Karyopharm TherapeuticsKPTI
13F holders, Q4 2024 (December 31)87holders −4
10new positions
18sold out
4famous investors
$0.68avg. 13F price*
At the end of Q4 2024, 87 institutions reported holding Karyopharm Therapeutics Inc. (KPTI) in their 13F filings, down 4 from Q3 2024. 10 opened new positions and 18 sold out. The largest holders were Vanguard Group Inc. ($5.2M), Adage Capital Partners Gp, L.L.C. ($4.3M) and Palo Alto Investors LP ($3.3M). 4 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Karyopharm Therapeutics Inc.
- CUSIP
- 48576U106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2024 → Q4 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 10 | $339K |
| Exits | 18 | $1.4M |
All 13F filers, Q3 2024 → Q4 2024: 7,858,284 shares bought and 8,722,775 shares sold, net −864,491 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 87 holders
| Vanguard Group Inc. | 0.00% | No change | 7,654,482 | $5.2M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | Add +46.3% | 6,319,842 | $4.3M |
| Palo Alto Investors LP | 0.51% | Reduce -3.8% | 4,907,001 | $3.3M |
| BlackRock, Inc. | 0.00% | Add +3.6% | 3,768,875 | $2.5M |
| Morgan Stanley | 0.00% | Add +2741.3% | 3,513,188 | $2.4M |
| Citadel Advisors | 0.00% | No change | 3,103,669 | $2.1M |
| Marshall Wace, LLP | 0.00% | Add +15.3% | 2,401,413 | $1.6M |
| Catalio Capital Management, LP | 0.35% | — | 2,334,375 | $1.6M |
| Eversept Partners, LP | 0.15% | Reduce -62.4% | 2,088,757 | $1.4M |
| Avidity Partners Management LP | 0.14% | No change | 2,018,500 | $1.4M |
| Gsa Capital Partners LLP | 0.08% | Reduce -10.0% | 1,598,435 | $1.1M |
| C WorldWide Group Holding A/S | 0.01% | No change | 1,500,000 | $1.0M |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0.03% | Add +24.0% | 1,483,727 | $1.0M |
| Geode Capital Management, LLC | 0.00% | Add +2.7% | 1,392,314 | $942K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -0.1% | 1,335,771 | $903K |
| BNP Paribas Financial Markets | 0.00% | Reduce -33.7% | 1,313,893 | $889K |
| Deutsche Bank AG | 0.00% | No change | 1,268,777 | $863K |
| Renaissance Technologies | 0.00% | Reduce -3.1% | 1,202,590 | $813K |
| Kennedy Capital Management LLC | 0.02% | Reduce -0.7% | 1,195,293 | $808K |
| Millennium Management | 0.00% | Reduce -8.0% | 1,154,414 | $781K |
| Jane Street Group, LLC | 0.00% | Add +265.5% | 748,306 | $506K |
| Altium Capital Management LLC | 0.16% | No change | 740,000 | $500K |
| Susquehanna International Group, LLP | 0.00% | Add +119.5% | 664,145 | $449K |
| Silverarc Capital Management, LLC | 0.09% | Add +6.7% | 595,990 | $403K |
| Macquarie Group Ltd. | 0.00% | No change | 500,000 | $338K |
| State Street Corp. | 0.00% | Add +8.1% | 442,510 | $299K |
| Birchview Capital, LP | 0.23% | Reduce -10.6% | 419,832 | $284K |
| FMR LLC | 0.00% | Add +11.6% | 412,456 | $279K |
| Ikarian Capital, LLC | 0.08% | Reduce -0.1% | 408,899 | $277K |
| Acadian Asset Management LLC | 0.00% | Reduce -7.0% | 342,847 | $230K |
| Cubist Systematic Strategies, LLC | 0.00% | Reduce -33.7% | 328,807 | $222K |
| Northern Trust Corp. | 0.00% | Add +23.5% | 283,729 | $192K |
| JPMorgan Chase & Co. | 0.00% | Reduce -80.1% | 276,208 | $187K |
| Atom Investors LP | 0.02% | No change | 259,824 | $176K |
| Bridgeway Capital Management, LLC | 0.00% | No change | 239,500 | $162K |
| D. E. Shaw & Co. | 0.00% | Reduce -78.1% | 229,685 | $155K |
| Exchange Traded Concepts, LLC | 0.00% | No change | 218,791 | $148K |
| Shay Capital LLC | 0.03% | New | 172,153 | $116K |
| Bank of New York Mellon Corp | 0.00% | Add +0.0% | 166,317 | $112K |
| Bank of America Corp. | 0.00% | Reduce -29.4% | 161,708 | $109K |
| UBS Group AG | 0.00% | Add +8.4% | 145,791 | $99K |
| Two Sigma Investments, LP | 0.00% | Add +60.4% | 137,786 | $93K |
| Woodline Partners LP | 0.00% | No change | 134,112 | $91K |
| Opti Capital Management, LP | 33.89% | New | 125,000 | $85K |
| Citigroup Inc. | 0.00% | Reduce -0.0% | 105,679 | $71K |
| Barclays PLC | 0.00% | Reduce -0.2% | 95,611 | $65K |
| Boothbay Fund Management, LLC | 0.00% | Reduce -0.5% | 90,635 | $61K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.02% | Add +2.7% | 84,698 | $57K |
| Two Sigma Advisers, LP | 0.00% | Add +145.5% | 76,600 | $52K |
| Prudential Financial Inc. | 0.00% | No change | 74,600 | $50K |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -52.3% | 64,300 | $44K |
| Charles Schwab Investment Management Inc. | 0.00% | Add +0.3% | 51,173 | $35K |
| TD Waterhouse Canada Inc. | 0.00% | New | 48,049 | $32K |
| Focus Partners Wealth | 0.00% | New | 45,818 | $31K |
| Baird Financial Group, Inc. | 0.00% | Add +18.5% | 44,800 | $30K |
| Velan Capital Investment Management LP | 0.02% | New | 40,000 | $27K |
| HSBC Holdings PLC | 0.00% | No change | 40,301 | $27K |
| Freedom Investment Management, Inc. | 0.00% | Add +4.0% | 38,684 | $26K |
| Kennedy Investment Group, Inc. | 0.01% | No change | 35,000 | $24K |
| R Squared Ltd | 0.02% | — | 29,670 | $20K |
| Engineers Gate Manager LP | 0.00% | Reduce -40.4% | 28,699 | $19K |
| Commonwealth Equity Services, LLC | 0.00% | Add +0.4% | 22,288 | $15K |
| Squarepoint Ops LLC | 0.00% | New | 20,786 | $14K |
| Corient Private Wealth LP | 0.00% | Reduce -2.8% | 20,500 | $14K |
| ADAR1 Capital Management, LLC | 0.00% | New | 20,000 | $14K |
| ELCO Management Co., LLC | 0.01% | No change | 16,177 | $11K |
| Winthrop Advisory Group LLC | 0.00% | No change | 15,000 | $10K |
| Caprock Group, LLC | 0.00% | New | 11,600 | $8K |
| Snowden Capital Advisors LLC | 0.00% | No change | 11,000 | $7K |
| Wolverine Trading, LLC | 0.00% | Reduce -25.2% | 10,273 | $7K |
| Walleye Capital LLC | 0.00% | New | 10,451 | $7K |
| Janney Montgomery Scott LLC | 0.00% | No change | 10,000 | $7K |
| BLB&B Advisors, LLC | 0.00% | No change | 10,150 | $7K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 7,696 | $5K |
| Royal Bank of Canada | 0.00% | Reduce -18.2% | 6,500 | $4K |
| Osaic Holdings, Inc. | 0.00% | Add +22.8% | 5,390 | $4K |
| Quent Capital, LLC | 0.00% | No change | 3,489 | $2K |
| VSM Wealth Advisory, LLC | 0.00% | — | 2,000 | $1K |
| Mb, Levis & Associates, LLC | 0.00% | No change | 1,500 | $1K |
| Harbour Investments, Inc. | 0.00% | No change | 1,300 | $879 |
| Activest Wealth Management | 0.00% | No change | 1,000 | $676 |
| SBI Securities Co., Ltd. | 0.00% | — | 717 | $485 |
| Wells Fargo & Company | 0.00% | No change | 666 | $450 |
| Allworth Financial LP | 0.00% | No change | 500 | $334 |
| Bruce G. Allen Investments, LLC | 0.00% | No change | 338 | $229 |
| CIBC Private Wealth Group LLC | 0.00% | No change | 50 | $36 |
| West Branch Capital LLC | 0.00% | No change | 48 | $33 |
"% of holder's portfolio" is KPTI's weight in each manager's 13F, not the share of Karyopharm Therapeutics Inc. the manager owns.