Apellis PharmaceuticalsAPLS
13F holders, Q4 2025 (December 31)At the end of Q4 2025, 280 institutions reported holding Apellis Pharmaceuticals Inc. (APLS) in their 13F filings, up 7 from Q3 2025. 49 opened new positions and 47 sold out. The largest holders were Wellington Management Group LLP ($319.6M), Avoro Capital Advisors LLC ($307.0M) and Vanguard Group Inc. ($268.2M). 9 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), Cliff Asness (0.0% of AQR Capital Management's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Apellis Pharmaceuticals Inc.
- CUSIP
- 03753U106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 49 | $250.9M |
| Exits | 47 | $132.9M |
All 13F filers, Q3 2025 → Q4 2025: 23,837,220 shares bought and 20,549,105 shares sold, net +3,288,115 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 280 holders
| Wellington Management Group LLP | 0.06% | Add +36.9% | 12,721,352 | $319.6M |
| Avoro Capital Advisors LLC | 3.02% | No change | 12,222,222 | $307.0M |
| Vanguard Group Inc. | 0.00% | Add +6.9% | 10,674,865 | $268.2M |
| Morgan Stanley | 0.01% | Reduce -4.9% | 9,173,004 | $230.4M |
| Deep Track Capital, LP | 4.44% | Reduce -3.1% | 7,750,000 | $194.7M |
| RTW Investments, LP | 1.93% | New | 7,666,764 | $192.6M |
| BlackRock, Inc. | 0.00% | Reduce -0.1% | 6,260,113 | $157.3M |
| State Street Corp. | 0.00% | Add +14.3% | 4,613,446 | $115.9M |
| UBS Group AG | 0.02% | Add +22.1% | 4,186,222 | $105.2M |
| Montanova Capital, LLC | 2.59% | Add +43.8% | 4,139,426 | $104.0M |
| Polar Capital Holdings Plc | 0.43% | Add +39.9% | 3,706,510 | $93.1M |
| Siren, L.L.C. | 1.93% | No change | 2,578,396 | $64.8M |
| Orbimed Advisors LLC | 1.25% | Add +4.6% | 2,429,868 | $61.0M |
| AQR Capital Management | 0.03% | Reduce -49.3% | 2,276,687 | $57.2M |
| Geode Capital Management, LLC | 0.00% | Reduce -2.3% | 2,025,669 | $50.9M |
| Jennison Associates LLC | 0.02% | Reduce -65.4% | 1,504,299 | $37.8M |
| Deutsche Bank AG | 0.01% | Reduce -7.9% | 1,385,263 | $34.8M |
| Norges Bank | 0.00% | — | 1,198,444 | $30.1M |
| Hudson Bay Capital Management LP | 0.19% | Add +181.9% | 1,179,828 | $29.6M |
| Bank of Nova Scotia | 0.04% | Reduce -26.5% | 1,070,141 | $26.9M |
| Marshall Wace, LLP | 0.02% | Add +149.8% | 990,848 | $24.9M |
| Bank of America Corp. | 0.00% | Reduce -35.2% | 956,773 | $24.0M |
| Millennium Management | 0.02% | Reduce -29.6% | 946,459 | $23.8M |
| Kynam Capital Management, LP | 1.49% | Add +12.4% | 908,607 | $22.8M |
| Los Angeles Capital Management LLC | 0.07% | Add +53.3% | 951,716 | $19.7M |
| Northern Trust Corp. | 0.00% | Add +26.8% | 696,521 | $17.5M |
| Nuveen, LLC | 0.00% | Add +2.5% | 681,819 | $17.1M |
| Citadel Advisors | 0.01% | Add +10.5% | 648,229 | $16.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -0.4% | 644,445 | $16.2M |
| Renaissance Technologies | 0.02% | Reduce -12.4% | 633,058 | $15.9M |
| Citigroup Inc. | 0.01% | Add +39.8% | 622,158 | $15.6M |
| Point72 Asset Management | 0.02% | Add +175.3% | 597,672 | $15.0M |
| Ameriprise Financial Inc. | 0.00% | Reduce -17.9% | 589,597 | $14.8M |
| SG Americas Securities, LLC | 0.02% | Add +35.9% | 567,046 | $14.2M |
| Two Sigma Investments, LP | 0.02% | Add +123.1% | 562,361 | $14.1M |
| BNP Paribas Financial Markets | 0.01% | Reduce -42.7% | 557,591 | $14.0M |
| Woodline Partners LP | 0.05% | No change | 542,981 | $13.6M |
| Simplify Asset Management Inc. | 0.22% | Add +403.3% | 538,008 | $13.5M |
| Susquehanna International Group, LLP | 0.02% | Add +70.1% | 533,909 | $13.4M |
| First Trust Advisors LP | 0.01% | New | 495,947 | $12.5M |
| Voloridge Investment Management, LLC | 0.04% | Reduce -53.5% | 461,186 | $11.6M |
| D. E. Shaw & Co. | 0.01% | Reduce -1.6% | 449,676 | $11.3M |
| Ossiam | 0.22% | Reduce -22.3% | 431,779 | $10.8M |
| Pictet Asset Management Holding SA | 0.01% | Add +7.5% | 390,884 | $9.8M |
| Rhenman & Partners Asset Management AB | 0.88% | Add +61.2% | 374,450 | $9.4M |
| Schroder Investment Management Group | 0.01% | Add +90.2% | 329,134 | $8.3M |
| 683 Capital Management, LLC | 0.73% | Add +14.6% | 330,000 | $8.3M |
| Granite Investment Partners, LLC | 0.49% | New | 327,094 | $8.2M |
| J. Goldman & Co LP | 0.28% | Add +1.0% | 285,992 | $7.2M |
| Bank of New York Mellon Corp | 0.00% | Add +9.6% | 271,925 | $6.8M |
| Natixis | 0.03% | Add +392.5% | 257,268 | $6.5M |
| Caption Management, LLC | 0.29% | Reduce -16.5% | 254,563 | $6.4M |
| Sphera Funds Management LTD. | 1.32% | Add +294.2% | 250,961 | $6.3M |
| Janus Henderson Group PLC | 0.00% | Add +569.3% | 230,320 | $5.8M |
| Invesco Ltd. | 0.00% | Add +23.5% | 225,976 | $5.7M |
| Canada Pension Plan Investment Board | 0.00% | Add +2.4% | 222,200 | $5.6M |
| Tudor Investment Corporation | 0.03% | New | 215,000 | $5.4M |
| Acadian Asset Management LLC | 0.01% | Add +1554.1% | 205,986 | $5.2M |
| Integral Health Asset Management, LLC | 0.25% | Reduce -20.0% | 200,000 | $5.0M |
| Trexquant Investment LP | 0.04% | Reduce -66.8% | 194,592 | $4.9M |
| Jump Financial, LLC | 0.07% | Reduce -30.2% | 193,876 | $4.9M |
| HRT Financial LP | 0.02% | Reduce -45.6% | 192,488 | $4.8M |
| Squarepoint Ops LLC | 0.01% | Add +263.7% | 192,156 | $4.8M |
| Apis Capital Advisors, LLC | 0.84% | New | 192,000 | $4.8M |
| Silvercrest Asset Management Group LLC | 0.03% | Add +0.1% | 190,759 | $4.8M |
| Goldman Sachs Group Inc. | 0.00% | Add +52.1% | 189,205 | $4.8M |
| Barclays PLC | 0.00% | Reduce -30.4% | 187,712 | $4.7M |
| California Public Employees Retirement System | 0.00% | Add +27.5% | 186,328 | $4.7M |
| Dimensional Fund Advisors LP | 0.00% | Add +868.0% | 180,925 | $4.5M |
| Fiduciary Trust Co | 0.05% | Reduce -9.0% | 180,254 | $4.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +6.8% | 178,888 | $4.5M |
| Bank of Montreal | 0.00% | Add +10.2% | 176,571 | $4.4M |
| Rafferty Asset Management, LLC | 0.01% | Add +1.8% | 171,456 | $4.3M |
| ExodusPoint Capital Management, LP | 0.05% | Reduce -12.1% | 171,156 | $4.3M |
| Gotham Asset Management | 0.02% | Add +32.5% | 168,455 | $4.2M |
| JPMorgan Chase & Co. | 0.00% | Add +194.8% | 157,754 | $4.0M |
| HighVista Strategies LLC | 0.98% | Add +3.5% | 150,776 | $3.8M |
| Rock Springs Capital Management LP | 0.19% | Add +63.6% | 150,500 | $3.8M |
| Swiss National Bank | 0.00% | Add +2.3% | 149,500 | $3.8M |
| Man Group plc | 0.01% | Add +114.7% | 144,271 | $3.6M |
| Bridgewater Associates | 0.01% | New | 143,805 | $3.6M |
| DekaBank Deutsche Girozentrale | 0.01% | No change | 55,000 | $3.5M |
| ING Groep NV | 0.02% | Reduce -88.2% | 139,000 | $3.5M |
| Exome Asset Management LLC | 1.69% | New | 135,849 | $3.4M |
| Rhumbline Advisers | 0.00% | Reduce -0.4% | 116,917 | $2.9M |
| Two Sigma Advisers, LP | 0.01% | New | 110,900 | $2.8M |
| Algert Global LLC | 0.04% | No change | 109,733 | $2.8M |
| New York State Common Retirement Fund | 0.00% | Add +113.0% | 104,018 | $2.6M |
| Wells Fargo & Company | 0.00% | Add +4115.0% | 103,815 | $2.6M |
| Alps Advisors Inc. | 0.02% | Add +65.1% | 103,696 | $2.6M |
| Edgestream Partners, L.P. | 0.07% | Reduce -24.9% | 97,443 | $2.4M |
| Mackenzie Financial Corp. | 0.00% | Add +25.4% | 96,211 | $2.4M |
| State Board of Administration of Florida Retirement System | 0.00% | Add +0.6% | 96,125 | $2.4M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +107.7% | 95,755 | $2.4M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -3.0% | 95,035 | $2.4M |
| Royal Bank of Canada | 0.00% | Reduce -39.3% | 88,687 | $2.2M |
| WINTON GROUP Ltd | 0.08% | New | 86,653 | $2.2M |
| Legal & General Group Plc | 0.00% | Reduce -7.5% | 85,489 | $2.1M |
| Steward Partners Investment Advisory, LLC | 0.01% | Reduce -28.4% | 81,698 | $2.1M |
| Coppell Advisory Solutions LLC | 0.19% | New | 77,390 | $2.0M |
| California State Teachers Retirement System | 0.00% | Reduce -0.1% | 73,203 | $1.8M |
| Ikarian Capital, LLC | 0.23% | Reduce -84.1% | 71,747 | $1.8M |
| Raymond James Financial Inc. | 0.00% | Reduce -13.8% | 66,997 | $1.7M |
| State of Wisconsin Investment Board | 0.00% | Reduce -22.0% | 66,916 | $1.7M |
| Balyasny Asset Management L.P. | 0.00% | New | 65,133 | $1.6M |
| Profund Advisors LLC | 0.05% | Add +78.1% | 61,832 | $1.6M |
| Sei Investments Co. | 0.00% | Reduce -61.1% | 60,291 | $1.5M |
| PDT Partners, LLC | 0.09% | No change | 53,951 | $1.4M |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -1.0% | 53,526 | $1.3M |
| Hennion & Walsh Asset Management, Inc. | 0.04% | Add +7.9% | 51,933 | $1.3M |
| Jane Street Group, LLC | 0.00% | Reduce -82.9% | 50,114 | $1.3M |
| Ishara Investments LP | 1.46% | — | 50,000 | $1.3M |
| Elmind Capital, LP | 0.37% | — | 50,000 | $1.3M |
| Police & Firemen's Retirement System of New Jersey | 0.01% | Reduce -4.9% | 46,009 | $1.2M |
| Treasurer of the State of North Carolina | 0.00% | Reduce -6.8% | 45,170 | $1.1M |
| Voya Investment Management LLC | 0.00% | Reduce -74.8% | 43,661 | $1.1M |
| Panagora Asset Management Inc. | 0.00% | New | 42,134 | $1.1M |
| Cwm, LLC | 0.00% | Reduce -55.6% | 41,880 | $1.1M |
| Prelude Capital Management, LLC | 0.07% | New | 38,521 | $968K |
| Stifel Financial Corp. | 0.00% | New | 36,661 | $921K |
| Guggenheim Capital LLC | 0.01% | Add +8.3% | 36,647 | $921K |
| Handelsbanken Fonder AB | 0.00% | Reduce -9.5% | 35,400 | $889K |
| Alliancebernstein L.P. | 0.00% | Reduce -57.2% | 34,530 | $867K |
| Vontobel Holding Ltd. | 0.00% | New | 34,039 | $855K |
| Public Employees Retirement System of Ohio | 0.00% | Reduce -3.7% | 32,448 | $815K |
| FMR LLC | 0.00% | Add +73.8% | 32,163 | $808K |
| Quantinno Capital Management LP | 0.00% | Reduce -34.4% | 31,763 | $798K |
| Y-Intercept (Hong Kong) Ltd | 0.02% | Reduce -80.7% | 31,581 | $793K |
| Dark Forest Capital Management LP | 0.04% | New | 31,091 | $781K |
| Amundi | 0.00% | Reduce -97.9% | 30,721 | $772K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -61.1% | 30,175 | $722K |
| Simplex Trading, LLC | 0.02% | Reduce -49.6% | 27,187 | $683K |
| Virtus Investment Advisers, LLC | 0.18% | Add +17.4% | 27,086 | $680K |
| State of New Jersey Common Pension Fund D | 0.00% | New | 25,863 | $650K |
| Ieq Capital, LLC | 0.00% | Reduce -91.4% | 25,500 | $641K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +19.0% | 25,364 | $637K |
| Erste Asset Management GmbH | 0.01% | No change | 25,300 | $637K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | Reduce -4.3% | 24,365 | $612K |
| Quadrature Capital Ltd | 0.01% | New | 24,075 | $605K |
| Cerity Partners LLC | 0.00% | Reduce -81.3% | 23,971 | $602K |
| Entropy Technologies, LP | 0.03% | Reduce -6.0% | 23,128 | $581K |
| Marex Group Ltd | 0.01% | New | 23,000 | $578K |
| Manufacturers Life Insurance Company, The | 0.00% | Add +0.6% | 22,852 | $574K |
| PSP Research LLC | 0.48% | — | 21,866 | $549K |
| Boothbay Fund Management, LLC | 0.01% | Reduce -88.0% | 21,415 | $538K |
| IMC-Chicago, LLC | 0.01% | New | 21,324 | $536K |
| Arizona State Retirement System | 0.00% | Reduce -5.8% | 21,010 | $528K |
| China Universal Asset Management Co., Ltd. | 0.04% | Reduce -6.9% | 20,617 | $518K |
| ADAR1 Capital Management, LLC | 0.04% | No change | 20,000 | $502K |
| Odyssean, LLC | 0.35% | — | 19,207 | $482K |
| Diversified Trust Co. | 0.01% | New | 18,942 | $476K |
| Qube Research & Technologies Ltd | 0.00% | Reduce -84.3% | 18,843 | $473K |
| Xponance LLC | 0.00% | Add +3.9% | 18,164 | $456K |
| Advent Capital Management | 0.74% | New | 18,000 | $452K |
| Mercer Global Advisors Inc. | 0.00% | Reduce -54.8% | 17,668 | $444K |
| Allianz Asset Management GmbH | 0.00% | No change | 17,000 | $427K |
| Jain Global LLC | 0.00% | New | 16,877 | $424K |
| Creative Planning | 0.00% | Reduce -53.9% | 16,439 | $413K |
| KLP Kapitalforvaltning As | 0.00% | Add +3.9% | 16,200 | $407K |
| Brevan Howard Capital Management LP | 0.01% | Reduce -82.3% | 16,117 | $405K |
| Duncan Williams Asset Management, LLC | 0.10% | No change | 17,005 | $394K |
| Vident Advisory, LLC | 0.00% | Reduce -56.0% | 15,553 | $391K |
| Victory Capital Management Inc. | 0.00% | Reduce -0.5% | 15,197 | $382K |
| Maven Securities LTD | 0.05% | New | 15,000 | $377K |
| NewEdge Advisors, LLC | 0.00% | New | 14,570 | $366K |
| M&T Bank Corp | 0.00% | Add +11.2% | 14,477 | $364K |
| Nomura Holdings Inc. | 0.00% | Reduce -61.2% | 14,200 | $357K |
| Birchview Capital, LP | 0.21% | No change | 14,000 | $352K |
| Pallas Capital Advisors LLC | 0.01% | Reduce -58.0% | 13,885 | $349K |
| Summit Trail Advisors, LLC | 0.01% | Add +34.8% | 13,851 | $348K |
| Empowered Funds, LLC | 0.01% | Add +0.3% | 13,381 | $336K |
| Twinbeech Capital LP | 0.02% | Add +47.3% | 13,152 | $330K |
| Walleye Trading LLC | 0.01% | Add +21.6% | 12,699 | $319K |
| Freestone Grove Partners LP | 0.00% | New | 12,537 | $315K |
| Wedmont Private Capital | 0.01% | Add +4.1% | 11,883 | $315K |
| AlphaQuest LLC | 0.02% | Reduce -49.2% | 11,741 | $295K |
| Bridgefront Capital, LLC | 0.07% | New | 11,326 | $285K |
| Franklin Resources Inc. | 0.00% | New | 11,304 | $284K |
| Teacher Retirement System of Texas | 0.00% | Reduce -39.4% | 11,225 | $282K |
| Swiss Life Asset Management Ltd | 0.00% | New | 10,832 | $272K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0.04% | New | 10,806 | $271K |
| Perbak Capital Partners LLP | 0.08% | New | 10,217 | $257K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +16.7% | 10,044 | $254K |
| Russell Investments Group, Ltd. | 0.00% | Add +1.0% | 9,998 | $251K |
| Graham Capital Management, L.P. | 0.01% | Reduce -59.9% | 9,302 | $234K |
| Dynasty Wealth Management, LLC | 0.00% | New | 9,227 | $232K |
| Mirabella Financial Services LLP | 0.02% | New | 9,078 | $228K |
| Vise Technologies, Inc. | 0.00% | New | 9,012 | $226K |
| Amalgamated Bank | 0.00% | Add +0.7% | 8,736 | $219K |
| Jefferies Financial Group Inc. | 0.00% | Reduce -96.5% | 8,718 | $219K |
| Quantitative Investment Management, LLC | 0.02% | New | 8,611 | $216K |
| CANADA LIFE ASSURANCE Co | 0.00% | Reduce -52.1% | 8,495 | $214K |
| Laurel Oak Wealth Management, LLC | 0.04% | — | 8,465 | $213K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 8,362 | $210K |
| AlphaGrep UK Ltd | 0.07% | — | 8,323 | $209K |
| MetLife Investment Management, LLC | 0.00% | Add +0.9% | 6,962 | $175K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +25.9% | 6,148 | $154K |
| Quantbot Technologies LP | 0.00% | Add +99.4% | 5,608 | $141K |
| Stelac Advisory Services LLC | 0.05% | No change | 5,520 | $139K |
| Essential Partners LLC | 0.04% | Reduce -71.2% | 5,107 | $128K |
| Quarry LP | 0.02% | Reduce -68.8% | 5,000 | $126K |
| Ensign Peak Advisors, Inc | 0.00% | Reduce -71.3% | 4,747 | $119K |
| Bellevue Group AG | 0.00% | New | 4,210 | $106K |
| Walleye Capital LLC | 0.00% | Reduce -97.2% | 3,955 | $99K |
| US Bancorp \de | 0.00% | Add +14.1% | 3,042 | $76K |
| Osaic Holdings, Inc. | 0.00% | Reduce -13.4% | 2,730 | $69K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -46.5% | 2,602 | $65K |
| STRS Ohio | 0.00% | Add +0.2% | 2,582 | $65K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -8.5% | 2,485 | $62K |
| KBC Group NV | 0.00% | No change | 2,313 | $58K |
| Jones Financial Companies LLLP | 0.00% | No change | 2,037 | $51K |
| T. Rowe Price Investment Management, Inc. | 0.00% | Reduce -96.0% | 1,974 | $50K |
| Parallel Advisors, LLC | 0.00% | Reduce -14.1% | 1,692 | $43K |
| Signaturefd, LLC | 0.00% | No change | 1,489 | $37K |
| Pinnacle Wealth Planning Services, Inc. | 0.00% | New | 1,012 | $25K |
| Allworth Financial LP | 0.00% | Reduce -54.0% | 1,010 | $25K |
| Atlantic Private Wealth, LLC | 0.02% | Add +66.7% | 1,000 | $25K |
| IFP Advisors, Inc | 0.00% | Reduce -11.4% | 982 | $25K |
| Leonteq Securities AG | 0.00% | Reduce -20.0% | 895 | $22K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | Add +41.4% | 840 | $21K |
| Quadrant Capital Group LLC | 0.00% | Add +388.2% | 825 | $21K |
| EFG International AG | 0.00% | — | 788 | $20K |
| Sterling Capital Management LLC | 0.00% | Add +370.7% | 772 | $19K |
| Aster Capital Management (DIFC) Ltd | 0.01% | Add +15.9% | 643 | $16K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -0.2% | 600 | $15K |
| Versant Capital Management, Inc | 0.00% | No change | 573 | $14K |
| Rockefeller Capital Management L.P. | 0.00% | Reduce -51.2% | 503 | $13K |
| Archer Investment Corp | 0.00% | No change | 500 | $13K |
| Sound Income Strategies, LLC | 0.00% | New | 621 | $12K |
| GAMMA Investing LLC | 0.00% | Add +108.3% | 479 | $12K |
| Larson Financial Group LLC | 0.00% | Add +18.6% | 466 | $12K |
| Covestor Ltd | 0.01% | Reduce -89.8% | 419 | $11K |
| Farther Finance Advisors, LLC | 0.00% | Add +10.5% | 367 | $9K |
| Daiwa Securities Group Inc. | 0.00% | Reduce -14.0% | 369 | $9K |
| CIBC Private Wealth Group LLC | 0.00% | Reduce -9.0% | 343 | $9K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -95.7% | 319 | $8K |
| Comerica Bank | 0.00% | Reduce -13.9% | 315 | $8K |
| TFC Financial Management, Inc. | 0.00% | New | 212 | $5K |
| Bessemer Group Inc. | 0.00% | New | 205 | $5K |
| Torren Management, LLC | 0.00% | — | 189 | $5K |
| True Wealth Design, LLC | 0.00% | Reduce -80.0% | 189 | $5K |
| Elevation Wealth Partners, LLC | 0.00% | New | 151 | $4K |
| Evelyn Partners Investment Management LLP | 0.00% | No change | 150 | $4K |
| Quent Capital, LLC | 0.00% | Reduce -66.7% | 148 | $4K |
| SBI Securities Co., Ltd. | 0.00% | Add +47.3% | 137 | $3K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | Reduce -41.4% | 106 | $3K |
| Financial Gravity Asset Management, Inc. | 0.00% | No change | 100 | $3K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | No change | 97 | $3K |
| Brown Brothers Harriman & Co. | 0.00% | No change | 95 | $2K |
| Crewe Advisors LLC | 0.00% | No change | 88 | $2K |
| Hughes Financial Services, LLC | 0.00% | New | 71 | $2K |
| Smartleaf Asset Management LLC | 0.00% | Add +5900.0% | 60 | $2K |
| Sachetta, LLC | 0.00% | No change | 60 | $2K |
| TD Private Client Wealth LLC | 0.00% | Reduce -40.4% | 56 | $1K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 50 | $1K |
| Arax Advisory Partners | 0.00% | Reduce -99.9% | 46 | $1K |
| Global Retirement Partners, LLC | 0.00% | Add +105.0% | 41 | $1K |
| Capital Analysts, LLC | 0.00% | No change | 57 | $1K |
| Sunbelt Securities, Inc. | 0.00% | Reduce -53.6% | 39 | $980 |
| Clearstead Trust, LLC | 0.00% | Reduce -59.3% | 35 | $880 |
| SageView Advisory Group, LLC | 0.00% | New | 35 | $880 |
| Parkside Financial Bank & Trust | 0.00% | Reduce -8.3% | 33 | $829 |
| Basecamp Wealth Advisors LLC | 0.00% | — | 31 | $779 |
| Manchester Capital Management LLC | 0.00% | Add +833.3% | 28 | $704 |
| Turning Point Benefit Group, Inc. | 0.00% | New | 27 | $678 |
| Bare Financial Services, Inc | 0.00% | Add +19.1% | 25 | $628 |
| United Financial Planning Group LLC | 0.00% | New | 24 | $603 |
| Greenline Wealth Management LLC | 0.00% | — | 21 | $537 |
| SouthState Bank Corp | 0.00% | No change | 15 | $377 |
| Blue Trust, Inc. | 0.00% | New | 14 | $352 |
| Clearstead Advisors, LLC | 0.00% | Reduce -99.2% | 13 | $327 |
| UMB Bank, n.a. | 0.00% | New | 12 | $301 |
| Assetmark, Inc. | 0.00% | New | 10 | $251 |
| MV Capital Management, Inc. | 0.00% | Add +12.5% | 9 | $227 |
| WPG Advisers, LLC | 0.00% | No change | 5 | $126 |
| Rothschild Investment LLC | 0.00% | Reduce -66.7% | 4 | $100 |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 0.00% | — | 4 | $100 |
| Dunhill Financial, LLC | 0.00% | New | 2 | $53 |
| Transamerica Financial Advisors, LLC | 0.00% | Reduce -66.7% | 1 | $25 |
| Capital Advisors, Ltd. LLC | 0.00% | Reduce -99.3% | 1 | $0 |
"% of holder's portfolio" is APLS's weight in each manager's 13F, not the share of Apellis Pharmaceuticals Inc. the manager owns.