Ikarian Capital, LLC
In its 13F for Q4 2024 (holdings as of December 31, 2024, filed February 14, 2025), Ikarian Capital, LLC reported 122 stock positions worth $350.2 million. Its top holding was Tarsus Pharmaceuticals (TARS) at 9.6% of the portfolio, followed by Crinetics Pharmaceuticals (CRNX, 7.5%) and Scholar Rock (SRRK, 4.4%). Compared with Q3 2024, it opened 43 new positions, sold out of 17, added to 21 and reduced 56. The biggest buy was a new position in Scholar Rock (SRRK) and the biggest sale an exit from Soleno Therapeutics (SLNO).
- Most Recent 13F
- Q2 2026
- Location
- DALLAS, TX
- CIK
- 0001778253
- Portfolio Value
- $350.2M (Q4 2024)
- SEC Filing
- 0001420506-25-000610 ↗ filed Feb 14, 2025
Holdings Value
Holdings 122 stocks · $350.2M
| TARS Tarsus Pharmaceuticals Inc. | 9.61% | 607,689 | $33.6M | Reduce -41.0% |
| CRNX Crinetics Pharmaceuticals Inc. | 7.54% | 516,431 | $26.4M | Add +21.0% |
| SRRK Scholar Rock Holding Corp. | 4.41% | 357,185 | $15.4M | New |
| BPMC Blueprint Medicines Corp. | 4.22% | 169,374 | $14.8M | Add +99.3% |
| FBRX Forte Biosciences Inc. | 3.95% | 609,225 | $13.8M | New |
| VRDN Viridian Therapeutics Inc. | 2.57% | 469,949 | $9.0M | Reduce -6.0% |
| ELVN Enliven Therapeutics Inc. | 2.53% | 394,538 | $8.9M | Reduce -21.0% |
| TGTX TG Therapeutics Inc. | 2.50% | 291,240 | $8.8M | New |
| INSM Insmed Inc. | 2.36% | 119,800 | $8.3M | Reduce -22.6% |
| GPCR Structure Therapeutics Inc. | 2.20% | 284,085 | $7.7M | Add +146.6% |
| RARE Ultragenyx Pharmaceutical Inc. | 2.15% | 178,989 | $7.5M | Reduce -0.0% |
| CPRX Catalyst Pharmaceuticals Inc. | 2.08% | 349,649 | $7.3M | Reduce -16.3% |
| AVTX Avalo Therapeutics Inc. | 2.06% | 970,259 | $7.2M | Reduce -0.0% |
| CYTK Cytokinetics Inc. | 2.01% | 149,982 | $7.1M | Reduce -11.8% |
| VIR Vir Biotechnology Inc. | 1.88% | 897,862 | $6.6M | New |
| TECX Tectonic Therapeutic Inc. | 1.88% | 142,328 | $6.6M | Reduce -46.7% |
| SYRE Spyre Therapeutics Inc. | 1.88% | 282,159 | $6.6M | Reduce -6.7% |
| BBIO Bridgebio Pharma Inc. | 1.69% | 215,713 | $5.9M | Reduce -24.5% |
| KOD Kodiak Sciences Inc. | 1.64% | 576,166 | $5.7M | Add +20.9% |
| RCUS Arcus Biosciences Inc. | 1.61% | 378,363 | $5.6M | Reduce -49.1% |
| DRUG Bright Minds Biosciences Inc. | 1.57% | 152,211 | $5.5M | New |
| ELDN Eledon Pharmaceuticals Inc. | 1.33% | 1,126,637 | $4.6M | New |
| ACOG Alpha Cognition Inc. | 1.27% | 755,867 | $4.5M | New |
| LENZ Lenz Therapeutics Inc. | 1.23% | 149,502 | $4.3M | Reduce -26.9% |
| RZLT Rezolute Inc. | 1.20% | 857,230 | $4.2M | Reduce -3.4% |
| SRPT Sarepta Therapeutics Inc. | 1.18% | 34,087 | $4.1M | Reduce -37.1% |
| EOLS Evolus Inc. | 1.18% | 373,265 | $4.1M | Add +44.5% |
| MLYS Mineralys Therapeutics Inc. | 1.17% | 332,390 | $4.1M | Add +84.7% |
| NUVL Nuvalent Inc. Class A | 1.17% | 52,216 | $4.1M | Reduce -0.0% |
| JANX Janux Therapeutics Inc. | 1.14% | 74,691 | $4.0M | New |
| VRNA Verona Pharma Ltd. | 1.06% | 80,000 | $3.7M | New |
| HELP Cybin Inc. | 1.00% | 397,175 | $3.5M | Add +8.2% |
| ARCT Arcturus Therapeutics Holdin | 0.97% | 200,000 | $3.4M | New |
| LXEO Lexeo Therapeutics Inc. | 0.94% | 499,301 | $3.3M | Add +94.1% |
| ABEO Abeona Therapeutics Inc. | 0.85% | 533,581 | $3.0M | Reduce -8.6% |
| RLAY Relay Therapeutics Inc. | 0.82% | 693,308 | $2.9M | Reduce -0.0% |
| RCKT Rocket Pharmaceuticals Inc. | 0.80% | 221,911 | $2.8M | Add +12.6% |
| PTGX Protagonist Therapeutics Inc. | 0.77% | 70,000 | $2.7M | New |
| ALGS Aligos Therapeutics Inc. | 0.73% | 64,300 | $2.6M | New |
| ZVRA Zevra Therapeutics Inc. | 0.70% | 292,772 | $2.4M | New |
| XENE Xenon Pharmaceuticals Inc. | 0.69% | 62,052 | $2.4M | Reduce -42.1% |
| VTYX Ventyx Biosciences Inc. | 0.68% | 1,092,590 | $2.4M | Add +467.1% |
| OKUR Onkure Therapeutics Inc. Class A | 0.62% | 253,754 | $2.2M | New |
| GLUE Monte Rosa Therapeutics Inc. | 0.62% | 311,575 | $2.2M | Reduce -0.0% |
| SLRN Acelyrin Inc. | 0.61% | 676,608 | $2.1M | Reduce -0.1% |
| CRDF Cardiff Oncology Inc. | 0.56% | 450,000 | $2.0M | New |
| SGMOQ Sangamo Therapeutics Inc. | 0.54% | 1,860,179 | $1.9M | New |
| NKTR Nektar Therapeutics | 0.54% | 2,029,028 | $1.9M | Add +54.6% |
| TARA Protara Therapeutic Inc. | 0.53% | 350,489 | $1.9M | Add +125.1% |
| ALEC Alector Inc. | 0.51% | 950,000 | $1.8M | New |
| TERN Terns Pharmaceuticals Inc. | 0.49% | 308,491 | $1.7M | Reduce 0.0% |
| ACHL Achilles Therapeutics PL-ADR | 0.47% | 1,441,141 | $1.6M | Reduce -0.1% |
| IMUX Immunic Inc. | 0.46% | 1,614,170 | $1.6M | Add +227.1% |
| ANRO Alto Neuroscience Inc. | 0.42% | 350,000 | $1.5M | New |
| IBIO Ibio Inc. | 0.42% | 599,913 | $1.5M | Reduce -0.0% |
| CDTX Cidara Therapeutics Inc. | 0.41% | 53,940 | $1.4M | New |
| TRML Tourmaline Bio Inc. | 0.39% | 67,927 | $1.4M | Reduce -37.4% |
| SWTX Springworks Therapeutics Inc. | 0.39% | 37,519 | $1.4M | New |
| TRVI Trevi Therapeutics Inc. | 0.38% | 325,000 | $1.3M | New |
| DCTH Delcath Systems Inc. | 0.35% | 100,365 | $1.2M | Reduce 0.0% |
| JSPR Jasper Therapeutics Inc. | 0.34% | 55,107 | $1.2M | Reduce -0.1% |
| ALLK Allakos LLC | 0.34% | 971,950 | $1.2M | Reduce -0.1% |
| LXRX Lexicon Pharmaceuticals Inc. | 0.33% | 1,550,000 | $1.1M | New |
| MIST Milestone Pharmaceuticals Inc. | 0.31% | 466,030 | $1.1M | Add +0.0% |
| THRD Third Harmonic Bio Inc. | 0.29% | 100,000 | $1.0M | New |
| VERV Verve Therapeutics Inc. | 0.27% | 169,991 | $959K | Reduce -0.0% |
| PYXS Pyxis Oncology Inc. | 0.27% | 613,253 | $957K | Reduce -36.0% |
| FULC Fulcrum Therapeutics Inc. | 0.27% | 200,096 | $940K | Add +166.8% |
| RNAC Cartesian Therapeutics Inc. | 0.27% | 52,166 | $934K | Reduce -0.1% |
| TRAW Traws Pharma Inc. | 0.25% | 98,493 | $875K | New |
| ACRS Aclaris Therapeutics Inc. | 0.25% | 350,000 | $868K | New |
| VIGL Vigil Neuroscience Inc. | 0.24% | 500,000 | $850K | New |
| TYRA Tyra Biosciences Inc. | 0.24% | 60,000 | $834K | New |
| LYEL Lyell Immunopharma Inc. | 0.23% | 1,276,037 | $817K | Add +142.6% |
| CMPS Compass Pathways PLC | 0.22% | 202,894 | $767K | Reduce -0.0% |
| AMLX Amylyx Pharmaceuticals Inc. | 0.22% | 201,187 | $760K | Reduce -26.7% |
| KZR Kezar Life Sciences Inc. | 0.21% | 106,901 | $718K | No change |
| NRIX Nurix Therapeutics Inc. | 0.19% | 34,985 | $659K | Reduce -86.5% |
| BIOMX INC | 0.19% | 892,976 | $652K | Reduce 0.0% |
| INBX Inhibrx Biosciences Inc. | 0.19% | 42,122 | $649K | Reduce 0.0% |
| AETHLON MEDICAL INC | 0.18% | 750,000 | $645K | New |
| VERU Veru Inc. | 0.18% | 945,239 | $615K | Reduce -0.1% |
| CRBP Corbus Pharmaceuticals Holdi | 0.17% | 51,431 | $607K | Reduce -81.9% |
| ITOS Iteos Therapeutics Inc. | 0.17% | 78,585 | $604K | Add +0.0% |
| SANA Sana Biotechnology Inc. | 0.17% | 365,000 | $595K | New |
| OLMA Olema Pharmaceuticals Inc. | 0.15% | 91,994 | $536K | Reduce -0.0% |
| ABOS Acumen Pharmaceuticals Inc. | 0.13% | 265,769 | $457K | Reduce -0.3% |
| MIND MEDICINE MINDMED INC | 0.12% | 62,691 | $436K | Add +0.3% |
| SPRB Spruce Biosciences Inc. | 0.12% | 1,000,000 | $420K | New |
| TVTX Travere Therapeutics Inc. | 0.11% | 22,600 | $394K | New |
| ELEV Elevation Oncology Inc. | 0.11% | 690,050 | $388K | Reduce -0.0% |
| CMMB Chemomab Therapeutics Ltd. | 0.11% | 213,052 | $386K | Reduce -0.2% |
| CATX Perspective Therapeutics Inc. | 0.10% | 108,300 | $345K | New |
| SENSEI BIOTHERAPEUTICS INC | 0.09% | 649,963 | $319K | Reduce -0.0% |
| VYGR Voyager Therapeutics Inc. | 0.09% | 55,766 | $316K | Reduce -0.2% |
| CLYM Climb Bio Inc. | 0.09% | 175,088 | $315K | Reduce -0.0% |
| ATXI Avenue Therapeutics Inc. | 0.08% | 140,000 | $280K | New |
| KPTI Karyopharm Therapeutics Inc. | 0.08% | 408,899 | $277K | Reduce -0.1% |
| ANEB Anebulo Pharmaceuticals Inc. | 0.08% | 157,720 | $265K | Reduce -0.1% |
| MGNX Macrogenics Inc. | 0.07% | 80,071 | $260K | Reduce -0.0% |
| VTGN Vistagen Therapeutics Inc. | 0.07% | 77,616 | $229K | New |
| LRMR Larimar Therapeutics Inc. | 0.06% | 58,526 | $226K | Reduce 0.0% |
| NUVB Nuvation Bio Inc. | 0.06% | 83,407 | $222K | Add +0.1% |
| LYRA Lyra Therapeutics Inc. | 0.06% | 1,058,148 | $218K | Add +0.1% |
| QUOIN PHARMACEUTICALS LTD | 0.05% | 275,000 | $179K | New |
| AEON BIOPHARMA INC | 0.04% | 257,563 | $139K | Reduce -0.2% |
| MNPR Monopar Therapeutics Inc. | 0.04% | 5,908 | $130K | New |
| APLS Apellis Pharmaceuticals Inc. | 0.03% | 3,594 | $115K | New |
| HOOK Hookipa Pharma Inc. | 0.03% | 52,996 | $107K | Reduce -0.1% |
| TPST Tempest Therapeutics Inc. | 0.03% | 105,285 | $88K | Reduce -0.3% |
| AUTONOMIX MED INC | 0.02% | 20,000 | $75K | New |
| STOK Stoke Therapeutics Inc. | 0.02% | 6,798 | $75K | Reduce -0.3% |
| SGMT Sagimet Biosciences Inc. Class A | 0.02% | 11,984 | $54K | Reduce -96.9% |
| SYBX Synlogic Inc. | 0.01% | 20,422 | $28K | Reduce -0.1% |
| RLMD Relmada Therapeutics Inc. | 0.01% | 40,270 | $21K | Reduce -0.3% |
| IMVT Immunovant Inc. | 0.00% | 600 | $15K | New |
| BCLI Brainstorm Cell Therapeutics | 0.00% | 6,016 | $14K | New |
| CADL Candel Therapeutics Inc. | 0.00% | 1,400 | $12K | New |
| CTMX Cytomx Therapeutics Inc. | 0.00% | 8,924 | $9K | No change |
| GLYCOMIMETICS INC | 0.00% | 6,501 | $2K | New |
| FDMT 4D Molecular Therapeutics Inc. | 0.00% | 40 | $223 | Add +2.6% |
| GALT Galectin Therapeutics Inc. | 0.00% | 100 | $129 | New |
Options reported separately and not counted above: XBI puts ($67.5M), XBI calls ($63.0M), TSN puts ($36.2M), AMGN calls ($19.3M), BBIO calls ($19.2M), PPC puts ($13.6M), RNAM puts ($11.6M), INSM calls ($10.4M), SRPT calls ($9.8M), NMRA calls ($9.5M), AXSM calls ($8.5M), CALM puts ($7.7M), and 37 more.
Portfolio Sells Q3 2024 → Q4 2024
| SLNO Soleno Therapeutics Inc. | Sold out | 0.00% | −3.47 |
| RCUS Arcus Biosciences Inc. | Reduce -49.1% | 1.61% | −1.92 |
| CRBP Corbus Pharmaceuticals Holdi | Reduce -81.9% | 0.17% | −1.65 |
| NRIX Nurix Therapeutics Inc. | Reduce -86.5% | 0.19% | −1.63 |
| ELVN Enliven Therapeutics Inc. | Reduce -21.0% | 2.53% | −1.43 |
| CAPR Capricor Therapeutics Inc. | Sold out | 0.00% | −1.42 |
| WVE Wave Life Sciences Ltd. | Sold out | 0.00% | −1.39 |
| AMGN Amgen Inc. | Sold out | 0.00% | −1.33 |
| INSM Insmed Inc. | Reduce -22.6% | 2.36% | −1.15 |
| SLN Silence Therapeutics PLC-ADR | Sold out | 0.00% | −1.05 |
| VRDN Viridian Therapeutics Inc. | Reduce -6.0% | 2.57% | −0.96 |
| RARE Ultragenyx Pharmaceutical Inc. | Reduce -0.0% | 2.15% | −0.94 |
| SRPT Sarepta Therapeutics Inc. | Reduce -37.1% | 1.18% | −0.92 |
| CRVO Cervomed Inc. | Sold out | 0.00% | −0.92 |
| TARS Tarsus Pharmaceuticals Inc. | Reduce -41.0% | 9.61% | −0.91 |
| SYRE Spyre Therapeutics Inc. | Reduce -6.7% | 1.88% | −0.88 |
| PYXS Pyxis Oncology Inc. | Reduce -36.0% | 0.27% | −0.82 |
| AVTX Avalo Therapeutics Inc. | Reduce -0.0% | 2.06% | −0.80 |
| CYTK Cytokinetics Inc. | Reduce -11.8% | 2.01% | −0.78 |
| ALNY Alnylam Pharmaceuticals Inc. | Sold out | 0.00% | −0.75 |
| RLAY Relay Therapeutics Inc. | Reduce -0.0% | 0.82% | −0.71 |
| TECX Tectonic Therapeutic Inc. | Reduce -46.7% | 1.88% | −0.64 |
| XENE Xenon Pharmaceuticals Inc. | Reduce -42.1% | 0.69% | −0.62 |
| BBIO Bridgebio Pharma Inc. | Reduce -24.5% | 1.69% | −0.57 |
| RENEO PHARMACEUTICALS INC | Sold out | 0.00% | −0.54 |
| ONC Beone Medicines Ltd.-ADR | Sold out | 0.00% | −0.51 |
| CPRX Catalyst Pharmaceuticals Inc. | Reduce -16.3% | 2.08% | −0.50 |
| NUVL Nuvalent Inc. Class A | Reduce -0.0% | 1.17% | −0.49 |
| TRML Tourmaline Bio Inc. | Reduce -37.4% | 0.39% | −0.47 |
| SLRN Acelyrin Inc. | Reduce -0.1% | 0.61% | −0.43 |
| MRNS Marinus Pharmaceuticals Inc. | Sold out | 0.00% | −0.39 |
| ROIV Roivant Sciences Ltd. | Sold out | 0.00% | −0.36 |
| IFRX Inflarx NV | Sold out | 0.00% | −0.34 |
| SGMT Sagimet Biosciences Inc. Class A | Reduce -96.9% | 0.02% | −0.32 |
| TERN Terns Pharmaceuticals Inc. | Reduce 0.0% | 0.49% | −0.31 |
| ABEO Abeona Therapeutics Inc. | Reduce -8.6% | 0.85% | −0.30 |
| LENZ Lenz Therapeutics Inc. | Reduce -26.9% | 1.23% | −0.28 |
| PRQR Proqr Therapeutics NV | Sold out | 0.00% | −0.27 |
| AEROVATE THERAPEUTICS INC | Sold out | 0.00% | −0.24 |
| OLMA Olema Pharmaceuticals Inc. | Reduce -0.0% | 0.15% | −0.19 |
| CLYM Climb Bio Inc. | Reduce -0.0% | 0.09% | −0.19 |
| CMPS Compass Pathways PLC | Reduce -0.0% | 0.22% | −0.18 |
| IMTX Immatics NV | Sold out | 0.00% | −0.18 |
| NYXH Nyxoah SA | Sold out | 0.00% | −0.15 |
| RZLT Rezolute Inc. | Reduce -3.4% | 1.20% | −0.14 |
| BIOMX INC | Reduce 0.0% | 0.19% | −0.10 |
| RAPT THERAPEUTICS INC | Sold out | 0.00% | −0.10 |
| ABOS Acumen Pharmaceuticals Inc. | Reduce -0.3% | 0.13% | −0.07 |
| AMLX Amylyx Pharmaceuticals Inc. | Reduce -26.7% | 0.22% | −0.06 |
| LRMR Larimar Therapeutics Inc. | Reduce 0.0% | 0.06% | −0.05 |
Portfolio Buys Q3 2024 → Q4 2024
| SRRK Scholar Rock Holding Corp. | New | 4.41% | +4.41 |
| FBRX Forte Biosciences Inc. | New | 3.95% | +3.95 |
| TGTX TG Therapeutics Inc. | New | 2.50% | +2.50 |
| VIR Vir Biotechnology Inc. | New | 1.88% | +1.88 |
| BPMC Blueprint Medicines Corp. | Add +99.3% | 4.22% | +1.78 |
| DRUG Bright Minds Biosciences Inc. | New | 1.57% | +1.57 |
| ELDN Eledon Pharmaceuticals Inc. | New | 1.33% | +1.33 |
| ACOG Alpha Cognition Inc. | New | 1.27% | +1.27 |
| KOD Kodiak Sciences Inc. | Add +20.9% | 1.64% | +1.25 |
| JANX Janux Therapeutics Inc. | New | 1.14% | +1.14 |
| VRNA Verona Pharma Ltd. | New | 1.06% | +1.06 |
| ARCT Arcturus Therapeutics Holdin | New | 0.97% | +0.97 |
| PTGX Protagonist Therapeutics Inc. | New | 0.77% | +0.77 |
| CRNX Crinetics Pharmaceuticals Inc. | Add +21.0% | 7.54% | +0.77 |
| ALGS Aligos Therapeutics Inc. | New | 0.73% | +0.73 |
| ZVRA Zevra Therapeutics Inc. | New | 0.70% | +0.70 |
| GPCR Structure Therapeutics Inc. | Add +146.6% | 2.20% | +0.63 |
| OKUR Onkure Therapeutics Inc. Class A | New | 0.62% | +0.62 |
| CRDF Cardiff Oncology Inc. | New | 0.56% | +0.56 |
| VTYX Ventyx Biosciences Inc. | Add +467.1% | 0.68% | +0.55 |
| SGMOQ Sangamo Therapeutics Inc. | New | 0.54% | +0.54 |
| ALEC Alector Inc. | New | 0.51% | +0.51 |
| MLYS Mineralys Therapeutics Inc. | Add +84.7% | 1.17% | +0.49 |
| TARA Protara Therapeutic Inc. | Add +125.1% | 0.53% | +0.44 |
| ANRO Alto Neuroscience Inc. | New | 0.42% | +0.42 |
| CDTX Cidara Therapeutics Inc. | New | 0.41% | +0.41 |
| SWTX Springworks Therapeutics Inc. | New | 0.39% | +0.39 |
| TRVI Trevi Therapeutics Inc. | New | 0.38% | +0.38 |
| LXRX Lexicon Pharmaceuticals Inc. | New | 0.33% | +0.33 |
| THRD Third Harmonic Bio Inc. | New | 0.29% | +0.29 |
| TRAW Traws Pharma Inc. | New | 0.25% | +0.25 |
| ACRS Aclaris Therapeutics Inc. | New | 0.25% | +0.25 |
| VIGL Vigil Neuroscience Inc. | New | 0.24% | +0.24 |
| TYRA Tyra Biosciences Inc. | New | 0.24% | +0.24 |
| LXEO Lexeo Therapeutics Inc. | Add +94.1% | 0.94% | +0.22 |
| IMUX Immunic Inc. | Add +227.1% | 0.46% | +0.21 |
| FULC Fulcrum Therapeutics Inc. | Add +166.8% | 0.27% | +0.19 |
| AETHLON MEDICAL INC | New | 0.18% | +0.18 |
| SANA Sana Biotechnology Inc. | New | 0.17% | +0.17 |
| SPRB Spruce Biosciences Inc. | New | 0.12% | +0.12 |
| TVTX Travere Therapeutics Inc. | New | 0.11% | +0.11 |
| CATX Perspective Therapeutics Inc. | New | 0.10% | +0.10 |
| MIST Milestone Pharmaceuticals Inc. | Add +0.0% | 0.31% | +0.09 |
| ATXI Avenue Therapeutics Inc. | New | 0.08% | +0.08 |
| VTGN Vistagen Therapeutics Inc. | New | 0.07% | +0.07 |
| QUOIN PHARMACEUTICALS LTD | New | 0.05% | +0.05 |
| MNPR Monopar Therapeutics Inc. | New | 0.04% | +0.04 |
| APLS Apellis Pharmaceuticals Inc. | New | 0.03% | +0.03 |
| AUTONOMIX MED INC | New | 0.02% | +0.02 |
| MIND MEDICINE MINDMED INC | Add +0.3% | 0.12% | +0.01 |
Options Activity Q3 2024 → Q4 2024
| XBI SS SPDR S&P Biotech ETF | put | Add +50.0% | 750,000 | $67.5M |
| XBI SS SPDR S&P Biotech ETF | call | New | 700,000 | $63.0M |
| VRTX Vertex Pharmaceuticals Inc. | put | Sold out | 100,000 | $46.5Mbefore exit |
| VRTX Vertex Pharmaceuticals Inc. | call | Sold out | 100,000 | $46.5Mbefore exit |
| TSN Tyson Foods Inc. Class A | put | New | 630,000 | $36.2M |
| AMGN Amgen Inc. | call | Reduce -49.3% | 74,000 | $19.3M |
| BBIO Bridgebio Pharma Inc. | call | New | 700,000 | $19.2M |
| JANX Janux Therapeutics Inc. | put | Sold out | 365,200 | $16.6Mbefore exit |
| BHVN Biohaven Ltd. | put | Sold out | 325,600 | $16.3Mbefore exit |
| PPC Pilgrim's Pride Corp. | put | New | 300,000 | $13.6M |
| RNAM Avidity Biosciences Inc. | put | New | 400,000 | $11.6M |
| CLDX Celldex Therapeutics Inc. | call | Sold out | 305,500 | $10.4Mbefore exit |
| INSM Insmed Inc. | call | New | 150,000 | $10.4M |
| SRPT Sarepta Therapeutics Inc. | call | New | 81,000 | $9.8M |
| NMRA Neumora Therapeutics Inc. | call | Add +125.0% | 900,000 | $9.5M |
| AXSM Axsome Therapeutics Inc. | call | New | 100,000 | $8.5M |
| CALM Cal-Maine Foods Inc. | put | New | 75,000 | $7.7M |
| DNA Ginkgo Bioworks Holdings Inc. | call | New | 769,700 | $7.6M |
| IMVT Immunovant Inc. | call | Reduce -40.0% | 300,000 | $7.4M |
| DYN Dyne Therapeutics Inc. | put | Add +111.1% | 280,800 | $6.6M |
| APLS Apellis Pharmaceuticals Inc. | put | Sold out | 200,000 | $5.8Mbefore exit |
| SLNO Soleno Therapeutics Inc. | call | Sold out | 110,000 | $5.6Mbefore exit |
| AKRO Akero Therapeutics Inc. | put | Add +0.1% | 199,000 | $5.5M |
| VIR Vir Biotechnology Inc. | call | New | 720,300 | $5.3M |
| CLDX Celldex Therapeutics Inc. | put | Reduce -32.7% | 205,500 | $5.2M |
| ANRO Alto Neuroscience Inc. | put | Sold out | 450,000 | $5.1Mbefore exit |
| MDGL Madrigal Pharmaceuticals Inc. | put | Sold out | 23,500 | $5.0Mbefore exit |
| CAPR Capricor Therapeutics Inc. | call | Add +20.4% | 361,100 | $5.0M |
| ANRO Alto Neuroscience Inc. | call | Sold out | 431,000 | $4.9Mbefore exit |
| CRBP Corbus Pharmaceuticals Holdi | put | Sold out | 233,100 | $4.8Mbefore exit |
| SRRK Scholar Rock Holding Corp. | call | Reduce -49.5% | 102,100 | $4.4M |
| APLS Apellis Pharmaceuticals Inc. | call | Sold out | 150,000 | $4.3Mbefore exit |
| MRNA Moderna Inc. | put | New | 100,000 | $4.2M |
| BDTX Black Diamond Therapeutics I | put | Sold out | 950,000 | $4.1Mbefore exit |
| ANAB Anaptysbio Inc. | put | Reduce -23.1% | 310,800 | $4.1M |
| CRVS Corvus Pharmaceuticals Inc. | call | Add +245.6% | 754,400 | $4.0M |
| NMRA Neumora Therapeutics Inc. | put | Reduce -12.5% | 350,000 | $3.7M |
| SLNO Soleno Therapeutics Inc. | put | New | 75,000 | $3.4M |
| VRDN Viridian Therapeutics Inc. | call | Reduce -12.4% | 175,100 | $3.4M |
| ANAB Anaptysbio Inc. | call | Reduce -28.6% | 250,000 | $3.3M |
| BDTX Black Diamond Therapeutics I | call | Sold out | 700,000 | $3.0Mbefore exit |
| RNAM Avidity Biosciences Inc. | call | New | 100,000 | $2.9M |
| CYTK Cytokinetics Inc. | call | Sold out | 52,300 | $2.8Mbefore exit |
| CRVS Corvus Pharmaceuticals Inc. | put | New | 500,000 | $2.7M |
| NVAX Novavax Inc. | call | New | 300,000 | $2.4M |
| CRBP Corbus Pharmaceuticals Holdi | call | Sold out | 107,800 | $2.2Mbefore exit |
| TEVA Teva Pharmaceutical-SP ADR | call | New | 100,000 | $2.2M |
| RCUS Arcus Biosciences Inc. | call | Add +24.0% | 141,000 | $2.1M |
| HROW Harrow Inc. | call | New | 58,300 | $2.0M |
| BMEA Biomea Fusion Inc. | put | Add +713.4% | 431,100 | $1.7M |
Showing the first 50 of 70.
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 126 | $610.9M | ABVX, KOD, ALMS, PRAX, PCVX |
| Q1 2026 | 127 | $699.0M | TERN, KOD, ALMS, PCVX, PRAX |
| Q4 2025 | 135 | $772.6M | TERN, CDTX, ABVX, JAZZ, MAZE |
| Q3 2025 | 116 | $494.3M | GMAB, ABVX, IONS, CDTX, MAZE |
| Q2 2025 | 103 | $302.2M | CDTX, ALNY, INSM, VRNA, CRNX |
| Q1 2025 | 116 | $306.9M | TARS, CRNX, SPY, SRPT, BPMC |
| Q4 2024 | 122 | $350.2M | TARS, CRNX, SRRK, BPMC, FBRX |
| Q3 2024 | 96 | $322.0M | TARS, CRNX, ELVN, RCUS, VRDN |
| Q2 2024 | 85 | $320.5M | SRPT, CRNX, TARS, SLNO, CRBP |
| Q1 2024Amended | 82 | $367.7M | CRNX, TARS, SLNO, CRBP, SRPT |