Design TherapeuticsDSGN
13F holders, Q1 2026 (March 31)125holders +8
18new positions
12sold out
6famous investors
$10.64avg. 13F price*
At the end of Q1 2026, 125 institutions reported holding Design Therapeutics Inc. (DSGN) in their 13F filings, up 8 from Q4 2025. 18 opened new positions and 12 sold out. The largest holders were SR One Capital Management, LP ($69.4M), Ra Capital Management, L.P. ($31.6M) and Point72 Asset Management ($29.0M). 6 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Design Therapeutics Inc.
- CUSIP
- 25056L103
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 18 | $12.0M |
| Exits | 12 | $7.4M |
All 13F filers, Q4 2025 → Q1 2026: 4,831,383 shares bought and 5,003,491 shares sold, net −172,108 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 125 holders
| SR One Capital Management, LP | 7.59% | No change | 6,526,476 | $69.4M |
| Ra Capital Management, L.P. | 0.34% | Add +103.4% | 2,972,973 | $31.6M |
| Point72 Asset Management | 0.05% | Reduce -49.3% | 2,722,754 | $29.0M |
| Baker Bros. Advisors LP | 0.16% | Add +15.8% | 2,585,978 | $27.5M |
| BlackRock, Inc. | 0.00% | Add +0.8% | 2,133,764 | $22.7M |
| Logos Global Management LP | 1.07% | Reduce -22.0% | 1,950,000 | $20.7M |
| Driehaus Capital Management LLC | 0.14% | Add +47.9% | 1,744,987 | $18.6M |
| Vivo Capital, LLC | 1.43% | No change | 1,612,903 | $17.2M |
| Almitas Capital LLC | 3.68% | Reduce -0.0% | 1,530,335 | $16.3M |
| Vanguard Capital Management LLC | 0.00% | — | 1,349,850 | $14.4M |
| Woodline Partners LP | 0.04% | Add +1.9% | 961,501 | $10.2M |
| Trails Edge Capital Partners, LP | 2.13% | New | 852,013 | $9.1M |
| FMR LLC | 0.00% | Add +3.5% | 798,411 | $8.5M |
| Kynam Capital Management, LP | 0.53% | No change | 784,606 | $8.3M |
| Geode Capital Management, LLC | 0.00% | Add +1.9% | 692,518 | $7.4M |
| State Street Corp. | 0.00% | Add +1.8% | 659,575 | $7.0M |
| Morgan Stanley | 0.00% | Reduce -6.5% | 656,565 | $7.0M |
| Acadian Asset Management LLC | 0.01% | Add +0.6% | 616,481 | $6.6M |
| Goldman Sachs Group Inc. | 0.00% | Add +86.5% | 504,718 | $5.4M |
| D. E. Shaw & Co. | 0.00% | Add +7.2% | 470,270 | $5.0M |
| Dimensional Fund Advisors LP | 0.00% | Add +45.0% | 431,840 | $4.6M |
| Renaissance Technologies | 0.01% | Add +42.2% | 408,200 | $4.3M |
| Northern Trust Corp. | 0.00% | Add +4.8% | 300,279 | $3.2M |
| Jacobs Levy Equity Management, Inc. | 0.01% | Add +48.7% | 289,385 | $3.1M |
| Kennedy Capital Management LLC | 0.06% | Add +442.9% | 271,554 | $2.9M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +1.9% | 241,485 | $2.6M |
| Citadel Advisors | 0.00% | Reduce -49.7% | 231,513 | $2.5M |
| Elmind Capital, LP | 0.63% | No change | 207,900 | $2.2M |
| Algert Global LLC | 0.03% | Add +9.0% | 204,739 | $2.2M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 195,658 | $2.1M |
| Marshall Wace, LLP | 0.00% | Reduce -33.0% | 151,008 | $1.6M |
| Acuta Capital Partners, LLC | 1.10% | Reduce -3.3% | 145,900 | $1.6M |
| Invesco Ltd. | 0.00% | Reduce -53.6% | 141,920 | $1.5M |
| Vanguard Portfolio Management LLC | 0.00% | — | 138,565 | $1.5M |
| Sei Investments Co. | 0.00% | Add +152.6% | 133,203 | $1.4M |
| Nuveen, LLC | 0.00% | Add +1.2% | 126,815 | $1.3M |
| Lynx1 Capital Management LP | 0.20% | Add +71.9% | 119,516 | $1.3M |
| Trexquant Investment LP | 0.01% | Add +17.1% | 117,111 | $1.2M |
| Millennium Management | 0.00% | Reduce -39.8% | 108,928 | $1.2M |
| Raymond James Financial Inc. | 0.00% | Reduce -1.2% | 108,449 | $1.2M |
| Jane Street Group, LLC | 0.00% | Reduce -54.1% | 103,902 | $1.1M |
| Verdad Advisers, LP | 1.11% | New | 92,310 | $982K |
| Caption Management, LLC | 0.05% | New | 86,708 | $923K |
| Squarepoint Ops LLC | 0.00% | Add +86.6% | 86,117 | $916K |
| Bank of New York Mellon Corp | 0.00% | Reduce -6.3% | 79,645 | $847K |
| Informed Momentum Co LLC | 0.10% | No change | 78,949 | $840K |
| Palumbo Wealth Management LLC | 0.19% | Add +2.9% | 71,408 | $760K |
| American Century Companies Inc. | 0.00% | Add +13.6% | 65,638 | $698K |
| XTX Topco Ltd | 0.01% | Add +72.7% | 60,939 | $648K |
| Canada Pension Plan Investment Board | 0.00% | Add +10.6% | 60,400 | $643K |
| Barclays PLC | 0.00% | Reduce -35.9% | 55,790 | $594K |
| Bridgeway Capital Management, LLC | 0.01% | Reduce -33.8% | 52,000 | $553K |
| BNP Paribas Financial Markets | 0.00% | Reduce -47.0% | 50,272 | $535K |
| Alps Advisors Inc. | 0.00% | Add +7.3% | 50,209 | $534K |
| State of Wisconsin Investment Board | 0.00% | Reduce -2.9% | 49,214 | $524K |
| Prudential Financial Inc. | 0.00% | Add +7.3% | 45,810 | $487K |
| STRS Ohio | 0.00% | Add +77.4% | 44,700 | $476K |
| Alliancebernstein L.P. | 0.00% | No change | 46,120 | $433K |
| China Universal Asset Management Co., Ltd. | 0.03% | Add +2.4% | 35,109 | $374K |
| Ameriprise Financial Inc. | 0.00% | Reduce -77.9% | 34,990 | $372K |
| Rhumbline Advisers | 0.00% | Add +0.2% | 34,860 | $371K |
| Qube Research & Technologies Ltd | 0.00% | New | 34,183 | $364K |
| Corient Private Wealth LP | 0.00% | Add +0.8% | 27,169 | $289K |
| AQR Capital Management | 0.00% | Add +89.0% | 25,957 | $276K |
| Russell Investments Group, Ltd. | 0.00% | Add +0.8% | 25,437 | $271K |
| Bank of America Corp. | 0.00% | Reduce -15.2% | 23,264 | $248K |
| AlphaCentric Advisors LLC | 0.23% | Add +4.8% | 21,231 | $226K |
| Deutsche Bank AG | 0.00% | Add +32.8% | 20,644 | $220K |
| Velan Capital Investment Management LP | 0.13% | No change | 20,000 | $213K |
| UBS Group AG | 0.00% | Reduce -33.1% | 17,091 | $182K |
| T. Rowe Price Associates Inc. | 0.00% | Add +4.2% | 16,370 | $175K |
| Two Sigma Investments, LP | 0.00% | Reduce -64.8% | 16,300 | $173K |
| Engineers Gate Manager LP | 0.00% | Add +14.8% | 16,090 | $171K |
| Brevan Howard Capital Management LP | 0.00% | New | 15,294 | $163K |
| MetLife Investment Management, LLC | 0.00% | No change | 15,249 | $162K |
| Public Employees Retirement System of Ohio | 0.00% | Add +114.2% | 15,193 | $162K |
| Nisa Investment Advisors, LLC | 0.00% | Add +25.4% | 14,824 | $158K |
| Dynamic Technology Lab Private Ltd | 0.03% | New | 14,749 | $157K |
| Quantinno Capital Management LP | 0.00% | New | 14,128 | $150K |
| JPMorgan Chase & Co. | 0.00% | Reduce -2.2% | 14,134 | $147K |
| Mariner, LLC | 0.00% | Add +1.9% | 13,066 | $139K |
| Baader Bank Aktiengesellschaft | 0.01% | Reduce -36.0% | 12,792 | $136K |
| Vanguard Global Advisers, LLC | 0.00% | — | 11,839 | $126K |
| Mirabella Financial Services LLP | 0.01% | New | 11,814 | $126K |
| Royal Bank of Canada | 0.00% | Add +1681.5% | 11,366 | $121K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +2.5% | 11,363 | $121K |
| ADAR1 Capital Management, LLC | 0.01% | New | 10,000 | $106K |
| Wells Fargo & Company | 0.00% | Reduce -66.3% | 9,027 | $96K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 6,598 | $70K |
| Citigroup Inc. | 0.00% | Add +36.9% | 4,263 | $45K |
| Rockefeller Capital Management L.P. | 0.00% | Add +399.2% | 3,684 | $39K |
| Caz Investments LP | 0.04% | No change | 3,500 | $37K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +7.3% | 2,971 | $32K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 2,570 | $27K |
| Legal & General Group Plc | 0.00% | No change | 2,077 | $22K |
| New York State Common Retirement Fund | 0.00% | No change | 2,026 | $22K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 1,816 | $19K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +29.9% | 1,594 | $17K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -63.8% | 1,545 | $16K |
| GAMMA Investing LLC | 0.00% | Add +96.3% | 1,472 | $16K |
| California State Teachers Retirement System | 0.00% | Reduce -12.2% | 1,292 | $14K |
| GF Fund Management Co. LTD. | 0.00% | Add +13.7% | 1,271 | $14K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +200.8% | 1,143 | $12K |
| Sterling Capital Management LLC | 0.00% | Reduce -42.6% | 791 | $8K |
| Clearstead Advisors, LLC | 0.00% | No change | 610 | $6K |
| Private Wealth Management Group, LLC | 0.00% | Reduce -4.5% | 533 | $6K |
| Cwm, LLC | 0.00% | Add +77.0% | 423 | $5K |
| Farther Finance Advisors, LLC | 0.00% | Add +0.3% | 386 | $4K |
| Osaic Holdings, Inc. | 0.00% | Add +2960.0% | 306 | $3K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 268 | $3K |
| Stone House Investment Management, LLC | 0.00% | New | 239 | $3K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | No change | 239 | $3K |
| Optiver Holding B.V. | 0.00% | Reduce -31.7% | 224 | $2K |
| Larson Financial Group LLC | 0.00% | Add +5933.3% | 181 | $2K |
| Allworth Financial LP | 0.00% | New | 130 | $1K |
| US Bancorp \de | 0.00% | New | 61 | $649 |
| Root Financial Partners, LLC | 0.00% | New | 38 | $404 |
| Rothschild Investment LLC | 0.00% | New | 23 | $245 |
| EverSource Wealth Advisors, LLC | 0.00% | Add +233.3% | 10 | $107 |
| National Bank of Canada | 0.00% | New | 9 | $96 |
| MAI Capital Management | 0.00% | New | 8 | $86 |
| Caitong International Asset Management Co., Ltd | 0.00% | New | 1 | $11 |
| True Wealth Design, LLC | 0.00% | No change | 1 | $11 |
| Essential Partners LLC | 0.00% | New | 1 | $11 |
| Capital Advisors, Ltd. LLC | 0.00% | No change | 12 | $0 |
"% of holder's portfolio" is DSGN's weight in each manager's 13F, not the share of Design Therapeutics Inc. the manager owns.