Siren, L.L.C.

In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 13, 2026), Siren, L.L.C. reported 113 stock positions worth $3.4 billion. Its top holding was Scholar Rock (SRRK) at 14.2% of the portfolio, followed by Kymera Therapeutics (KYMR, 7.6%) and Beone Medicines Ltd.-ADR (ONC, 4.5%). Compared with Q3 2025, it opened 26 new positions, sold out of 28, added to 29 and reduced 24. The biggest buy was a new position in Olema Pharmaceuticals (OLMA) and the biggest sale an exit from Avidity Biosciences (RNAM).

Most Recent 13F
Q2 2026
Location
New York, NY
CIK
0002005245
Portfolio Value
$3.4B (Q4 2025)
SEC Filing
0002005245-26-000003 ↗ filed Feb 13, 2026

Holdings Value

0$1.0B$2.0B$3.0B$4.0B$5.0B Q3 2024: $2.0B Q3 2024 Q4 2024: $2.3B Q4 2024 Q1 2025: $1.8B Q1 2025 Q2 2025: $1.9B Q2 2025 Q3 2025: $2.6B Q3 2025 Q4 2025: $3.4B $3.4B Q4 2025 Q1 2026: $3.6B Q1 2026 Q2 2026: $4.9B Q2 2026

Holdings 113 stocks · $3.4B
SRRK Scholar Rock Holding Corp. 14.22% 10,825,013 $476.8M Add +17.0%
KYMR Kymera Therapeutics Inc. 7.63% 3,286,830 $255.7M Reduce -4.1%
ONC Beone Medicines Ltd.-ADR 4.53% 500,000 $151.9M Add +1.4%
EWTX Edgewise Therapeutics Inc. 3.35% 4,529,990 $112.4M Add +16.2%
RVMD Revolution Medicines Inc. 3.17% 1,335,075 $106.3M Add +27.9%
CNTA Centessa Pharmaceuticals Ltd. 3.00% 4,027,517 $100.7M Add +24.8%
ARWR Arrowhead Pharmaceuticals Inc. 2.97% 1,500,476 $99.6M Reduce -43.8%
BCAX Bicara Therapeutics Inc. 2.62% 5,216,969 $87.8M No change
OLMA Olema Pharmaceuticals Inc. 2.46% 3,300,700 $82.5M New
IRON Disc Medicine Inc. 2.34% 988,401 $78.5M Add +8.2%
GPCR Structure Therapeutics Inc. 2.24% 1,078,698 $75.0M Add +5.0%
TNGX Tango Therapeutics Inc. 2.16% 8,165,374 $72.3M Add +38.8%
RCUS Arcus Biosciences Inc. 2.14% 3,007,077 $71.7M Add +3.3%
STOK Stoke Therapeutics Inc. 2.13% 2,247,347 $71.3M No change
CRNX Crinetics Pharmaceuticals Inc. 2.09% 1,507,636 $70.2M Reduce -10.7%
DYN Dyne Therapeutics Inc. 2.04% 3,502,941 $68.5M Reduce -25.9%
APLS Apellis Pharmaceuticals Inc. 1.93% 2,578,396 $64.8M No change
COGT Cogent Biosciences Inc. 1.73% 1,629,279 $57.9M Reduce -5.5%
SEPN Septerna Inc. 1.66% 2,000,000 $55.8M Reduce -9.2%
TSHA Taysha Gene Therapies Inc. 1.66% 10,129,913 $55.7M Reduce -8.0%
RYTM Rhythm Pharmaceuticals Inc. 1.60% 499,975 $53.5M No change
ASND Ascendis Pharma A/S 1.50% 235,862 $50.3M No change
RAPT Rapt Therapeutics Inc. 1.39% 1,375,000 $46.6M Add +136.9%
TBLA Taboola.com Ltd. 1.37% 9,969,495 $46.0M No change
LXRX Lexicon Pharmaceuticals Inc. 1.34% 38,918,903 $44.8M No change
ZYME Zymeworks Inc. 1.32% 1,680,121 $44.2M New
SLDB Solid Biosciences Inc. 1.29% 7,690,405 $43.4M Add +3.7%
WVE Wave Life Sciences Ltd. 1.24% 2,450,000 $41.6M Reduce -33.7%
XENE Xenon Pharmaceuticals Inc. 1.09% 812,761 $36.4M No change
DBVT DBV Technologies SA-Spon ADR 1.06% 1,857,362 $35.6M New
ERAS Erasca Inc. 0.97% 8,757,249 $32.6M No change
ENGN Engene Holdings Inc. 0.90% 3,336,264 $30.1M New
TRVI Trevi Therapeutics Inc. 0.85% 2,286,867 $28.6M Reduce -9.8%
SYRE Spyre Therapeutics Inc. 0.80% 818,598 $26.8M Add +122.1%
MLYS Mineralys Therapeutics Inc. 0.76% 699,999 $25.4M New
DNLI Denali Therapeutics Inc. 0.69% 1,396,513 $23.1M Add +70.0%
RELY Remitly Global Inc. 0.67% 1,618,271 $22.3M No change
FULC Fulcrum Therapeutics Inc. 0.66% 1,950,000 $22.1M New
RAPP Rapport Therapeutics Inc. 0.64% 708,469 $21.5M Reduce -32.8%
SLN Silence Therapeutics PLC-ADR 0.53% 2,911,438 $17.7M No change
IHS Ihs Holding Ltd. 0.52% 2,357,520 $17.6M No change
GOSS Gossamer Bio Inc. 0.48% 5,208,968 $16.1M No change
UPB Upstream Bio Inc. 0.48% 588,450 $16.0M Reduce -25.4%
BCYC Bicycle Therapeutics PLC-ADR 0.43% 2,012,752 $14.3M No change
MNPR Monopar Therapeutics Inc. 0.41% 212,298 $13.9M New
CGEM Cullinan Therapeutics Inc. 0.37% 1,193,410 $12.4M No change
SION Sionna Therapeutics Inc. 0.37% 300,000 $12.3M Reduce -7.7%
IKT Inhibikase Therapeutics Inc. 0.36% 5,850,000 $12.0M New
NBP Novabridge Biosciences 0.36% 3,000,000 $11.9M Add +157.3%
AMZN Amazon.com Inc. 0.35% 51,500 $11.9M Reduce -12.0%
NMRA Neumora Therapeutics Inc. 0.34% 6,288,783 $11.3M Add +44.3%
MIND MEDICINE MINDMED INC 0.32% 800,000 $10.7M New
BNTC Benitec Biopharma Inc. 0.31% 775,000 $10.4M New
IVVD Invivyd Inc. 0.29% 4,000,000 $9.9M New
TSM Taiwan Semiconductor-SP ADR 0.25% 27,700 $8.4M Reduce -1.8%
ORIC Oric Pharmaceuticals Inc. 0.25% 1,007,575 $8.2M No change
MPLT Maplight Therapeutics Inc. 0.24% 450,000 $7.9M New
PVLA Palvella Therapeutics Inc. 0.23% 75,000 $7.9M New
CRWD CrowdStrike Holdings Inc. Class A 0.23% 16,500 $7.7M Reduce -10.8%
IONQ Ionq Inc. 0.23% 170,000 $7.6M No change
SEER Seer Inc. 0.22% 4,000,000 $7.3M No change
MSFT Microsoft Corp. 0.22% 15,000 $7.3M Reduce -12.5%
PDD PDD Holdings Inc. 0.21% 63,401 $7.2M Add +46.1%
LXEO Lexeo Therapeutics Inc. 0.21% 720,622 $7.2M Add +19.4%
NVDA Nvidia Corp. 0.21% 37,485 $7.0M No change
CRM Salesforce Inc. 0.21% 26,100 $6.9M Reduce -13.3%
CMPS Compass Pathways PLC 0.21% 1,000,000 $6.9M New
BLLN Billiontoone Inc. Class A 0.20% 83,833 $6.9M New
WK Workiva Inc. 0.20% 79,123 $6.8M Add +163.7%
ZURA Zura Bio Ltd. 0.20% 1,300,000 $6.8M New
VTVT VTV Therapeutics Inc. Class A 0.19% 163,000 $6.5M No change
GOOGL Alphabet Inc. Class A 0.19% 20,703 $6.5M Reduce -2.4%
NBIS Nebius Group NV 0.19% 76,218 $6.4M Add +5.0%
SVRA Savara Inc. 0.18% 1,000,000 $6.0M New
XFOR X4 Pharmaceuticals Inc. 0.18% 1,500,000 $6.0M New
FROG Jfrog Ltd. 0.17% 93,616 $5.8M Reduce -12.6%
NOW ServiceNow Inc. 0.16% 35,630 $5.5M No change
TENX Tenax Therapeutics Inc. 0.16% 427,141 $5.2M Add +21.2%
WHWK Whitehawk Therapeutics Inc. 0.15% 2,082,000 $5.0M No change
DT Dynatrace Inc. 0.15% 115,229 $5.0M Add +15.0%
DDOG Datadog Inc. Class A 0.15% 36,425 $5.0M Add +10.6%
ALMS Alumis Inc. 0.15% 500,000 $4.9M New
META Meta Platforms Inc. Class A 0.14% 7,169 $4.7M New
PEPG Pepgen Inc. 0.14% 700,000 $4.6M No change
SGMT Sagimet Biosciences Inc. Class A 0.13% 724,771 $4.3M No change
ADBE Adobe Inc. 0.13% 12,051 $4.2M Reduce -19.9%
FHTX Foghorn Therapeutics Inc. 0.12% 720,720 $3.9M No change
GTLB Gitlab Inc. Class A 0.11% 99,000 $3.7M Add +54.7%
KLRS Kalaris Therapeutics Inc. 0.11% 435,798 $3.7M Add +36.9%
EDU New Oriental Educatio-SP ADR 0.10% 62,000 $3.4M No change
AGEN Agenus Inc. 0.10% 1,064,250 $3.3M No change
MDLN Medline Inc. Class A 0.09% 75,000 $3.1M New
KRRO Korro Bio Inc. 0.08% 347,718 $2.8M Reduce -17.0%
CLBT Cellebrite Di Ltd. 0.08% 150,000 $2.7M Add +66.7%
RANI Rani Therapeutics Holdings Class A 0.08% 2,000,000 $2.7M New
ZS Zscaler Inc. 0.08% 12,000 $2.7M New
BDTX Black Diamond Therapeutics I 0.08% 1,046,517 $2.5M No change
MNDY Monday.com Ltd. 0.07% 17,000 $2.5M Add +142.9%
AVGO Broadcom Inc. 0.07% 7,000 $2.4M New
QCOM Qualcomm Inc. 0.07% 14,000 $2.4M No change
ARM Arm Holdings PLC-ADR 0.07% 21,500 $2.4M New
BEKE Ke Holdings Inc.-ADR filed as KE HLDGS INC 0.07% 145,000 $2.3M No change
TIL Instil Bio Inc. 0.07% 203,933 $2.2M No change
PANW Palo Alto Networks Inc. 0.06% 11,450 $2.1M Reduce -14.9%
CRWV Coreweave Inc. Class A 0.06% 27,500 $2.0M Add +14.6%
IREN Iren Ltd. filed as IREN LIMITED 0.05% 43,100 $1.6M Add +115.5%
VRNS Varonis Systems Inc. 0.04% 37,500 $1.2M New
PRMB Primo Brands Corp. 0.04% 75,000 $1.2M No change
GBIO Generation Bio Co. 0.03% 201,419 $1.1M Reduce -32.2%
FIG Figma Inc. Class A 0.03% 25,000 $934K Add +66.7%
TSLA Tesla Inc. 0.02% 1,500 $675K No change
CRBU Caribou Biosciences Inc. 0.01% 105,347 $168K No change
CYCLERION THERAPEUTICS INC 0.00% 115,603 $147K Reduce -0.5%

Portfolio Sells Q3 2025 → Q4 2025
RNAM Avidity Biosciences Inc. Sold out 0.00% −2.19
RZLT Rezolute Inc. Sold out 0.00% −1.79
SLNO Soleno Therapeutics Inc. Sold out 0.00% −1.24
NAMS Newamsterdam Pharma Co. NV Sold out 0.00% −0.85
KRRO Korro Bio Inc. Reduce -17.0% 0.08% −0.70
CRNX Crinetics Pharmaceuticals Inc. Reduce -10.7% 2.09% −0.66
ARWR Arrowhead Pharmaceuticals Inc. Reduce -43.8% 2.97% −0.63
QURE Uniqure NV Sold out 0.00% −0.63
RAPP Rapport Therapeutics Inc. Reduce -32.8% 0.64% −0.58
AVBP Arrivent Biopharma Inc. Sold out 0.00% −0.51
DYN Dyne Therapeutics Inc. Reduce -25.9% 2.04% −0.30
RNAC Cartesian Therapeutics Inc. Sold out 0.00% −0.23
ELDN Eledon Pharmaceuticals Inc. Sold out 0.00% −0.21
AMZN Amazon.com Inc. Reduce -12.0% 0.35% −0.15
MSFT Microsoft Corp. Reduce -12.5% 0.22% −0.13
PRQR Proqr Therapeutics NV Sold out 0.00% −0.13
CRWD CrowdStrike Holdings Inc. Class A Reduce -10.8% 0.23% −0.12
UPB Upstream Bio Inc. Reduce -25.4% 0.48% −0.10
BIOA Bioage Labs Inc. Sold out 0.00% −0.09
ADBE Adobe Inc. Reduce -19.9% 0.13% −0.08
KDP Keurig Dr Pepper Inc. Sold out 0.00% −0.08
HUBS HubSpot Inc. Sold out 0.00% −0.07
CMG Chipotle Mexican Grill Inc. Sold out 0.00% −0.07
CRM Salesforce Inc. Reduce -13.3% 0.21% −0.07
SPOT Spotify Technology SA Sold out 0.00% −0.06
NIQ Niq Global Intelligence PLC Sold out 0.00% −0.06
TSM Taiwan Semiconductor-SP ADR Reduce -1.8% 0.25% −0.06
TRVI Trevi Therapeutics Inc. Reduce -9.8% 0.85% −0.05
PANW Palo Alto Networks Inc. Reduce -14.9% 0.06% −0.04
SAIL Sailpoint Inc. Sold out 0.00% −0.04
ESTC Elastic NV Sold out 0.00% −0.04
GBIO Generation Bio Co. Reduce -32.2% 0.03% −0.04
SEMR Semrush Holdings Inc. Class A Sold out 0.00% −0.03
AS Amer Sports Inc. Sold out 0.00% −0.03
PINS Pinterest Inc. Class A Sold out 0.00% −0.03
CFLT Confluent Inc. Class A Sold out 0.00% −0.03
PCOR Procore Technologies Inc. Sold out 0.00% −0.03
ALAB Astera Labs Inc. Sold out 0.00% −0.03
FROG Jfrog Ltd. Reduce -12.6% 0.17% −0.02
CHYM Chime Financial Inc. Class A Sold out 0.00% −0.02
CCC CCC Intelligent Solutions Ho Sold out 0.00% −0.02
KVUE Kenvue Inc. Sold out 0.00% −0.02
VRT Vertiv Holdings Co. Class A Sold out 0.00% −0.01
GOOGL Alphabet Inc. Class A Reduce -2.4% 0.19% −0.01
CYCLERION THERAPEUTICS INC Reduce -0.5% 0.00% −0.01
SION Sionna Therapeutics Inc. Reduce -7.7% 0.37% −0.01
IRWD Ironwood Pharmaceuticals Inc. Sold out 0.00% −0.01
KYMR Kymera Therapeutics Inc. Reduce -4.1% 7.63% +0.04
SEPN Septerna Inc. Reduce -9.2% 1.66% +0.04
WVE Wave Life Sciences Ltd. Reduce -33.7% 1.24% +0.18

Portfolio Buys Q3 2025 → Q4 2025
OLMA Olema Pharmaceuticals Inc. New 2.46% +2.46
ZYME Zymeworks Inc. New 1.32% +1.32
RVMD Revolution Medicines Inc. Add +27.9% 3.17% +1.27
GPCR Structure Therapeutics Inc. Add +5.0% 2.24% +1.11
DBVT DBV Technologies SA-Spon ADR New 1.06% +1.06
ENGN Engene Holdings Inc. New 0.90% +0.90
EWTX Edgewise Therapeutics Inc. Add +16.2% 3.35% +0.88
RAPT Rapt Therapeutics Inc. Add +136.9% 1.39% +0.80
MLYS Mineralys Therapeutics Inc. New 0.76% +0.76
SRRK Scholar Rock Holding Corp. Add +17.0% 14.22% +0.75
FULC Fulcrum Therapeutics Inc. New 0.66% +0.66
RCUS Arcus Biosciences Inc. Add +3.3% 2.14% +0.59
SYRE Spyre Therapeutics Inc. Add +122.1% 0.80% +0.56
MNPR Monopar Therapeutics Inc. New 0.41% +0.41
IKT Inhibikase Therapeutics Inc. New 0.36% +0.36
MIND MEDICINE MINDMED INC New 0.32% +0.32
BNTC Benitec Biopharma Inc. New 0.31% +0.31
IVVD Invivyd Inc. New 0.29% +0.29
MPLT Maplight Therapeutics Inc. New 0.24% +0.24
PVLA Palvella Therapeutics Inc. New 0.23% +0.23
TNGX Tango Therapeutics Inc. Add +38.8% 2.16% +0.22
DNLI Denali Therapeutics Inc. Add +70.0% 0.69% +0.22
CMPS Compass Pathways PLC New 0.21% +0.21
BLLN Billiontoone Inc. Class A New 0.20% +0.20
ZURA Zura Bio Ltd. New 0.20% +0.20
NBP Novabridge Biosciences Add +157.3% 0.36% +0.18
SVRA Savara Inc. New 0.18% +0.18
XFOR X4 Pharmaceuticals Inc. New 0.18% +0.18
ALMS Alumis Inc. New 0.15% +0.15
META Meta Platforms Inc. Class A New 0.14% +0.14
WK Workiva Inc. Add +163.7% 0.20% +0.10
MDLN Medline Inc. Class A New 0.09% +0.09
RANI Rani Therapeutics Holdings Class A New 0.08% +0.08
ZS Zscaler Inc. New 0.08% +0.08
AVGO Broadcom Inc. New 0.07% +0.07
ARM Arm Holdings PLC-ADR New 0.07% +0.07
LXEO Lexeo Therapeutics Inc. Add +19.4% 0.21% +0.06
TENX Tenax Therapeutics Inc. Add +21.2% 0.16% +0.05
KLRS Kalaris Therapeutics Inc. Add +36.9% 0.11% +0.04
VRNS Varonis Systems Inc. New 0.04% +0.04
NMRA Neumora Therapeutics Inc. Add +44.3% 0.34% +0.03
MNDY Monday.com Ltd. Add +142.9% 0.07% +0.02
CLBT Cellebrite Di Ltd. Add +66.7% 0.08% +0.02
IREN Iren Ltd. Add +115.5% 0.05% +0.01
GTLB Gitlab Inc. Class A Add +54.7% 0.11% −0.00
FIG Figma Inc. Class A Add +66.7% 0.03% −0.00
PDD PDD Holdings Inc. Add +46.1% 0.21% −0.01
IRON Disc Medicine Inc. Add +8.2% 2.34% −0.02
DDOG Datadog Inc. Class A Add +10.6% 0.15% −0.04
DT Dynatrace Inc. Add +15.0% 0.15% −0.04

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 115$4.9BSRRK, KYMR, ERAS, MANE, TNGX
Q1 2026 100$3.6BSRRK, KYMR, ERAS, EWTX, ONC
Q4 2025 113$3.4BSRRK, KYMR, ONC, EWTX, RVMD
Q3 2025 115$2.6BSRRK, KYMR, ONC, ARWR, BCAX
Q2 2025 110$1.9BSRRK, KYMR, ONC, IRON, CRNX
Q1 2025Amended 116$1.8BSRRK, ONC, KYMR, BPMC, CRNX
Q4 2024 117$2.3BSRRK, ONC, KYMR, APLS, CRNX
Q3 2024 109$2.0BKYMR, ONC, SRRK, BCAX, ARGX