Apellis PharmaceuticalsAPLS

13F holders, Q4 2025 (December 31)
280holders +7
49new positions
47sold out
9famous investors
$25.10avg. 13F price*

At the end of Q4 2025, 280 institutions reported holding Apellis Pharmaceuticals Inc. (APLS) in their 13F filings, up 7 from Q3 2025. 49 opened new positions and 47 sold out. The largest holders were Wellington Management Group LLP ($319.6M), Avoro Capital Advisors LLC ($307.0M) and Vanguard Group Inc. ($268.2M). 9 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), Cliff Asness (0.0% of AQR Capital Management's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).

Company
Apellis Pharmaceuticals Inc.
CUSIP
03753U106
Latest filing quarter
Q2 2026

History

Number of 13F holders

0100200300400 Q1 2024: 302Q1 2024Q2 2024: 263Q2 2024Q3 2024: 265Q3 2024Q4 2024: 260Q4 2024Q1 2025: 255Q1 2025Q2 2025: 247Q2 2025Q3 2025: 273Q3 2025Q4 2025: 280Q4 2025Q1 2026: 324Q1 2026Q2 2026: 1Q2 2026

Total Exit/New Position Q3 2025 → Q4 2025

InstitutionsTotal Value
New Positions49$250.9M
Exits47$132.9M

All 13F filers, Q3 2025 → Q4 2025: 23,837,220 shares bought and 20,549,105 shares sold, net +3,288,115 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 280 holders

Wellington Management Group LLP 0.06% Add +36.9% 12,721,352 $319.6M
Avoro Capital Advisors LLC 3.02% No change 12,222,222 $307.0M
Vanguard Group Inc. 0.00% Add +6.9% 10,674,865 $268.2M
Morgan Stanley 0.01% Reduce -4.9% 9,173,004 $230.4M
Deep Track Capital, LP 4.44% Reduce -3.1% 7,750,000 $194.7M
RTW Investments, LP 1.93% New 7,666,764 $192.6M
BlackRock, Inc. 0.00% Reduce -0.1% 6,260,113 $157.3M
State Street Corp. 0.00% Add +14.3% 4,613,446 $115.9M
UBS Group AG 0.02% Add +22.1% 4,186,222 $105.2M
Montanova Capital, LLC 2.59% Add +43.8% 4,139,426 $104.0M
Polar Capital Holdings Plc 0.43% Add +39.9% 3,706,510 $93.1M
Siren, L.L.C. 1.93% No change 2,578,396 $64.8M
Orbimed Advisors LLC 1.25% Add +4.6% 2,429,868 $61.0M
AQR Capital Management 0.03% Reduce -49.3% 2,276,687 $57.2M
Geode Capital Management, LLC 0.00% Reduce -2.3% 2,025,669 $50.9M
Jennison Associates LLC 0.02% Reduce -65.4% 1,504,299 $37.8M
Deutsche Bank AG 0.01% Reduce -7.9% 1,385,263 $34.8M
Norges Bank 0.00% — 1,198,444 $30.1M
Hudson Bay Capital Management LP 0.19% Add +181.9% 1,179,828 $29.6M
Bank of Nova Scotia 0.04% Reduce -26.5% 1,070,141 $26.9M
Marshall Wace, LLP 0.02% Add +149.8% 990,848 $24.9M
Bank of America Corp. 0.00% Reduce -35.2% 956,773 $24.0M
Millennium Management 0.02% Reduce -29.6% 946,459 $23.8M
Kynam Capital Management, LP 1.49% Add +12.4% 908,607 $22.8M
Los Angeles Capital Management LLC 0.07% Add +53.3% 951,716 $19.7M
Northern Trust Corp. 0.00% Add +26.8% 696,521 $17.5M
Nuveen, LLC 0.00% Add +2.5% 681,819 $17.1M
Citadel Advisors 0.01% Add +10.5% 648,229 $16.3M
Charles Schwab Investment Management Inc. 0.00% Reduce -0.4% 644,445 $16.2M
Renaissance Technologies 0.02% Reduce -12.4% 633,058 $15.9M
Citigroup Inc. 0.01% Add +39.8% 622,158 $15.6M
Point72 Asset Management 0.02% Add +175.3% 597,672 $15.0M
Ameriprise Financial Inc. 0.00% Reduce -17.9% 589,597 $14.8M
SG Americas Securities, LLC 0.02% Add +35.9% 567,046 $14.2M
Two Sigma Investments, LP 0.02% Add +123.1% 562,361 $14.1M
BNP Paribas Financial Markets 0.01% Reduce -42.7% 557,591 $14.0M
Woodline Partners LP 0.05% No change 542,981 $13.6M
Simplify Asset Management Inc. 0.22% Add +403.3% 538,008 $13.5M
Susquehanna International Group, LLP 0.02% Add +70.1% 533,909 $13.4M
First Trust Advisors LP 0.01% New 495,947 $12.5M
Voloridge Investment Management, LLC 0.04% Reduce -53.5% 461,186 $11.6M
D. E. Shaw & Co. 0.01% Reduce -1.6% 449,676 $11.3M
Ossiam 0.22% Reduce -22.3% 431,779 $10.8M
Pictet Asset Management Holding SA 0.01% Add +7.5% 390,884 $9.8M
Rhenman & Partners Asset Management AB 0.88% Add +61.2% 374,450 $9.4M
Schroder Investment Management Group 0.01% Add +90.2% 329,134 $8.3M
683 Capital Management, LLC 0.73% Add +14.6% 330,000 $8.3M
Granite Investment Partners, LLC 0.49% New 327,094 $8.2M
J. Goldman & Co LP 0.28% Add +1.0% 285,992 $7.2M
Bank of New York Mellon Corp 0.00% Add +9.6% 271,925 $6.8M
Natixis 0.03% Add +392.5% 257,268 $6.5M
Caption Management, LLC 0.29% Reduce -16.5% 254,563 $6.4M
Sphera Funds Management LTD. 1.32% Add +294.2% 250,961 $6.3M
Janus Henderson Group PLC 0.00% Add +569.3% 230,320 $5.8M
Invesco Ltd. 0.00% Add +23.5% 225,976 $5.7M
Canada Pension Plan Investment Board 0.00% Add +2.4% 222,200 $5.6M
Tudor Investment Corporation 0.03% New 215,000 $5.4M
Acadian Asset Management LLC 0.01% Add +1554.1% 205,986 $5.2M
Integral Health Asset Management, LLC 0.25% Reduce -20.0% 200,000 $5.0M
Trexquant Investment LP 0.04% Reduce -66.8% 194,592 $4.9M
Jump Financial, LLC 0.07% Reduce -30.2% 193,876 $4.9M
HRT Financial LP 0.02% Reduce -45.6% 192,488 $4.8M
Squarepoint Ops LLC 0.01% Add +263.7% 192,156 $4.8M
Apis Capital Advisors, LLC 0.84% New 192,000 $4.8M
Silvercrest Asset Management Group LLC 0.03% Add +0.1% 190,759 $4.8M
Goldman Sachs Group Inc. 0.00% Add +52.1% 189,205 $4.8M
Barclays PLC 0.00% Reduce -30.4% 187,712 $4.7M
California Public Employees Retirement System 0.00% Add +27.5% 186,328 $4.7M
Dimensional Fund Advisors LP 0.00% Add +868.0% 180,925 $4.5M
Fiduciary Trust Co 0.05% Reduce -9.0% 180,254 $4.5M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% Add +6.8% 178,888 $4.5M
Bank of Montreal 0.00% Add +10.2% 176,571 $4.4M
Rafferty Asset Management, LLC 0.01% Add +1.8% 171,456 $4.3M
ExodusPoint Capital Management, LP 0.05% Reduce -12.1% 171,156 $4.3M
Gotham Asset Management 0.02% Add +32.5% 168,455 $4.2M
JPMorgan Chase & Co. 0.00% Add +194.8% 157,754 $4.0M
HighVista Strategies LLC 0.98% Add +3.5% 150,776 $3.8M
Rock Springs Capital Management LP 0.19% Add +63.6% 150,500 $3.8M
Swiss National Bank 0.00% Add +2.3% 149,500 $3.8M
Man Group plc 0.01% Add +114.7% 144,271 $3.6M
Bridgewater Associates 0.01% New 143,805 $3.6M
DekaBank Deutsche Girozentrale 0.01% No change 55,000 $3.5M
ING Groep NV 0.02% Reduce -88.2% 139,000 $3.5M
Exome Asset Management LLC 1.69% New 135,849 $3.4M
Rhumbline Advisers 0.00% Reduce -0.4% 116,917 $2.9M
Two Sigma Advisers, LP 0.01% New 110,900 $2.8M
Algert Global LLC 0.04% No change 109,733 $2.8M
New York State Common Retirement Fund 0.00% Add +113.0% 104,018 $2.6M
Wells Fargo & Company 0.00% Add +4115.0% 103,815 $2.6M
Alps Advisors Inc. 0.02% Add +65.1% 103,696 $2.6M
Edgestream Partners, L.P. 0.07% Reduce -24.9% 97,443 $2.4M
Mackenzie Financial Corp. 0.00% Add +25.4% 96,211 $2.4M
State Board of Administration of Florida Retirement System 0.00% Add +0.6% 96,125 $2.4M
Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% Add +107.7% 95,755 $2.4M
T. Rowe Price Associates Inc. 0.00% Reduce -3.0% 95,035 $2.4M
Royal Bank of Canada 0.00% Reduce -39.3% 88,687 $2.2M
WINTON GROUP Ltd 0.08% New 86,653 $2.2M
Legal & General Group Plc 0.00% Reduce -7.5% 85,489 $2.1M
Steward Partners Investment Advisory, LLC 0.01% Reduce -28.4% 81,698 $2.1M
Coppell Advisory Solutions LLC 0.19% New 77,390 $2.0M
California State Teachers Retirement System 0.00% Reduce -0.1% 73,203 $1.8M
Ikarian Capital, LLC 0.23% Reduce -84.1% 71,747 $1.8M
Raymond James Financial Inc. 0.00% Reduce -13.8% 66,997 $1.7M
State of Wisconsin Investment Board 0.00% Reduce -22.0% 66,916 $1.7M
Balyasny Asset Management L.P. 0.00% New 65,133 $1.6M
Profund Advisors LLC 0.05% Add +78.1% 61,832 $1.6M
Sei Investments Co. 0.00% Reduce -61.1% 60,291 $1.5M
PDT Partners, LLC 0.09% No change 53,951 $1.4M
PNC Financial Services Group, Inc. 0.00% Reduce -1.0% 53,526 $1.3M
Hennion & Walsh Asset Management, Inc. 0.04% Add +7.9% 51,933 $1.3M
Jane Street Group, LLC 0.00% Reduce -82.9% 50,114 $1.3M
Ishara Investments LP 1.46% — 50,000 $1.3M
Elmind Capital, LP 0.37% — 50,000 $1.3M
Police & Firemen's Retirement System of New Jersey 0.01% Reduce -4.9% 46,009 $1.2M
Treasurer of the State of North Carolina 0.00% Reduce -6.8% 45,170 $1.1M
Voya Investment Management LLC 0.00% Reduce -74.8% 43,661 $1.1M
Panagora Asset Management Inc. 0.00% New 42,134 $1.1M
Cwm, LLC 0.00% Reduce -55.6% 41,880 $1.1M
Prelude Capital Management, LLC 0.07% New 38,521 $968K
Stifel Financial Corp. 0.00% New 36,661 $921K
Guggenheim Capital LLC 0.01% Add +8.3% 36,647 $921K
Handelsbanken Fonder AB 0.00% Reduce -9.5% 35,400 $889K
Alliancebernstein L.P. 0.00% Reduce -57.2% 34,530 $867K
Vontobel Holding Ltd. 0.00% New 34,039 $855K
Public Employees Retirement System of Ohio 0.00% Reduce -3.7% 32,448 $815K
FMR LLC 0.00% Add +73.8% 32,163 $808K
Quantinno Capital Management LP 0.00% Reduce -34.4% 31,763 $798K
Y-Intercept (Hong Kong) Ltd 0.02% Reduce -80.7% 31,581 $793K
Dark Forest Capital Management LP 0.04% New 31,091 $781K
Amundi 0.00% Reduce -97.9% 30,721 $772K
Wealth Enhancement Advisory Services, LLC 0.00% Reduce -61.1% 30,175 $722K
Simplex Trading, LLC 0.02% Reduce -49.6% 27,187 $683K
Virtus Investment Advisers, LLC 0.18% Add +17.4% 27,086 $680K
State of New Jersey Common Pension Fund D 0.00% New 25,863 $650K
Ieq Capital, LLC 0.00% Reduce -91.4% 25,500 $641K
Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% Add +19.0% 25,364 $637K
Erste Asset Management GmbH 0.01% No change 25,300 $637K
VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% Reduce -4.3% 24,365 $612K
Quadrature Capital Ltd 0.01% New 24,075 $605K
Cerity Partners LLC 0.00% Reduce -81.3% 23,971 $602K
Entropy Technologies, LP 0.03% Reduce -6.0% 23,128 $581K
Marex Group Ltd 0.01% New 23,000 $578K
Manufacturers Life Insurance Company, The 0.00% Add +0.6% 22,852 $574K
PSP Research LLC 0.48% — 21,866 $549K
Boothbay Fund Management, LLC 0.01% Reduce -88.0% 21,415 $538K
IMC-Chicago, LLC 0.01% New 21,324 $536K
Arizona State Retirement System 0.00% Reduce -5.8% 21,010 $528K
China Universal Asset Management Co., Ltd. 0.04% Reduce -6.9% 20,617 $518K
ADAR1 Capital Management, LLC 0.04% No change 20,000 $502K
Odyssean, LLC 0.35% — 19,207 $482K
Diversified Trust Co. 0.01% New 18,942 $476K
Qube Research & Technologies Ltd 0.00% Reduce -84.3% 18,843 $473K
Xponance LLC 0.00% Add +3.9% 18,164 $456K
Advent Capital Management 0.74% New 18,000 $452K
Mercer Global Advisors Inc. 0.00% Reduce -54.8% 17,668 $444K
Allianz Asset Management GmbH 0.00% No change 17,000 $427K
Jain Global LLC 0.00% New 16,877 $424K
Creative Planning 0.00% Reduce -53.9% 16,439 $413K
KLP Kapitalforvaltning As 0.00% Add +3.9% 16,200 $407K
Brevan Howard Capital Management LP 0.01% Reduce -82.3% 16,117 $405K
Duncan Williams Asset Management, LLC 0.10% No change 17,005 $394K
Vident Advisory, LLC 0.00% Reduce -56.0% 15,553 $391K
Victory Capital Management Inc. 0.00% Reduce -0.5% 15,197 $382K
Maven Securities LTD 0.05% New 15,000 $377K
NewEdge Advisors, LLC 0.00% New 14,570 $366K
M&T Bank Corp 0.00% Add +11.2% 14,477 $364K
Nomura Holdings Inc. 0.00% Reduce -61.2% 14,200 $357K
Birchview Capital, LP 0.21% No change 14,000 $352K
Pallas Capital Advisors LLC 0.01% Reduce -58.0% 13,885 $349K
Summit Trail Advisors, LLC 0.01% Add +34.8% 13,851 $348K
Empowered Funds, LLC 0.01% Add +0.3% 13,381 $336K
Twinbeech Capital LP 0.02% Add +47.3% 13,152 $330K
Walleye Trading LLC 0.01% Add +21.6% 12,699 $319K
Freestone Grove Partners LP 0.00% New 12,537 $315K
Wedmont Private Capital 0.01% Add +4.1% 11,883 $315K
AlphaQuest LLC 0.02% Reduce -49.2% 11,741 $295K
Bridgefront Capital, LLC 0.07% New 11,326 $285K
Franklin Resources Inc. 0.00% New 11,304 $284K
Teacher Retirement System of Texas 0.00% Reduce -39.4% 11,225 $282K
Swiss Life Asset Management Ltd 0.00% New 10,832 $272K
Arrowpoint Investment Partners (Singapore) Pte. Ltd. 0.04% New 10,806 $271K
Perbak Capital Partners LLP 0.08% New 10,217 $257K
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% Add +16.7% 10,044 $254K
Russell Investments Group, Ltd. 0.00% Add +1.0% 9,998 $251K
Graham Capital Management, L.P. 0.01% Reduce -59.9% 9,302 $234K
Dynasty Wealth Management, LLC 0.00% New 9,227 $232K
Mirabella Financial Services LLP 0.02% New 9,078 $228K
Vise Technologies, Inc. 0.00% New 9,012 $226K
Amalgamated Bank 0.00% Add +0.7% 8,736 $219K
Jefferies Financial Group Inc. 0.00% Reduce -96.5% 8,718 $219K
Quantitative Investment Management, LLC 0.02% New 8,611 $216K
CANADA LIFE ASSURANCE Co 0.00% Reduce -52.1% 8,495 $214K
Laurel Oak Wealth Management, LLC 0.04% — 8,465 $213K
Public Employees Retirement Association of Colorado 0.00% No change 8,362 $210K
AlphaGrep UK Ltd 0.07% — 8,323 $209K
MetLife Investment Management, LLC 0.00% Add +0.9% 6,962 $175K
Mirae Asset Global Investments Co., Ltd. 0.00% Add +25.9% 6,148 $154K
Quantbot Technologies LP 0.00% Add +99.4% 5,608 $141K
Stelac Advisory Services LLC 0.05% No change 5,520 $139K
Essential Partners LLC 0.04% Reduce -71.2% 5,107 $128K
Quarry LP 0.02% Reduce -68.8% 5,000 $126K
Ensign Peak Advisors, Inc 0.00% Reduce -71.3% 4,747 $119K
Bellevue Group AG 0.00% New 4,210 $106K
Walleye Capital LLC 0.00% Reduce -97.2% 3,955 $99K
US Bancorp \de 0.00% Add +14.1% 3,042 $76K
Osaic Holdings, Inc. 0.00% Reduce -13.4% 2,730 $69K
EverSource Wealth Advisors, LLC 0.00% Reduce -46.5% 2,602 $65K
STRS Ohio 0.00% Add +0.2% 2,582 $65K
GF Fund Management Co. LTD. 0.00% Reduce -8.5% 2,485 $62K
KBC Group NV 0.00% No change 2,313 $58K
Jones Financial Companies LLLP 0.00% No change 2,037 $51K
T. Rowe Price Investment Management, Inc. 0.00% Reduce -96.0% 1,974 $50K
Parallel Advisors, LLC 0.00% Reduce -14.1% 1,692 $43K
Signaturefd, LLC 0.00% No change 1,489 $37K
Pinnacle Wealth Planning Services, Inc. 0.00% New 1,012 $25K
Allworth Financial LP 0.00% Reduce -54.0% 1,010 $25K
Atlantic Private Wealth, LLC 0.02% Add +66.7% 1,000 $25K
IFP Advisors, Inc 0.00% Reduce -11.4% 982 $25K
Leonteq Securities AG 0.00% Reduce -20.0% 895 $22K
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.00% Add +41.4% 840 $21K
Quadrant Capital Group LLC 0.00% Add +388.2% 825 $21K
EFG International AG 0.00% — 788 $20K
Sterling Capital Management LLC 0.00% Add +370.7% 772 $19K
Aster Capital Management (DIFC) Ltd 0.01% Add +15.9% 643 $16K
Northwestern Mutual Wealth Management Co. 0.00% Reduce -0.2% 600 $15K
Versant Capital Management, Inc 0.00% No change 573 $14K
Rockefeller Capital Management L.P. 0.00% Reduce -51.2% 503 $13K
Archer Investment Corp 0.00% No change 500 $13K
Sound Income Strategies, LLC 0.00% New 621 $12K
GAMMA Investing LLC 0.00% Add +108.3% 479 $12K
Larson Financial Group LLC 0.00% Add +18.6% 466 $12K
Covestor Ltd 0.01% Reduce -89.8% 419 $11K
Farther Finance Advisors, LLC 0.00% Add +10.5% 367 $9K
Daiwa Securities Group Inc. 0.00% Reduce -14.0% 369 $9K
CIBC Private Wealth Group LLC 0.00% Reduce -9.0% 343 $9K
Tower Research Capital LLC (TRC) 0.00% Reduce -95.7% 319 $8K
Comerica Bank 0.00% Reduce -13.9% 315 $8K
TFC Financial Management, Inc. 0.00% New 212 $5K
Bessemer Group Inc. 0.00% New 205 $5K
Torren Management, LLC 0.00% — 189 $5K
True Wealth Design, LLC 0.00% Reduce -80.0% 189 $5K
Elevation Wealth Partners, LLC 0.00% New 151 $4K
Evelyn Partners Investment Management LLP 0.00% No change 150 $4K
Quent Capital, LLC 0.00% Reduce -66.7% 148 $4K
SBI Securities Co., Ltd. 0.00% Add +47.3% 137 $3K
MassMutual Private Wealth & Trust, FSB 0.00% Reduce -41.4% 106 $3K
Financial Gravity Asset Management, Inc. 0.00% No change 100 $3K
Mitsubishi UFJ Asset Management Co., Ltd. 0.00% No change 97 $3K
Brown Brothers Harriman & Co. 0.00% No change 95 $2K
Crewe Advisors LLC 0.00% No change 88 $2K
Hughes Financial Services, LLC 0.00% New 71 $2K
Smartleaf Asset Management LLC 0.00% Add +5900.0% 60 $2K
Sachetta, LLC 0.00% No change 60 $2K
TD Private Client Wealth LLC 0.00% Reduce -40.4% 56 $1K
Nisa Investment Advisors, LLC 0.00% No change 50 $1K
Arax Advisory Partners 0.00% Reduce -99.9% 46 $1K
Global Retirement Partners, LLC 0.00% Add +105.0% 41 $1K
Capital Analysts, LLC 0.00% No change 57 $1K
Sunbelt Securities, Inc. 0.00% Reduce -53.6% 39 $980
Clearstead Trust, LLC 0.00% Reduce -59.3% 35 $880
SageView Advisory Group, LLC 0.00% New 35 $880
Parkside Financial Bank & Trust 0.00% Reduce -8.3% 33 $829
Basecamp Wealth Advisors LLC 0.00% — 31 $779
Manchester Capital Management LLC 0.00% Add +833.3% 28 $704
Turning Point Benefit Group, Inc. 0.00% New 27 $678
Bare Financial Services, Inc 0.00% Add +19.1% 25 $628
United Financial Planning Group LLC 0.00% New 24 $603
Greenline Wealth Management LLC 0.00% — 21 $537
SouthState Bank Corp 0.00% No change 15 $377
Blue Trust, Inc. 0.00% New 14 $352
Clearstead Advisors, LLC 0.00% Reduce -99.2% 13 $327
UMB Bank, n.a. 0.00% New 12 $301
Assetmark, Inc. 0.00% New 10 $251
MV Capital Management, Inc. 0.00% Add +12.5% 9 $227
WPG Advisers, LLC 0.00% No change 5 $126
Rothschild Investment LLC 0.00% Reduce -66.7% 4 $100
Fideuram - Intesa Sanpaolo Private Banking S.P.A. 0.00% — 4 $100
Dunhill Financial, LLC 0.00% New 2 $53
Transamerica Financial Advisors, LLC 0.00% Reduce -66.7% 1 $25
Capital Advisors, Ltd. LLC 0.00% Reduce -99.3% 1 $0

"% of holder's portfolio" is APLS's weight in each manager's 13F, not the share of Apellis Pharmaceuticals Inc. the manager owns.