Karyopharm TherapeuticsKPTI
13F holders, Q2 2025 (June 30)At the end of Q2 2025, 49 institutions reported holding Karyopharm Therapeutics Inc. (KPTI) in their 13F filings, up 2 from Q1 2025. 12 opened new positions and 9 sold out. The largest holders were T. Rowe Price Investment Management, Inc. ($3.1M), Vanguard Group Inc. ($2.2M) and Adage Capital Partners Gp, L.L.C. ($1.8M). 3 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Karyopharm Therapeutics Inc.
- CUSIP
- 48576U205
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 12 | $1.9M |
| Exits | 9 | $309K |
All 13F filers, Q1 2025 → Q2 2025: 1,291,877 shares bought and 129,884 shares sold, net +1,161,993 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 49 holders
| T. Rowe Price Investment Management, Inc. | 0.00% | Add +421.9% | 728,766 | $3.1M |
| Vanguard Group Inc. | 0.00% | Add +1.6% | 518,269 | $2.2M |
| Adage Capital Partners Gp, L.L.C. | 0.00% | No change | 421,322 | $1.8M |
| Eversept Partners, LP | 0.11% | No change | 257,154 | $1.1M |
| JPMorgan Chase & Co. | 0.00% | Add +50.1% | 256,443 | $1.1M |
| BlackRock, Inc. | 0.00% | Reduce -2.5% | 236,641 | $1.0M |
| Citadel Advisors | 0.00% | Reduce -0.1% | 206,781 | $891K |
| Palo Alto Investors LP | 0.17% | New | 187,911 | $810K |
| Bank of America Corp. | 0.00% | Add +26.8% | 168,534 | $726K |
| UBS Group AG | 0.00% | Add +73.0% | 161,900 | $698K |
| Catalio Capital Management, LP | 0.13% | Reduce -6.2% | 146,013 | $629K |
| Avidity Partners Management LP | 0.12% | No change | 134,566 | $580K |
| Marshall Wace, LLP | 0.00% | No change | 128,451 | $554K |
| Goldman Sachs Group Inc. | 0.00% | Add +28.1% | 109,404 | $472K |
| C WorldWide Group Holding A/S | 0.01% | No change | 100,000 | $431K |
| Group One Trading LLC | 0.01% | New | 97,900 | $422K |
| Geode Capital Management, LLC | 0.00% | Reduce -7.8% | 91,841 | $396K |
| Silverback Asset Management LLC | 1.20% | New | 70,000 | $302K |
| Renaissance Technologies | 0.00% | Add +7.5% | 65,814 | $284K |
| Bridgeway Capital Management, LLC | 0.00% | New | 37,836 | $163K |
| State Street Corp. | 0.00% | Add +12.9% | 33,295 | $144K |
| Millennium Management | 0.00% | Reduce -42.5% | 31,847 | $137K |
| BNP Paribas Financial Markets | 0.00% | Add +2.3% | 29,637 | $128K |
| Ikarian Capital, LLC | 0.04% | No change | 27,257 | $117K |
| Morgan Stanley | 0.00% | Add +140.7% | 25,091 | $108K |
| Northern Trust Corp. | 0.00% | No change | 18,910 | $82K |
| Gsa Capital Partners LLP | 0.00% | New | 13,894 | $60K |
| XTX Topco Ltd | 0.00% | New | 13,056 | $56K |
| Bank of New York Mellon Corp | 0.00% | No change | 11,086 | $48K |
| T. Rowe Price Associates Inc. | 0.00% | New | 10,886 | $47K |
| Baird Financial Group, Inc. | 0.00% | New | 10,532 | $45K |
| Simplex Trading, LLC | 0.00% | New | 8,233 | $35K |
| Royal Bank of Canada | 0.00% | Add +409.2% | 7,429 | $32K |
| Citigroup Inc. | 0.00% | Reduce -0.1% | 7,040 | $30K |
| Barclays PLC | 0.00% | No change | 5,333 | $23K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 3,203 | $14K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 850 | $4K |
| FMR LLC | 0.00% | Add +45.2% | 765 | $3K |
| Osaic Holdings, Inc. | 0.00% | No change | 346 | $1K |
| Mb, Levis & Associates, LLC | 0.00% | No change | 100 | $431 |
| Raymond James Financial Inc. | 0.00% | New | 90 | $388 |
| Harbour Investments, Inc. | 0.00% | No change | 85 | $366 |
| Fortitude Family Office, LLC | 0.00% | New | 81 | $349 |
| SBI Securities Co., Ltd. | 0.00% | No change | 74 | $319 |
| Activest Wealth Management | 0.00% | No change | 66 | $284 |
| Allworth Financial LP | 0.00% | No change | 32 | $138 |
| Bruce G. Allen Investments, LLC | 0.00% | No change | 22 | $95 |
| CIBC Private Wealth Group LLC | 0.00% | No change | 3 | $13 |
| West Branch Capital LLC | 0.00% | No change | 3 | $13 |
"% of holder's portfolio" is KPTI's weight in each manager's 13F, not the share of Karyopharm Therapeutics Inc. the manager owns.