Knott David M Jr

In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 12, 2025), Knott David M Jr reported 87 stock positions worth $238.7 million. Its top holding was Calumet (CLMT) at 21.6% of the portfolio, followed by Apollo Global Management (APO, 12.6%) and Alphabet Class C (GOOG, 11.4%). Compared with Q2 2025, it opened 14 new positions, sold out of 12, added to 15 and reduced 9. The biggest buy was Syndax Pharmaceuticals (SNDX, shares +21%) and the biggest sale Janus Henderson Aaa Clo ETF (JAAA, shares −12%).

Most Recent 13F
Q2 2026
Location
SYOSSET, NY
CIK
0001892770
Portfolio Value
$238.7M (Q3 2025)
SEC Filing
0001104659-25-110124 ↗ filed Nov 12, 2025

Holdings Value

0$100.0M$200.0M$300.0M Q1 2024: $282.8M Q1 2024 Q2 2024: $250.6M Q2 2024 Q3 2024: $284.6M Q3 2024 Q4 2024: $276.5M Q4 2024 Q1 2025: $212.0M Q1 2025 Q2 2025: $220.6M Q2 2025 Q3 2025: $238.7M $238.7M Q3 2025 Q4 2025: $215.9M Q4 2025 Q1 2026: $168.0M Q1 2026 Q2 2026: $189.2M Q2 2026

Holdings 87 stocks · $238.7M

CLMT Calumet Inc. 21.60% 2,825,231 $51.6M Reduce -13.7%
APO Apollo Global Management Inc. 12.56% 225,000 $30.0M No change
GOOG Alphabet Inc. Class C 11.45% 112,220 $27.3M No change
JAAA Janus Henderson Aaa Clo ETF 9.31% 437,754 $22.2M Reduce -11.6%
XERS Xeris Biopharma Holdings Inc. 3.46% 1,015,000 $8.3M Reduce -4.3%
SNDX Syndax Pharmaceuticals Inc. 2.76% 428,000 $6.6M Add +21.3%
JPM JPMorgan Chase & Co. 2.69% 20,374 $6.4M Reduce -2.9%
TVTX Travere Therapeutics Inc. 2.60% 260,000 $6.2M No change
AVDL Avadel Pharmaceuticals Ltd. 2.32% 363,000 $5.5M Reduce -14.8%
PTGX Protagonist Therapeutics Inc. 2.31% 83,000 $5.5M Add +3.8%
BBIO Bridgebio Pharma Inc. 1.85% 85,000 $4.4M Add +6.3%
DCGO Docgo Inc. 1.75% 3,070,850 $4.2M No change
VRNA Verona Pharma Ltd. 1.71% 38,355 $4.1M Reduce -30.3%
LENZ Lenz Therapeutics Inc. 1.60% 82,000 $3.8M No change
CPRX Catalyst Pharmaceuticals Inc. 1.56% 189,000 $3.7M Add +7.4%
RZLT Rezolute Inc. 1.08% 275,000 $2.6M New
VRDN Viridian Therapeutics Inc. 1.05% 116,574 $2.5M Add +27.4%
CSX CSX Corp. 1.04% 70,000 $2.5M No change
LQDA Liquidia Corp. 1.03% 107,783 $2.5M Add +19.8%
ACLX Arcellx Inc. 0.88% 25,700 $2.1M No change
PFE Pfizer Inc. 0.80% 74,537 $1.9M No change
AB Alliancebernstein Holding LP 0.77% 48,000 $1.8M No change
ATRC Atricure Inc. 0.71% 48,000 $1.7M Add +3.4%
CYTK Cytokinetics Inc. 0.69% 30,000 $1.6M New
RARE Ultragenyx Pharmaceutical Inc. 0.66% 52,000 $1.6M No change
PRAX Praxis Precision Medicines I 0.62% 28,000 $1.5M New
RCUS Arcus Biosciences Inc. 0.54% 95,200 $1.3M Add +36.0%
JNJ Johnson & Johnson 0.54% 6,922 $1.3M No change
CLOZ Eldridge BBB-B Clo ETF 0.54% 47,807 $1.3M No change
BMY Bristol-Myers Squibb Co. 0.51% 27,000 $1.2M No change
ABBV Abbvie Inc. 0.49% 5,037 $1.2M No change
TECX Tectonic Therapeutic Inc. 0.49% 74,000 $1.2M No change
RHP Ryman Hospitality Properties 0.45% 12,000 $1.1M No change
SLDB Solid Biosciences Inc. 0.42% 162,440 $1.0M No change
DAWN Day One Biopharmaceuticals I 0.39% 130,500 $920K Add +287.1%
MDGL Madrigal Pharmaceuticals Inc. 0.38% 2,000 $917K No change
MSFT Microsoft Corp. 0.35% 1,600 $829K No change
HELP Cybin Inc. 0.35% 140,242 $826K Add +109.7%
VERA Vera Therapeutics Inc. 0.32% 26,000 $756K Add +30.0%
CTVA Corteva Inc. 0.31% 11,051 $747K No change
KMB Kimberly-Clark Corp. 0.31% 6,000 $746K No change
DD Dupont DE Nemours Inc. 0.31% 9,418 $734K No change
WVE Wave Life Sciences Ltd. 0.28% 90,000 $659K Add +125.0%
IBB iShares Biotechnology ETF 0.27% 4,500 $650K Add +125.0%
AAPL Apple Inc. 0.27% 2,494 $635K No change
MREO Mereo Biopharma Group PL-ADR 0.26% 300,337 $619K Reduce -6.0%
IBM Intl Business Machines Corp. filed as INTERNATIONAL BUSINESS MACHS 0.25% 2,142 $604K No change
KURA Kura Oncology Inc. 0.25% 67,302 $596K New
ALKS Alkermes PLC 0.24% 19,300 $579K Reduce -60.6%
CNQ Canadian Natural Resources 0.22% 16,800 $537K No change
XBI SS SPDR S&P Biotech ETF 0.21% 5,000 $501K Add +66.7%
MDLZ Mondelez International Inc. Class A 0.21% 8,000 $500K New
OBIO Orchestra Biomed Holdings Inc. 0.20% 195,000 $484K Add +95.0%
FATE Fate Therapeutics Inc. 0.19% 365,000 $460K New
XENE Xenon Pharmaceuticals Inc. 0.18% 10,962 $440K No change
JSPR Jasper Therapeutics Inc. 0.17% 171,389 $408K New
SRRK Scholar Rock Holding Corp. 0.14% 9,000 $335K New
BIIB Biogen Inc. 0.12% 2,000 $280K New
BCRX Biocryst Pharmaceuticals Inc. 0.10% 32,570 $247K Reduce -90.2%
NVDA Nvidia Corp. 0.10% 1,280 $239K No change
AVGO Broadcom Inc. 0.10% 710 $234K No change
LLY Eli Lilly & Co. 0.10% 300 $229K No change
PTHS Pelthos Therapeutics Inc. 0.07% 6,112 $171K New
QURE Uniqure NV 0.05% 2,000 $117K New
LEGH Legacy Housing Corp. 0.05% 4,000 $110K No change
IVVD Invivyd Inc. 0.05% 100,000 $110K New
IWR iShares Russell Mid-Cap ETF 0.04% 695 $99K New
EBC Eastern Bankshares Inc. 0.04% 5,000 $91K No change
URI United Rentals Inc. 0.03% 78 $74K No change
PWR Quanta Services Inc. 0.03% 176 $73K No change
GOOGL Alphabet Inc. Class A 0.03% 300 $73K No change
TTE Totalenergies SE -Spon ADR 0.03% 1,200 $72K No change
AMZN Amazon.com Inc. 0.03% 300 $66K No change
BRSL Brightstar Lottery PLC 0.02% 2,500 $43K No change
FSK FS KKR Capital Corp. 0.02% 2,875 $43K New
BX Blackstone Inc. 0.01% 210 $36K No change
DHR Danaher Corp. 0.01% 180 $36K No change
DOW Dow Inc. 0.01% 1,206 $28K No change
OXY Occidental Petroleum Corp. 0.01% 663 $26K No change
TMO Thermo Fisher Scientific Inc. 0.01% 45 $22K No change
AETUF Arc Resources Ltd. 0.01% 1,110 $20K No change
UNH Unitedhealth Group Inc. 0.01% 57 $20K No change
CRM Salesforce Inc. 0.01% 77 $18K No change
KD Kyndryl Holdings Inc. 0.01% 428 $13K No change
STWD Starwood Property Trust Inc. 0.00% 400 $8K No change
GEHC GE Healthcare Technology 0.00% 50 $4K No change
WAB Wabtec Corp. 0.00% 6 $1K No change

Options reported separately and not counted above: DAR calls ($9.3M).

Portfolio Sells Q2 2025 → Q3 2025

JAAA Janus Henderson Aaa Clo ETF Reduce -11.6% 9.31% −2.08
CLMT Calumet Inc. Reduce -13.7% 21.60% −1.79
BCRX Biocryst Pharmaceuticals Inc. Reduce -90.2% 0.10% −1.25
INZY Inozyme Pharma Inc. Sold out 0.00% −1.21
ESGR Enstar Group Ltd. Sold out 0.00% −1.14
VRNA Verona Pharma Ltd. Reduce -30.3% 1.71% −0.64
MYGN Myriad Genetics Inc. Sold out 0.00% −0.43
ALKS Alkermes PLC Reduce -60.6% 0.24% −0.39
COLL Collegium Pharmaceutical Inc. Sold out 0.00% −0.32
AXSM Axsome Therapeutics Inc. Sold out 0.00% −0.28
AUTL Autolus Therapeutics PLC Sold out 0.00% −0.28
KRAFT FOODS INC Sold out 0.00% −0.28
MREO Mereo Biopharma Group PL-ADR Reduce -6.0% 0.26% −0.13
ATYR Atyr Pharma Inc. Sold out 0.00% −0.12
JPM JPMorgan Chase & Co. Reduce -2.9% 2.69% −0.07
KO The Coca-Cola Co. Sold out 0.00% −0.06
IWP iShares Russell Mid-Cap Grow Sold out 0.00% −0.04
FSK FS KKR Capital Corp. Sold out 0.00% −0.03
FSBW FS Bancorp Inc. Sold out 0.00% −0.03
AVDL Avadel Pharmaceuticals Ltd. Reduce -14.8% 2.32% +0.61
XERS Xeris Biopharma Holdings Inc. Reduce -4.3% 3.46% +1.22

Portfolio Buys Q2 2025 → Q3 2025

SNDX Syndax Pharmaceuticals Inc. Add +21.3% 2.76% +1.26
RZLT Rezolute Inc. New 1.08% +1.08
CYTK Cytokinetics Inc. New 0.69% +0.69
PRAX Praxis Precision Medicines I New 0.62% +0.62
LQDA Liquidia Corp. Add +19.8% 1.03% +0.52
VRDN Viridian Therapeutics Inc. Add +27.4% 1.05% +0.47
PTGX Protagonist Therapeutics Inc. Add +3.8% 2.31% +0.31
DAWN Day One Biopharmaceuticals I Add +287.1% 0.39% +0.29
RCUS Arcus Biosciences Inc. Add +36.0% 0.54% +0.28
BBIO Bridgebio Pharma Inc. Add +6.3% 1.85% +0.28
KURA Kura Oncology Inc. New 0.25% +0.25
MDLZ Mondelez International Inc. Class A New 0.21% +0.21
FATE Fate Therapeutics Inc. New 0.19% +0.19
JSPR Jasper Therapeutics Inc. New 0.17% +0.17
WVE Wave Life Sciences Ltd. Add +125.0% 0.28% +0.16
IBB iShares Biotechnology ETF Add +125.0% 0.27% +0.16
SRRK Scholar Rock Holding Corp. New 0.14% +0.14
BIIB Biogen Inc. New 0.12% +0.12
VERA Vera Therapeutics Inc. Add +30.0% 0.32% +0.10
XBI SS SPDR S&P Biotech ETF Add +66.7% 0.21% +0.10
HELP Cybin Inc. Add +109.7% 0.35% +0.09
OBIO Orchestra Biomed Holdings Inc. Add +95.0% 0.20% +0.08
PTHS Pelthos Therapeutics Inc. New 0.07% +0.07
QURE Uniqure NV New 0.05% +0.05
IVVD Invivyd Inc. New 0.05% +0.05
IWR iShares Russell Mid-Cap ETF New 0.04% +0.04
ATRC Atricure Inc. Add +3.4% 0.71% +0.02
FSK FS KKR Capital Corp. New 0.02% +0.02
CPRX Catalyst Pharmaceuticals Inc. Add +7.4% 1.56% −0.17

Options Activity Q2 2025 → Q3 2025

DAR Darling Ingredients Inc. call New 300,000 $9.3M

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 83$189.2MGOOG, APO, SNDX, XERS, TVTX
Q1 2026 85$168.0MGOOG, APO, SNDX, BBIO, PTGX
Q4 2025 87$215.9MCLMT, APO, GOOG, SNDX, XERS
Q3 2025 87$238.7MCLMT, APO, GOOG, JAAA, XERS
Q2 2025 85$220.6MCLMT, APO, JAAA, GOOG, JPM
Q1 2025 84$212.0MCLMT, APO, JAAA, GOOG, DCGO
Q4 2024 89$276.5MCLMT, APO, JAAA, GOOG, DCGO
Q3 2024 92$284.6MCLMT, APO, GOOG, AB, CLOZ
Q2 2024 99$250.6MCLMT, APO, GOOG, CLOZ, DCGO
Q1 2024 106$282.8MCLMT, APO, CLOZ, GOOG, FTAI