Siren, L.L.C.
In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 13, 2026), Siren, L.L.C. reported 113 stock positions worth $3.4 billion. Its top holding was Scholar Rock (SRRK) at 14.2% of the portfolio, followed by Kymera Therapeutics (KYMR, 7.6%) and Beone Medicines Ltd.-ADR (ONC, 4.5%). Compared with Q3 2025, it opened 26 new positions, sold out of 28, added to 29 and reduced 24. The biggest buy was a new position in Olema Pharmaceuticals (OLMA) and the biggest sale an exit from Avidity Biosciences (RNAM).
- Most Recent 13F
- Q2 2026
- Location
- New York, NY
- CIK
- 0002005245
- Portfolio Value
- $3.4B (Q4 2025)
- SEC Filing
- 0002005245-26-000003 ↗ filed Feb 13, 2026
Holdings Value
Holdings 113 stocks · $3.4B
| SRRK Scholar Rock Holding Corp. | 14.22% | 10,825,013 | $476.8M | Add +17.0% |
| KYMR Kymera Therapeutics Inc. | 7.63% | 3,286,830 | $255.7M | Reduce -4.1% |
| ONC Beone Medicines Ltd.-ADR | 4.53% | 500,000 | $151.9M | Add +1.4% |
| EWTX Edgewise Therapeutics Inc. | 3.35% | 4,529,990 | $112.4M | Add +16.2% |
| RVMD Revolution Medicines Inc. | 3.17% | 1,335,075 | $106.3M | Add +27.9% |
| CNTA Centessa Pharmaceuticals Ltd. | 3.00% | 4,027,517 | $100.7M | Add +24.8% |
| ARWR Arrowhead Pharmaceuticals Inc. | 2.97% | 1,500,476 | $99.6M | Reduce -43.8% |
| BCAX Bicara Therapeutics Inc. | 2.62% | 5,216,969 | $87.8M | No change |
| OLMA Olema Pharmaceuticals Inc. | 2.46% | 3,300,700 | $82.5M | New |
| IRON Disc Medicine Inc. | 2.34% | 988,401 | $78.5M | Add +8.2% |
| GPCR Structure Therapeutics Inc. | 2.24% | 1,078,698 | $75.0M | Add +5.0% |
| TNGX Tango Therapeutics Inc. | 2.16% | 8,165,374 | $72.3M | Add +38.8% |
| RCUS Arcus Biosciences Inc. | 2.14% | 3,007,077 | $71.7M | Add +3.3% |
| STOK Stoke Therapeutics Inc. | 2.13% | 2,247,347 | $71.3M | No change |
| CRNX Crinetics Pharmaceuticals Inc. | 2.09% | 1,507,636 | $70.2M | Reduce -10.7% |
| DYN Dyne Therapeutics Inc. | 2.04% | 3,502,941 | $68.5M | Reduce -25.9% |
| APLS Apellis Pharmaceuticals Inc. | 1.93% | 2,578,396 | $64.8M | No change |
| COGT Cogent Biosciences Inc. | 1.73% | 1,629,279 | $57.9M | Reduce -5.5% |
| SEPN Septerna Inc. | 1.66% | 2,000,000 | $55.8M | Reduce -9.2% |
| TSHA Taysha Gene Therapies Inc. | 1.66% | 10,129,913 | $55.7M | Reduce -8.0% |
| RYTM Rhythm Pharmaceuticals Inc. | 1.60% | 499,975 | $53.5M | No change |
| ASND Ascendis Pharma A/S | 1.50% | 235,862 | $50.3M | No change |
| RAPT Rapt Therapeutics Inc. | 1.39% | 1,375,000 | $46.6M | Add +136.9% |
| TBLA Taboola.com Ltd. | 1.37% | 9,969,495 | $46.0M | No change |
| LXRX Lexicon Pharmaceuticals Inc. | 1.34% | 38,918,903 | $44.8M | No change |
| ZYME Zymeworks Inc. | 1.32% | 1,680,121 | $44.2M | New |
| SLDB Solid Biosciences Inc. | 1.29% | 7,690,405 | $43.4M | Add +3.7% |
| WVE Wave Life Sciences Ltd. | 1.24% | 2,450,000 | $41.6M | Reduce -33.7% |
| XENE Xenon Pharmaceuticals Inc. | 1.09% | 812,761 | $36.4M | No change |
| DBVT DBV Technologies SA-Spon ADR | 1.06% | 1,857,362 | $35.6M | New |
| ERAS Erasca Inc. | 0.97% | 8,757,249 | $32.6M | No change |
| ENGN Engene Holdings Inc. | 0.90% | 3,336,264 | $30.1M | New |
| TRVI Trevi Therapeutics Inc. | 0.85% | 2,286,867 | $28.6M | Reduce -9.8% |
| SYRE Spyre Therapeutics Inc. | 0.80% | 818,598 | $26.8M | Add +122.1% |
| MLYS Mineralys Therapeutics Inc. | 0.76% | 699,999 | $25.4M | New |
| DNLI Denali Therapeutics Inc. | 0.69% | 1,396,513 | $23.1M | Add +70.0% |
| RELY Remitly Global Inc. | 0.67% | 1,618,271 | $22.3M | No change |
| FULC Fulcrum Therapeutics Inc. | 0.66% | 1,950,000 | $22.1M | New |
| RAPP Rapport Therapeutics Inc. | 0.64% | 708,469 | $21.5M | Reduce -32.8% |
| SLN Silence Therapeutics PLC-ADR | 0.53% | 2,911,438 | $17.7M | No change |
| IHS Ihs Holding Ltd. | 0.52% | 2,357,520 | $17.6M | No change |
| GOSS Gossamer Bio Inc. | 0.48% | 5,208,968 | $16.1M | No change |
| UPB Upstream Bio Inc. | 0.48% | 588,450 | $16.0M | Reduce -25.4% |
| BCYC Bicycle Therapeutics PLC-ADR | 0.43% | 2,012,752 | $14.3M | No change |
| MNPR Monopar Therapeutics Inc. | 0.41% | 212,298 | $13.9M | New |
| CGEM Cullinan Therapeutics Inc. | 0.37% | 1,193,410 | $12.4M | No change |
| SION Sionna Therapeutics Inc. | 0.37% | 300,000 | $12.3M | Reduce -7.7% |
| IKT Inhibikase Therapeutics Inc. | 0.36% | 5,850,000 | $12.0M | New |
| NBP Novabridge Biosciences | 0.36% | 3,000,000 | $11.9M | Add +157.3% |
| AMZN Amazon.com Inc. | 0.35% | 51,500 | $11.9M | Reduce -12.0% |
| NMRA Neumora Therapeutics Inc. | 0.34% | 6,288,783 | $11.3M | Add +44.3% |
| MIND MEDICINE MINDMED INC | 0.32% | 800,000 | $10.7M | New |
| BNTC Benitec Biopharma Inc. | 0.31% | 775,000 | $10.4M | New |
| IVVD Invivyd Inc. | 0.29% | 4,000,000 | $9.9M | New |
| TSM Taiwan Semiconductor-SP ADR | 0.25% | 27,700 | $8.4M | Reduce -1.8% |
| ORIC Oric Pharmaceuticals Inc. | 0.25% | 1,007,575 | $8.2M | No change |
| MPLT Maplight Therapeutics Inc. | 0.24% | 450,000 | $7.9M | New |
| PVLA Palvella Therapeutics Inc. | 0.23% | 75,000 | $7.9M | New |
| CRWD CrowdStrike Holdings Inc. Class A | 0.23% | 16,500 | $7.7M | Reduce -10.8% |
| IONQ Ionq Inc. | 0.23% | 170,000 | $7.6M | No change |
| SEER Seer Inc. | 0.22% | 4,000,000 | $7.3M | No change |
| MSFT Microsoft Corp. | 0.22% | 15,000 | $7.3M | Reduce -12.5% |
| PDD PDD Holdings Inc. | 0.21% | 63,401 | $7.2M | Add +46.1% |
| LXEO Lexeo Therapeutics Inc. | 0.21% | 720,622 | $7.2M | Add +19.4% |
| NVDA Nvidia Corp. | 0.21% | 37,485 | $7.0M | No change |
| CRM Salesforce Inc. | 0.21% | 26,100 | $6.9M | Reduce -13.3% |
| CMPS Compass Pathways PLC | 0.21% | 1,000,000 | $6.9M | New |
| BLLN Billiontoone Inc. Class A | 0.20% | 83,833 | $6.9M | New |
| WK Workiva Inc. | 0.20% | 79,123 | $6.8M | Add +163.7% |
| ZURA Zura Bio Ltd. | 0.20% | 1,300,000 | $6.8M | New |
| VTVT VTV Therapeutics Inc. Class A | 0.19% | 163,000 | $6.5M | No change |
| GOOGL Alphabet Inc. Class A | 0.19% | 20,703 | $6.5M | Reduce -2.4% |
| NBIS Nebius Group NV | 0.19% | 76,218 | $6.4M | Add +5.0% |
| SVRA Savara Inc. | 0.18% | 1,000,000 | $6.0M | New |
| XFOR X4 Pharmaceuticals Inc. | 0.18% | 1,500,000 | $6.0M | New |
| FROG Jfrog Ltd. | 0.17% | 93,616 | $5.8M | Reduce -12.6% |
| NOW ServiceNow Inc. | 0.16% | 35,630 | $5.5M | No change |
| TENX Tenax Therapeutics Inc. | 0.16% | 427,141 | $5.2M | Add +21.2% |
| WHWK Whitehawk Therapeutics Inc. | 0.15% | 2,082,000 | $5.0M | No change |
| DT Dynatrace Inc. | 0.15% | 115,229 | $5.0M | Add +15.0% |
| DDOG Datadog Inc. Class A | 0.15% | 36,425 | $5.0M | Add +10.6% |
| ALMS Alumis Inc. | 0.15% | 500,000 | $4.9M | New |
| META Meta Platforms Inc. Class A | 0.14% | 7,169 | $4.7M | New |
| PEPG Pepgen Inc. | 0.14% | 700,000 | $4.6M | No change |
| SGMT Sagimet Biosciences Inc. Class A | 0.13% | 724,771 | $4.3M | No change |
| ADBE Adobe Inc. | 0.13% | 12,051 | $4.2M | Reduce -19.9% |
| FHTX Foghorn Therapeutics Inc. | 0.12% | 720,720 | $3.9M | No change |
| GTLB Gitlab Inc. Class A | 0.11% | 99,000 | $3.7M | Add +54.7% |
| KLRS Kalaris Therapeutics Inc. | 0.11% | 435,798 | $3.7M | Add +36.9% |
| EDU New Oriental Educatio-SP ADR | 0.10% | 62,000 | $3.4M | No change |
| AGEN Agenus Inc. | 0.10% | 1,064,250 | $3.3M | No change |
| MDLN Medline Inc. Class A | 0.09% | 75,000 | $3.1M | New |
| KRRO Korro Bio Inc. | 0.08% | 347,718 | $2.8M | Reduce -17.0% |
| CLBT Cellebrite Di Ltd. | 0.08% | 150,000 | $2.7M | Add +66.7% |
| RANI Rani Therapeutics Holdings Class A | 0.08% | 2,000,000 | $2.7M | New |
| ZS Zscaler Inc. | 0.08% | 12,000 | $2.7M | New |
| BDTX Black Diamond Therapeutics I | 0.08% | 1,046,517 | $2.5M | No change |
| MNDY Monday.com Ltd. | 0.07% | 17,000 | $2.5M | Add +142.9% |
| AVGO Broadcom Inc. | 0.07% | 7,000 | $2.4M | New |
| QCOM Qualcomm Inc. | 0.07% | 14,000 | $2.4M | No change |
Portfolio Sells Q3 2025 → Q4 2025
| RNAM Avidity Biosciences Inc. | Sold out | 0.00% | −2.19 |
| RZLT Rezolute Inc. | Sold out | 0.00% | −1.79 |
| SLNO Soleno Therapeutics Inc. | Sold out | 0.00% | −1.24 |
| NAMS Newamsterdam Pharma Co. NV | Sold out | 0.00% | −0.85 |
| KRRO Korro Bio Inc. | Reduce -17.0% | 0.08% | −0.70 |
| CRNX Crinetics Pharmaceuticals Inc. | Reduce -10.7% | 2.09% | −0.66 |
| ARWR Arrowhead Pharmaceuticals Inc. | Reduce -43.8% | 2.97% | −0.63 |
| QURE Uniqure NV | Sold out | 0.00% | −0.63 |
| RAPP Rapport Therapeutics Inc. | Reduce -32.8% | 0.64% | −0.58 |
| AVBP Arrivent Biopharma Inc. | Sold out | 0.00% | −0.51 |
| DYN Dyne Therapeutics Inc. | Reduce -25.9% | 2.04% | −0.30 |
| RNAC Cartesian Therapeutics Inc. | Sold out | 0.00% | −0.23 |
| ELDN Eledon Pharmaceuticals Inc. | Sold out | 0.00% | −0.21 |
| AMZN Amazon.com Inc. | Reduce -12.0% | 0.35% | −0.15 |
| MSFT Microsoft Corp. | Reduce -12.5% | 0.22% | −0.13 |
| PRQR Proqr Therapeutics NV | Sold out | 0.00% | −0.13 |
| CRWD CrowdStrike Holdings Inc. Class A | Reduce -10.8% | 0.23% | −0.12 |
| UPB Upstream Bio Inc. | Reduce -25.4% | 0.48% | −0.10 |
| BIOA Bioage Labs Inc. | Sold out | 0.00% | −0.09 |
| ADBE Adobe Inc. | Reduce -19.9% | 0.13% | −0.08 |
| KDP Keurig Dr Pepper Inc. | Sold out | 0.00% | −0.08 |
| HUBS HubSpot Inc. | Sold out | 0.00% | −0.07 |
| CMG Chipotle Mexican Grill Inc. | Sold out | 0.00% | −0.07 |
| CRM Salesforce Inc. | Reduce -13.3% | 0.21% | −0.07 |
| SPOT Spotify Technology SA | Sold out | 0.00% | −0.06 |
| NIQ Niq Global Intelligence PLC | Sold out | 0.00% | −0.06 |
| TSM Taiwan Semiconductor-SP ADR | Reduce -1.8% | 0.25% | −0.06 |
| TRVI Trevi Therapeutics Inc. | Reduce -9.8% | 0.85% | −0.05 |
| PANW Palo Alto Networks Inc. | Reduce -14.9% | 0.06% | −0.04 |
| SAIL Sailpoint Inc. | Sold out | 0.00% | −0.04 |
| ESTC Elastic NV | Sold out | 0.00% | −0.04 |
| GBIO Generation Bio Co. | Reduce -32.2% | 0.03% | −0.04 |
| SEMR Semrush Holdings Inc. Class A | Sold out | 0.00% | −0.03 |
| AS Amer Sports Inc. | Sold out | 0.00% | −0.03 |
| PINS Pinterest Inc. Class A | Sold out | 0.00% | −0.03 |
| CFLT Confluent Inc. Class A | Sold out | 0.00% | −0.03 |
| PCOR Procore Technologies Inc. | Sold out | 0.00% | −0.03 |
| ALAB Astera Labs Inc. | Sold out | 0.00% | −0.03 |
| FROG Jfrog Ltd. | Reduce -12.6% | 0.17% | −0.02 |
| CHYM Chime Financial Inc. Class A | Sold out | 0.00% | −0.02 |
| CCC CCC Intelligent Solutions Ho | Sold out | 0.00% | −0.02 |
| KVUE Kenvue Inc. | Sold out | 0.00% | −0.02 |
| VRT Vertiv Holdings Co. Class A | Sold out | 0.00% | −0.01 |
| GOOGL Alphabet Inc. Class A | Reduce -2.4% | 0.19% | −0.01 |
| CYCLERION THERAPEUTICS INC | Reduce -0.5% | 0.00% | −0.01 |
| SION Sionna Therapeutics Inc. | Reduce -7.7% | 0.37% | −0.01 |
| IRWD Ironwood Pharmaceuticals Inc. | Sold out | 0.00% | −0.01 |
| KYMR Kymera Therapeutics Inc. | Reduce -4.1% | 7.63% | +0.04 |
| SEPN Septerna Inc. | Reduce -9.2% | 1.66% | +0.04 |
| WVE Wave Life Sciences Ltd. | Reduce -33.7% | 1.24% | +0.18 |
Portfolio Buys Q3 2025 → Q4 2025
| OLMA Olema Pharmaceuticals Inc. | New | 2.46% | +2.46 |
| ZYME Zymeworks Inc. | New | 1.32% | +1.32 |
| RVMD Revolution Medicines Inc. | Add +27.9% | 3.17% | +1.27 |
| GPCR Structure Therapeutics Inc. | Add +5.0% | 2.24% | +1.11 |
| DBVT DBV Technologies SA-Spon ADR | New | 1.06% | +1.06 |
| ENGN Engene Holdings Inc. | New | 0.90% | +0.90 |
| EWTX Edgewise Therapeutics Inc. | Add +16.2% | 3.35% | +0.88 |
| RAPT Rapt Therapeutics Inc. | Add +136.9% | 1.39% | +0.80 |
| MLYS Mineralys Therapeutics Inc. | New | 0.76% | +0.76 |
| SRRK Scholar Rock Holding Corp. | Add +17.0% | 14.22% | +0.75 |
| FULC Fulcrum Therapeutics Inc. | New | 0.66% | +0.66 |
| RCUS Arcus Biosciences Inc. | Add +3.3% | 2.14% | +0.59 |
| SYRE Spyre Therapeutics Inc. | Add +122.1% | 0.80% | +0.56 |
| MNPR Monopar Therapeutics Inc. | New | 0.41% | +0.41 |
| IKT Inhibikase Therapeutics Inc. | New | 0.36% | +0.36 |
| MIND MEDICINE MINDMED INC | New | 0.32% | +0.32 |
| BNTC Benitec Biopharma Inc. | New | 0.31% | +0.31 |
| IVVD Invivyd Inc. | New | 0.29% | +0.29 |
| MPLT Maplight Therapeutics Inc. | New | 0.24% | +0.24 |
| PVLA Palvella Therapeutics Inc. | New | 0.23% | +0.23 |
| TNGX Tango Therapeutics Inc. | Add +38.8% | 2.16% | +0.22 |
| DNLI Denali Therapeutics Inc. | Add +70.0% | 0.69% | +0.22 |
| CMPS Compass Pathways PLC | New | 0.21% | +0.21 |
| BLLN Billiontoone Inc. Class A | New | 0.20% | +0.20 |
| ZURA Zura Bio Ltd. | New | 0.20% | +0.20 |
| NBP Novabridge Biosciences | Add +157.3% | 0.36% | +0.18 |
| SVRA Savara Inc. | New | 0.18% | +0.18 |
| XFOR X4 Pharmaceuticals Inc. | New | 0.18% | +0.18 |
| ALMS Alumis Inc. | New | 0.15% | +0.15 |
| META Meta Platforms Inc. Class A | New | 0.14% | +0.14 |
| WK Workiva Inc. | Add +163.7% | 0.20% | +0.10 |
| MDLN Medline Inc. Class A | New | 0.09% | +0.09 |
| RANI Rani Therapeutics Holdings Class A | New | 0.08% | +0.08 |
| ZS Zscaler Inc. | New | 0.08% | +0.08 |
| AVGO Broadcom Inc. | New | 0.07% | +0.07 |
| ARM Arm Holdings PLC-ADR | New | 0.07% | +0.07 |
| LXEO Lexeo Therapeutics Inc. | Add +19.4% | 0.21% | +0.06 |
| TENX Tenax Therapeutics Inc. | Add +21.2% | 0.16% | +0.05 |
| KLRS Kalaris Therapeutics Inc. | Add +36.9% | 0.11% | +0.04 |
| VRNS Varonis Systems Inc. | New | 0.04% | +0.04 |
| NMRA Neumora Therapeutics Inc. | Add +44.3% | 0.34% | +0.03 |
| MNDY Monday.com Ltd. | Add +142.9% | 0.07% | +0.02 |
| CLBT Cellebrite Di Ltd. | Add +66.7% | 0.08% | +0.02 |
| IREN Iren Ltd. | Add +115.5% | 0.05% | +0.01 |
| GTLB Gitlab Inc. Class A | Add +54.7% | 0.11% | −0.00 |
| FIG Figma Inc. Class A | Add +66.7% | 0.03% | −0.00 |
| PDD PDD Holdings Inc. | Add +46.1% | 0.21% | −0.01 |
| IRON Disc Medicine Inc. | Add +8.2% | 2.34% | −0.02 |
| DDOG Datadog Inc. Class A | Add +10.6% | 0.15% | −0.04 |
| DT Dynatrace Inc. | Add +15.0% | 0.15% | −0.04 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 115 | $4.9B | SRRK, KYMR, ERAS, MANE, TNGX |
| Q1 2026 | 100 | $3.6B | SRRK, KYMR, ERAS, EWTX, ONC |
| Q4 2025 | 113 | $3.4B | SRRK, KYMR, ONC, EWTX, RVMD |
| Q3 2025 | 115 | $2.6B | SRRK, KYMR, ONC, ARWR, BCAX |
| Q2 2025 | 110 | $1.9B | SRRK, KYMR, ONC, IRON, CRNX |
| Q1 2025Amended | 116 | $1.8B | SRRK, ONC, KYMR, BPMC, CRNX |
| Q4 2024 | 117 | $2.3B | SRRK, ONC, KYMR, APLS, CRNX |
| Q3 2024 | 109 | $2.0B | KYMR, ONC, SRRK, BCAX, ARGX |