Karyopharm TherapeuticsKPTI
13F holders, Q1 2026 (March 31)76holders +8
20new positions
13sold out
2famous investors
$5.57avg. 13F price*
At the end of Q1 2026, 76 institutions reported holding Karyopharm Therapeutics Inc. (KPTI) in their 13F filings, up 8 from Q4 2025. 20 opened new positions and 13 sold out. The largest holders were Commodore Capital LP ($10.9M), Ra Capital Management, L.P. ($10.7M) and Adage Capital Partners Gp, L.L.C. ($10.1M). 2 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Karyopharm Therapeutics Inc.
- CUSIP
- 48576U205
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 20 | $35.9M |
| Exits | 13 | $15.8M |
All 13F filers, Q4 2025 → Q1 2026: 10,621,866 shares bought and 2,710,017 shares sold, net +7,911,849 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 76 holders
| Commodore Capital LP | 0.63% | New | 1,950,000 | $10.9M |
| Ra Capital Management, L.P. | 0.11% | New | 1,917,354 | $10.7M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | Add +328.7% | 1,806,322 | $10.1M |
| T. Rowe Price Investment Management, Inc. | 0.01% | Add +3.4% | 1,542,090 | $8.6M |
| Goldman Sachs Group Inc. | 0.00% | New | 947,579 | $5.3M |
| Catalio Capital Management, LP | 1.04% | Add +527.8% | 897,709 | $5.0M |
| Vanguard Capital Management LLC | 0.00% | — | 739,745 | $4.1M |
| Ikarian Capital, LLC | 0.58% | Add +34.7% | 733,435 | $4.1M |
| Affinity Asset Advisors, LLC | 0.17% | Reduce -43.8% | 500,000 | $2.8M |
| Avidity Partners Management LP | 0.52% | Add +244.6% | 463,741 | $2.6M |
| Soleus Capital Management, L.P. | 0.10% | No change | 440,000 | $2.5M |
| Millennium Management | 0.00% | New | 420,571 | $2.3M |
| Boxer Capital Management, LLC | 0.22% | Add +19.8% | 302,536 | $1.7M |
| Davidson Kempner Capital Management LP | 0.05% | Reduce -3.2% | 300,000 | $1.7M |
| Acorn Capital Advisors, LLC | 0.46% | New | 287,826 | $1.6M |
| Eversept Partners, LP | 0.10% | New | 276,174 | $1.5M |
| Jump Financial, LLC | 0.02% | Add +387.1% | 262,146 | $1.5M |
| Trexquant Investment LP | 0.01% | Add +518.0% | 257,903 | $1.4M |
| Acadian Asset Management LLC | 0.00% | Add +6581.6% | 248,957 | $1.4M |
| BlackRock, Inc. | 0.00% | Reduce -1.1% | 244,899 | $1.4M |
| Boothbay Fund Management, LLC | 0.03% | Add +47.8% | 213,810 | $1.2M |
| Brevan Howard Capital Management LP | 0.01% | New | 212,367 | $1.2M |
| Geode Capital Management, LLC | 0.00% | Add +9.8% | 206,133 | $1.1M |
| UBS Group AG | 0.00% | Add +119.3% | 194,017 | $1.1M |
| Group One Trading LLC | 0.04% | Add +87.0% | 191,527 | $1.1M |
| XTX Topco Ltd | 0.02% | Add +1281.4% | 164,443 | $916K |
| Two Sigma Investments, LP | 0.00% | Add +1.6% | 151,232 | $842K |
| ADAR1 Capital Management, LLC | 0.05% | Add +173.5% | 136,736 | $762K |
| Marshall Wace, LLP | 0.00% | No change | 128,451 | $715K |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 114,934 | $640K |
| Engineers Gate Manager LP | 0.01% | New | 112,432 | $626K |
| Jane Street Group, LLC | 0.00% | Add +198.0% | 105,901 | $590K |
| Renaissance Technologies | 0.00% | Add +75.9% | 105,414 | $587K |
| C WorldWide Group Holding A/S | 0.01% | No change | 100,000 | $557K |
| State Street Corp. | 0.00% | Add +37.0% | 80,742 | $450K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | Add +38.2% | 79,081 | $440K |
| Bridgeway Capital Management, LLC | 0.01% | Add +9.1% | 71,873 | $400K |
| Balyasny Asset Management L.P. | 0.00% | New | 70,748 | $394K |
| Silverback Asset Management LLC | 1.35% | Add +62.5% | 65,000 | $362K |
| Royal Bank of Canada | 0.00% | Add +4.1% | 60,399 | $336K |
| Tetragon Partners GP Ltd | 0.06% | New | 52,984 | $295K |
| DAFNA Capital Management LLC | 0.06% | Reduce -10.2% | 45,800 | $255K |
| Northern Trust Corp. | 0.00% | Add +32.9% | 38,556 | $215K |
| Zimmer Partners, LP | 0.01% | New | 37,500 | $209K |
| Centiva Capital, LP | 0.01% | New | 30,210 | $168K |
| China Universal Asset Management Co., Ltd. | 0.01% | New | 30,000 | $167K |
| Baird Financial Group, Inc. | 0.00% | Add +6.4% | 29,791 | $166K |
| Susquehanna Portfolio Strategies, LLC | 0.00% | New | 25,021 | $139K |
| Susquehanna International Group, LLP | 0.00% | Reduce -83.7% | 24,138 | $134K |
| Bank of America Corp. | 0.00% | Reduce -59.5% | 19,472 | $108K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 19,400 | $108K |
| Morgan Stanley | 0.00% | Add +109.6% | 18,570 | $103K |
| Invesco Ltd. | 0.00% | New | 16,738 | $93K |
| Velan Capital Investment Management LP | 0.05% | New | 15,000 | $84K |
| Charles Schwab Investment Management Inc. | 0.00% | New | 13,429 | $75K |
| HSBC Holdings PLC | 0.00% | New | 11,495 | $66K |
| Bank of New York Mellon Corp | 0.00% | Add +2.8% | 11,399 | $63K |
| T. Rowe Price Associates Inc. | 0.00% | No change | 10,886 | $61K |
| Vanguard Global Advisers, LLC | 0.00% | — | 8,207 | $46K |
| Barclays PLC | 0.00% | Add +80.7% | 7,424 | $41K |
| Citigroup Inc. | 0.00% | Add +494000.0% | 4,941 | $28K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 3,203 | $19K |
| Rockefeller Capital Management L.P. | 0.00% | No change | 733 | $4K |
| FMR LLC | 0.00% | Reduce -2.1% | 665 | $4K |
| JPMorgan Chase & Co. | 0.00% | Reduce -73.0% | 471 | $2K |
| Osaic Holdings, Inc. | 0.00% | Add +42.5% | 402 | $2K |
| Harbour Investments, Inc. | 0.00% | Add +235.3% | 285 | $2K |
| Quent Capital, LLC | 0.00% | No change | 235 | $1K |
| Mb, Levis & Associates, LLC | 0.00% | No change | 100 | $557 |
| BNP Paribas Financial Markets | 0.00% | Add +2.4% | 84 | $468 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -9.5% | 67 | $373 |
| Activest Wealth Management | 0.00% | No change | 66 | $368 |
| Allworth Financial LP | 0.00% | No change | 26 | $145 |
| Advisory Services Network, LLC | 0.00% | New | 12 | $67 |
| West Branch Capital LLC | 0.00% | No change | 3 | $17 |
| PlanVest Financial, Inc | 0.00% | — | 1 | $6 |
"% of holder's portfolio" is KPTI's weight in each manager's 13F, not the share of Karyopharm Therapeutics Inc. the manager owns.