Karyopharm TherapeuticsKPTI
13F holders, Q4 2025 (December 31)68holders +17
26new positions
9sold out
3famous investors
$7.36avg. 13F price*
At the end of Q4 2025, 68 institutions reported holding Karyopharm Therapeutics Inc. (KPTI) in their 13F filings, up 17 from Q3 2025. 26 opened new positions and 9 sold out. The largest holders were T. Rowe Price Investment Management, Inc. ($11.0M), Opaleye Management Inc. ($6.8M) and Affinity Asset Advisors, LLC ($6.5M). 3 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Karyopharm Therapeutics Inc.
- CUSIP
- 48576U205
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 26 | $34.1M |
| Exits | 9 | $359K |
All 13F filers, Q3 2025 → Q4 2025: 6,587,807 shares bought and 79,644 shares sold, net +6,508,163 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 68 holders
| T. Rowe Price Investment Management, Inc. | 0.01% | Add +112.8% | 1,491,409 | $11.0M |
| Opaleye Management Inc. | 0.90% | New | 930,000 | $6.8M |
| Affinity Asset Advisors, LLC | 0.49% | New | 889,575 | $6.5M |
| Vanguard Group Inc. | 0.00% | Add +37.1% | 559,619 | $4.1M |
| Ikarian Capital, LLC | 0.52% | Add +1897.8% | 544,554 | $4.0M |
| Soleus Capital Management, L.P. | 0.14% | New | 440,000 | $3.2M |
| Adage Capital Partners Gp, L.L.C. | 0.00% | No change | 421,322 | $3.1M |
| Davidson Kempner Capital Management LP | 0.05% | New | 310,020 | $2.3M |
| Braidwell LP | 0.09% | New | 303,370 | $2.2M |
| Exome Asset Management LLC | 1.07% | New | 295,541 | $2.2M |
| Ameriprise Financial Inc. | 0.00% | New | 276,881 | $2.0M |
| Boxer Capital Management, LLC | 0.41% | New | 252,536 | $1.9M |
| BlackRock, Inc. | 0.00% | Add +6.7% | 247,558 | $1.8M |
| Geode Capital Management, LLC | 0.00% | Add +101.2% | 187,734 | $1.4M |
| Two Sigma Investments, LP | 0.00% | New | 148,793 | $1.1M |
| Susquehanna International Group, LLP | 0.00% | Add +317.9% | 147,698 | $1.1M |
| Boothbay Fund Management, LLC | 0.03% | New | 144,628 | $1.1M |
| Catalio Capital Management, LP | 0.19% | No change | 142,984 | $1.1M |
| Avidity Partners Management LP | 0.29% | No change | 134,566 | $990K |
| Marshall Wace, LLP | 0.00% | No change | 128,451 | $945K |
| Group One Trading LLC | 0.02% | Add +49.7% | 102,419 | $754K |
| C WorldWide Group Holding A/S | 0.01% | No change | 100,000 | $736K |
| Walleye Capital LLC | 0.00% | New | 95,672 | $704K |
| Two Sigma Advisers, LP | 0.00% | New | 89,729 | $660K |
| UBS Group AG | 0.00% | Add +48.2% | 88,455 | $651K |
| Bridgeway Capital Management, LLC | 0.01% | Add +88.9% | 65,873 | $485K |
| Context Capital Management, LLC | 0.15% | New | 62,995 | $464K |
| Renaissance Technologies | 0.00% | Reduce -7.4% | 59,914 | $441K |
| Quadrature Capital Ltd | 0.00% | New | 59,708 | $439K |
| State Street Corp. | 0.00% | Add +27.2% | 58,942 | $434K |
| Royal Bank of Canada | 0.00% | Add +761.3% | 58,000 | $427K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | New | 57,212 | $421K |
| Jump Financial, LLC | 0.01% | New | 53,816 | $396K |
| DAFNA Capital Management LLC | 0.09% | New | 51,000 | $375K |
| ADAR1 Capital Management, LLC | 0.03% | Add +100.0% | 50,000 | $368K |
| Bank of America Corp. | 0.00% | Add +51057.4% | 48,088 | $354K |
| Trexquant Investment LP | 0.00% | New | 41,733 | $307K |
| Silverback Asset Management LLC | 0.81% | No change | 40,000 | $294K |
| Jane Street Group, LLC | 0.00% | New | 35,533 | $262K |
| Simplex Trading, LLC | 0.01% | Add +460.7% | 32,868 | $242K |
| Citadel Advisors | 0.00% | New | 31,709 | $233K |
| Northern Trust Corp. | 0.00% | Add +53.8% | 29,023 | $214K |
| Prelude Capital Management, LLC | 0.02% | New | 28,723 | $211K |
| Baird Financial Group, Inc. | 0.00% | Add +8.0% | 27,993 | $206K |
| Persistent Asset Partners Ltd | 0.06% | New | 18,316 | $135K |
| Tudor Investment Corporation | 0.00% | New | 12,922 | $95K |
| XTX Topco Ltd | 0.00% | Reduce -17.3% | 11,904 | $88K |
| Bank of New York Mellon Corp | 0.00% | Add +0.0% | 11,087 | $82K |
| T. Rowe Price Associates Inc. | 0.00% | No change | 10,886 | $81K |
| Morgan Stanley | 0.00% | Reduce -65.6% | 8,858 | $65K |
| Barclays PLC | 0.00% | No change | 4,109 | $30K |
| Acadian Asset Management LLC | 0.00% | New | 3,726 | $27K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 3,203 | $24K |
| JPMorgan Chase & Co. | 0.00% | Add +216.6% | 1,741 | $13K |
| Rockefeller Capital Management L.P. | 0.00% | New | 733 | $5K |
| FMR LLC | 0.00% | No change | 679 | $5K |
| Aspect Partners, LLC | 0.00% | New | 391 | $3K |
| Osaic Holdings, Inc. | 0.00% | Reduce -18.5% | 282 | $2K |
| Quent Capital, LLC | 0.00% | Add +1.7% | 235 | $2K |
| Mb, Levis & Associates, LLC | 0.00% | No change | 100 | $736 |
| Harbour Investments, Inc. | 0.00% | No change | 85 | $626 |
| BNP Paribas Financial Markets | 0.00% | No change | 82 | $604 |
| SBI Securities Co., Ltd. | 0.00% | No change | 74 | $545 |
| Activest Wealth Management | 0.00% | No change | 66 | $486 |
| Allworth Financial LP | 0.00% | No change | 26 | $192 |
| West Branch Capital LLC | 0.00% | No change | 3 | $23 |
| CIBC Private Wealth Group LLC | 0.00% | No change | 3 | $22 |
| Citigroup Inc. | 0.00% | Reduce -99.8% | 1 | $7 |
"% of holder's portfolio" is KPTI's weight in each manager's 13F, not the share of Karyopharm Therapeutics Inc. the manager owns.