Knott David M Jr

In its 13F for Q1 2026 (holdings as of March 31, 2026, filed May 14, 2026), Knott David M Jr reported 85 stock positions worth $168.0 million. Its top holding was Alphabet Class C (GOOG) at 15.6% of the portfolio, followed by Apollo Global Management (APO, 14.9%) and Syndax Pharmaceuticals (SNDX, 5.9%). Compared with Q4 2025, it opened 10 new positions, sold out of 12, added to 17 and reduced 13. The biggest buy was a new position in Iovance Biotherapeutics (IOVA) and the biggest sale an exit from Calumet (CLMT).

Most Recent 13F
Q2 2026
Location
SYOSSET, NY
CIK
0001892770
Portfolio Value
$168.0M (Q1 2026)
SEC Filing
0001104659-26-060750 ↗ filed May 14, 2026

Holdings Value

0$100.0M$200.0M$300.0M Q1 2024: $282.8M Q1 2024 Q2 2024: $250.6M Q2 2024 Q3 2024: $284.6M Q3 2024 Q4 2024: $276.5M Q4 2024 Q1 2025: $212.0M Q1 2025 Q2 2025: $220.6M Q2 2025 Q3 2025: $238.7M Q3 2025 Q4 2025: $215.9M Q4 2025 Q1 2026: $168.0M $168.0M Q1 2026 Q2 2026: $189.2M Q2 2026

Holdings 85 stocks · $168.0M

GOOG Alphabet Inc. Class C 15.61% 91,420 $26.2M No change
APO Apollo Global Management Inc. 14.92% 225,000 $25.1M No change
SNDX Syndax Pharmaceuticals Inc. 5.87% 422,000 $9.9M Add +1.7%
BBIO Bridgebio Pharma Inc. 3.98% 90,000 $6.7M Add +5.9%
PTGX Protagonist Therapeutics Inc. 3.95% 63,000 $6.6M Reduce -13.7%
XERS Xeris Biopharma Holdings Inc. 3.66% 1,060,000 $6.1M Add +9.3%
JPM JPMorgan Chase & Co. 3.41% 19,477 $5.7M No change
IOVA Iovance Biotherapeutics Inc. 3.34% 1,600,000 $5.6M New
LPL Financial Holdings Inc. 2.95% 16,500 $5.0M New
JAAA Janus Henderson Aaa Clo ETF 2.80% 93,528 $4.7M No change
ALKS Alkermes PLC 2.53% 120,000 $4.2M Add +26.3%
TVTX Travere Therapeutics Inc. 2.49% 140,633 $4.2M Reduce -24.4%
COGT Cogent Biosciences Inc. 2.38% 104,000 $4.0M Add +2.0%
VRDN Viridian Therapeutics Inc. 2.11% 181,000 $3.5M Add +24.8%
AGIO Agios Pharmaceuticals Inc. 1.87% 93,058 $3.1M Add +417.0%
RLMD Relmada Therapeutics Inc. 1.82% 439,300 $3.1M New
TGTX TG Therapeutics Inc. 1.78% 90,001 $3.0M Add +100.0%
CPRX Catalyst Pharmaceuticals Inc. 1.77% 120,000 $3.0M Reduce -36.5%
ACLX Arcellx Inc. 1.33% 19,433 $2.2M Reduce -24.4%
XBI SS SPDR S&P Biotech ETF 1.14% 15,000 $1.9M Add +15.4%
AB Alliancebernstein Holding LP 1.07% 48,000 $1.8M No change
RCUS Arcus Biosciences Inc. 1.04% 81,241 $1.8M Reduce -33.0%
DCGO Docgo Inc. 1.00% 2,670,850 $1.7M No change
HELP Cybin Inc. 1.00% 350,000 $1.7M Add +22.7%
CYTK Cytokinetics Inc. 0.93% 23,644 $1.6M Reduce -30.5%
CNTA Centessa Pharmaceuticals Ltd. 0.92% 39,000 $1.5M Add +875.0%
ATRC Atricure Inc. 0.87% 51,400 $1.5M No change
ARDX Ardelyx Inc. 0.74% 207,000 $1.2M New
CLOZ Eldridge BBB-B Clo ETF 0.73% 47,807 $1.2M No change
JNJ Johnson & Johnson 0.72% 4,922 $1.2M Reduce -28.9%
RZLT Rezolute Inc. 0.67% 370,000 $1.1M Add +8.8%
OBIO Orchestra Biomed Holdings Inc. 0.64% 253,651 $1.1M Add +1.5%
MDGL Madrigal Pharmaceuticals Inc. 0.62% 2,000 $1.0M No change
VERA Vera Therapeutics Inc. 0.62% 26,000 $1.0M No change
CNTB Connect Biopharma Holdings L 0.60% 387,835 $1.0M Add +93.9%
IBB iShares Biotechnology ETF 0.55% 5,500 $929K No change
PFE Pfizer Inc. 0.54% 32,337 $908K No change
BMY Bristol-Myers Squibb Co. 0.49% 13,622 $826K Reduce -38.1%
CNQ Canadian Natural Resources 0.49% 16,800 $819K No change
BIIB Biogen Inc. 0.44% 4,000 $733K Reduce -33.3%
RARE Ultragenyx Pharmaceutical Inc. 0.41% 33,069 $693K Add +65.3%
AAPL Apple Inc. 0.38% 2,494 $633K No change
MSFT Microsoft Corp. 0.35% 1,600 $592K No change
VSTM Verastem Inc. 0.33% 104,000 $551K New
ADMA Adma Biologics Inc. 0.32% 60,200 $542K No change
IBM Intl Business Machines Corp. filed as INTERNATIONAL BUSINESS MACHS 0.31% 2,142 $519K No change
Biohaven Pharmaceutical Holding Co. Ltd 0.31% 60,720 $514K New
PTHS Pelthos Therapeutics Inc. 0.26% 21,073 $443K Add +9.3%
KURA Kura Oncology Inc. 0.26% 52,767 $429K Add +34.6%
EOLS Evolus Inc. 0.24% 99,338 $408K No change
CGEM Cullinan Therapeutics Inc. 0.20% 24,200 $344K New
SLDB Solid Biosciences Inc. 0.20% 47,143 $339K Reduce -71.0%
LENZ Lenz Therapeutics Inc. 0.18% 33,732 $309K Reduce -37.2%
WVE Wave Life Sciences Ltd. 0.17% 40,000 $290K Reduce -55.6%
RAIN Rain Enhancement Techno Class A 0.15% 101,686 $258K New
KMB Kimberly-Clark Corp. 0.14% 2,400 $232K No change
NVDA Nvidia Corp. 0.13% 1,280 $223K No change
RHP Ryman Hospitality Properties 0.13% 2,400 $221K No change
AVGO Broadcom Inc. 0.13% 710 $220K No change
MDLZ Mondelez International Inc. Class A 0.10% 3,000 $173K No change
DD Dupont DE Nemours Inc. 0.10% 3,767 $173K No change
JSPR Jasper Therapeutics Inc. 0.08% 160,789 $141K Reduce -11.4%
IVVD Invivyd Inc. 0.08% 100,000 $130K No change
CTVA Corteva Inc. 0.06% 1,206 $101K No change
MREO Mereo Biopharma Group PL-ADR 0.06% 300,337 $99K No change
EBC Eastern Bankshares Inc. 0.06% 5,000 $98K No change
PWR Quanta Services Inc. 0.06% 176 $97K No change
IWP iShares Russell Mid-Cap Grow 0.05% 695 $89K No change
GOOGL Alphabet Inc. Class A 0.05% 300 $86K No change
LEGH Legacy Housing Corp. 0.05% 4,000 $82K No change
AMZN Amazon.com Inc. 0.04% 300 $62K No change
URI United Rentals Inc. 0.03% 78 $57K No change
DOW Dow Inc. filed as DOW HLDGS INC 0.03% 1,206 $50K No change
OXY Occidental Petroleum Corp. 0.02% 663 $35K No change
DHR Danaher Corp. 0.02% 180 $34K No change
BRSL Brightstar Lottery PLC 0.02% 2,500 $32K New
FSK FS KKR Capital Corp. 0.02% 2,875 $29K New
BX Blackstone Inc. 0.01% 210 $24K No change
TMO Thermo Fisher Scientific Inc. 0.01% 45 $22K No change
UNH Unitedhealth Group Inc. 0.01% 57 $15K No change
CRM Salesforce Inc. 0.01% 77 $14K No change
STWD Starwood Property Trust Inc. 0.00% 400 $7K No change
KD Kyndryl Holdings Inc. 0.00% 428 $6K No change
GEHC GE Healthcare Technology 0.00% 50 $4K No change
WAB Wabtec Corp. 0.00% 6 $1K No change

Portfolio Sells Q4 2025 → Q1 2026

CLMT Calumet Inc. Sold out 0.00% −20.38
TVTX Travere Therapeutics Inc. Reduce -24.4% 2.49% −0.80
TECX Tectonic Therapeutic Inc. Sold out 0.00% −0.71
BHVN Biohaven Ltd. Sold out 0.00% −0.58
WVE Wave Life Sciences Ltd. Reduce -55.6% 0.17% −0.54
NKTR Nektar Therapeutics Sold out 0.00% −0.30
RCUS Arcus Biosciences Inc. Reduce -33.0% 1.04% −0.29
SRRK Scholar Rock Holding Corp. Sold out 0.00% −0.28
CPRX Catalyst Pharmaceuticals Inc. Reduce -36.5% 1.77% −0.27
XENE Xenon Pharmaceuticals Inc. Sold out 0.00% −0.23
SLDB Solid Biosciences Inc. Reduce -71.0% 0.20% −0.22
LENZ Lenz Therapeutics Inc. Reduce -37.2% 0.18% −0.21
MRSN Mersana Therapeutics Inc. Sold out 0.00% −0.20
FATE Fate Therapeutics Inc. Sold out 0.00% −0.17
DAWN Day One Biopharmaceuticals I Sold out 0.00% −0.11
CYTK Cytokinetics Inc. Reduce -30.5% 0.93% −0.07
JSPR Jasper Therapeutics Inc. Reduce -11.4% 0.08% −0.07
BMY Bristol-Myers Squibb Co. Reduce -38.1% 0.49% −0.06
BIIB Biogen Inc. Reduce -33.3% 0.44% −0.05
QURE Uniqure NV Sold out 0.00% −0.04
FSK FS KKR Capital Corp. Sold out 0.00% −0.02
INTL GAME TECHNOLOGY Sold out 0.00% −0.02
JNJ Johnson & Johnson Reduce -28.9% 0.72% +0.05
ACLX Arcellx Inc. Reduce -24.4% 1.33% +0.55
PTGX Protagonist Therapeutics Inc. Reduce -13.7% 3.95% +1.00

Portfolio Buys Q4 2025 → Q1 2026

IOVA Iovance Biotherapeutics Inc. New 3.34% +3.34
LPL Financial Holdings Inc. New 2.95% +2.95
SNDX Syndax Pharmaceuticals Inc. Add +1.7% 5.87% +1.83
RLMD Relmada Therapeutics Inc. New 1.82% +1.82
AGIO Agios Pharmaceuticals Inc. Add +417.0% 1.87% +1.65
ALKS Alkermes PLC Add +26.3% 2.53% +1.29
TGTX TG Therapeutics Inc. Add +100.0% 1.78% +1.16
BBIO Bridgebio Pharma Inc. Add +5.9% 3.98% +0.97
CNTA Centessa Pharmaceuticals Ltd. Add +875.0% 0.92% +0.88
ARDX Ardelyx Inc. New 0.74% +0.74
COGT Cogent Biosciences Inc. Add +2.0% 2.38% +0.70
XBI SS SPDR S&P Biotech ETF Add +15.4% 1.14% +0.41
CNTB Connect Biopharma Holdings L Add +93.9% 0.60% +0.34
VSTM Verastem Inc. New 0.33% +0.33
Biohaven Pharmaceutical Holding Co. Ltd New 0.31% +0.31
RZLT Rezolute Inc. Add +8.8% 0.67% +0.30
CGEM Cullinan Therapeutics Inc. New 0.20% +0.20
RARE Ultragenyx Pharmaceutical Inc. Add +65.3% 0.41% +0.20
OBIO Orchestra Biomed Holdings Inc. Add +1.5% 0.64% +0.16
RAIN Rain Enhancement Techno Class A New 0.15% +0.15
XERS Xeris Biopharma Holdings Inc. Add +9.3% 3.66% +0.13
KURA Kura Oncology Inc. Add +34.6% 0.26% +0.07
BRSL Brightstar Lottery PLC New 0.02% +0.02
FSK FS KKR Capital Corp. New 0.02% +0.02
VRDN Viridian Therapeutics Inc. Add +24.8% 2.11% +0.02
PTHS Pelthos Therapeutics Inc. Add +9.3% 0.26% −0.01
HELP Cybin Inc. Add +22.7% 1.00% −0.08

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 83$189.2MGOOG, APO, SNDX, XERS, TVTX
Q1 2026 85$168.0MGOOG, APO, SNDX, BBIO, PTGX
Q4 2025 87$215.9MCLMT, APO, GOOG, SNDX, XERS
Q3 2025 87$238.7MCLMT, APO, GOOG, JAAA, XERS
Q2 2025 85$220.6MCLMT, APO, JAAA, GOOG, JPM
Q1 2025 84$212.0MCLMT, APO, JAAA, GOOG, DCGO
Q4 2024 89$276.5MCLMT, APO, JAAA, GOOG, DCGO
Q3 2024 92$284.6MCLMT, APO, GOOG, AB, CLOZ
Q2 2024 99$250.6MCLMT, APO, GOOG, CLOZ, DCGO
Q1 2024 106$282.8MCLMT, APO, CLOZ, GOOG, FTAI