Knott David M Jr

In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 12, 2026), Knott David M Jr reported 87 stock positions worth $215.9 million. Its top holding was Calumet (CLMT) at 20.4% of the portfolio, followed by Apollo Global Management (APO, 15.1%) and Alphabet Class C (GOOG, 13.3%). Compared with Q3 2025, it opened 13 new positions, sold out of 13, added to 15 and reduced 20. The biggest buy was a new position in Cogent Biosciences (COGT) and the biggest sale Janus Henderson Aaa Clo ETF (JAAA, shares −79%).

Most Recent 13F
Q2 2026
Location
SYOSSET, NY
CIK
0001892770
Portfolio Value
$215.9M (Q4 2025)
SEC Filing
0001104659-26-014058 ↗ filed Feb 12, 2026

Holdings Value

0$100.0M$200.0M$300.0M Q1 2024: $282.8M Q1 2024 Q2 2024: $250.6M Q2 2024 Q3 2024: $284.6M Q3 2024 Q4 2024: $276.5M Q4 2024 Q1 2025: $212.0M Q1 2025 Q2 2025: $220.6M Q2 2025 Q3 2025: $238.7M Q3 2025 Q4 2025: $215.9M $215.9M Q4 2025 Q1 2026: $168.0M Q1 2026 Q2 2026: $189.2M Q2 2026

Holdings 87 stocks · $215.9M

CLMT Calumet Inc. 20.38% 2,214,969 $44.0M Reduce -21.6%
APO Apollo Global Management Inc. 15.08% 225,000 $32.6M No change
GOOG Alphabet Inc. Class C 13.28% 91,420 $28.7M Reduce -18.5%
SNDX Syndax Pharmaceuticals Inc. 4.04% 415,000 $8.7M Reduce -3.0%
XERS Xeris Biopharma Holdings Inc. 3.53% 970,000 $7.6M Reduce -4.4%
TVTX Travere Therapeutics Inc. 3.29% 186,000 $7.1M Reduce -28.5%
BBIO Bridgebio Pharma Inc. 3.01% 85,000 $6.5M No change
PTGX Protagonist Therapeutics Inc. 2.95% 73,000 $6.4M Reduce -12.1%
JPM JPMorgan Chase & Co. 2.91% 19,477 $6.3M Reduce -4.4%
JAAA Janus Henderson Aaa Clo ETF 2.19% 93,528 $4.7M Reduce -78.6%
VRDN Viridian Therapeutics Inc. 2.09% 145,000 $4.5M Add +24.4%
CPRX Catalyst Pharmaceuticals Inc. 2.04% 189,000 $4.4M No change
COGT Cogent Biosciences Inc. 1.68% 102,000 $3.6M New
RCUS Arcus Biosciences Inc. 1.34% 121,241 $2.9M Add +27.4%
ALKS Alkermes PLC 1.23% 95,000 $2.7M Add +392.2%
DCGO Docgo Inc. 1.09% 2,670,850 $2.3M Reduce -13.0%
HELP Cybin Inc. 1.08% 285,182 $2.3M Add +103.3%
CYTK Cytokinetics Inc. 1.00% 34,000 $2.2M Add +13.3%
ATRC Atricure Inc. 0.94% 51,400 $2.0M Add +7.1%
AB Alliancebernstein Holding LP 0.86% 48,000 $1.8M No change
ACLX Arcellx Inc. 0.78% 25,700 $1.7M No change
XBI SS SPDR S&P Biotech ETF 0.73% 13,000 $1.6M Add +160.0%
TECX Tectonic Therapeutic Inc. 0.71% 74,000 $1.5M No change
WVE Wave Life Sciences Ltd. 0.71% 90,000 $1.5M No change
JNJ Johnson & Johnson 0.66% 6,922 $1.4M No change
TGTX TG Therapeutics Inc. 0.62% 45,000 $1.3M New
VERA Vera Therapeutics Inc. 0.61% 26,000 $1.3M No change
CLOZ Eldridge BBB-B Clo ETF 0.59% 47,807 $1.3M No change
BHVN Biohaven Ltd. 0.58% 110,720 $1.3M New
BMY Bristol-Myers Squibb Co. 0.55% 22,000 $1.2M Reduce -18.5%
MDGL Madrigal Pharmaceuticals Inc. 0.54% 2,000 $1.2M No change
ADMA Adma Biologics Inc. 0.51% 60,200 $1.1M New
BIIB Biogen Inc. 0.49% 6,000 $1.1M Add +200.0%
OBIO Orchestra Biomed Holdings Inc. 0.48% 250,000 $1.0M Add +28.2%
IBB iShares Biotechnology ETF 0.43% 5,500 $928K Add +22.2%
SLDB Solid Biosciences Inc. 0.42% 162,440 $916K No change
LENZ Lenz Therapeutics Inc. 0.40% 53,732 $860K Reduce -34.5%
PFE Pfizer Inc. 0.37% 32,337 $805K Reduce -56.6%
RZLT Rezolute Inc. 0.37% 340,000 $802K Add +23.6%
MSFT Microsoft Corp. 0.36% 1,600 $774K No change
AAPL Apple Inc. 0.31% 2,494 $678K No change
EOLS Evolus Inc. 0.31% 99,338 $661K New
NKTR Nektar Therapeutics 0.30% 15,500 $655K New
IBM Intl Business Machines Corp. filed as INTERNATIONAL BUSINESS MACHS 0.29% 2,142 $634K No change
SRRK Scholar Rock Holding Corp. 0.28% 13,913 $613K Add +54.6%
PTHS Pelthos Therapeutics Inc. 0.28% 19,281 $598K Add +215.5%
CNQ Canadian Natural Resources 0.26% 16,800 $569K No change
CNTB Connect Biopharma Holdings L 0.26% 200,000 $564K New
XENE Xenon Pharmaceuticals Inc. 0.23% 10,962 $491K No change
AGIO Agios Pharmaceuticals Inc. 0.23% 18,000 $490K New
RARE Ultragenyx Pharmaceutical Inc. 0.21% 20,006 $460K Reduce -61.5%
MRSN Mersana Therapeutics Inc. 0.20% 111,686 $438K New
KURA Kura Oncology Inc. 0.19% 39,209 $407K Reduce -41.7%
FATE Fate Therapeutics Inc. 0.17% 365,000 $359K No change
JSPR Jasper Therapeutics Inc. 0.15% 181,389 $332K Add +5.8%
IVVD Invivyd Inc. 0.11% 100,000 $247K No change
AVGO Broadcom Inc. 0.11% 710 $246K No change
KMB Kimberly-Clark Corp. 0.11% 2,400 $242K Reduce -60.0%
DAWN Day One Biopharmaceuticals I 0.11% 25,884 $241K Reduce -80.2%
NVDA Nvidia Corp. 0.11% 1,280 $239K No change
RHP Ryman Hospitality Properties 0.11% 2,400 $227K Reduce -80.0%
MDLZ Mondelez International Inc. Class A 0.07% 3,000 $161K Reduce -62.5%
DD Dupont DE Nemours Inc. 0.07% 3,767 $151K Reduce -60.0%
MREO Mereo Biopharma Group PL-ADR 0.06% 300,337 $125K No change
CNTA Centessa Pharmaceuticals Ltd. 0.05% 4,000 $100K New
QURE Uniqure NV 0.04% 4,000 $96K Add +100.0%
IWP iShares Russell Mid-Cap Grow 0.04% 695 $95K New
GOOGL Alphabet Inc. Class A 0.04% 300 $94K No change
EBC Eastern Bankshares Inc. 0.04% 5,000 $92K No change
CTVA Corteva Inc. 0.04% 1,206 $81K Reduce -89.1%
LEGH Legacy Housing Corp. 0.04% 4,000 $78K No change
PWR Quanta Services Inc. 0.03% 176 $74K No change
AMZN Amazon.com Inc. 0.03% 300 $69K No change
URI United Rentals Inc. 0.03% 78 $63K No change
FSK FS KKR Capital Corp. 0.02% 2,875 $43K New
DHR Danaher Corp. 0.02% 180 $41K No change
INTL GAME TECHNOLOGY filed as International Game Technology PLC 0.02% 2,500 $39K New
BX Blackstone Inc. 0.01% 210 $32K No change
DOW Dow Inc. 0.01% 1,206 $28K No change
TMO Thermo Fisher Scientific Inc. 0.01% 45 $26K No change
OXY Occidental Petroleum Corp. 0.01% 663 $24K No change
CRM Salesforce Inc. 0.01% 77 $20K No change
UNH Unitedhealth Group Inc. 0.01% 57 $19K No change
KD Kyndryl Holdings Inc. 0.01% 428 $11K No change
STWD Starwood Property Trust Inc. 0.00% 400 $7K No change
GEHC GE Healthcare Technology 0.00% 50 $4K No change
WAB Wabtec Corp. 0.00% 6 $1K No change

Portfolio Sells Q3 2025 → Q4 2025

JAAA Janus Henderson Aaa Clo ETF Reduce -78.6% 2.19% −7.12
AVDL Avadel Pharmaceuticals Ltd. Sold out 0.00% −2.32
VRNA Verona Pharma Ltd. Sold out 0.00% −1.71
CLMT Calumet Inc. Reduce -21.6% 20.38% −1.22
LENZ Lenz Therapeutics Inc. Reduce -34.5% 0.40% −1.20
CSX CSX Corp. Sold out 0.00% −1.04
LQDA Liquidia Corp. Sold out 0.00% −1.03
DCGO Docgo Inc. Reduce -13.0% 1.09% −0.66
PRAX Praxis Precision Medicines I Sold out 0.00% −0.62
ABBV Abbvie Inc. Sold out 0.00% −0.49
RARE Ultragenyx Pharmaceutical Inc. Reduce -61.5% 0.21% −0.44
PFE Pfizer Inc. Reduce -56.6% 0.37% −0.42
RHP Ryman Hospitality Properties Reduce -80.0% 0.11% −0.35
CTVA Corteva Inc. Reduce -89.1% 0.04% −0.28
DAWN Day One Biopharmaceuticals I Reduce -80.2% 0.11% −0.27
DD Dupont DE Nemours Inc. Reduce -60.0% 0.07% −0.24
KMB Kimberly-Clark Corp. Reduce -60.0% 0.11% −0.20
MDLZ Mondelez International Inc. Class A Reduce -62.5% 0.07% −0.13
BCRX Biocryst Pharmaceuticals Inc. Sold out 0.00% −0.10
LLY Eli Lilly & Co. Sold out 0.00% −0.10
KURA Kura Oncology Inc. Reduce -41.7% 0.19% −0.06
IWR iShares Russell Mid-Cap ETF Sold out 0.00% −0.04
TTE Totalenergies SE -Spon ADR Sold out 0.00% −0.03
BRSL Brightstar Lottery PLC Sold out 0.00% −0.02
FSK FS KKR Capital Corp. Sold out 0.00% −0.02
AETUF Arc Resources Ltd. Sold out 0.00% −0.01
BMY Bristol-Myers Squibb Co. Reduce -18.5% 0.55% +0.04
XERS Xeris Biopharma Holdings Inc. Reduce -4.4% 3.53% +0.07
JPM JPMorgan Chase & Co. Reduce -4.4% 2.91% +0.21
PTGX Protagonist Therapeutics Inc. Reduce -12.1% 2.95% +0.64
TVTX Travere Therapeutics Inc. Reduce -28.5% 3.29% +0.69
SNDX Syndax Pharmaceuticals Inc. Reduce -3.0% 4.04% +1.28
GOOG Alphabet Inc. Class C Reduce -18.5% 13.28% +1.84

Portfolio Buys Q3 2025 → Q4 2025

COGT Cogent Biosciences Inc. New 1.68% +1.68
VRDN Viridian Therapeutics Inc. Add +24.4% 2.09% +1.04
ALKS Alkermes PLC Add +392.2% 1.23% +0.99
RCUS Arcus Biosciences Inc. Add +27.4% 1.34% +0.80
HELP Cybin Inc. Add +103.3% 1.08% +0.73
TGTX TG Therapeutics Inc. New 0.62% +0.62
BHVN Biohaven Ltd. New 0.58% +0.58
XBI SS SPDR S&P Biotech ETF Add +160.0% 0.73% +0.52
ADMA Adma Biologics Inc. New 0.51% +0.51
BIIB Biogen Inc. Add +200.0% 0.49% +0.37
CYTK Cytokinetics Inc. Add +13.3% 1.00% +0.31
EOLS Evolus Inc. New 0.31% +0.31
NKTR Nektar Therapeutics New 0.30% +0.30
OBIO Orchestra Biomed Holdings Inc. Add +28.2% 0.48% +0.28
CNTB Connect Biopharma Holdings L New 0.26% +0.26
ATRC Atricure Inc. Add +7.1% 0.94% +0.23
AGIO Agios Pharmaceuticals Inc. New 0.23% +0.23
PTHS Pelthos Therapeutics Inc. Add +215.5% 0.28% +0.21
MRSN Mersana Therapeutics Inc. New 0.20% +0.20
IBB iShares Biotechnology ETF Add +22.2% 0.43% +0.16
SRRK Scholar Rock Holding Corp. Add +54.6% 0.28% +0.14
CNTA Centessa Pharmaceuticals Ltd. New 0.05% +0.05
IWP iShares Russell Mid-Cap Grow New 0.04% +0.04
FSK FS KKR Capital Corp. New 0.02% +0.02
INTL GAME TECHNOLOGY New 0.02% +0.02
QURE Uniqure NV Add +100.0% 0.04% −0.00
JSPR Jasper Therapeutics Inc. Add +5.8% 0.15% −0.02
RZLT Rezolute Inc. Add +23.6% 0.37% −0.71

Options Activity Q3 2025 → Q4 2025

DAR Darling Ingredients Inc. call Sold out 300,000 $9.3Mbefore exit

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 83$189.2MGOOG, APO, SNDX, XERS, TVTX
Q1 2026 85$168.0MGOOG, APO, SNDX, BBIO, PTGX
Q4 2025 87$215.9MCLMT, APO, GOOG, SNDX, XERS
Q3 2025 87$238.7MCLMT, APO, GOOG, JAAA, XERS
Q2 2025 85$220.6MCLMT, APO, JAAA, GOOG, JPM
Q1 2025 84$212.0MCLMT, APO, JAAA, GOOG, DCGO
Q4 2024 89$276.5MCLMT, APO, JAAA, GOOG, DCGO
Q3 2024 92$284.6MCLMT, APO, GOOG, AB, CLOZ
Q2 2024 99$250.6MCLMT, APO, GOOG, CLOZ, DCGO
Q1 2024 106$282.8MCLMT, APO, CLOZ, GOOG, FTAI