Lexicon PharmaceuticalsLXRX
13F holders, Q3 2025 (September 30)123holders
18new positions
17sold out
4famous investors
$1.35avg. 13F price*
At the end of Q3 2025, 123 institutions reported holding Lexicon Pharmaceuticals Inc. (LXRX) in their 13F filings, unchanged from Q2 2025. 18 opened new positions and 17 sold out. The largest holders were Artal Group S.A. ($183.8M), Siren, L.L.C. ($52.5M) and FMR LLC ($52.2M). 4 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Lexicon Pharmaceuticals Inc.
- CUSIP
- 528872302
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 18 | $5.6M |
| Exits | 17 | $1.1M |
All 13F filers, Q2 2025 → Q3 2025: 8,926,639 shares bought and 10,059,363 shares sold, net −1,132,724 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 123 holders
| Artal Group S.A. | 24.25% | No change | 136,180,481 | $183.8M |
| Siren, L.L.C. | 2.06% | No change | 38,918,903 | $52.5M |
| FMR LLC | 0.00% | Add +1.4% | 38,679,748 | $52.2M |
| Vanguard Group Inc. | 0.00% | Add +7.6% | 9,521,874 | $12.9M |
| Millennium Management | 0.00% | Add +133.1% | 3,830,660 | $5.2M |
| BlackRock, Inc. | 0.00% | Add +1.2% | 3,394,972 | $4.6M |
| Sessa Capital IM, L.P. | 0.10% | No change | 3,000,000 | $4.0M |
| Citadel Advisors | 0.00% | New | 2,634,027 | $3.6M |
| CIBC Private Wealth Group LLC | 0.01% | Reduce -2.0% | 2,400,257 | $3.2M |
| Geode Capital Management, LLC | 0.00% | Add +0.8% | 2,397,923 | $3.2M |
| Gsa Capital Partners LLP | 0.14% | Reduce -57.5% | 1,202,906 | $1.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +29.6% | 1,144,632 | $1.5M |
| Susquehanna International Group, LLP | 0.00% | Add +27.3% | 962,060 | $1.3M |
| State Street Corp. | 0.00% | Add +7.5% | 880,121 | $1.2M |
| Schonfeld Strategic Advisors LLC | 0.01% | Reduce -82.0% | 825,633 | $1.1M |
| Hennion & Walsh Asset Management, Inc. | 0.04% | Reduce -1.8% | 779,212 | $1.1M |
| Royal Bank of Canada | 0.00% | Reduce -6.7% | 722,435 | $975K |
| Jacobs Levy Equity Management, Inc. | 0.00% | New | 692,727 | $935K |
| Two Sigma Investments, LP | 0.00% | Add +38.4% | 559,008 | $755K |
| Invesco Ltd. | 0.00% | Add +23.9% | 521,403 | $704K |
| Jane Street Group, LLC | 0.00% | Reduce -43.3% | 456,530 | $616K |
| Compagnie Lombard Odier SCmA | 0.01% | Add +24.2% | 410,000 | $554K |
| Northern Trust Corp. | 0.00% | Reduce -11.2% | 369,794 | $499K |
| UBS Group AG | 0.00% | Reduce -11.9% | 352,922 | $476K |
| Monaco Asset Management SAM | 0.18% | Reduce -34.2% | 350,000 | $473K |
| XTX Topco Ltd | 0.02% | Add +397.2% | 329,536 | $445K |
| AQR Capital Management | 0.00% | Reduce -78.4% | 302,931 | $409K |
| Renaissance Technologies | 0.00% | New | 292,400 | $395K |
| Quadrature Capital Ltd | 0.00% | New | 228,209 | $309K |
| Group One Trading LLC | 0.01% | Reduce -37.6% | 216,244 | $292K |
| Ikarian Capital, LLC | 0.05% | No change | 176,479 | $238K |
| Morgan Stanley | 0.00% | Add +28.6% | 169,018 | $228K |
| Cerity Partners LLC | 0.00% | Reduce -23.4% | 158,040 | $213K |
| Jefferies Financial Group Inc. | 0.00% | New | 97,400 | $131K |
| LPL Financial LLC | 0.00% | Reduce -12.6% | 91,258 | $123K |
| Optiver Holding B.V. | 0.00% | Add +2400.6% | 75,893 | $102K |
| Simplex Trading, LLC | 0.00% | Add +39.1% | 73,287 | $98K |
| Bank of Montreal | 0.00% | Reduce -30.0% | 70,000 | $95K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Add +1.9% | 66,567 | $90K |
| China Universal Asset Management Co., Ltd. | 0.01% | Reduce -12.7% | 63,698 | $86K |
| Cubist Systematic Strategies, LLC | 0.00% | Reduce -59.9% | 63,484 | $86K |
| Straight Path Wealth Management | 0.02% | No change | 62,666 | $85K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -81.8% | 59,347 | $80K |
| Fortis Group Advisors, LLC | 0.01% | No change | 57,800 | $80K |
| Squarepoint Ops LLC | 0.00% | Reduce -38.6% | 58,676 | $79K |
| Bank of America Corp. | 0.00% | Add +80.1% | 57,804 | $78K |
| Boothbay Fund Management, LLC | 0.00% | No change | 56,120 | $76K |
| Pinnacle Associates Ltd. | 0.00% | No change | 50,815 | $69K |
| Headlands Technologies LLC | 0.01% | New | 49,647 | $67K |
| HRT Financial LP | 0.00% | Reduce -90.5% | 46,447 | $62K |
| Wedbush Securities Inc. | 0.00% | No change | 40,850 | $55K |
| Catalyst Funds Management Pty Ltd | 0.01% | Reduce -24.9% | 40,300 | $54K |
| Acadian Asset Management LLC | 0.00% | New | 36,905 | $49K |
| University of Texas/Texas Am Investment Management Co. | 0.01% | No change | 35,714 | $48K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -60.7% | 35,738 | $48K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.01% | Reduce -50.0% | 35,024 | $47K |
| Prudential Financial Inc. | 0.00% | New | 35,000 | $47K |
| Vermillion & White Wealth Management Group, LLC | 0.03% | Add +400.0% | 32,500 | $44K |
| R Squared Ltd | 0.02% | Add +8.4% | 32,049 | $43K |
| Barclays PLC | 0.00% | Reduce -1.3% | 31,862 | $43K |
| Pathstone Holdings, LLC | 0.00% | Add +0.6% | 30,208 | $41K |
| JPMorgan Chase & Co. | 0.00% | Add +21.7% | 30,037 | $41K |
| KWB Wealth | 0.00% | No change | 40,640 | $38K |
| Cwm, LLC | 0.00% | Reduce -75.5% | 26,744 | $36K |
| Scientech Research LLC | 0.01% | Reduce -57.0% | 24,884 | $34K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Add +8.8% | 23,400 | $32K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +86.6% | 23,679 | $32K |
| Oppenheimer & Co. Inc. | 0.00% | No change | 23,500 | $32K |
| Wolverine Trading, LLC | 0.00% | New | 21,191 | $29K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -74.7% | 18,877 | $29K |
| Victory Capital Management Inc. | 0.00% | Reduce -0.4% | 21,023 | $28K |
| Invera Wealth Advisors, LLC | 0.02% | No change | 20,000 | $27K |
| Tiaa Trust, National Association | 0.00% | No change | 20,000 | $27K |
| Bank of New York Mellon Corp | 0.00% | No change | 19,124 | $26K |
| Citigroup Inc. | 0.00% | Reduce -62.7% | 18,119 | $24K |
| Cetera Investment Advisers | 0.00% | New | 17,524 | $24K |
| Ieq Capital, LLC | 0.00% | Reduce -91.5% | 16,266 | $22K |
| Two Sigma Securities, LLC | 0.00% | Reduce -62.5% | 15,881 | $21K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -21.8% | 15,047 | $20K |
| Captrust Financial Advisors | 0.00% | Reduce -60.5% | 14,069 | $19K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +0.1% | 14,049 | $19K |
| Truist Financial Corp. | 0.00% | No change | 14,000 | $19K |
| HBK Sorce Advisory LLC | 0.00% | No change | 11,786 | $18K |
| ProShare Advisors LLC | 0.00% | Reduce -4.5% | 12,946 | $17K |
| Chemistry Wealth Management LLC | 0.00% | No change | 12,000 | $16K |
| North Star Asset Management Inc. | 0.00% | No change | 11,500 | $16K |
| SG Americas Securities, LLC | 0.00% | Reduce -21.6% | 10,830 | $15K |
| Perennial Investment Advisors, LLC | 0.00% | No change | 10,990 | $15K |
| Berger Financial Group, Inc | 0.00% | No change | 10,929 | $15K |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -49.7% | 10,785 | $15K |
| NBT Bank, N.A. | 0.00% | No change | 10,000 | $14K |
| State of Wyoming | 0.00% | New | 8,526 | $12K |
| GF Fund Management Co. LTD. | 0.00% | New | 7,818 | $11K |
| Arax Advisory Partners | 0.00% | New | 5,097 | $7K |
| BNP Paribas Financial Markets | 0.00% | Reduce -42.7% | 4,988 | $7K |
| Golden State Wealth Management, LLC | 0.00% | No change | 3,700 | $5K |
| Advisory Services Network, LLC | 0.00% | New | 3,242 | $4K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 2,592 | $3K |
| Daiwa Securities Group Inc. | 0.00% | No change | 1,369 | $2K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 1,461 | $2K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 1,412 | $2K |
| Rialto Wealth Management, LLC | 0.00% | No change | 1,313 | $2K |
| Farther Finance Advisors, LLC | 0.00% | Add +25.3% | 1,255 | $2K |
| Global Retirement Partners, LLC | 0.00% | No change | 1,000 | $1K |
| Caitong International Asset Management Co., Ltd | 0.00% | New | 959 | $1K |
| Jones Financial Companies LLLP | 0.00% | Reduce -56.3% | 892 | $1K |
| Avion Wealth | 0.00% | No change | 1,333 | $1K |
| Fortitude Family Office, LLC | 0.00% | No change | 706 | $953 |
| Osaic Holdings, Inc. | 0.00% | No change | 742 | $816 |
| Federation des caisses Desjardins du Quebec | 0.00% | New | 571 | $771 |
| Northwestern Mutual Wealth Management Co. | 0.00% | Add +2.8% | 514 | $694 |
| Essential Partners LLC | 0.00% | Reduce -76.0% | 511 | $690 |
| TFC Financial Management, Inc. | 0.00% | New | 500 | $675 |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -60.9% | 455 | $615 |
| Rockefeller Capital Management L.P. | 0.00% | New | 335 | $452 |
| Wells Fargo & Company | 0.00% | Reduce -98.9% | 301 | $406 |
| Syntax Research, Inc. | 0.00% | No change | 142 | $192 |
| Comerica Bank | 0.00% | No change | 122 | $165 |
| Larson Financial Group LLC | 0.00% | No change | 100 | $135 |
| True Wealth Design, LLC | 0.00% | Reduce -88.6% | 85 | $115 |
| Point72 (DIFC) Ltd | 0.00% | Reduce -99.8% | 15 | $20 |
| IFP Advisors, Inc | 0.00% | No change | 1 | $1 |
| Covestor Ltd | 0.00% | No change | 81 | $0 |
"% of holder's portfolio" is LXRX's weight in each manager's 13F, not the share of Lexicon Pharmaceuticals Inc. the manager owns.