Reduce -26.8%
QSR Restaurant Brands Intern 0.52% 20,300 $1.4M New
PFSI Pennymac Financial Services 0.52% 13,437 $1.3M Add +1.5%
DAL Delta Air Lines Inc. 0.52% 30,800 $1.3M Add +12.0%
AAL American Airlines Group Inc. 0.51% 126,100 $1.3M Add +46.5%
SNPS Synopsys Inc. 0.51% 3,100 $1.3M New
WDAY Workday Inc. Class A 0.50% 5,600 $1.3M Add +9.8%
RXO Rxo Inc. 0.50% 68,400 $1.3M Add +21.7%
DUOL Duolingo 0.50% 4,200 $1.3M New
AGIO Agios Pharmaceuticals Inc. 0.50% 44,105 $1.3M New
ON On Semiconductor 0.49% 31,400 $1.3M New
BVN Cia DE Minas Buenaventur-ADR filed as COMPANIA DE MINAS BUENAVENTU 0.49% 80,631 $1.3M New
VERA Vera Therapeutics Inc. 0.48% 52,197 $1.3M No change
PCVX Vaxcyte Inc. 0.48% 33,102 $1.2M Reduce -25.9%
MRVL Marvell Technology Inc. 0.48% 20,200 $1.2M New
IBN Icici Bank Ltd.-Spon ADR 0.47% 38,747 $1.2M Reduce -31.5%
HDB HDFC Bank Ltd.-ADR 0.47% 18,241 $1.2M Reduce -32.5%
MAGN Magnera Corp. 0.47% 66,600 $1.2M New
ROIV Roivant Sciences Ltd. 0.45% 115,326 $1.2M No change
PBR.A Petroleo Brasil-SP Pref ADR 0.45% 89,000 $1.2M New
BBD Banco Bradesco-ADR 0.44% 517,000 $1.2M Reduce -29.4%
CAAP Corp. America Airports SA filed as CORPORACION AMER ARPTS S A 0.42% 60,200 $1.1M New
RBC RBC Bearings Inc. 0.42% 3,400 $1.1M New
VRNA Verona Pharma Ltd. 0.41% 16,701 $1.1M Reduce -29.6%
CPNG Coupang Inc. 0.40% 47,500 $1.0M Reduce -31.9%
HUBS HubSpot Inc. 0.40% 1,800 $1.0M New
SLNO Soleno Therapeutics Inc. 0.39% 14,344 $1.0M No change
NU Nu Holdings Ltd./Cayman Isl-A filed as NU HLDGS LTD 0.39% 99,737 $1.0M Reduce -20.3%
SRRK Scholar Rock Holding Corp. 0.39% 31,230 $1.0M New
BABA Alibaba Group Holding-SP ADR 0.38% 7,457 $986K Reduce -64.3%
AKRO Akero Therapeutics Inc. 0.38% 24,067 $974K Add +92.1%
CRNX Crinetics Pharmaceuticals Inc. 0.37% 28,911 $970K No change
ASND Ascendis Pharma A/S 0.36% 6,072 $946K No change
DYN Dyne Therapeutics Inc. 0.32% 78,420 $820K No change
OLMA Olema Pharmaceuticals Inc. 0.31% 212,185 $798K No change
TCOM Trip.com Group Ltd.-ADR 0.31% 12,456 $792K Add +20.3%
MDGL Madrigal Pharmaceuticals Inc. 0.28% 2,211 $732K No change
OCUL Ocular Therapeutix Inc. 0.24% 85,241 $625K No change
DNTH Dianthus Therapeutics Inc. 0.22% 31,387 $569K No change
ACN Accenture PLC Class A 0.22% 1,800 $562K New
CNTA Centessa Pharmaceuticals Ltd. 0.22% 39,020 $561K Reduce -15.4%
CGON CG Oncology Inc. 0.21% 22,305 $546K No change
NTRA Natera Inc. 0.21% 3,850 $544K Reduce -20.3%
KROS Keros Therapeutics Inc. 0.20% 52,107 $531K No change
ZYME Zymeworks Inc. 0.19% 41,607 $496K New
RARE Ultragenyx Pharmaceutical Inc. 0.19% 13,328 $483K New
JD Jd.com Inc.-ADR 0.18% 11,183 $460K Add +3.7%
WVE Wave Life Sciences Ltd. 0.17% 53,374 $431K New
MIRM Mirum Pharmaceuticals Inc. 0.16% 8,942 $403K No change
CRBP Corbus Pharmaceuticals Holdi 0.15% 75,292 $400K No change
KALV Kalvista Pharmaceuticals Inc. 0.15% 33,305 $384K No change
PHVS Pharvaris NV 0.14% 22,768 $357K No change
XNCR Xencor Inc. 0.13% 31,942 $340K No change
SRPT Sarepta Therapeutics Inc. 0.13% 5,212 $333K New
IRON Disc Medicine Inc. 0.12% 6,458 $321K No change
ABVX Abivax SA-ADR 0.12% 49,064 $307K No change
GPCR Structure Therapeutics Inc. 0.12% 17,561 $304K No change
CATX Perspective Therapeutics Inc. 0.11% 138,350 $295K No change
ARVN Arvinas Inc. 0.11% 41,271 $290K Reduce -28.8%
CGEM Cullinan Therapeutics Inc. 0.09% 31,893 $241K No change
KYMR Kymera Therapeutics Inc. 0.09% 8,733 $239K No change
BZ Kanzhun Ltd. - ADR 0.09% 11,900 $228K New
TYRA Tyra Biosciences Inc. 0.09% 23,941 $223K No change
GERN Geron Corp. 0.08% 127,284 $202K No change
ERAS Erasca Inc. 0.07% 135,667 $186K No change
PLRX Pliant Therapeutics Inc. 0.06% 109,938 $148K New

Portfolio Sells Q4 2024 → Q1 2025
HCP Hashicorp Inc. Class A Sold out 0.00% −1.66
AMZN Amazon.com Inc. Reduce -45.3% 1.37% −1.42
PCVX Vaxcyte Inc. Reduce -25.9% 0.48% −0.88
TEVA Teva Pharmaceutical-SP ADR Sold out 0.00% −0.83
LYV Live Nation Entertainment Inc. Sold out 0.00% −0.75
INDV Indivior Ltd. Sold out 0.00% −0.68
BCYC Bicycle Therapeutics PLC-ADR Sold out 0.00% −0.65
ARGX Argenx SE - ADR Reduce -44.2% 0.73% −0.58
BKNG Booking Holdings Inc. Reduce -45.7% 0.63% −0.58
WRBY Warby Parker Inc. Class A Sold out 0.00% −0.56
WMG Warner Music Group Corp. Class A Sold out 0.00% −0.54
UPWK Upwork Inc. Sold out 0.00% −0.51
STNE Stoneco Ltd. Class A Sold out 0.00% −0.50
FIS Fidelity National Info Serv Sold out 0.00% −0.49
VST Vistra Corp. Sold out 0.00% −0.49
LAUR Laureate Education Inc. Sold out 0.00% −0.49
UBER Uber Technologies Inc. Sold out 0.00% −0.49
TMUS T-Mobile US Inc. Sold out 0.00% −0.48
FCNCA First Citizens Bcshs Class A Sold out 0.00% −0.47
AUTL Autolus Therapeutics PLC Sold out 0.00% −0.47
DIS The Walt Disney Co. Sold out 0.00% −0.46
IDYA Ideaya Biosciences Inc. Sold out 0.00% −0.46
ADBE Adobe Inc. Sold out 0.00% −0.45
META Meta Platforms Inc. Class A Reduce -39.6% 0.71% −0.44
CZR Caesars Entertainment Inc. Sold out 0.00% −0.44
ARVN Arvinas Inc. Reduce -28.8% 0.11% −0.30
GEHC GE Healthcare Technology Reduce -33.7% 0.72% −0.30
BABA Alibaba Group Holding-SP ADR Reduce -64.3% 0.38% −0.28
TERN Terns Pharmaceuticals Inc. Sold out 0.00% −0.27
TSM Taiwan Semiconductor-SP ADR Reduce -19.8% 0.57% −0.25
KRYS Krystal Biotech Inc. Sold out 0.00% −0.25
MSFT Microsoft Corp. Reduce -7.6% 1.41% −0.24
DVAX Dynavax Technologies Corp. Reduce -21.2% 1.18% −0.24
ITCI Intra-Cellular Therapies Inc. Sold out 0.00% −0.23
CRM Salesforce Inc. Reduce -3.1% 0.96% −0.23
GH Guardant Health Inc. Reduce -45.0% 0.85% −0.22
HDB HDFC Bank Ltd.-ADR Reduce -32.5% 0.47% −0.18
CPNG Coupang Inc. Reduce -31.9% 0.40% −0.17
IBN Icici Bank Ltd.-Spon ADR Reduce -31.5% 0.47% −0.16
KURA Kura Oncology Inc. Sold out 0.00% −0.15
NU Nu Holdings Ltd./Cayman Isl-A Reduce -20.3% 0.39% −0.09
INSM Insmed Inc. Reduce -22.4% 0.63% −0.08
BBD Banco Bradesco-ADR Reduce -29.4% 0.44% −0.08
NTRA Natera Inc. Reduce -20.3% 0.21% −0.07
CNTA Centessa Pharmaceuticals Ltd. Reduce -15.4% 0.22% −0.07
RYTM Rhythm Pharmaceuticals Inc. Reduce -6.4% 0.72% −0.06
PGR Progressive Corp. Reduce -26.5% 0.55% −0.06
TKO Tko Group Holdings Inc. Reduce -17.1% 0.54% −0.05
SE Sea Ltd.-ADR Reduce -26.8% 0.54% −0.04
VRNA Verona Pharma Ltd. Reduce -29.6% 0.41% −0.00

Portfolio Buys Q4 2024 → Q1 2025
PWR Quanta Services Inc. New 0.79% +0.79
BHC Bausch Health Cos Inc. New 0.78% +0.78
MA Mastercard Inc. Class A New 0.78% +0.78
MMM 3M Co. New 0.76% +0.76
MTZ Mastec Inc. New 0.73% +0.73
IMVT Immunovant Inc. New 0.63% +0.63
NATL NCR Atleos Corp. New 0.63% +0.63
LKQ LKQ Corp. New 0.60% +0.60
AGX Argan Inc. New 0.59% +0.59
APH Amphenol Corp. Class A New 0.58% +0.58
CNX CNX Resources Corp. New 0.57% +0.57
CRH CRH PLC New 0.57% +0.57
PTGX Protagonist Therapeutics Inc. Add +25.5% 1.46% +0.56
ELV Elevance Health Inc. New 0.55% +0.55
BN Brookfield Corp. New 0.55% +0.55
EYE National Vision Holdings Inc. New 0.55% +0.55
QSR Restaurant Brands Intern New 0.52% +0.52
SNPS Synopsys Inc. New 0.51% +0.51
DUOL Duolingo New 0.50% +0.50
AGIO Agios Pharmaceuticals Inc. New 0.50% +0.50
ON On Semiconductor New 0.49% +0.49
BVN Cia DE Minas Buenaventur-ADR New 0.49% +0.49
MRVL Marvell Technology Inc. New 0.48% +0.48
MAGN Magnera Corp. New 0.47% +0.47
PBR.A Petroleo Brasil-SP Pref ADR New 0.45% +0.45
CYTK Cytokinetics Inc. Add +213.8% 0.69% +0.44
AXSM Axsome Therapeutics Inc. Add +25.6% 0.97% +0.43
CAAP Corp. America Airports SA New 0.42% +0.42
RBC RBC Bearings Inc. New 0.42% +0.42
HUBS HubSpot Inc. New 0.40% +0.40
SRRK Scholar Rock Holding Corp. New 0.39% +0.39
HPE Hewlett Packard Enterprise Add +126.7% 0.79% +0.33
GEV GE Vernova Inc. Add +44.1% 1.15% +0.32
ALKS Alkermes PLC Add +30.0% 0.90% +0.32
INTU Intuit Inc. Add +50.7% 0.91% +0.31
CEG Constellation Energy Add +65.6% 0.78% +0.28
PRAX Praxis Precision Medicines I Add +258.7% 0.57% +0.26
AKRO Akero Therapeutics Inc. Add +92.1% 0.38% +0.25
AVGO Broadcom Inc. Add +74.7% 1.03% +0.24
PM Philip Morris International Add +5.2% 0.74% +0.23
ACN Accenture PLC Class A New 0.22% +0.22
STX Seagate Technology Holdings Add +33.0% 0.75% +0.20
ZYME Zymeworks Inc. New 0.19% +0.19
STZ Constellation Brands Inc. Class A Add +59.7% 0.70% +0.19
RARE Ultragenyx Pharmaceutical Inc. New 0.19% +0.19
WDC Western Digital Corp. Add +85.8% 0.75% +0.18
WVE Wave Life Sciences Ltd. New 0.17% +0.17
RCL Royal Caribbean Cruises Ltd. Add +41.9% 0.70% +0.16
CORZ Core Scientific Inc. Add +144.9% 0.56% +0.13
SRPT Sarepta Therapeutics Inc. New 0.13% +0.13

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 147$438.6MDBC, ABVX, RVMD, DFTX, IMVT
Q1 2026 156$362.2MDBC, ABVX, PRAX, COGT, SYRE
Q4 2025 145$388.3MDBC, GPCR, COGT, VRDN, ABVX
Q3 2025 148$408.0MDBC, ABVX, MRUS, VRDN, RVMD
Q2 2025 146$272.1MDBC, VRDN, ANSS, MSFT, MRUS
Q1 2025 148$259.5MDBC, HES, JNPR, ACI, ANSS
Q4 2024 137$268.8MDBC, AMZN, HCP, MSFT, ANSS
Q3 2024 142$290.0MDBC, AMZN, PCVX, ACLX, CTLT
Q2 2024 137$273.8MDBC, INSM, MRUS, CRM, AXSM
Q1 2024 131$280.4MDBC, APGE, SYRE, MRUS, MSFT