Karyopharm TherapeuticsKPTI
13F holders, Q3 2025 (September 30)At the end of Q3 2025, 51 institutions reported holding Karyopharm Therapeutics Inc. (KPTI) in their 13F filings, up 2 from Q2 2025. 7 opened new positions and 5 sold out. The largest holders were T. Rowe Price Investment Management, Inc. ($4.6M), Adage Capital Partners Gp, L.L.C. ($2.8M) and Vanguard Group Inc. ($2.7M). One famous investor held it Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Karyopharm Therapeutics Inc.
- CUSIP
- 48576U205
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 7 | $492K |
| Exits | 5 | $2.9M |
All 13F filers, Q2 2025 → Q3 2025: 107,616 shares bought and 1,544,415 shares sold, net −1,436,799 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 51 holders
| T. Rowe Price Investment Management, Inc. | 0.00% | Reduce -3.8% | 700,992 | $4.6M |
| Adage Capital Partners Gp, L.L.C. | 0.00% | No change | 421,322 | $2.8M |
| Vanguard Group Inc. | 0.00% | Reduce -21.2% | 408,222 | $2.7M |
| BlackRock, Inc. | 0.00% | Reduce -2.0% | 231,951 | $1.5M |
| Catalio Capital Management, LP | 0.17% | Reduce -2.1% | 142,984 | $935K |
| Avidity Partners Management LP | 0.20% | No change | 134,566 | $880K |
| Marshall Wace, LLP | 0.00% | No change | 128,451 | $840K |
| C WorldWide Group Holding A/S | 0.01% | No change | 100,000 | $654K |
| Geode Capital Management, LLC | 0.00% | Add +1.6% | 93,289 | $610K |
| Group One Trading LLC | 0.01% | Reduce -30.1% | 68,436 | $448K |
| Renaissance Technologies | 0.00% | Reduce -1.7% | 64,714 | $423K |
| UBS Group AG | 0.00% | Reduce -63.1% | 59,685 | $390K |
| State Street Corp. | 0.00% | Add +39.2% | 46,342 | $303K |
| Silverback Asset Management LLC | 0.74% | Reduce -42.9% | 40,000 | $262K |
| Susquehanna International Group, LLP | 0.00% | New | 35,339 | $231K |
| Bridgeway Capital Management, LLC | 0.00% | Reduce -7.8% | 34,873 | $228K |
| Ikarian Capital, LLC | 0.04% | No change | 27,257 | $178K |
| Baird Financial Group, Inc. | 0.00% | Add +146.2% | 25,932 | $170K |
| Morgan Stanley | 0.00% | Add +2.7% | 25,766 | $169K |
| ADAR1 Capital Management, LLC | 0.02% | New | 25,000 | $164K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -77.3% | 24,885 | $163K |
| Northern Trust Corp. | 0.00% | Reduce -0.2% | 18,876 | $123K |
| Belvedere Trading LLC | 0.01% | New | 14,563 | $95K |
| XTX Topco Ltd | 0.00% | Add +10.3% | 14,402 | $94K |
| Gsa Capital Partners LLP | 0.01% | Add +1.3% | 14,076 | $92K |
| Bank of New York Mellon Corp | 0.00% | No change | 11,086 | $73K |
| T. Rowe Price Associates Inc. | 0.00% | No change | 10,886 | $72K |
| Royal Bank of Canada | 0.00% | Reduce -9.4% | 6,734 | $44K |
| Simplex Trading, LLC | 0.00% | Reduce -28.8% | 5,862 | $38K |
| Barclays PLC | 0.00% | Reduce -22.9% | 4,109 | $27K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 3,203 | $20K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +28.1% | 1,089 | $7K |
| FMR LLC | 0.00% | Reduce -11.2% | 679 | $4K |
| JPMorgan Chase & Co. | 0.00% | Reduce -99.8% | 550 | $4K |
| Citigroup Inc. | 0.00% | Reduce -92.7% | 513 | $3K |
| Osaic Holdings, Inc. | 0.00% | No change | 346 | $2K |
| Quent Capital, LLC | 0.00% | New | 231 | $2K |
| Rise Advisors, LLC | 0.00% | New | 131 | $857 |
| Mb, Levis & Associates, LLC | 0.00% | No change | 100 | $654 |
| Bank of America Corp. | 0.00% | Reduce -99.9% | 94 | $615 |
| Harbour Investments, Inc. | 0.00% | No change | 85 | $556 |
| BNP Paribas Financial Markets | 0.00% | Reduce -99.7% | 82 | $536 |
| Fortitude Family Office, LLC | 0.00% | No change | 81 | $530 |
| SBI Securities Co., Ltd. | 0.00% | No change | 74 | $484 |
| Activest Wealth Management | 0.00% | No change | 66 | $432 |
| Allworth Financial LP | 0.00% | Reduce -18.8% | 26 | $171 |
| Bruce G. Allen Investments, LLC | 0.00% | No change | 22 | $144 |
| Advisory Services Network, LLC | 0.00% | New | 12 | $78 |
| Pittenger & Anderson Inc. | 0.00% | New | 3 | $20 |
| CIBC Private Wealth Group LLC | 0.00% | No change | 3 | $20 |
| West Branch Capital LLC | 0.00% | No change | 3 | $20 |
"% of holder's portfolio" is KPTI's weight in each manager's 13F, not the share of Karyopharm Therapeutics Inc. the manager owns.