Karyopharm TherapeuticsKPTI
13F holders, Q3 2024 (September 30)91holders −23
9new positions
31sold out
5famous investors
$0.83avg. 13F price*
At the end of Q3 2024, 91 institutions reported holding Karyopharm Therapeutics Inc. (KPTI) in their 13F filings, down 23 from Q2 2024. 9 opened new positions and 31 sold out. The largest holders were Vanguard Group Inc. ($6.4M), Eversept Partners, LP ($4.6M) and Palo Alto Investors LP ($4.2M). 5 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Karyopharm Therapeutics Inc.
- CUSIP
- 48576U106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2024 → Q3 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 9 | $191K |
| Exits | 31 | $3.3M |
All 13F filers, Q2 2024 → Q3 2024: 3,096,443 shares bought and 10,710,700 shares sold, net −7,614,257 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 91 holders
| Vanguard Group Inc. | 0.00% | No change | 7,654,482 | $6.4M |
| Eversept Partners, LP | 0.35% | Add +11.2% | 5,547,880 | $4.6M |
| Palo Alto Investors LP | 0.55% | No change | 5,102,193 | $4.2M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | No change | 4,319,842 | $3.6M |
| BlackRock, Inc. | 0.00% | — | 3,638,378 | $3.0M |
| Citadel Advisors | 0.00% | Add +0.1% | 3,103,669 | $2.6M |
| Marshall Wace, LLP | 0.00% | Reduce -19.3% | 2,082,226 | $1.7M |
| Avidity Partners Management LP | 0.09% | No change | 2,018,500 | $1.7M |
| BNP Paribas Financial Markets | 0.00% | Reduce -12.8% | 1,982,354 | $1.6M |
| Gsa Capital Partners LLP | 0.11% | Add +80.6% | 1,775,700 | $1.5M |
| C WorldWide Group Holding A/S | 0.01% | No change | 1,500,000 | $1.2M |
| JPMorgan Chase & Co. | 0.00% | Add +8.6% | 1,385,724 | $1.2M |
| Geode Capital Management, LLC | 0.00% | Add +3.3% | 1,355,392 | $1.1M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -41.6% | 1,336,715 | $1.1M |
| Deutsche Bank AG | 0.00% | No change | 1,268,777 | $1.1M |
| Millennium Management | 0.00% | Reduce -40.0% | 1,255,264 | $1.0M |
| Renaissance Technologies | 0.00% | Add +64.2% | 1,241,407 | $1.0M |
| Kennedy Capital Management LLC | 0.02% | Add +0.6% | 1,204,009 | $999K |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0.03% | Add +8.5% | 1,196,174 | $993K |
| AlphaCentric Advisors LLC | 0.69% | No change | 1,125,000 | $934K |
| D. E. Shaw & Co. | 0.00% | Add +24.1% | 1,047,396 | $869K |
| Altium Capital Management LLC | 0.18% | No change | 740,000 | $614K |
| Silverarc Capital Management, LLC | 0.10% | No change | 558,466 | $464K |
| Macquarie Group Ltd. | 0.00% | Reduce -1.1% | 500,000 | $415K |
| Cubist Systematic Strategies, LLC | 0.01% | Reduce -12.8% | 496,236 | $412K |
| Birchview Capital, LP | 0.34% | No change | 469,832 | $390K |
| State Street Corp. | 0.00% | Reduce -9.8% | 409,510 | $340K |
| Ikarian Capital, LLC | 0.11% | No change | 409,355 | $340K |
| FMR LLC | 0.00% | Add +26.1% | 369,723 | $307K |
| Acadian Asset Management LLC | 0.00% | Add +89.8% | 368,511 | $304K |
| Susquehanna International Group, LLP | 0.00% | Reduce -31.8% | 302,548 | $251K |
| Atom Investors LP | 0.02% | Reduce -0.8% | 259,824 | $216K |
| Bridgeway Capital Management, LLC | 0.00% | Reduce -9.4% | 239,500 | $199K |
| Northern Trust Corp. | 0.00% | Reduce -73.6% | 229,668 | $191K |
| Bank of America Corp. | 0.00% | Reduce -23.4% | 228,941 | $190K |
| Exchange Traded Concepts, LLC | 0.00% | Add +34.9% | 218,791 | $182K |
| Jane Street Group, LLC | 0.00% | Reduce -86.8% | 204,750 | $170K |
| DAFNA Capital Management LLC | 0.04% | No change | 192,678 | $160K |
| Bank of New York Mellon Corp | 0.00% | Add +0.0% | 166,316 | $138K |
| T. Rowe Price Associates Inc. | 0.00% | Add +38.7% | 134,700 | $112K |
| UBS Group AG | 0.00% | Reduce -4.4% | 134,478 | $112K |
| Woodline Partners LP | 0.00% | No change | 134,112 | $111K |
| Morgan Stanley | 0.00% | Reduce -38.2% | 123,647 | $103K |
| Citigroup Inc. | 0.00% | Reduce -34.8% | 105,693 | $88K |
| Barclays PLC | 0.00% | Reduce -89.0% | 95,767 | $79K |
| Boothbay Fund Management, LLC | 0.00% | No change | 91,091 | $76K |
| Two Sigma Investments, LP | 0.00% | Add +519.7% | 85,930 | $71K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.01% | Reduce -50.1% | 82,446 | $68K |
| Prudential Financial Inc. | 0.00% | New | 74,600 | $62K |
| Qube Research & Technologies Ltd | 0.00% | Reduce -41.7% | 62,026 | $51K |
| Invesco Ltd. | 0.00% | Add +43.5% | 58,152 | $48K |
| Cerity Partners LLC | 0.00% | New | 51,533 | $43K |
| Charles Schwab Investment Management Inc. | 0.00% | No change | 51,000 | $42K |
| Engineers Gate Manager LP | 0.00% | Add +67.7% | 48,133 | $40K |
| Baird Financial Group, Inc. | 0.00% | Add +2.7% | 37,800 | $31K |
| HSBC Holdings PLC | 0.00% | Reduce -24.1% | 40,301 | $31K |
| Freedom Investment Management, Inc. | 0.00% | Reduce -2.9% | 37,201 | $31K |
| Kennedy Investment Group, Inc. | 0.01% | No change | 35,000 | $29K |
| Two Sigma Advisers, LP | 0.00% | New | 31,200 | $26K |
| Monashee Investment Management LLC | 0.00% | New | 132,435 | $26K |
| Catalyst Funds Management Pty Ltd | 0.01% | No change | 28,600 | $24K |
| XTX Topco Ltd | 0.00% | Reduce -81.6% | 25,905 | $22K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -11.9% | 22,206 | $18K |
| Corient Private Wealth LP | 0.00% | Add +55.0% | 21,084 | $18K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | New | 17,188 | $14K |
| ELCO Management Co., LLC | 0.01% | Reduce -17.7% | 16,177 | $13K |
| Winthrop Advisory Group LLC | 0.00% | No change | 15,000 | $12K |
| Victory Capital Management Inc. | 0.00% | Add +3.6% | 14,496 | $12K |
| AQR Capital Management | 0.00% | Reduce -98.4% | 12,221 | $10K |
| Wolverine Trading, LLC | 0.00% | New | 13,735 | $10K |
| Snowden Capital Advisors LLC | 0.00% | No change | 11,000 | $9K |
| BLB&B Advisors, LLC | 0.00% | Reduce -9.0% | 10,150 | $8K |
| Avidian Wealth Enterprises, LLC | 0.00% | New | 10,100 | $8K |
| Janney Montgomery Scott LLC | 0.00% | No change | 10,000 | $8K |
| Royal Bank of Canada | 0.00% | Reduce -85.9% | 7,950 | $6K |
| Osaic Holdings, Inc. | 0.00% | Reduce -39.1% | 4,390 | $4K |
| Quent Capital, LLC | 0.00% | No change | 3,489 | $3K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 3,000 | $2K |
| Founders Capital Management | 0.00% | No change | 2,000 | $2K |
| Ascentis Independent Advisors | 0.00% | New | 1,800 | $1K |
| Mb, Levis & Associates, LLC | 0.00% | No change | 1,500 | $1K |
| Harbour Investments, Inc. | 0.00% | No change | 1,300 | $1K |
| Lazard Asset Management LLC | 0.00% | New | 1,570 | $1K |
| Activest Wealth Management | 0.00% | No change | 1,000 | $830 |
| Wells Fargo & Company | 0.00% | Add +4657.1% | 666 | $553 |
| Arax Advisory Partners | 0.00% | No change | 538 | $447 |
| Allworth Financial LP | 0.00% | No change | 500 | $415 |
| Bruce G. Allen Investments, LLC | 0.00% | Reduce -33.3% | 338 | $281 |
| AdvisorNet Financial, Inc | 0.00% | No change | 200 | $166 |
| CIBC Private Wealth Group LLC | 0.00% | No change | 50 | $42 |
| West Branch Capital LLC | 0.00% | No change | 48 | $40 |
"% of holder's portfolio" is KPTI's weight in each manager's 13F, not the share of Karyopharm Therapeutics Inc. the manager owns.