Knott David M Jr

In its 13F for Q1 2025 (holdings as of March 31, 2025, filed May 12, 2025), Knott David M Jr reported 84 stock positions worth $212.0 million. Its top holding was Calumet (CLMT) at 19.7% of the portfolio, followed by Apollo Global Management (APO, 14.5%) and Janus Henderson Aaa Clo ETF (JAAA, 13.2%). Compared with Q4 2024, it opened 15 new positions, sold out of 20, added to 10 and reduced 14. The biggest buy was Xeris Biopharma (XERS, shares +11%) and the biggest sale Calumet (CLMT, shares −10%).

Most Recent 13F
Q2 2026
Location
SYOSSET, NY
CIK
0001892770
Portfolio Value
$212.0M (Q1 2025)
SEC Filing
0001104659-25-047243 ↗ filed May 12, 2025

Holdings Value

0$100.0M$200.0M$300.0M Q1 2024: $282.8M Q1 2024 Q2 2024: $250.6M Q2 2024 Q3 2024: $284.6M Q3 2024 Q4 2024: $276.5M Q4 2024 Q1 2025: $212.0M $212.0M Q1 2025 Q2 2025: $220.6M Q2 2025 Q3 2025: $238.7M Q3 2025 Q4 2025: $215.9M Q4 2025 Q1 2026: $168.0M Q1 2026 Q2 2026: $189.2M Q2 2026

Holdings 84 stocks · $212.0M

CLMT Calumet Inc. 19.73% 3,297,194 $41.8M Reduce -9.7%
APO Apollo Global Management Inc. 14.54% 225,000 $30.8M No change
JAAA Janus Henderson Aaa Clo ETF 13.20% 551,763 $28.0M Reduce -6.5%
GOOG Alphabet Inc. Class C 8.27% 112,220 $17.5M No change
DCGO Docgo Inc. 3.82% 3,070,850 $8.1M No change
PFE Pfizer Inc. 3.04% 254,537 $6.4M No change
XERS Xeris Biopharma Holdings Inc. 2.88% 1,110,000 $6.1M Add +11.0%
VRNA Verona Pharma Ltd. 2.64% 88,000 $5.6M Reduce -44.8%
JPM JPMorgan Chase & Co. 2.43% 20,985 $5.1M No change
CPRX Catalyst Pharmaceuticals Inc. 2.43% 212,000 $5.1M Add +0.9%
TVTX Travere Therapeutics Inc. 1.93% 228,000 $4.1M No change
PTGX Protagonist Therapeutics Inc. 1.73% 76,000 $3.7M Add +45.1%
BCRX Biocryst Pharmaceuticals Inc. 1.63% 460,000 $3.5M Add +4.5%
AVDL Avadel Pharmaceuticals Ltd. 1.57% 426,000 $3.3M Add +22.8%
ESGR Enstar Group Ltd. 1.18% 7,500 $2.5M No change
ARDX Ardelyx Inc. 1.14% 493,807 $2.4M Reduce -19.4%
OABI Omniab Inc. 1.11% 982,336 $2.4M Reduce -10.3%
CSX CSX Corp. 0.97% 70,000 $2.1M No change
AB Alliancebernstein Holding LP 0.87% 48,000 $1.8M No change
ICLO Invesco Aaa Clo F/R Note ETF 0.85% 70,502 $1.8M Reduce -65.0%
RARE Ultragenyx Pharmaceutical Inc. 0.82% 48,000 $1.7M New
SNDX Syndax Pharmaceuticals Inc. 0.74% 128,000 $1.6M No change
MYGN Myriad Genetics Inc. 0.67% 160,000 $1.4M New
COGT Cogent Biosciences Inc. 0.60% 213,302 $1.3M New
CLOZ Eldridge BBB-B Clo ETF 0.60% 47,807 $1.3M No change
REGN Regeneron Pharmaceuticals 0.60% 2,000 $1.3M New
BMY Bristol-Myers Squibb Co. 0.55% 19,000 $1.2M New
COLL Collegium Pharmaceutical Inc. 0.54% 38,473 $1.1M Add +16.8%
XBI SS SPDR S&P Biotech ETF 0.52% 13,643 $1.1M Add +36.4%
RHP Ryman Hospitality Properties 0.52% 12,000 $1.1M No change
ABBV Abbvie Inc. 0.50% 5,037 $1.1M No change
ACLX Arcellx Inc. 0.46% 15,000 $984K New
KMB Kimberly-Clark Corp. 0.40% 6,000 $853K No change
MGTX Meiragtx Holdings PLC 0.40% 125,010 $848K Add +31.5%
ATRC Atricure Inc. 0.37% 24,620 $794K New
MREO Mereo Biopharma Group PL-ADR 0.34% 319,337 $719K Reduce -3.5%
TECX Tectonic Therapeutic Inc. 0.33% 40,000 $708K New
DD Dupont DE Nemours Inc. 0.33% 9,418 $703K Reduce -5.2%
CTVA Corteva Inc. 0.33% 11,051 $695K Reduce -4.4%
ATYR Atyr Pharma Inc. 0.32% 223,407 $675K Reduce -27.5%
AUTL Autolus Therapeutics PLC 0.31% 420,000 $651K New
MDLZ Mondelez International Inc. Class A 0.29% 9,000 $611K No change
INZY Inozyme Pharma Inc. 0.29% 666,204 $606K Reduce -4.1%
MSFT Microsoft Corp. 0.28% 1,600 $601K No change
AAPL Apple Inc. 0.26% 2,494 $554K No change
IBM Intl Business Machines Corp. filed as INTERNATIONAL BUSINESS MACHS 0.25% 2,142 $533K No change
XENE Xenon Pharmaceuticals Inc. 0.25% 15,866 $532K Reduce -24.0%
CNQ Canadian Natural Resources 0.24% 16,800 $517K No change
SLDB Solid Biosciences Inc. 0.23% 132,000 $488K New
HELP Cybin Inc. 0.20% 66,880 $424K Add +10.6%
VRDN Viridian Therapeutics Inc. 0.19% 30,000 $404K Add +20.0%
IMVT Immunovant Inc. 0.18% 22,443 $384K Reduce -75.6%
LLY Eli Lilly & Co. 0.12% 300 $248K No change
VERA Vera Therapeutics Inc. 0.11% 10,000 $240K New
LEGH Legacy Housing Corp. 0.08% 6,500 $164K No change
JNJ Johnson & Johnson 0.07% 922 $153K No change
CLOX Eldridge Aaa Clo ETF 0.07% 5,766 $147K No change
KO The Coca-Cola Co. 0.07% 2,000 $143K No change
NVDA Nvidia Corp. 0.07% 1,280 $139K No change
AVGO Broadcom Inc. 0.06% 710 $119K No change
RCUS Arcus Biosciences Inc. 0.04% 12,000 $94K New
EBC Eastern Bankshares Inc. 0.04% 5,000 $82K No change
IWP iShares Russell Mid-Cap Grow 0.04% 695 $82K No change
WVE Wave Life Sciences Ltd. 0.04% 10,000 $81K New
TTE Totalenergies SE -Spon ADR 0.04% 1,200 $78K No change
FSK FS KKR Capital Corp. 0.03% 2,875 $60K No change
AMZN Amazon.com Inc. 0.03% 300 $57K No change
FSBW FS Bancorp Inc. 0.03% 1,460 $55K No change
URI United Rentals Inc. 0.02% 78 $49K No change
GOOGL Alphabet Inc. Class A 0.02% 300 $46K No change
PWR Quanta Services Inc. 0.02% 176 $45K No change
DOW Dow Inc. 0.02% 1,206 $42K No change
BRSL Brightstar Lottery PLC filed as INTERNATIONAL GAME TECHNOLOG 0.02% 2,500 $41K New
DHR Danaher Corp. 0.02% 180 $37K No change
UNH Unitedhealth Group Inc. 0.01% 57 $30K No change
BX Blackstone Inc. 0.01% 210 $29K No change
OXY Occidental Petroleum Corp. 0.01% 663 $27K Reduce -46.9%
TMO Thermo Fisher Scientific Inc. 0.01% 45 $22K No change
AETUF Arc Resources Ltd. 0.01% 1,110 $22K New
CRM Salesforce Inc. 0.01% 77 $21K No change
KD Kyndryl Holdings Inc. 0.01% 428 $13K No change
STWD Starwood Property Trust Inc. 0.00% 400 $8K No change
GEHC GE Healthcare Technology 0.00% 50 $4K No change
WAB Wabtec Corp. 0.00% 6 $1K No change

Portfolio Sells Q4 2024 → Q1 2025

CLMT Calumet Inc. Reduce -9.7% 19.73% −9.35
Janus Henderson AAA CLO ETF Sold out 0.00% −2.90
ICLO Invesco Aaa Clo F/R Note ETF Reduce -65.0% 0.85% −1.02
IMVT Immunovant Inc. Reduce -75.6% 0.18% −0.64
VKTX Viking Therapeutics Inc. Sold out 0.00% −0.57
INZY Inozyme Pharma Inc. Reduce -4.1% 0.29% −0.41
VRTX Vertex Pharmaceuticals Inc. Sold out 0.00% −0.29
OABI Omniab Inc. Reduce -10.3% 1.11% −0.29
MDT Medtronic PLC Sold out 0.00% −0.23
EOLS Evolus Inc. Sold out 0.00% −0.23
XOMA Xoma Royalty Corporation Sold out 0.00% −0.19
BMRN Biomarin Pharmaceutical Inc. Sold out 0.00% −0.14
ATYR Atyr Pharma Inc. Reduce -27.5% 0.32% −0.09
MREO Mereo Biopharma Group PL-ADR Reduce -3.5% 0.34% −0.08
DAKT Daktronics Inc. Sold out 0.00% −0.05
XENE Xenon Pharmaceuticals Inc. Reduce -24.0% 0.25% −0.04
XFOR X4 Pharmaceuticals Inc. Sold out 0.00% −0.04
VRNA Verona Pharma Ltd. Reduce -44.8% 2.64% −0.04
CYPH Cypherpunk Technologies Inc. Sold out 0.00% −0.02
SSB Southstate Bank Corp. Sold out 0.00% −0.02
KVUE Kenvue Inc. Sold out 0.00% −0.02
ROIV Roivant Sciences Ltd. Sold out 0.00% −0.02
INTL GAME TECHNOLOGY Sold out 0.00% −0.02
HD Home Depot Inc. Sold out 0.00% −0.01
CMG Chipotle Mexican Grill Inc. Sold out 0.00% −0.01
LIN Linde PLC Sold out 0.00% −0.01
ARCH Arch Resources Inc. Sold out 0.00% −0.01
GE General Electric Sold out 0.00% −0.01
OXY Occidental Petroleum Corp. Reduce -46.9% 0.01% −0.01
ADBE Adobe Inc. Sold out 0.00% −0.01
ARDX Ardelyx Inc. Reduce -19.4% 1.14% +0.02
DD Dupont DE Nemours Inc. Reduce -5.2% 0.33% +0.06
CTVA Corteva Inc. Reduce -4.4% 0.33% +0.09
JAAA Janus Henderson Aaa Clo ETF Reduce -6.5% 13.20% +2.37

Portfolio Buys Q4 2024 → Q1 2025

XERS Xeris Biopharma Holdings Inc. Add +11.0% 2.88% +1.65
PTGX Protagonist Therapeutics Inc. Add +45.1% 1.73% +1.00
CPRX Catalyst Pharmaceuticals Inc. Add +0.9% 2.43% +0.84
RARE Ultragenyx Pharmaceutical Inc. New 0.82% +0.82
MYGN Myriad Genetics Inc. New 0.67% +0.67
COGT Cogent Biosciences Inc. New 0.60% +0.60
REGN Regeneron Pharmaceuticals New 0.60% +0.60
BMY Bristol-Myers Squibb Co. New 0.55% +0.55
ACLX Arcellx Inc. New 0.46% +0.46
BCRX Biocryst Pharmaceuticals Inc. Add +4.5% 1.63% +0.43
ATRC Atricure Inc. New 0.37% +0.37
TECX Tectonic Therapeutic Inc. New 0.33% +0.33
AUTL Autolus Therapeutics PLC New 0.31% +0.31
AVDL Avadel Pharmaceuticals Ltd. Add +22.8% 1.57% +0.26
SLDB Solid Biosciences Inc. New 0.23% +0.23
COLL Collegium Pharmaceutical Inc. Add +16.8% 0.54% +0.20
XBI SS SPDR S&P Biotech ETF Add +36.4% 0.52% +0.20
MGTX Meiragtx Holdings PLC Add +31.5% 0.40% +0.19
VERA Vera Therapeutics Inc. New 0.11% +0.11
RCUS Arcus Biosciences Inc. New 0.04% +0.04
WVE Wave Life Sciences Ltd. New 0.04% +0.04
BRSL Brightstar Lottery PLC New 0.02% +0.02
VRDN Viridian Therapeutics Inc. Add +20.0% 0.19% +0.02
AETUF Arc Resources Ltd. New 0.01% +0.01
HELP Cybin Inc. Add +10.6% 0.20% +0.01

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 83$189.2MGOOG, APO, SNDX, XERS, TVTX
Q1 2026 85$168.0MGOOG, APO, SNDX, BBIO, PTGX
Q4 2025 87$215.9MCLMT, APO, GOOG, SNDX, XERS
Q3 2025 87$238.7MCLMT, APO, GOOG, JAAA, XERS
Q2 2025 85$220.6MCLMT, APO, JAAA, GOOG, JPM
Q1 2025 84$212.0MCLMT, APO, JAAA, GOOG, DCGO
Q4 2024 89$276.5MCLMT, APO, JAAA, GOOG, DCGO
Q3 2024 92$284.6MCLMT, APO, GOOG, AB, CLOZ
Q2 2024 99$250.6MCLMT, APO, GOOG, CLOZ, DCGO
Q1 2024 106$282.8MCLMT, APO, CLOZ, GOOG, FTAI