Structure TherapeuticsGPCR
13F holders, Q4 2025 (December 31)197holders +41
63new positions
27sold out
5famous investors
$69.63avg. 13F price*
At the end of Q4 2025, 197 institutions reported holding Structure Therapeutics Inc. (GPCR) in their 13F filings, up 41 from Q3 2025. 63 opened new positions and 27 sold out. The largest holders were FMR LLC ($605.9M), Wellington Management Group LLP ($495.3M) and Avoro Capital Advisors LLC ($455.9M). 5 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Structure Therapeutics Inc.
- CUSIP
- 86366E106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 63 | $377.8M |
| Exits | 27 | $110.6M |
All 13F filers, Q3 2025 → Q4 2025: 19,797,860 shares bought and 10,857,412 shares sold, net +8,940,448 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 197 holders
| FMR LLC | 0.03% | Add +65.9% | 8,712,251 | $605.9M |
| Wellington Management Group LLP | 0.09% | Add +25.2% | 7,121,984 | $495.3M |
| Avoro Capital Advisors LLC | 4.48% | Add +27.2% | 6,555,555 | $455.9M |
| Janus Henderson Group PLC | 0.16% | Add +14.4% | 5,090,148 | $354.0M |
| Deep Track Capital, LP | 6.52% | Reduce -2.5% | 4,111,782 | $286.0M |
| BVF Inc. | 8.15% | Add +8.6% | 3,479,022 | $242.0M |
| Morgan Stanley | 0.01% | Add +261.4% | 2,087,834 | $145.2M |
| T. Rowe Price Associates Inc. | 0.01% | Add +477.5% | 1,671,138 | $116.2M |
| Driehaus Capital Management LLC | 0.78% | Add +88.0% | 1,642,444 | $114.2M |
| Baker Bros. Advisors LP | 0.59% | Reduce -7.9% | 1,432,529 | $99.6M |
| Principal Financial Group Inc. | 0.05% | Add +63.1% | 1,284,210 | $89.3M |
| Casdin Capital, LLC | 5.08% | Reduce -24.4% | 1,175,000 | $81.7M |
| Orbimed Advisors LLC | 1.65% | Add +2.0% | 1,161,803 | $80.8M |
| Siren, L.L.C. | 2.24% | Add +5.0% | 1,078,698 | $75.0M |
| TCG Crossover Management, LLC | 2.12% | Reduce -13.4% | 920,857 | $64.0M |
| Capitolis Liquid Global Markets LLC | 0.36% | New | 878,300 | $61.1M |
| Franklin Resources Inc. | 0.02% | Add +16.7% | 870,582 | $60.5M |
| Alliancebernstein L.P. | 0.02% | Add +2771.7% | 848,851 | $59.0M |
| Deutsche Bank AG | 0.02% | New | 841,162 | $58.5M |
| Citadel Advisors | 0.04% | Add +74.1% | 772,518 | $53.7M |
| Deerfield Management Company, L.P. | 0.78% | Add +105.7% | 767,993 | $53.4M |
| Rock Springs Capital Management LP | 2.68% | Reduce -21.3% | 748,236 | $52.0M |
| Pacific Heights Asset Management LLC | 1.83% | No change | 700,000 | $48.7M |
| Logos Global Management LP | 2.78% | Reduce -29.4% | 600,000 | $41.7M |
| American Century Companies Inc. | 0.02% | Add +4.1% | 506,959 | $35.3M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.06% | New | 467,800 | $32.5M |
| Farallon Capital Management, L.L.C. | 0.16% | New | 454,000 | $31.6M |
| BlackRock, Inc. | 0.00% | Add +63.0% | 430,082 | $29.9M |
| HSG Holding Ltd | 1.29% | No change | 266,062 | $24.4M |
| Stempoint Capital LP | 4.19% | Add +171.4% | 351,073 | $24.4M |
| EcoR1 Capital, LLC | 1.07% | New | 334,380 | $23.3M |
| Ameriprise Financial Inc. | 0.00% | Reduce -76.7% | 285,518 | $19.9M |
| ArrowMark Colorado Holdings LLC | 0.42% | Reduce -16.1% | 271,213 | $18.9M |
| National Bank of Canada | 0.02% | Add +84.3% | 265,400 | $18.5M |
| Aberdeen Group plc | 0.03% | Reduce -54.9% | 264,869 | $18.4M |
| Catalio Capital Management, LP | 3.11% | Reduce -61.2% | 252,901 | $17.6M |
| Capricorn Fund Managers Ltd | 4.23% | New | 252,600 | $17.6M |
| Voloridge Investment Management, LLC | 0.06% | New | 250,000 | $17.4M |
| Monashee Investment Management LLC | 9.24% | Add +12.5% | 225,000 | $15.6M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -55.5% | 224,332 | $15.6M |
| Balyasny Asset Management L.P. | 0.03% | Reduce -53.2% | 216,199 | $15.0M |
| UBS Group AG | 0.00% | Reduce -2.7% | 202,477 | $14.1M |
| Sio Capital Management, LLC | 2.32% | New | 201,500 | $14.0M |
| HighVista Strategies LLC | 3.46% | Reduce -18.3% | 193,001 | $13.4M |
| TD Asset Management Inc | 0.01% | Add +384.1% | 174,674 | $12.1M |
| Marshall Wace, LLP | 0.01% | New | 168,584 | $11.7M |
| Millennium Management | 0.01% | Reduce -88.0% | 152,560 | $10.6M |
| Rhenman & Partners Asset Management AB | 0.96% | Reduce -18.1% | 147,600 | $10.3M |
| Jane Street Group, LLC | 0.01% | New | 147,217 | $10.2M |
| Bellevue Group AG | 0.19% | Reduce -54.0% | 145,167 | $10.1M |
| Eversept Partners, LP | 0.50% | Reduce -23.3% | 127,561 | $8.9M |
| Woodline Partners LP | 0.03% | Add +89.3% | 123,902 | $8.6M |
| Renaissance Technologies | 0.01% | Reduce -25.1% | 115,200 | $8.0M |
| Alyeska Investment Group, L.P. | 0.02% | Reduce -53.0% | 115,000 | $8.0M |
| Jefferies Financial Group Inc. | 0.06% | Reduce -39.5% | 102,993 | $7.2M |
| RTW Investments, LP | 0.07% | New | 100,000 | $7.0M |
| Jain Global LLC | 0.07% | New | 99,996 | $7.0M |
| Susquehanna Fundamental Investments, LLC | 0.24% | No change | 99,617 | $6.9M |
| Two Sigma Investments, LP | 0.01% | Reduce -47.8% | 95,543 | $6.6M |
| SummitTX Capital, L.P. | 0.20% | New | 94,671 | $6.6M |
| NEXTBio Capital Management LP | 3.85% | — | 94,443 | $6.6M |
| Manufacturers Life Insurance Company, The | 0.01% | Add +237.8% | 96,387 | $6.5M |
| Simplex Trading, LLC | 0.18% | Add +268.3% | 92,668 | $6.4M |
| B Group, Inc. | 4.64% | New | 90,000 | $6.3M |
| Birchview Capital, LP | 3.66% | Add +15.4% | 90,000 | $6.3M |
| Soleus Capital Management, L.P. | 0.27% | New | 90,000 | $6.3M |
| Trexquant Investment LP | 0.06% | Add +345.4% | 89,945 | $6.3M |
| Platinum Investment Management Ltd. | 1.41% | Reduce -28.4% | 87,874 | $6.1M |
| Brevan Howard Capital Management LP | 0.12% | New | 86,310 | $6.0M |
| Peregrine Capital Management LLC | 0.18% | New | 84,324 | $5.9M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Add +428.5% | 83,052 | $5.8M |
| Nomura Asset Management International Inc. | 0.01% | — | 82,645 | $5.7M |
| Verition Fund Management LLC | 0.03% | Add +98.6% | 78,149 | $5.4M |
| Boxer Capital Management, LLC | 1.14% | New | 75,000 | $5.2M |
| PFM Health Sciences, LP | 0.49% | Reduce -40.7% | 68,248 | $4.7M |
| Susquehanna Portfolio Strategies, LLC | 0.07% | Add +21.7% | 68,089 | $4.7M |
| Longaeva Partners L.P. | 0.50% | New | 60,000 | $4.2M |
| Burkehill Global Management, LP | 0.29% | New | 60,000 | $4.2M |
| Banque Pictet & Cie SA | 0.04% | Reduce -6.7% | 59,881 | $4.2M |
| Osaic Holdings, Inc. | 0.01% | Reduce -5.7% | 59,238 | $4.1M |
| Voya Investment Management LLC | 0.00% | Add +236.7% | 55,300 | $3.8M |
| Geode Capital Management, LLC | 0.00% | Reduce -4.8% | 55,148 | $3.8M |
| Parkman Healthcare Partners LLC | 0.36% | New | 55,000 | $3.8M |
| Bank of Montreal | 0.00% | Reduce -10.5% | 54,341 | $3.7M |
| Buckland Partners Management Co LLC | 1.93% | — | 50,000 | $3.5M |
| Seven Grand Managers, LLC | 0.26% | New | 50,000 | $3.5M |
| Integral Health Asset Management, LLC | 0.18% | New | 50,000 | $3.5M |
| Alps Advisors Inc. | 0.02% | Add +77.9% | 49,726 | $3.5M |
| Pier Capital, LLC | 0.54% | Reduce -75.3% | 48,757 | $3.4M |
| Flax Pond Capital, LLC | 2.52% | — | 48,721 | $3.4M |
| State Street Corp. | 0.00% | Add +4.8% | 48,224 | $3.4M |
| ANTIPODES PARTNERS Ltd | 0.07% | Add +1035.1% | 46,291 | $3.2M |
| Raymond James Financial Inc. | 0.00% | New | 44,388 | $3.1M |
| Mariner, LLC | 0.00% | Add +0.0% | 44,155 | $3.1M |
| Headlands Technologies LLC | 0.25% | Add +63.1% | 43,729 | $3.0M |
| Sphera Funds Management LTD. | 0.60% | Reduce -76.4% | 41,000 | $2.9M |
| Act Capital Management, LLC | 2.17% | — | 38,500 | $2.7M |
| Informed Momentum Co LLC | 0.29% | New | 38,054 | $2.6M |
| DAFNA Capital Management LLC | 0.61% | Reduce -37.3% | 37,000 | $2.6M |
| Tudor Investment Corporation | 0.01% | New | 35,053 | $2.4M |
"% of holder's portfolio" is GPCR's weight in each manager's 13F, not the share of Structure Therapeutics Inc. the manager owns.