Structure TherapeuticsGPCR
13F holders, Q3 2025 (September 30)156holders −16
22new positions
37sold out
5famous investors
$27.94avg. 13F price*
At the end of Q3 2025, 156 institutions reported holding Structure Therapeutics Inc. (GPCR) in their 13F filings, down 16 from Q2 2025. 22 opened new positions and 37 sold out. The largest holders were Wellington Management Group LLP ($159.3M), FMR LLC ($147.0M) and Avoro Capital Advisors LLC ($144.4M). 5 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Steve Cohen (0.0% of Point72 Asset Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Structure Therapeutics Inc.
- CUSIP
- 86366E106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 22 | $222.9M |
| Exits | 37 | $89.3M |
All 13F filers, Q2 2025 → Q3 2025: 12,999,390 shares bought and 10,998,714 shares sold, net +2,000,676 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 156 holders
| Wellington Management Group LLP | 0.03% | Reduce -17.3% | 5,689,187 | $159.3M |
| FMR LLC | 0.01% | Add +6.8% | 5,250,368 | $147.0M |
| Avoro Capital Advisors LLC | 1.87% | New | 5,155,555 | $144.4M |
| Janus Henderson Group PLC | 0.06% | Reduce -2.7% | 4,448,826 | $124.6M |
| Deep Track Capital, LP | 3.29% | Reduce -17.9% | 4,215,811 | $118.0M |
| BVF Inc. | 3.64% | Add +80.9% | 3,203,917 | $89.7M |
| Baker Bros. Advisors LP | 0.32% | Reduce -38.0% | 1,556,109 | $43.6M |
| Casdin Capital, LLC | 3.63% | Add +26.9% | 1,555,000 | $43.5M |
| Ra Capital Management, L.P. | 0.52% | No change | 1,517,418 | $42.5M |
| Millennium Management | 0.03% | Add +4.5% | 1,274,551 | $35.7M |
| Ameriprise Financial Inc. | 0.01% | Reduce -22.9% | 1,224,144 | $34.3M |
| Orbimed Advisors LLC | 0.77% | Reduce -5.0% | 1,139,300 | $31.9M |
| TCG Crossover Management, LLC | 1.46% | No change | 1,063,000 | $29.8M |
| Siren, L.L.C. | 1.12% | New | 1,026,811 | $28.8M |
| Rock Springs Capital Management LP | 1.56% | Reduce -16.3% | 951,154 | $26.6M |
| Driehaus Capital Management LLC | 0.18% | Add +29.8% | 873,504 | $24.5M |
| Logos Global Management LP | 2.35% | No change | 850,000 | $23.8M |
| Principal Financial Group Inc. | 0.01% | Reduce -7.7% | 787,484 | $22.0M |
| Franklin Resources Inc. | 0.01% | Add +0.5% | 745,734 | $20.9M |
| Pacific Heights Asset Management LLC | 0.87% | Add +52.2% | 700,000 | $19.6M |
| Catalio Capital Management, LP | 3.37% | Reduce -2.8% | 651,810 | $18.3M |
| Aberdeen Group plc | 0.03% | Add +46.1% | 586,869 | $16.4M |
| Morgan Stanley | 0.00% | Reduce -37.0% | 577,741 | $16.2M |
| Goldman Sachs Group Inc. | 0.00% | Add +129.1% | 504,396 | $14.1M |
| American Century Companies Inc. | 0.01% | Reduce -0.9% | 486,786 | $13.6M |
| Balyasny Asset Management L.P. | 0.03% | New | 461,553 | $12.9M |
| Citadel Advisors | 0.01% | Reduce -66.6% | 443,800 | $12.4M |
| Invesco Ltd. | 0.00% | Add +4.5% | 443,737 | $12.4M |
| Point72 Asset Management | 0.03% | Add +23.6% | 407,700 | $11.4M |
| Deerfield Management Company, L.P. | 0.17% | No change | 373,407 | $10.5M |
| Paradigm Biocapital Advisors LP | 0.31% | New | 372,869 | $10.4M |
| Nantahala Capital Management, LLC | 0.64% | Add +118.7% | 368,553 | $10.3M |
| ArrowMark Colorado Holdings LLC | 0.17% | Add +8.1% | 323,166 | $9.0M |
| Bellevue Group AG | 0.18% | Reduce -9.4% | 315,857 | $8.8M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -18.0% | 289,393 | $8.1M |
| BlackRock, Inc. | 0.00% | Add +8.5% | 263,938 | $7.4M |
| Two Sigma Advisers, LP | 0.01% | Add +590.6% | 249,299 | $7.0M |
| Alyeska Investment Group, L.P. | 0.02% | New | 244,848 | $6.9M |
| Readystate Asset Management LP | 0.65% | Add +32.8% | 237,188 | $6.6M |
| HighVista Strategies LLC | 1.62% | Add +172.7% | 236,236 | $6.6M |
| Sectoral Asset Management Inc. | 3.83% | Add +331.9% | 221,872 | $6.2M |
| Susquehanna International Group, LLP | 0.01% | Add +181.8% | 213,608 | $6.0M |
| UBS Group AG | 0.00% | Add +36.0% | 208,092 | $5.8M |
| Monashee Investment Management LLC | 2.89% | Reduce -53.5% | 200,000 | $5.6M |
| Pier Capital, LLC | 0.86% | Reduce -0.5% | 197,509 | $5.5M |
| First Light Asset Management, LLC | 0.52% | Add +61.5% | 197,350 | $5.5M |
| Two Sigma Investments, LP | 0.01% | New | 182,911 | $5.1M |
| Rhenman & Partners Asset Management AB | 0.56% | Add +33.3% | 180,100 | $5.0M |
| Sphera Funds Management LTD. | 1.16% | Add +81.3% | 173,931 | $4.9M |
| Jefferies Financial Group Inc. | 0.05% | New | 170,345 | $4.8M |
| Handelsbanken Fonder AB | 0.01% | Reduce -55.8% | 168,000 | $4.7M |
| Eversept Partners, LP | 0.36% | Add +67.5% | 166,391 | $4.7M |
| HSG Holding Ltd | 0.24% | No change | 266,062 | $4.6M |
| Ikarian Capital, LLC | 0.92% | Reduce -10.8% | 163,237 | $4.6M |
| Renaissance Technologies | 0.01% | Add +37.5% | 153,900 | $4.3M |
| National Bank of Canada | 0.00% | Add +71900.0% | 144,000 | $4.0M |
| Stempoint Capital LP | 0.73% | New | 129,335 | $3.6M |
| Platinum Investment Management Ltd. | 0.22% | Add +63.9% | 122,758 | $3.4M |
| Point72 Europe (London) LLP | 0.18% | No change | 116,697 | $3.3M |
| PFM Health Sciences, LP | 0.28% | Add +103.3% | 115,073 | $3.2M |
| Octagon Capital Advisors LP | 0.50% | New | 115,000 | $3.2M |
| Jump Financial, LLC | 0.04% | Add +68.3% | 106,400 | $3.0M |
| Susquehanna Fundamental Investments, LLC | 0.11% | Reduce -28.7% | 99,617 | $2.8M |
| BNP Paribas Financial Markets | 0.00% | Add +37.4% | 90,431 | $2.5M |
| Birchview Capital, LP | 1.65% | Add +116.7% | 78,000 | $2.2M |
| Woodline Partners LP | 0.01% | Reduce -62.9% | 65,440 | $1.8M |
| Banque Pictet & Cie SA | 0.02% | Reduce -8.8% | 64,185 | $1.8M |
| Bank of Montreal | 0.00% | Add +4.6% | 60,722 | $1.7M |
| DAFNA Capital Management LLC | 0.41% | No change | 59,000 | $1.7M |
| Exchange Traded Concepts, LLC | 0.02% | Reduce -5.7% | 58,222 | $1.6M |
| JPMorgan Chase & Co. | 0.00% | Add +37.0% | 58,148 | $1.6M |
| Macquarie Group Ltd. | 0.00% | No change | 58,000 | $1.6M |
| Geode Capital Management, LLC | 0.00% | Add +7.0% | 57,958 | $1.6M |
| Caption Management, LLC | 0.10% | Add +101.2% | 56,682 | $1.6M |
| Susquehanna Portfolio Strategies, LLC | 0.02% | Add +40.0% | 55,942 | $1.6M |
| Private Capital Advisors, Inc. | 0.17% | New | 55,185 | $1.5M |
| State Street Corp. | 0.00% | Add +37.5% | 46,017 | $1.3M |
| Mariner, LLC | 0.00% | Add +11.7% | 44,136 | $1.2M |
| Osaic Holdings, Inc. | 0.00% | Reduce -0.8% | 62,839 | $1.2M |
| Boothbay Fund Management, LLC | 0.03% | Reduce -24.2% | 43,674 | $1.2M |
| Quinn Opportunity Partners LLC | 0.09% | No change | 42,000 | $1.2M |
| SG Americas Securities, LLC | 0.00% | Add +106.3% | 39,700 | $1.1M |
| Verition Fund Management LLC | 0.01% | Reduce -46.1% | 39,349 | $1.1M |
| D. E. Shaw & Co. | 0.00% | Add +198.8% | 36,346 | $1.0M |
| TD Asset Management Inc | 0.00% | Reduce -17.4% | 36,086 | $1.0M |
| TrueMark Investments, LLC | 0.17% | Reduce -7.7% | 34,861 | $976K |
| Alliancebernstein L.P. | 0.00% | Add +31.4% | 29,559 | $828K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -30.1% | 28,532 | $799K |
| Alps Advisors Inc. | 0.00% | Reduce -10.0% | 27,958 | $783K |
| Headlands Technologies LLC | 0.06% | Add +20.0% | 26,814 | $751K |
| Nomura Asset Management Co. Ltd. | 0.00% | Add +4.0% | 25,856 | $724K |
| Simplex Trading, LLC | 0.02% | Add +8.9% | 25,161 | $704K |
| LPL Financial LLC | 0.00% | Add +98.3% | 23,003 | $644K |
| Trexquant Investment LP | 0.01% | Reduce -75.3% | 20,192 | $565K |
| Bleichroeder LP | 0.11% | Add +100.0% | 20,000 | $560K |
| Voya Investment Management LLC | 0.00% | Reduce -46.4% | 16,425 | $460K |
| Cubist Systematic Strategies, LLC | 0.01% | Reduce -77.3% | 16,312 | $457K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +31.9% | 15,714 | $440K |
| ADAR1 Capital Management, LLC | 0.04% | Add +1.3% | 15,200 | $426K |
| Bank of America Corp. | 0.00% | Reduce -0.9% | 13,779 | $386K |
"% of holder's portfolio" is GPCR's weight in each manager's 13F, not the share of Structure Therapeutics Inc. the manager owns.